Kyung‐Bok Lee
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View article: Reading the immune clock: a machine learning model predicts mouse immune age from cellular patterns
Reading the immune clock: a machine learning model predicts mouse immune age from cellular patterns Open
Aging is accompanied by profound alterations in the immune system; yet, an accurate prediction of immunological age remains challenging. While transcriptomic approaches have yielded insights into immune aging, protein-level profiling and m…
View article: Distinct spatiotemporal patterns of white matter hyperintensity progression
Distinct spatiotemporal patterns of white matter hyperintensity progression Open
White matter hyperintensity, a key imaging biomarker for brain health, has prognostic implications for stroke. Using a multicenter MRI dataset of 9179 stroke patients plus the UK Biobank (n = 36,210 low/high risk controls), we employ Subty…
View article: Acute Stroke Neurologist Certification: Expected Effects and Significance
Acute Stroke Neurologist Certification: Expected Effects and Significance Open
View article: Oxiracetam and physical activity in preventing cognitive decline after stroke: A multicenter, randomized controlled trial
Oxiracetam and physical activity in preventing cognitive decline after stroke: A multicenter, randomized controlled trial Open
Introduction: This multicenter, double-blind, placebo-controlled trial, commissioned by South Korea’s Ministry of Food and Drug Safety, evaluated the effect of oxiracetam for preventing post-stroke cognitive impairment (PSCI) and explored …
View article: Imaging the Binding Between Dasatinib and Its Target Protein in Living Cells Using an SLP Tag System on Intracellular Compartments
Imaging the Binding Between Dasatinib and Its Target Protein in Living Cells Using an SLP Tag System on Intracellular Compartments Open
Interactions between chemical drugs and their target proteins are fundamental to drug screening and precision therapy in modern clinical medicine. However, elucidating these interactions within living cells remains challenging due to the l…
View article: Imaging the Binding between Dasatinib and Its Target Protein in Living Cells Using an SPL Tag System on Intracellular Compartments
Imaging the Binding between Dasatinib and Its Target Protein in Living Cells Using an SPL Tag System on Intracellular Compartments Open
Interactions between chemical drugs and their target proteins are fundamental to drug screening and precision therapy in modern clinical medicine. However, elucidating these interactions within living cells remains challenging due to the l…
View article: Distinct Spatiotemporal Patterns of White Matter Hyperintensity Progression
Distinct Spatiotemporal Patterns of White Matter Hyperintensity Progression Open
White matter hyperintensity (WMH), a key imaging marker for brain health and the most prevalent brain abnormality in the general population, has prognostic implications for stroke. However, as a prognostic factor, WMH is hard to apply beca…
View article: Audio Visual Segmentation Through Text Embeddings
Audio Visual Segmentation Through Text Embeddings Open
The goal of Audio-Visual Segmentation (AVS) is to localize and segment the sounding source objects from video frames. Research on AVS suffers from data scarcity due to the high cost of fine-grained manual annotations. Recent works attempt …
View article: Facile Electrode Manufacturing Strategy for Ultra-Low Cobalt Consumption in Oxygen Evolution Reaction
Facile Electrode Manufacturing Strategy for Ultra-Low Cobalt Consumption in Oxygen Evolution Reaction Open
Water splitting is a sustainable method of hydrogen production that is crucial for achieving carbon neutrality. However, the high cost of green hydrogen remains a major challenge. One strategy to reduce costs is the use of non-precious met…
View article: Imaging the Binding between a Chemical Drug and its Target Proteins in Living Cells via CID and Protein Redistribution
Imaging the Binding between a Chemical Drug and its Target Proteins in Living Cells via CID and Protein Redistribution Open
View article: Magnetic resonance imaging‐negative cerebral amyloid angiopathy: cerebrospinal fluid amyloid‐β<sub>42</sub> over amyloid positron emission tomography
Magnetic resonance imaging‐negative cerebral amyloid angiopathy: cerebrospinal fluid amyloid‐β<sub>42</sub> over amyloid positron emission tomography Open
Background Cerebral amyloid angiopathy (CAA) pathology is becoming increasingly important in Alzheimer’s disease (AD) because of its potential link to amyloid‐related imaging abnormalities, a critical side effect observed during AD immunot…
View article: Imaging the Raf–MEK–ERK Signaling Cascade in Living Cells
Imaging the Raf–MEK–ERK Signaling Cascade in Living Cells Open
Conventional biochemical methods for studying cellular signaling cascades have relied on destructive cell disruption. In contrast, the live cell imaging of fluorescent-tagged transfected proteins offers a non-invasive approach to understan…
View article: Effects of white matter hyperintensity burden on functional outcome after mild versus moderate-to-severe ischemic stroke
Effects of white matter hyperintensity burden on functional outcome after mild versus moderate-to-severe ischemic stroke Open
It is uncertain whether the prognostic power of white matter hyperintensity (WMH) on post-stroke outcomes is modulated as a function of initial neurological severity, a critical determinant of outcome after stroke. This multi-center MRI st…
View article: Imaging the Raf–MEK–ERK Signaling Cascade in Living Cells
Imaging the Raf–MEK–ERK Signaling Cascade in Living Cells Open
Conventional biochemical methods for studying cellular signaling cascades have relied on destructive cell disruption. In contrast, live cell imaging of fluorescent-tagged transfected proteins offers a non-invasive approach to understanding…
View article: A Multi-Stream Fusion Approach with One-Class Learning for Audio-Visual Deepfake Detection
A Multi-Stream Fusion Approach with One-Class Learning for Audio-Visual Deepfake Detection Open
This paper addresses the challenge of developing a robust audio-visual deepfake detection model. In practical use cases, new generation algorithms are continually emerging, and these algorithms are not encountered during the development of…
View article: Fugetaxis of Cell‐in‐Catalytic‐Coat Nanobiohybrids in Glucose Gradients (Small 41/2023)
Fugetaxis of Cell‐in‐Catalytic‐Coat Nanobiohybrids in Glucose Gradients (Small 41/2023) Open
Single-Cell Nanoencapsulation The chemotaxis of Jurkat cells in the glucose gradient is altered from positive to negative when glucose oxidase is attached to cell surfaces, forming cell-in-catalytic-coat structures. The redirected fugetaxi…
View article: Early Administration of Edoxaban After Acute Ischemic Stroke in Patients With Non-valvular Atrial Fibrillation: A Pilot Randomized Trial
Early Administration of Edoxaban After Acute Ischemic Stroke in Patients With Non-valvular Atrial Fibrillation: A Pilot Randomized Trial Open
Without anticoagulation, the risk of early recurrence in the first 14 days after atrial fibrillation (AF)-related ischemic stroke is approximately 0.5%-1.3%per day. 1 Anticoagulation is an essential strategy for preventing recurrent stroke…
View article: Biological Mechanism of Sex Difference in Stroke Manifestation and Outcomes
Biological Mechanism of Sex Difference in Stroke Manifestation and Outcomes Open
Female patients have more frequent MCA disease and striatocapsular motor pathway involvement with acute ischemic stroke, along with left parieto-occipital cortical infarcts showing greater severity for equivalent infarct volumes than in ma…
View article: Differences in Neurotransmitters Level as Biomarker on Sleep Effects in Dementia Patients with Insomnia after Essential Oils Treatment
Differences in Neurotransmitters Level as Biomarker on Sleep Effects in Dementia Patients with Insomnia after Essential Oils Treatment Open
This study aimed to examine the effects of several essential oils on insomnia in dementia patients following transdermal treatment (aromatherapy). The mean change rates (%) of sleep biomarkers were compared between the single essential and…
View article: Comparison of Electrochemical Performance of Lithium Ion Batteries Fabricated by Silica Nanoparticles with Different Surface Structure
Comparison of Electrochemical Performance of Lithium Ion Batteries Fabricated by Silica Nanoparticles with Different Surface Structure Open
리튬이온전지의 음극소재인 실리콘은 4,200 ㎃h/g의 높은 이론적 전기용량을 가지고 있지만, 충전과 방전 과정 중에서의 부피팽창률 또한 400 %로 크기 때문에 리튬이온전지의 음극소재로 적용하는데 한계가 있다. 이러한 문제점을 해결하기 위하여 다양한 연구가 진행되고 있다. 본 연구에서는 서로 다른 표면구조를 갖고 있는 구형의 실리카 나노입자를 Stöber 합성법(솔리드 실리카)과 마이크로에멀젼 합성법(메조포러스 실리카)으로…
View article: Workload in Emergency Rooms among Clinical Specialties and Overburdened Neurologists
Workload in Emergency Rooms among Clinical Specialties and Overburdened Neurologists Open
Background: To evaluate workload in emergency rooms (ERs) among clinical specialties including neurology and investigate characteristics of neurological consultations in ER.Methods: A nationwide survey was conducted to evaluate the number …
View article: Reply to Cattoretti: Specificity of anti-MYC antibodies
Reply to Cattoretti: Specificity of anti-MYC antibodies Open
View article: Author Index
Author Index Open
View article: Author Index
Author Index Open
View article: Cerium AminoclayA Potential Hybrid Biomaterialfor Anticancer Therapy
Cerium AminoclayA Potential Hybrid Biomaterialfor Anticancer Therapy Open
In this study, novel
biomedical properties of Ce-aminoclay (CeAC)
were investigated through in vitro and in vivo assays. CeAC (≥500
μg/mL) can selectively kill cancer cells (A549, Huh-1, AGS,
C33A, HCT116, and MCF-7 cells) while leaving mo…
View article: Mass cytometry–based single-cell analysis of human stem cell reprogramming uncovers differential regulation of specific pluripotency markers
Mass cytometry–based single-cell analysis of human stem cell reprogramming uncovers differential regulation of specific pluripotency markers Open
Human induced pluripotent stem cells (hiPSCs) are reprogrammed from somatic cells and are regarded as promising sources for regenerative medicine and disease research. Recently, techniques for analyses of individual cells, such as single-c…
View article: Improving collection efficiency in two-photon endoscopy with reflective waveguiding
Improving collection efficiency in two-photon endoscopy with reflective waveguiding Open
Two-photon endoscopy based on a gradient-index lens has been widely utilized for studying cellular behaviors in deep-lying tissues with minimal invasiveness in vivo. Although the efficient collection of emitted light is critical to attain …
View article: Meridianin C inhibits the growth of YD‐10B human tongue cancer cells through macropinocytosis and the down‐regulation of Dickkopf‐related protein‐3
Meridianin C inhibits the growth of YD‐10B human tongue cancer cells through macropinocytosis and the down‐regulation of Dickkopf‐related protein‐3 Open
Meridianin C is a marine natural product known for its anti‐cancer activity. At present, the anti‐tumour effects of meridianin C on oral squamous cell carcinoma are unknown. Here, we investigated the effect of meridianin C on the prolifera…
View article: Cordycepin induces apoptosis of human ovarian cancer cells by inhibiting CCL5-mediated Akt/NF-κB signaling pathway
Cordycepin induces apoptosis of human ovarian cancer cells by inhibiting CCL5-mediated Akt/NF-κB signaling pathway Open
View article: AZD1208, a pan‐Pim kinase inhibitor, inhibits adipogenesis and induces lipolysis in 3T3‐L1 adipocytes
AZD1208, a pan‐Pim kinase inhibitor, inhibits adipogenesis and induces lipolysis in 3T3‐L1 adipocytes Open
The proviral integration moloney murine leukaemia virus (Pim) kinases, consisting of Pim‐1, Pim‐2 and Pim‐3, are involved in the control of cell growth, metabolism and differentiation. Pim kinases are emerging as important mediators of adi…