Dongsheng Wei
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View article: An explainable dual-modal diagnostic model for coronary artery disease: a feature-gated approach using tongue and facial image features
An explainable dual-modal diagnostic model for coronary artery disease: a feature-gated approach using tongue and facial image features Open
Background and objective Coronary artery disease (CAD) is a major threat to human health, and early non-invasive identification is crucial for its prevention and management. However, current diagnostic methods still face limitations in ter…
View article: Genomic Insights Into Convergent Evolution: Adaptation to Rocky Habitats in Rock-Inhabiting Fungi
Genomic Insights Into Convergent Evolution: Adaptation to Rocky Habitats in Rock-Inhabiting Fungi Open
Rock-inhabiting fungi (RIF), obligate colonizers of bare rocks, are primarily distributed across two major phylogenetic classes: Dothideomycetes and Eurotiomycetes. These fungi display striking convergence in morphology and physiology, cha…
View article: Interlayer soil settlement prediction in the construction of under-crossing existing structures based on multi-parameter time series model
Interlayer soil settlement prediction in the construction of under-crossing existing structures based on multi-parameter time series model Open
View article: Iron acquisition in the mutualistic fungus <i>Penicillium herquei</i> : implications of mineral elements in insect-fungus symbiosis
Iron acquisition in the mutualistic fungus <i>Penicillium herquei</i> : implications of mineral elements in insect-fungus symbiosis Open
Mutualistic interactions between insects and fungi are pivotal in ecosystem dynamics, yet the underlying molecular mechanisms remain largely unexplored. This study investigates iron acquisition strategies of the mutualistic Penicillium her…
View article: Potential mechanisms of action of Jiao'ai decoction in the treatment of premature ovarian failure: Integrated molecular pathway, gut flora, and untargeted metabolism
Potential mechanisms of action of Jiao'ai decoction in the treatment of premature ovarian failure: Integrated molecular pathway, gut flora, and untargeted metabolism Open
Objective: To explore the pharmacological effects and molecular mechanisms of a Jiao'ai decoction (JAD) in treating premature ovarian failure. Specifically, we evaluated the receptor for advanced glycation end (RAGE) products pathway, meta…
View article: Sirtuin 5 inhibits mitochondrial metabolism in liver cancer cells and promotes apoptosis by mediating the desuccinylation of CS
Sirtuin 5 inhibits mitochondrial metabolism in liver cancer cells and promotes apoptosis by mediating the desuccinylation of CS Open
Background Citrate synthase (CS) is a key rate-limiting enzyme in the tricarboxylic acid (TCA) cycle and plays a crucial role in cancer progression. However, the mechanism by which CS promotes liver cancer growth remains unclear. The aim o…
View article: Exploring the clinical significance of anti-acetylcholine receptor antibody titers, changes, and change rates in Myasthenia Gravis
Exploring the clinical significance of anti-acetylcholine receptor antibody titers, changes, and change rates in Myasthenia Gravis Open
Introduction/Aims Myasthenia Gravis (MG) is a common neuromuscular junction disorder that is primarily mediated by anti-acetylcholine receptor antibodies (AChR-Ab). However, using AChR-Ab titers to predict MG severity and improvement remai…
View article: Bioinformatics-Based Exploration of the Ability of Ginkgetin to Alleviate the Senescence of Cardiomyocytes After Myocardial Infarction and Its Cardioprotective Effects
Bioinformatics-Based Exploration of the Ability of Ginkgetin to Alleviate the Senescence of Cardiomyocytes After Myocardial Infarction and Its Cardioprotective Effects Open
Ginkgetin inhibits postinfarction myocardial fibrosis and cardiomyocyte hypertrophy, scavenges oxygen free radicals, decreases postinfarction limbic cell inflammatory infiltration, suppresses activation of the inflammatory-immune pathway, …
View article: Targeted Modulation of Gut Microbiota by a Novel Fungal Protein Alleviates Obesity and Intestinal Inflammation
Targeted Modulation of Gut Microbiota by a Novel Fungal Protein Alleviates Obesity and Intestinal Inflammation Open
View article: Synergistic Bioremediation of Pentachloronitrobenzene-Contaminated Soil Via Engineered Fungal-Yeast Fusants and Agricultural Waste Amendments
Synergistic Bioremediation of Pentachloronitrobenzene-Contaminated Soil Via Engineered Fungal-Yeast Fusants and Agricultural Waste Amendments Open
View article: Appraising the Role of Circulating Concentrations of Micronutrients in Hypertension: A Two-sample, Multivariable Mendelian Randomization Study
Appraising the Role of Circulating Concentrations of Micronutrients in Hypertension: A Two-sample, Multivariable Mendelian Randomization Study Open
Background: Hypertension poses a significant global health challenge, warranting exploration of novel preventive measures. This study aimed to investigate the role of circulating concentrations of various micronutrients in hypertension usi…
View article: Simulation of Localized Stress Impact on Solidification Pattern during Plasma Cladding of WC Particles in Nickel-Based Alloys by Phase-Field Method
Simulation of Localized Stress Impact on Solidification Pattern during Plasma Cladding of WC Particles in Nickel-Based Alloys by Phase-Field Method Open
As materials science continues to advance, the correlation between microstructure and macroscopic properties has garnered growing interest for optimizing and predicting material performance under various operating conditions. The phase-fie…
View article: A Mixed-Criticality Traffic Scheduler with Mitigating Congestion for CAN-to-TSN Gateway
A Mixed-Criticality Traffic Scheduler with Mitigating Congestion for CAN-to-TSN Gateway Open
The network architecture that Time-Sensitive Networking (TSN) is used as the backbone network and the Controller Area Network (CAN) serves as the intra-domain network is considered as the CAN-TSN interconnection network architecture, which…
View article: Discovery of the first Tn630 member and the closest homolog of IS630 from viruses
Discovery of the first Tn630 member and the closest homolog of IS630 from viruses Open
Background: IS630/Tc1/mariner (ITm) represents the most widely distributed superfamily of DNA transposons in nature. Currently, bioinformatics research on ITm membersprimarily involves collecting data of existing and emerging members and o…
View article: A palisade-shaped membrane reservoir is required for rapid ring cell inflation in Drechslerella dactyloides
A palisade-shaped membrane reservoir is required for rapid ring cell inflation in Drechslerella dactyloides Open
View article: Enrichment Extraction and Activity Study of the Different Varieties of Hericium erinaceus against HCT-8 Colon Cancer Cells
Enrichment Extraction and Activity Study of the Different Varieties of Hericium erinaceus against HCT-8 Colon Cancer Cells Open
Hericium erinaceus (HE), a widely utilized natural remedy and dietary source, has garnered significant attention for its therapeutic potential in various diseases. In this study, we employed supercritical fluid extraction (SFE) technology …
View article: Myasthenia-like paraneoplastic syndrome with multiple cranial nerve tumor infiltration: A case report and literature review
Myasthenia-like paraneoplastic syndrome with multiple cranial nerve tumor infiltration: A case report and literature review Open
Rationale: Approximately 0.001% of patients with cancer have paraneoplastic nerve system syndrome, which can affect the central nervous system, neuromuscular junction, or peripheral nervous system. Although myasthenia gravis (MG) may exist…
View article: NR4A2 may be a potential diagnostic biomarker for myocardial infarction: A comprehensive bioinformatics analysis and experimental validation
NR4A2 may be a potential diagnostic biomarker for myocardial infarction: A comprehensive bioinformatics analysis and experimental validation Open
Background Myocardial infarction is a well-established severe consequence of coronary artery disease. However, the lack of effective early biomarkers accounts for the lag time before clinical diagnosis of myocardial infarction. The present…
View article: SNARE Protein DdVam7 of the Nematode-Trapping Fungus <i>Drechslerella dactyloides</i> Regulates Vegetative Growth, Conidiation, and the Predatory Process via Vacuole Assembly
SNARE Protein DdVam7 of the Nematode-Trapping Fungus <i>Drechslerella dactyloides</i> Regulates Vegetative Growth, Conidiation, and the Predatory Process via Vacuole Assembly Open
D. dactyloides is a nematode-trapping fungus that can capture nematodes through a constricting ring, the most sophisticated trapping device. It is amazing that constricting ring cells can inflate to triple their size within seconds to capt…
View article: Investigations on the Fusants From Wide Cross Between White-Rot Fungi and Saccharomyces cerevisiae Reveal Unknown Lignin Degradation Mechanism
Investigations on the Fusants From Wide Cross Between White-Rot Fungi and Saccharomyces cerevisiae Reveal Unknown Lignin Degradation Mechanism Open
The degradation of lignocellulose by fungi, especially white-rot fungi, contributes a lot to carbon cycle, bio-fuel production, and many other bio-based applications. However, the existing enzymatic and non-enzymatic degradation mechanisms…
View article: Full-Length Genome of an Ogataea polymorpha Strain CBS4732 ura3Δ Reveals Large Duplicated Segments in Subtelomeric Regions
Full-Length Genome of an Ogataea polymorpha Strain CBS4732 ura3Δ Reveals Large Duplicated Segments in Subtelomeric Regions Open
Background Currently, methylotrophic yeasts (e.g., Pichia pastoris , Ogataea polymorpha , and Candida boindii ) are subjects of intense genomics studies in basic research and industrial applications. In the genus Ogataea , most research is…
View article: Dicer promotes Atg8 expression through RNAi independent mechanism in <i>Cryptococcus neoformans</i>
Dicer promotes Atg8 expression through RNAi independent mechanism in <i>Cryptococcus neoformans</i> Open
ATG8 is one of the critical genes that participate in several essential autophagic steps. The expression of ATG8 must be exquisitely regulated to avoid physiological disorder and even cell death. However, the mechanisms of regulating ATG8 …
View article: Full-length Genome of a<i>Ogataea polymorpha</i>strain CBS4732<i>ura3</i>Δ reveals large duplicated segments in subtelomeric regions
Full-length Genome of a<i>Ogataea polymorpha</i>strain CBS4732<i>ura3</i>Δ reveals large duplicated segments in subtelomeric regions Open
Background Currently, methylotrophic yeasts (e.g., Pichia pastoris, Ogataea polymorpha , and Candida boindii ) are subjects of intense genomics studies in basic research and industrial applications. In the genus Ogataea , most research is …
View article: Effects of 5′-3′ Exonuclease Xrn1 on Cell Size, Proliferation and Division, and mRNA Levels of Periodic Genes in Cryptococcus neoformans
Effects of 5′-3′ Exonuclease Xrn1 on Cell Size, Proliferation and Division, and mRNA Levels of Periodic Genes in Cryptococcus neoformans Open
Cell size affects almost all biosynthetic processes by controlling the size of organelles and disrupting the nutrient uptake process. Yeast cells must reach a critical size to be able to enter a new cell cycle stage. Abnormal changes in ce…
View article: Conserved Autophagy Pathway Contributes to Stress Tolerance and Virulence and Differentially Controls Autophagic Flux Upon Nutrient Starvation in Cryptococcus neoformans
Conserved Autophagy Pathway Contributes to Stress Tolerance and Virulence and Differentially Controls Autophagic Flux Upon Nutrient Starvation in Cryptococcus neoformans Open
Autophagy is mainly a catabolic process, which is used to cope with nutrient deficiency and various stress conditions. Human environment often imposes various stresses on Cryptococcus neoformans, a major fungal pathogen of immunocom…
View article: Toonaciliatin K attenuates the lung injury induced by lung infection of H1N1 influenza virus by regulating the NF-κB/MyD88/TLR-7 pathway in mice
Toonaciliatin K attenuates the lung injury induced by lung infection of H1N1 influenza virus by regulating the NF-κB/MyD88/TLR-7 pathway in mice Open
Data of the study suggested that toonaciliatin K protects against lung injury in lung H1N1 lung infection by regulating the TLR-7/Myd88/NF-κB p65 pathway.
View article: A MYST Histone Acetyltransferase Modulates Conidia Development and Secondary Metabolism in Pestalotiopsis microspora, a Taxol Producer
A MYST Histone Acetyltransferase Modulates Conidia Development and Secondary Metabolism in Pestalotiopsis microspora, a Taxol Producer Open
Reverse genetics is a promising strategy for elucidating the regulatory mechanisms involved in secondary metabolism and development in fungi. Previous studies have demonstrated the key role of histone acetyltransferases in transcriptional …
View article: Distinct Roles of Velvet Complex in the Development, Stress Tolerance, and Secondary Metabolism in Pestalotiopsis microspora, a Taxol Producer
Distinct Roles of Velvet Complex in the Development, Stress Tolerance, and Secondary Metabolism in Pestalotiopsis microspora, a Taxol Producer Open
The velvet family proteins have been shown to play critical roles in fungal secondary metabolism and development. However, variations of the roles have been observed in different fungi. We report here the observation on the role of three v…
View article: The AMP-Activated Protein Kinase Homolog Snf1 Concerts Carbon Utilization, Conidia Production and the Biosynthesis of Secondary Metabolites in the Taxol-Producer Pestalotiopsis microspora
The AMP-Activated Protein Kinase Homolog Snf1 Concerts Carbon Utilization, Conidia Production and the Biosynthesis of Secondary Metabolites in the Taxol-Producer Pestalotiopsis microspora Open
Highly conserved, the Snf1/AMPK is a central regulator of carbon metabolism and energy production in the eukaryotes. However, its function in filamentous fungi has not been well established. In this study, we reported functional characteri…
View article: Seamless deletion of a large DNA fragment in the taxol-producing fungus Pestalotiopsis microspora
Seamless deletion of a large DNA fragment in the taxol-producing fungus Pestalotiopsis microspora Open
To reduce the unnecessary gene clusters in the taxol-producing fungus Pestalotiopsis microspora, we report the development of an effective DNA deletion method that relies on a deletion cassette constructed with the Gateway-technique and ov…