Explanipedia

A circular RNA derived from the ryanodine receptor 2 locus controls cardiac hypertrophy and calcium handling Open

Wen Pan, Hannah Jill Hunkler, Shambhabi Chatterjee, Dongchao Lu, Isabelle Riedel , et al. · 2025

Telomerase <span>modRNA</span> Offers a Novel <span>RNA</span> ‐Based Approach to Treat Human Pulmonary Fibrosis Open

Jiaqi Ye, Klaudia Grieger, Dongchao Lu, Christina Brandenberger, Malte Juchem , et al. · 2025

Pulmonary Fibrosis (PF) is a life‐threatening illness that is characterized by progressive scarring in the lung interstitium. There is an urgent need for new PF therapies because current treatments only slow down the progression of fibrosi…

EIF4A3 Promotes Muscle Atrophy and Aging by Inhibiting the FAK Pathway Through NEDD9 mRNA Destabilization Open

Qian Li, Xiaohang Yin, Wensi Wan, Yi Zhou, Siqi Wang , et al. · 2025

Background Muscle atrophy has a poor prognosis, caused by various factors. Identifying a shared treatment target could address an unmet clinical need. The exon junction complex (EJC), a protein complex assembly that binds to RNA, facilitat…

Circular RNA circIGF1R controls cardiac fibroblast proliferation through regulation of carbohydrate metabolism Open

Arne Schmidt, Kevin Schmidt, Sonja Groß, Dongchao Lu, Ke Xiao , et al. · 2025

Calcium Handling Machinery and Sarcomere Assembly are Impaired Through Multipronged Mechanisms in Cancer Cytokine‐Induced Cachexia Open

Luis Vincens Gand, Chiara Lanzuolo, Mugeng Li, Valentina Rosti, Natalie Weber , et al. · 2025

Background Cachexia is a severe form of muscle wasting disorder particularly observed in patients with advanced cancer. The absence of effective strategies to ameliorate cachexia indicates our poor understanding of the mechanisms of cachex…

Telomerase modRNA offers a novel RNA-based approach to treat human pulmonary fibrosis Open

Jiaqi Ye, Klaudia Grieger, Dongchao Lu, Christina Brandenberger, Malte Juchem , et al. · 2025

Pulmonary Fibrosis (PF) is a life-threatening illness that is characterized by progressive scarring in the lung interstitium. There is an urgent need for new PF therapies because current treatments only slow down the progression of fibrosi…

EIF4A3‐Induced Circular RNA CircDdb1 Promotes Muscle Atrophy through Encoding a Novel Protein CircDdb1‐867aa Open

Xiaolan Zhu, Tingting Yang, Yongjun Zheng, Qing Nie, Jingying Chen , et al. · 2024

Little is known about if and how circular RNAs (circRNAs) are involved in skeletal muscle atrophy. Here a conserved circular RNA Damage‐specific DNA binding protein 1 (circDdb1), derived from the host gene encoding Damage‐specific DNA bind…

A reporter system for live cell tracking of human cardiomyocyte proliferation Open

Alessia Costa, Hannah Jill Hunkler, Shambhabi Chatterjee, Sarah Cushman, Erika Hilbold , et al. · 2024

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Telomerase is essential for cardiac differentiation and sustained metabolism of human cardiomyocytes Open

Shambhabi Chatterjee, Megan Leach-Mehrwald, Cheng-Kai Huang, Ke Xiao, Maximilian Fuchs , et al. · 2024

Circular RNA circZFPM2 regulates cardiomyocyte hypertrophy and survival Open

Dimyana Neufeldt, Arne Schmidt, Elisa Mohr, Dongchao Lu, Shambhabi Chatterjee , et al. · 2024

Hypertrophic cardiomyopathy (HCM) constitutes the most common genetic cardiac disorder. However, current pharmacotherapeutics are mainly symptomatic and only partially address underlying molecular mechanisms. Circular RNAs (circRNAs) are a…

Telomerase is Essential for Cardiac Differentiation and Sustained Metabolism of Human Cardiomyocytes Open

Shambhabi Chatterjee, Megan Leach-Mehrwald, Cheng-Kai Huang, Ke Xiao, Maximilian Fuchs , et al. · 2023

A circular RNA derived from the insulin receptor locus protects against doxorubicin-induced cardiotoxicity Open

Dongchao Lu, Shambhabi Chatterjee, Ke Xiao, Isabelle Riedel, Cheng-Kai Huang , et al. · 2022

Aims Cardiotoxicity leading to heart failure (HF) is a growing problem in many cancer survivors. As specific treatment strategies are not available, RNA discovery pipelines were employed and a new and powerful circular RNA (circRNA)-based …

miR-486 attenuates cardiac ischemia/reperfusion injury and mediates the beneficial effect of exercise for myocardial protection Open

Yihua Bei, Dongchao Lu, Christian Bär, Shambhabi Chatterjee, Alessia Costa , et al. · 2022

The long non-coding RNA NRON promotes the development of cardiac hypertrophy in the murine heart Open

Jeannine Hoepfner, Julia Leonardy, Dongchao Lu, K. E. Schmidt, Hannah Jill Hunkler , et al. · 2021

Telomerase therapy attenuates cardiotoxic effects of doxorubicin Open

Shambhabi Chatterjee, Teresa Hofer, Alessia Costa, Dongchao Lu, Sándor Bátkai , et al. · 2020

Doxorubicin is one of the most potent chemotherapeutic agents. However, its clinical use is restricted due to the severe risk of cardiotoxicity, partially attributed to elevated production of reactive oxygen species (ROS). Telomerase canon…

MicroRNAs targeting the SARS-CoV-2 entry receptor ACE2 in cardiomyocytes Open

Dongchao Lu, Shambhabi Chatterjee, Ke Xiao, Isabelle Riedel, Yibin Wang , et al. · 2020

The World Health Organization (WHO) declared coronavirus disease 2019 (COVID-19) as a public health emergency of international concern as more than 15 million cases were reported by 24th July 2020. Angiotensin-converting enzyme 2 (ACE2) is…

Integrated infection control strategy to minimize nosocomial infection of coronavirus disease 2019 among ENT healthcare workers Open

Dongchao Lu, Huajun Wang, Rentao Yu, Hui Yang, Yunuo Zhao · 2020

Circulating microRNAs in Fabry Disease Open

Ke Xiao, Dongchao Lu, Jeannine Hoepfner, Laura Santer, Shashi Kumar Gupta , et al. · 2019

A large shRNA library approach identifies lncRNA Ntep as an essential regulator of cell proliferation Open

Julia Beermann, Dominique Kirste, Katharina Iwanov, Dongchao Lu, Felix Kleemiß , et al. · 2017

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