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View article: A G358S mutation in the Plasmodium falciparum Na+ pump PfATP4 confers clinically-relevant resistance to cipargamin
A G358S mutation in the Plasmodium falciparum Na+ pump PfATP4 confers clinically-relevant resistance to cipargamin Open
Diverse compounds target the Plasmodium falciparum Na + pump PfATP4, with cipargamin and (+)-SJ733 the most clinically-advanced. In a recent clinical trial for cipargamin, recrudescent parasites emerged, with most having a G358S mutation i…
View article: Generation and characterisation of <i>P. falciparum</i> parasites with a G358S mutation in the PfATP4 Na<sup>+</sup> pump and clinically relevant levels of resistance to some PfATP4 inhibitors
Generation and characterisation of <i>P. falciparum</i> parasites with a G358S mutation in the PfATP4 Na<sup>+</sup> pump and clinically relevant levels of resistance to some PfATP4 inhibitors Open
Small-molecule inhibitors of PfATP4, a Plasmodium falciparum protein that is believed to pump Na + out of the parasite while importing H + , are on track to become much-needed new antimalarial drugs. The spiroindolone cipargamin is poised …
View article: Consensus mutagenesis and ancestral reconstruction provide insight into the substrate specificity and evolution of the front-end Δ6-desaturase family
Consensus mutagenesis and ancestral reconstruction provide insight into the substrate specificity and evolution of the front-end Δ6-desaturase family Open
Marine algae are a major source of omega (ω)-3 long-chain polyunsaturated fatty acids (ω3-LCPUFAs), which are conditionally essential nutrients in humans and a target for industrial production. The biosynthesis of these molecules in marine…
View article: Characterization of the ATP4 ion pump in Toxoplasma gondii
Characterization of the ATP4 ion pump in Toxoplasma gondii Open
The Plasmodium falciparum ATPase PfATP4 is the target of a diverse range of antimalarial compounds, including the clinical drug candidate cipargamin. PfATP4 was originally annotated as a Ca2+ transporter, but recent evidence suggests that …
View article: Bioinformatics-based approaches to engineer the transmembrane Δ6 desaturase from Micromonas pusilla
Bioinformatics-based approaches to engineer the transmembrane Δ6 desaturase from Micromonas pusilla Open
The increased awareness of the health benefits of ω3-long chain polyunsaturated fatty acids (ω3-LCPUFAs) has led to a drastic increase in the consumption of fish-oil supplements. This has resulted in environmental concerns and the identifi…