Danying Zheng
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View article: Exome Sequencing Analysis and Clinical Features of a Chinese Patient with 3M Syndrome and A Review of Literature
Exome Sequencing Analysis and Clinical Features of a Chinese Patient with 3M Syndrome and A Review of Literature Open
This study identified a novel splicing mutation in the CUL7 gene in a patient with 3M syndrome, expanding the genetic spectrum of this disorder and contributing novel insights for clinical diagnosis and management.
View article: Enhancing Urban Drainage Resilience Through Holistic Stormwater Regulation: A Review
Enhancing Urban Drainage Resilience Through Holistic Stormwater Regulation: A Review Open
Under the dual pressures of global climate change and rapid urbanization, urban drainage systems (UDS) face severe challenges caused by extreme precipitation events and altered surface hydrological processes. The drainage paradigm is shift…
View article: Optimization of Low Impact Development Layouts for Urban Stormwater Management: A Simulation-Based Approach Using Multi-Objective Scatter Search Algorithm
Optimization of Low Impact Development Layouts for Urban Stormwater Management: A Simulation-Based Approach Using Multi-Objective Scatter Search Algorithm Open
In recent years, the urgent need to mitigate stormwater runoff and address urban waterlogging has garnered significant attention. Low Impact Development (LID) has emerged as a promising strategy for managing urban runoff sustainably. Howev…
View article: An integrated multi-omics analysis identifies protein biomarkers and potential drug targets for psoriatic arthritis
An integrated multi-omics analysis identifies protein biomarkers and potential drug targets for psoriatic arthritis Open
Psoriatic arthritis (PsA) is a complex, chronic immune-mediated inflammatory arthropathy that currently lacks definitive biomarkers and treatment targets. Identifying biomarkers and treatment targets is urgently needed for effectively mana…
View article: Integrated analysis of multi-omics data for the discovery of biomarkers and therapeutic targets for juvenile idiopathic arthritis
Integrated analysis of multi-omics data for the discovery of biomarkers and therapeutic targets for juvenile idiopathic arthritis Open
View article: Association of Retinal Nerve Fiber Layer Thinning With Elevated High Density Lipoprotein Cholesterol in UK Biobank
Association of Retinal Nerve Fiber Layer Thinning With Elevated High Density Lipoprotein Cholesterol in UK Biobank Open
This study revealed an association between HDL-C levels and retinal markers of neurodegenerative diseases, suggesting that elevated HDL-C may serve as a new risk factor for neurodegenerative conditions. These findings may contribute to the…
View article: Depressive and anxiety symptoms in caregivers of children with congenital ectopia lentis: a prospective cross-sectional study
Depressive and anxiety symptoms in caregivers of children with congenital ectopia lentis: a prospective cross-sectional study Open
Objectives To evaluate the frequency and severity of depressive and anxiety symptoms and explore possible risk factors among caregivers of children with congenital ectopia lentis (CEL). Design A prospective cross-sectional study was conduc…
View article: The burden, causes, and determinants of blindness and vision impairment in Asia: An analysis of the Global Burden of Disease Study
The burden, causes, and determinants of blindness and vision impairment in Asia: An analysis of the Global Burden of Disease Study Open
The burden due to vision loss remains high in Asian populations. Cataracts, refractive error, and near vision loss were the primary causes of blindness and vision loss. Greater investment in ocular disease prevention and care by countries …
View article: Autosomal dominant Weill-Marchesani-like syndrome in a Chinese family due to novel haplotypic mutations in LTBP2
Autosomal dominant Weill-Marchesani-like syndrome in a Chinese family due to novel haplotypic mutations in LTBP2 Open
Introduction: Weill-Marchesani syndrome (WMS) is a hereditary connective tissue disorder with substantial heterogeneity in clinical features and genetic etiology, so it is essential to define the full mutation spectrum for earlier diagnosi…
View article: Predicting Marfan Syndrome in Children With Congenital Ectopia Lentis: Development and Validation of a Nomogram
Predicting Marfan Syndrome in Children With Congenital Ectopia Lentis: Development and Validation of a Nomogram Open
The prediction model may help clinicians identify MFS in its early stages, which could reduce the likelihood of developing severe symptoms and improve MFS outcomes.
View article: Clinical and Genetic Landscape of Ectopia Lentis Based on a Cohort of Patients From 156 Families
Clinical and Genetic Landscape of Ectopia Lentis Based on a Cohort of Patients From 156 Families Open
Variants in FBN1 are the predominant cause of EL, with the most common cysteine involvement variants. Early-stage EL manifests refractive error but gradually converts to axial myopia through defocus introduced by lens dislocation. Aberrant…
View article: Effect of lens surgery on health-related quality of life in preschool children with congenital ectopia lentis
Effect of lens surgery on health-related quality of life in preschool children with congenital ectopia lentis Open
AIM: To evaluate the effect of lens surgery on health-related quality of life (HRQoL) of preschool children with congenital ectopia lentis (CEL). METHODS: A prospective self-controlled study was conducted in Zhongshan Ophthalmic Center. Ch…
View article: Evaluation of functional vision and eye-related quality of life in children with congenital ectopia lentis: a prospective cross-sectional study
Evaluation of functional vision and eye-related quality of life in children with congenital ectopia lentis: a prospective cross-sectional study Open
Objectives This study aims to evaluate the effect of congenital ectopia lentis (CEL) on functional vision and eye-related quality of life (ER-QOL) in children and their families using the Paediatric Eye Questionnaire (PedEyeQ). Design A qu…
View article: Corneal Biomechanics and Their Association With Severity of Lens Dislocation in Marfan Syndrome
Corneal Biomechanics and Their Association With Severity of Lens Dislocation in Marfan Syndrome Open
Purpose: To investigate corneal biomechanical properties and its associations with the severity of lens dislocation in patients with Marfan syndrome. Methods: A total of 30patients with Marfan syndrome and 30 age-, sex- and axial length (A…
View article: Standard ophthalmology residency training in China: an evaluation of resident satisfaction on training program in Guangdong Province
Standard ophthalmology residency training in China: an evaluation of resident satisfaction on training program in Guangdong Province Open
View article: Visual prognosis and complications of congenital ectopia lentis: study protocol for a hospital-based cohort in Zhongshan Ophthalmic Center
Visual prognosis and complications of congenital ectopia lentis: study protocol for a hospital-based cohort in Zhongshan Ophthalmic Center Open
Introduction Congenital ectopia lentis (CEL) is a rare ocular disease characterised by the dislocation or displacement of the lens. Patients with mild lens dislocations can be treated with conservative methods (eg, corrective eyeglasses or…
View article: The burden, causes and determinants of blindness and vision impairment in Asia: An analysis based on the Global Burden of Disease Study 2019 (Preprint)
The burden, causes and determinants of blindness and vision impairment in Asia: An analysis based on the Global Burden of Disease Study 2019 (Preprint) Open
BACKGROUND Asia accounts for more than half of the world’s population and carries a substantial proportion of the global burden blindness and vision impairment. Characterizing the burden, causes and determinants of blindness and vision im…
View article: Longitudinal Changes of Refractive Error in Preschool Children with Congenital Ectopia Lentis
Longitudinal Changes of Refractive Error in Preschool Children with Congenital Ectopia Lentis Open
Background: Congenital ectopia lentis (CEL) is a hereditary eye disease which severely impacts preschool children’s visual function and development. This study aimed to evaluate the longitudinal changes in spherical equivalent (SE) refract…
View article: Time trends and heterogeneity in the disease burden of visual impairment due to cataract, 1990–2019: A global analysis
Time trends and heterogeneity in the disease burden of visual impairment due to cataract, 1990–2019: A global analysis Open
Objectives This study aimed to estimate the disease burden of cataract and evaluate the contributions of risk factors to cataract-associated disability-adjusted life years (DALYs). Materials and methods Prevalence and DALYs of visual impai…
View article: Biomechanical testing of a modified knotless transscleral suture fixation technique: an ex vivo study
Biomechanical testing of a modified knotless transscleral suture fixation technique: an ex vivo study Open
The minimum traction force required to loosen or rupture the suture in the sclera was associated with suture specification, suture span, and the number of passes, but was uncorrelated with double scleral grooves. The 8-0 polypropylene sutu…
View article: Comparison of Functional Vision and Eye‐Related Quality of Life between Myopic Children Treated with Orthokeratology and Single‐Vision Spectacles in Southern China
Comparison of Functional Vision and Eye‐Related Quality of Life between Myopic Children Treated with Orthokeratology and Single‐Vision Spectacles in Southern China Open
Objective . To compare eye‐related quality of life between Chinese children wearing orthokeratology (OK) contact lenses and single‐vision spectacles (SVS) using the Pediatric Eye Questionnaire (PedEyeQ) and to evaluate the impact of differ…
View article: Identification and phenotypic analysis of novel LTBP2 mutations in a Chinese cohort with congenital ectopia lentis.
Identification and phenotypic analysis of novel LTBP2 mutations in a Chinese cohort with congenital ectopia lentis. Open
This study reported the mutation frequency of the LTBP2 gene in a Chinese CEL cohort and provided novel insight into LTBP2-related genotype-phenotype associations in CEL.
View article: Metabolomic Profile in the Aqueous Humor of Congenital Ectopia Lentis
Metabolomic Profile in the Aqueous Humor of Congenital Ectopia Lentis Open
To explore the metabolic profiles in the aqueous humor (AH) of patients with congenital ectopia lentis (CEL). We conducted a comprehensive analysis of the metabolites of AH samples of patients with CEL (n = 22) and age-matched patie…
View article: Anterior Umbilication of Lens in a Family with Congenital Cataracts Associated with a Missense Mutation of MIP Gene
Anterior Umbilication of Lens in a Family with Congenital Cataracts Associated with a Missense Mutation of MIP Gene Open
Congenital cataracts (CCs) have significant genotypic and phenotypic heterogeneity. The major intrinsic protein (MIP) gene, one of the causative genes of CCs, plays a vital role in maintaining the homeostasis and transparency of the lens. …
View article: A Modified Knotless Transscleral Intraocular Lens Fixation Technology for Congenital Ectopia Lentis
A Modified Knotless Transscleral Intraocular Lens Fixation Technology for Congenital Ectopia Lentis Open
Modified knotless technique was a valid method to achieve optimal IOL position and reduce postoperative astigmatism for adolescents and young patients with CEL. It effectively reduced the incidence of knot-related complications, greatly im…
View article: Disease Burden of Glaucoma in China: Findings from the Global Burden of Disease 2019 Study
Disease Burden of Glaucoma in China: Findings from the Global Burden of Disease 2019 Study Open
Substantial increases in the prevalence of visual impairment and DALYs number of glaucoma were observed from 1990 to 2019. Efforts targeting glaucoma prevention and treatment in China are urgently required, especially for the elderly popul…
View article: Longitudinal Changes of Axial Length and Associated Factors in Congenital Ectopia Lentis Patients
Longitudinal Changes of Axial Length and Associated Factors in Congenital Ectopia Lentis Patients Open
Purpose. To investigate the longitudinal changes and associated factors of axial length (AL) in congenital ectopia lentis (CEL) patients. Methods. In this retrospective study, medical records of CEL patients were reviewed from January 2014…
View article: Characteristics of Anterior Segment in Congenital Ectopia Lentis: An SS-OCT Study
Characteristics of Anterior Segment in Congenital Ectopia Lentis: An SS-OCT Study Open
Purpose. To investigate the characteristics of anterior chamber angle parameters in congenital ectopia lentis (CEL) patients and to evaluate the sensitivity and specificity of anterior segment parameters in distinguishing CEL from healthy …
View article: Evaluation of Intraocular Lens Tilt and Decentration in Congenital Ectopia Lentis by the Pentacam Scheimpflug System
Evaluation of Intraocular Lens Tilt and Decentration in Congenital Ectopia Lentis by the Pentacam Scheimpflug System Open
Purpose. The purpose of this study was to quantify the characteristics of the tilt and decentration of the IOL after trans-scleral suture fixation surgery in congenital ectopia lentis (CEL) patients. Methods. The clinical characteristics o…
View article: Time trends, associations and prevalence of blindness and vision loss due to glaucoma: an analysis of observational data from the Global Burden of Disease Study 2017
Time trends, associations and prevalence of blindness and vision loss due to glaucoma: an analysis of observational data from the Global Burden of Disease Study 2017 Open
Objective To estimate global prevalence of blindness and vision loss caused by glaucoma, and to evaluate the impact of socioeconomic factors on it. Design A population-based observational study. Setting The prevalence of blindness and visi…