Explanipedia

Chinese Additive Anti-inflammatory Action for Aortopathy & Arteriopathy (5A) Registry protocol: rationale, design and methodology Open

Hong Liu, Si-chong Qian, Hai‐Yang Li, Yongfeng Shao, Hongjia Zhang , et al. · 2024

Background Acute aortic syndrome (AAS) is a life-threatening condition. Inflammation plays a key role in the pathogenesis, development and progression of AAS, and is associated with significant mortality and morbidity. Understanding the in…

Identification a novel autophagy-related long non-coding RNA prognostic signature for pancreatic adenocarcinoma Open

LuYao Chen, Yufeng Zhang, ShengAo Yin, ShuHan Liang, YaXing Liu , et al. · 2023

Pancreatic adenocarcinoma (PAAD) is one of the most common malignant tumors in the digestive system. At present, the prognosis and 5-year survival time are still unsatisfied. Autophagic genes have been demonstrated as a crucial factor in p…

Inflammatory risk stratification individualizes anti-inflammatory pharmacotherapy for acute type A aortic dissection Open

Hong Liu, Haiyang Li, Lu Han, Yingyuan Zhang, Ying Wu , et al. · 2023

The systemic benefits of anti-inflammatory pharmacotherapy vary across cardiovascular diseases in clinical practice. We aimed to evaluate the application of artificial intelligence to acute type A aortic dissection (ATAAD) patients to dete…

Linc-UROD stabilizes ENO1 and PKM to strengthen glycolysis, proliferation and migration of pancreatic cancer cells Open

Yuan He, Yaxing Liu, Dongkai Wu, Luyao Chen, Zhonglin Luo , et al. · 2022

Circulating biomarker-based risk stratifications individualize arch repair strategy of acute Type A aortic dissection via the XGBoosting algorithm Open

Hong Liu, Si-chong Qian, Lu Han, Yingyuan Zhang, Ying Wu , et al. · 2022

Aims The incremental usefulness of circulating biomarkers from different pathological pathways for predicting mortality has not been evaluated in acute Type A aortic dissection (ATAAD) patients. We aim to develop a risk prediction model an…

Post-operative uric acid: a predictor for 30-days mortality of acute type A aortic dissection repair Open

Shulun Ma, Qian Xu, Qinghua Hu, Lingjin Huang, Dongkai Wu , et al. · 2022

Research progress of proteomics in screening tumor markers of gastric cancer Open

Dongkai Wu, Chen Ling, Qiang Zhao · 2022

Gastric cancer is a significant disease that endangers human life and health, ranking 3rd in the spectrum of disease incidence and death in China. It is mostly locally progressive and advanced, with fewer early-stage patients and an overal…

GRP78 facilitates M2 macrophage polarization and tumour progression Open

Heng Zhang, Shaoqiang Wang, Hang Lin, Chunfang Zhang, Li Wang , et al. · 2021

Post-operative Uric Acid: A Predictor for 30-days Mortality of Acute Type A Aortic Dissection Repair Open

Qian Xu, Shulun Ma, Qinghua Hu, Lingjin Huang, Dongkai Wu , et al. · 2021

Background: Hyperuricemia is associated with aortic dissection and cardiovascular diseases. The implication of high serum uric acid (UA) level after acute aortic dissection repair remains unknown. The aim of this study is to explore the ro…

Long non-coding RNAs: a rising biotarget in colorectal cancer Open

Jian Luo, Jian Qu, Dongkai Wu, Zhili Lu, Yue-Sheng Sun , et al. · 2017

Colorectal cancer (CRC) is a common gastrointestinal cancer, with a high incidence and high mortality. Long non-coding RNAs (lncRNAs) are involved in the development, invasion and metastasis, early diagnosis, prognosis, the chemoresistance…

Inhibition of microRNA-101 attenuates hypoxia/reoxygenation-induced apoptosis through induction of autophagy in H9c2 cardiomyocytes Open

Dongkai Wu, Haihe Jiang, Shengxi Chen, Heng Zhang · 2015

Autophagy is a cellular self‑catabolic process responsible for the degradation of proteins and organelles. Autophagy is able to promote cell survival in response to stress, and increased autophagy amongst cardiomyocytes has been identified…

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