Explanipedia

Chemical activation of mitochondrial ClpP to modulate energy metabolism of CD4+ T cell for inflammatory bowel diseases treatment Open

Jiangnan Zhang, Yunhan Jiang, Dongmei Fan, Zhiqiang Qiu, Xinlian He , et al. · 2024

Frost Resistance Differences of Concrete in Frequent Natural Freeze–Thaw versus Standard Rapid Method Open

Changzhong Deng, Lei Yu, Haoyu Wang, Zhaolei Liu, Dongmei Fan · 2024

In order to find the anti-freezing durability differences between concrete in the frequent natural freeze–thaw conditions in the northwest of Sichuan Province, China, and concrete in the rapid freeze–thaw conditions of the standard rapid m…

Oral Nanoformulations in Cardiovascular Medicine: Advances in Atherosclerosis Treatment Open

Xu Sun, Xushuang Jia, Zhaolin Tan, Dongmei Fan, Meiqi Chen , et al. · 2024

Atherosclerosis (AS) is the formation of atherosclerotic plaques on the walls of the arteries, causing them to narrow. If this occurs in the coronary arteries, the blood vessels may be completely blocked, resulting in myocardial infarction…

Exploration of novel isoxazole-fused quinone derivatives as anti-colorectal cancer agents through inhibiting STAT3 and elevating ROS level Open

Lidan Zhang, Pingxian Liu, Yunhan Jiang, Dongmei Fan, Xinlian He , et al. · 2024

One-dimensional simulation and validation of divertor detachment induced through nitrogen seeding on HL-2A Open

Y. Zhou, B. Dudson, Ting Wu, Z. H. Wang, Tianyang Xia , et al. · 2024

Divertor detachment is a promising method to solve the power exhaust problem in tokamak devices or even in future magnetic fusion reactors. In this work, a detachment experiment (HL-2A shot #38008) with mixed gas seeding (60% nitrogen and …

Immune cells and Alzheimer's disease: a bidirectional two-sample Mendelian randomization study Open

Jian Zhang, Yueling Zhang, Hao Wang, Zhilin Huang, Shuyu Xie , et al. · 2024

Immune cells play a crucial role in the pathogenesis of Alzheimer's disease (AD). Although the relationship between immune cells and AD is uncertain, it is clinically important, as immune cells could be targets for therapy. The current stu…

Prospective Comparison of the Imaging Value of 99mTc-MDP Bone Scan and 68Ga-FAPI-04 PET/CT in Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis Syndrome Open

Tingting Xu, Haoyuan Ding, Dongmei Fan, Qingxue Shu, Guangfu Liu , et al. · 2023

Purpose This study aimed to explore the imaging value of 68 Ga-FAPI-04 PET/CT in synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome and compare it with that of 99m Tc-MDP bone scan. Methods Nineteen participants with …

Systemic administration of mesenchymal stem cells loaded with a novel oncolytic adenovirus carrying a bispecific T cell engager against hepatocellular carcinoma Open

Xiangfei Yuan, Lu Yang, Yuanyuan Yang, Wencong Tian, Dongmei Fan , et al. · 2023

We previously established a hepatocellular carcinoma (HCC) targeting system of conditionally replicative adenovirus (CRAd) delivered by human umbilical cord-derived mesenchymal stem cells (HUMSCs). However, this system needed to be develop…

Zinc finger and SCAN domain-containing protein 18 is a potential DNA methylation-modified tumor suppressor and biomarker in breast cancer Open

Yu Wang, Yuhao Luo, Shaozhi Fu, Lijia He, Guangrui Pan , et al. · 2023

Introduction Zinc finger and SCAN domain-containing protein 18 (ZSCAN18) has been investigated as a putative biomarker of multiple human cancers. However, the expression profile, epigenetic modification, prognostic value, transcription reg…

Efficacy of active ingredients in Qingdai on ulcerative colitis: a network pharmacology-based evaluation. Open

Lan-xin Yue, Shuting Wen, Zhao Runyuan, Dongmei Fan, Dike Zhao , et al. · 2023

The results of this study provide solid scientific evidence for the use of QD or its core active components in the clinical management of UC.

Benefits and Challenges of the Educational Metaverse: Evidence from Quantitative and Qualitative Data Open

Jiarong Liang, Gege Li, Feng Zhang, Dongmei Fan, Heng Luo · 2023

The metaverse, as a more advanced form of virtual reality, has great potential for education because of its unique affordances for enhancing immersion, interaction, and presence. However, because its development is still in its infancy, th…

Discovery and SAR Study of Quinoxaline–Arylfuran Derivatives as a New Class of Antitumor Agents Open

Dongmei Fan, Pingxian Liu, Yunhan Jiang, Xinlian He, Lidan Zhang , et al. · 2022

A novel class of quinoxaline–arylfuran derivatives were designed, synthesized, and preliminarily evaluated for their antiproliferative activities in vitro against several cancer cell lines and normal cells. The representative derivative QW…

SAR Study and Molecular Mechanism Investigation of Novel Naphthoquinone-furan-2-cyanoacryloyl Hybrids with Antitumor Activity Open

Pingxian Liu, Dongmei Fan, Wenliang Qiao, Xinlian He, Lidan Zhang , et al. · 2022

A series of novel naphthoquinone-furan-2-cyanoacryloyl hybrids were designed; they were synthesized and preliminarily evaluated for their anti-proliferative activities in vitro against several cancer cell lines and normal cells. The most p…

A Novel Blockade CD47 Antibody With Therapeutic Potential for Cancer Open

Fangzhen Lin, Mengshang Xiong, Hao Wei, Yuewen Song, Ruoqi Liu , et al. · 2021

Macrophages as components of the innate immune system play a critical role in antitumor responses. Strategies for targeting CD47 are becoming a hot spot for cancer therapy. The expression of CD47 is exercised by macrophages to make a disti…

Application of [68Ga]Ga-citrate PET/CT for Differentiating Prosthetic Joint Infection from Aseptic Loosening After Joint Replacement Surgery Open

Tingting Xu, Yalan Zeng, Hongbin Yang, Liang Cai, Haoyuan Ding , et al. · 2020

Purpose Preoperative differentiation of prosthetic joint infection (PJI) and aseptic loosening (AL) is challenging. We aimed to evaluate the utility of visual analysis and semi-quantitative parameters of [⁶⁸Ga]Ga-citrate positro…

An Engineered Fusion Protein Anti-CD19(Fab)-LDM Effectively Inhibits ADR-Resistant B Cell Lymphoma Open

Dongmei Fan, Linlin Jiang, Yuewen Song, Shiqi Bao, Yuanyuan Yang , et al. · 2019

The 5-year survival rate of patients with B cell lymphoma is about 50% after initial diagnosis, mainly because of resistance to chemotherapy. Hence, it is necessary to understand the mechanism of chemo-resistance and to explore novel metho…

Bispecific CD3-HAC carried by E1A-engineered mesenchymal stromal cells against metastatic breast cancer by blocking PD-L1 and activating T cells Open

Yuanyuan Yang, Xiaolong Zhang, Fangzhen Lin, Mengshang Xiong, Dongmei Fan , et al. · 2019

The development of bispecific antibodies and their applications in tumor immune escape Open

Xiaolong Zhang, Yuanyuan Yang, Dongmei Fan, Dongsheng Xiong · 2017

Mesenchymal stromal cells as vehicles of tetravalent bispecific Tandab (CD3/CD19) for the treatment of B cell lymphoma combined with IDO pathway inhibitor d-1-methyl-tryptophan Open

Xiaolong Zhang, Yuanyuan Yang, Leisheng Zhang, Lu Yang, Qing Zhang , et al. · 2017

These results suggest that UC-MSCs releasing Tandab (CD3/CD19) is an efficient therapeutic tool for the treatment of B cell lymphoma when combined with D-1MT.

E1A-engineered human umbilical cord mesenchymal stem cells as carriers and amplifiers for adenovirus suppress hepatocarcinoma in mice Open

Zhenzhen Li, Ye Zhou, Xiaolong Zhang, Qing Zhang, Dongmei Fan , et al. · 2016

Gene therapy is an attractive approach for hepatocellular carcinoma (HCC) patients. Nevertheless, efficient transgene delivery remains a challenge. In this study, we explored a new targeted system based on human umbilical cord-derived mese…

Redirection of CD4+ and CD8+ T lymphocytes via an anti-CD3 × anti-CD19 bi-specific antibody combined with cytosine arabinoside and the efficient lysis of patient-derived B-ALL cells Open

Dongmei Fan, Wei Li, Yuqi Yang, Xiaolong Zhang, Qing Zhang , et al. · 2015

The novel structure make LDM effectively remove CD123+ AML stem cells in combination with interleukin 3 Open

Yanjun Zhang, Rong Liu, Dongmei Fan, Rizan Shi, Ming Yang , et al. · 2015

CD123 became a therapeutic target for acute myelocytic leukemia(AML) because of its overexpression only on AML stem cells. It is α subunit of interleukin-3 (multi-CSF, IL3) receptor. Lidamycin(LDM) is a novel antibiotic composed of an apop…

AntiCD3Fv fused to human interleukin-3 deletion variant redirected T cells against human acute myeloid leukemic stem cells Open

Dongmei Fan, Zhenzhen Li, Xiaolong Zhang, Yuqi Yang, Xiangfei Yuan , et al. · 2015

These results suggest that both fusion proteins display the antileukemic activity against CD123-expressing cell lines as well as leukemic progenitors in vitro and in vivo, especially ds-antiCD3Fv-⊿IL3. They could be the promising candidate…

Mesenchymal stem cells as delivery vectors for anti-tumor therapy. Open

Zhenzhen Li, Dongmei Fan, Dongsheng Xiong · 2015

Recent studies have demonstrated mesenchymal stem cells (MSCs) are able to migrate specifically to tumors and their metastatic sites when administered intravenously. This characteristic tumor tropism has opened up an emerging field to util…

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