Dongmei Gu
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View article: Reconciling Bergmann's rule throughout the annual cycle in two congeneric large-bodied migratory waterbirds
Reconciling Bergmann's rule throughout the annual cycle in two congeneric large-bodied migratory waterbirds Open
Bergmann's rule predicts that the larger of two homeotherm species differing only in size would occur at higher latitudes, or in cooler climates than the smaller, because of relative thermoregulatory costs in relation to body mass/surface …
View article: How water–energy–food services and their interactions change along multiple environmental gradients
How water–energy–food services and their interactions change along multiple environmental gradients Open
With climate change and ongoing socioeconomic development, issues related to water, energy, and food security are becoming more pressing, threatening human well-being. Under the influence of environmental factors, water–energy–food resourc…
View article: Expression and clinical significance of programmed death ligand-1 evaluated by 22C3 antibody in pleural effusion metastatic non-small-cell lung cancer
Expression and clinical significance of programmed death ligand-1 evaluated by 22C3 antibody in pleural effusion metastatic non-small-cell lung cancer Open
Objective: Programmed death ligand-1 (PD-L1) is involved in tumor immune escape and is an important target molecule for the immunotherapy of non-small-cell lung cancer (NSCLC). The expression of PD-L1 affects NSCLC invasion, metastasis, an…
View article: Application of psychological intervention in intensive care unit nursing for patients with severe acute pancreatitis
Application of psychological intervention in intensive care unit nursing for patients with severe acute pancreatitis Open
BACKGROUND Severe acute pancreatitis (SAP) is a familiar critical disease in the intensive care unit (ICU) patients. Nursing staff are important spiritual pillars during the treatment of patients, and in addition to routine nursing, more a…
View article: Single-cell low-pass whole genome sequencing accurately detects circulating tumor cells for liquid biopsy-based multi-cancer diagnosis
Single-cell low-pass whole genome sequencing accurately detects circulating tumor cells for liquid biopsy-based multi-cancer diagnosis Open
Accurate detection of circulating tumor cells (CTCs) in blood and non-blood body fluids enables generation of deterministic cancer diagnosis and represent a less invasive and safer liquid biopsy approach. Although genomic alternations have…
View article: A Stable and Scalable Digital Composite Neurocognitive Test for Early Dementia Screening Based on Machine Learning: Model Development and Validation Study
A Stable and Scalable Digital Composite Neurocognitive Test for Early Dementia Screening Based on Machine Learning: Model Development and Validation Study Open
Background Dementia has become a major public health concern due to its heavy disease burden. Mild cognitive impairment (MCI) is a transitional stage between healthy aging and dementia. Early identification of MCI is an essential step in d…
View article: Canadine inhibits epithelial mesenchymal transformation of HPV-negative cervical cancer
Canadine inhibits epithelial mesenchymal transformation of HPV-negative cervical cancer Open
Although the majority of the population will be protected due to the advent and widespread use of the HPV vaccine, the treatment of cervical cancer for all causes, including HPV-negative cervical cancer, is still worthy of further research…
View article: MusREL
MusREL Open
In order to enhance the utility of online educational digital resources, the authors propose a practical and efficient multi-strategy relation extraction (RE) model in online education scenarios. First, the effective relation discriminatio…
View article: Is Prompt the Future?
Is Prompt the Future? Open
A vast amount of unstructured data is being generated in the age of big data. Relation extraction (RE) is the critical way to improve the utility of the data by extracting structured data, which has seen a great evolution in recent years. …
View article: Decrease in naturally occurring antibodies against epitopes of Alzheimer’s disease (AD) risk gene products is associated with cognitive decline in AD
Decrease in naturally occurring antibodies against epitopes of Alzheimer’s disease (AD) risk gene products is associated with cognitive decline in AD Open
Background Naturally occurring antibodies (NAbs) are germline-encoded immunoglobulins that can bind to and clear out self-neo-epitopes as well as apoptotic and necrotic cells. However, NAbs pathological relevance in Alzheimer’s disease (AD…
View article: Electroacupuncture Attenuates Post-Inflammatory IBS-Associated Visceral and Somatic Hypersensitivity and Correlates With the Regulatory Mechanism of Epac1–Piezo2 Axis
Electroacupuncture Attenuates Post-Inflammatory IBS-Associated Visceral and Somatic Hypersensitivity and Correlates With the Regulatory Mechanism of Epac1–Piezo2 Axis Open
Electroacupuncture (EA) is considered to have a therapeutic effect in the relief of irritable bowel syndrome (IBS)-associated visceral hypersensitivity via the reduction of the level of 5‐hydroxytryptamine (5‐HT) and 5-HT 3 receptors (5-HT…
View article: M2‐phenotype tumour‐associated macrophages upregulate the expression of prognostic predictors MMP14 and INHBA in pancreatic cancer
M2‐phenotype tumour‐associated macrophages upregulate the expression of prognostic predictors MMP14 and INHBA in pancreatic cancer Open
Pancreatic cancer is one of the most lethal gastrointestinal tumours, the most common pathological type is pancreatic adenocarcinoma (PAAD). In recent year, immune imbalanced in tumour microenvironment has been shown to play an important r…
View article: Correlation between sonographic features and pathological findings of cervical lymph node metastasis of differentiated thyroid carcinoma
Correlation between sonographic features and pathological findings of cervical lymph node metastasis of differentiated thyroid carcinoma Open
The relationship between sonographic features and follicular structure of metastatic lymph nodes are firmly related. A correct understanding of these features is practical to improve the diagnostic rate of conventional ultrasonography and …
View article: Trends in Piezo Channel Research Over the Past Decade: A Bibliometric Analysis
Trends in Piezo Channel Research Over the Past Decade: A Bibliometric Analysis Open
Purpose: We used bibliometric methods to evaluate the global scientific output of research on Piezo channels and explore the current status and trends in this field over the past decade. Methods: Piezo channel-related studies published in …
View article: Bidirectional association between irritable bowel syndrome and restless legs syndrome: a systematic review and meta-analysis
Bidirectional association between irritable bowel syndrome and restless legs syndrome: a systematic review and meta-analysis Open
In this systematic review and meta-analysis, we found a substantial bidirectional association between IBS and RLS. More prospective, high-quality, population-based studies are warranted in the future.
View article: Elevated matrix metalloproteinase‐9 levels in neuronal extracellular vesicles in Alzheimer’s disease
Elevated matrix metalloproteinase‐9 levels in neuronal extracellular vesicles in Alzheimer’s disease Open
Objective This study aimed to investigate plasma neuronally derived extracellular vesicle (NDEV) levels of core pathological markers [amyloid‐β (Aβ) and phosphorylated tau] and inflammatory biomarkers, including interleukin 6 (IL‐6) and ma…
View article: TDP-43 Is Elevated in Plasma Neuronal-Derived Exosomes of Patients With Alzheimer’s Disease
TDP-43 Is Elevated in Plasma Neuronal-Derived Exosomes of Patients With Alzheimer’s Disease Open
This study demonstrated increased TDP-43 accumulation in AD patients by examining plasma NDEs, which may provide a window into the effects of TDP-43 on AD progression.
View article: Research Trends of Acupuncture Therapy on Cancer Over the Past Two Decades: A Bibliometric Analysis
Research Trends of Acupuncture Therapy on Cancer Over the Past Two Decades: A Bibliometric Analysis Open
Purpose: Acupuncture has been used for managing cancer-related symptoms. However, there are still few studies concerning the overall trends in acupuncture therapy on cancer based on bibliometric analysis. This study aims to demonstrate the…
View article: Primary lung cancer firstly presents as nephrotic syndrome: one case report and literature review
Primary lung cancer firstly presents as nephrotic syndrome: one case report and literature review Open
Primary lung cancer presents as nephrotic syndrome firstly is a rare condition. Few data are available to address this question because of its seldom. Herein we present one case of primary lung cancer which showing nephrotic syndrome as fi…
View article: TDP-43 is elevated in plasma neuronal-derived exosomes of patients with Alzheimer's disease
TDP-43 is elevated in plasma neuronal-derived exosomes of patients with Alzheimer's disease Open
Background Recently, TDP-43 has been recognized as a common proteinopathy in the “oldest old” and a neuropathological comorbidity in patients with Alzheimer’s disease (AD). However, since it has a low concentration in cerebrospinal fluid, …
View article: MicroRNA‑363‑3p inhibits hepatocarcinogenesis by targeting HMGA2 and is associated with liver cancer stage
MicroRNA‑363‑3p inhibits hepatocarcinogenesis by targeting HMGA2 and is associated with liver cancer stage Open
The importance of microRNAs (miRNAs) in cancer development has been widely recognized in recent decades. In the present study, the function and mechanism of miRNA‑363‑3p (miR‑363‑3p), formerly characterized as a tumor suppressor, in the he…
View article: miR-145-5p Increases Osteoclast Numbers In Vitro and Aggravates Bone Erosion in Collagen-Induced Arthritis by Targeting Osteoprotegerin
miR-145-5p Increases Osteoclast Numbers In Vitro and Aggravates Bone Erosion in Collagen-Induced Arthritis by Targeting Osteoprotegerin Open
BACKGROUND Osteoprotegerin (OPG) inhibits bone resorption and binds with strong affinity to receptor activator of NF κB ligand (RANKL), thereby preventing RANKL from binding to its receptor RANK. Osteoclasts have documented effects on bone…
View article: Ginsenoside Rg3 targets cancer stem cells and tumor angiogenesis to inhibit colorectal cancer progression in vivo
Ginsenoside Rg3 targets cancer stem cells and tumor angiogenesis to inhibit colorectal cancer progression in vivo Open
Anti-angiogenic therapy has been successfully applied to treat colorectal cancer (CRC). Ginsenoside Rg3, derived from the Chinese herb ginseng, has anti-vascularization effects and can inhibit tumor growth and metastasis, and can sensitize…
View article: The long non-coding RNA NONHSAT062994 inhibits colorectal cancer by inactivating Akt signaling
The long non-coding RNA NONHSAT062994 inhibits colorectal cancer by inactivating Akt signaling Open
The aberrant expression of long noncoding RNAs (lncRNAs) is implicated in cancer development and progression. However, the clinical significance and mechanism by which NONHSAT062994 regulates colorectal cancer (CRC) is unknown. We here rep…
View article: CD73/NT5E is a target of miR-30a-5p and plays an important role in the pathogenesis of non-small cell lung cancer
CD73/NT5E is a target of miR-30a-5p and plays an important role in the pathogenesis of non-small cell lung cancer Open
Our findings reveal a new post-transcriptional mechanism of CD73 regulation via miR-30a-5p and EGFR-related drug resistance in non-small cell lung cancer.