Dongmei Xi
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View article: Dusp1 in osteolytic diseases-mechanisms and therapeutic potential
Dusp1 in osteolytic diseases-mechanisms and therapeutic potential Open
Osteolytic diseases are a significant and escalating global public health issue, driven by the acceleration of population aging and the rising incidence of degenerative, metabolic, and neoplastic diseases. The primary therapeutic strategy …
View article: De novo transcriptome assembly and annotation of the semi-wild Gayal (Bos frontalis)
De novo transcriptome assembly and annotation of the semi-wild Gayal (Bos frontalis) Open
The Gayal (Bos frontalis) is a rare semi-wild Bovine species that inhabits the harsh environments of Indo-China. Although the origins of the Gayal remain largely enigmatic, addressing the lack of comprehensive transcriptomic data is critic…
View article: Impact of Panax notoginseng Residue on Rumen Microbial Community, Blood Biochemical Parameters and Growth Performance in Cattle: A Preliminary Study on Its Potential as a Feed Resource
Impact of Panax notoginseng Residue on Rumen Microbial Community, Blood Biochemical Parameters and Growth Performance in Cattle: A Preliminary Study on Its Potential as a Feed Resource Open
This study aimed to investigate the effects of adding different proportions of Panax notoginseng residue (PNR) to the diet on the rumen microbial community structure, blood biochemical indices, and growth performance of Wenshan cattle. Fif…
View article: Multiple omics analysis reveals the regulation of SIRT4 on lipid deposition and metabolism during the differentiation of bovine preadipocytes
Multiple omics analysis reveals the regulation of SIRT4 on lipid deposition and metabolism during the differentiation of bovine preadipocytes Open
The differentiation and lipid metabolism of preadipocytes are crucial processes in IMF deposition. Studies have demonstrated that SIRT4 plays essential roles in energy metabolism and redox homeostasis, with its expression being coordinatel…
View article: Advances in Whole Genome Sequencing: Methods, Tools, and Applications in Population Genomics
Advances in Whole Genome Sequencing: Methods, Tools, and Applications in Population Genomics Open
With the rapid advancement of high-throughput sequencing technologies, whole genome sequencing (WGS) has emerged as a crucial tool for studying genetic variation and population structure. Utilizing population genomics tools to analyze rese…
View article: Michael-Addition Reaction Triggering Sensitive and Facile Detection of Glutathione Employing Lspr-Photonic Crystals
Michael-Addition Reaction Triggering Sensitive and Facile Detection of Glutathione Employing Lspr-Photonic Crystals Open
View article: Innovative Insights into Single-Cell Technologies and Multi-Omics Integration in Livestock and Poultry
Innovative Insights into Single-Cell Technologies and Multi-Omics Integration in Livestock and Poultry Open
In recent years, single-cell RNA sequencing (scRNA-seq) has marked significant strides in livestock and poultry research, especially when integrated with multi-omics approaches. These advancements provide a nuanced view into complex regula…
View article: Effects of Different Dietary Combinations on Blood Biochemical Indicators and Rumen Microbial Ecology in Wenshan Cattle
Effects of Different Dietary Combinations on Blood Biochemical Indicators and Rumen Microbial Ecology in Wenshan Cattle Open
With the continuous optimization of feed ingredients in livestock production, barley has garnered significant attention as a potential substitute for corn in feed. This study aims to investigate the effects of replacing part of the corn an…
View article: Genomic and transcriptomic landscape to decipher the genetic basis of hyperpigmentation in Lanping black-boned sheep (Ovis aries)
Genomic and transcriptomic landscape to decipher the genetic basis of hyperpigmentation in Lanping black-boned sheep (Ovis aries) Open
View article: Prevalence and genotypic characterization of zoonotic intestinal protozoan parasites in transboundary migratory Mongolian Gazelles (<i>Procapra gutturosa</i>): the first survey
Prevalence and genotypic characterization of zoonotic intestinal protozoan parasites in transboundary migratory Mongolian Gazelles (<i>Procapra gutturosa</i>): the first survey Open
The migration of Mongolian gazelles ( Procapra gutturosa ) poses a potential risk of outbreak for zoonotic intestinal protozoan parasite infections. This study aims to investigate the infection status of zoonotic intestinal protozoan paras…
View article: Application of Pan-Omics Technologies in Research on Important Economic Traits for Ruminants
Application of Pan-Omics Technologies in Research on Important Economic Traits for Ruminants Open
The economic significance of ruminants in agriculture underscores the need for advanced research methodologies to enhance their traits. This review aims to elucidate the transformative role of pan-omics technologies in ruminant research, f…
View article: Application of GWAS and mGWAS in Livestock and Poultry Breeding
Application of GWAS and mGWAS in Livestock and Poultry Breeding Open
In recent years, genome-wide association studies (GWAS) and metabolome genome-wide association studies (mGWAS) have emerged as crucial methods for investigating complex traits in animals and plants. These have played pivotal roles in resea…
View article: Exploring the additive effect of Ampelopsis grossedentata flavonoids and Tween 80 on feeding Nubian goats
Exploring the additive effect of Ampelopsis grossedentata flavonoids and Tween 80 on feeding Nubian goats Open
Introduction The ban on antibiotics in animal husbandry underscores the crucial need for safe, natural feed additives. This study investigates the effects of Ampelopsis grossedentata flavonoids (AGF) and Tween 80 on the growth performance,…
View article: Beef Cattle Genome Project: Advances in Genome Sequencing, Assembly, and Functional Genes Discovery
Beef Cattle Genome Project: Advances in Genome Sequencing, Assembly, and Functional Genes Discovery Open
Beef is a major global source of protein, playing an essential role in the human diet. The worldwide production and consumption of beef continue to rise, reflecting a significant trend. However, despite the critical importance of beef catt…
View article: Transcriptomic annotation of the Chungtien schizothoracin (Ptychobarbus chungtienensis) using Iso-seq and RNA-seq data
Transcriptomic annotation of the Chungtien schizothoracin (Ptychobarbus chungtienensis) using Iso-seq and RNA-seq data Open
The Chungtien schizothoracin ( Ptychobarbus chungtienensis ), an endangered fish species endemic to the Zhongdian Plateau, remains underexplored in terms of transcriptomic sequencing. This investigation used tissues from five distinct orga…
View article: Calcium-sensitive receptors-mediated macrophage polarization via the PLC-Ca 2+ and cAMP-NF-κB-NLRP3 inflammasome signalling pathways impact cardiac fibroblast activation through paracrine effects
Calcium-sensitive receptors-mediated macrophage polarization via the PLC-Ca 2+ and cAMP-NF-κB-NLRP3 inflammasome signalling pathways impact cardiac fibroblast activation through paracrine effects Open
The cardiac inflammatory response, characterized by immune cell infiltration, is involved in developing myocardial fibrosis during hypertension. Although calcium-sensitive receptor (CaSR) regulates inflammatory response, the specific mecha…
View article: Calcium-sensing receptor-mediated macrophage polarization improves myocardial remodeling in spontaneously hypertensive rats
Calcium-sensing receptor-mediated macrophage polarization improves myocardial remodeling in spontaneously hypertensive rats Open
Chronic inflammation is a key element in the progression of essential hypertension (EH). Calcium plays a key role in inflammation, so its receptor, the calcium-sensing receptor (CaSR), is an essential mediator of the inflammatory process. …
View article: Pan-Omics in Sheep: Unveiling Genetic Landscapes
Pan-Omics in Sheep: Unveiling Genetic Landscapes Open
Multi-omics-integrated analysis, known as panomics, represents an advanced methodology that harnesses various high-throughput technologies encompassing genomics, epigenomics, transcriptomics, proteomics, and metabolomics. Sheep, playing a …
View article: Multiple omics analysis reveals the regulation of SIRT5 on mitochondrial function and lipid metabolism during the differentiation of bovine preadipocytes
Multiple omics analysis reveals the regulation of SIRT5 on mitochondrial function and lipid metabolism during the differentiation of bovine preadipocytes Open
Preadipocyte differentiation represents a critical stage in adipogenesis, with mitochondria playing an undeniable pivotal role. Given the intricate interplay between transcription and metabolic signaling during adipogenesis, the regulation…
View article: Two High-Quality Cygnus Genome Assemblies Reveal Genomic Variations Associated with Plumage Color
Two High-Quality Cygnus Genome Assemblies Reveal Genomic Variations Associated with Plumage Color Open
As an exemplary model for examining molecular mechanisms responsible for extreme phenotypic variations, plumage color has garnered significant interest. The Cygnus genus features two species, Cygnus olor and Cygnus atratus, that exhibit st…
View article: Unveiling the common loci for six body measurement traits in Chinese Wenshan cattle
Unveiling the common loci for six body measurement traits in Chinese Wenshan cattle Open
Introduction: Body measurement traits are integral in cattle production, serving as pivotal criteria for breeding selection. Wenshan cattle, a local breed in China’s Yunnan province, exhibit remarkable genetic diversity. However, the molec…
View article: Comparative Analysis of PRNP Gene Indel Polymorphism and Expression among Zhongdian Yellow Cattle, Zhongdian Yak, and Their Hybrids
Comparative Analysis of PRNP Gene Indel Polymorphism and Expression among Zhongdian Yellow Cattle, Zhongdian Yak, and Their Hybrids Open
Bovine spongiform encephalopathy (BSE) is a fatal disease in cattle caused by misfolded prion proteins and linked to indel polymorphisms in the promoter and intron 1 of the PRNP gene. The aim of this study was to determine the allele, geno…
View article: Molecular Cloning and Functional Characterization of the 5′ Regulatory Region of the SLC11A1 Gene from Yaks
Molecular Cloning and Functional Characterization of the 5′ Regulatory Region of the SLC11A1 Gene from Yaks Open
The solute transport protein family 11 A1 (SLC11A1), also recognized as natural resistance-associated macrophage protein 1 (NRAMP1), represents a transmembrane protein encoded by the SLC11A1 gene. A variety of prior investigations have ill…
View article: Exploring the Impact of Ampelopsis Grossedentata Flavonoids on Growth Performance, Ruminal Microbiota, and Plasma Physiology and Biochemistry of Kids
Exploring the Impact of Ampelopsis Grossedentata Flavonoids on Growth Performance, Ruminal Microbiota, and Plasma Physiology and Biochemistry of Kids Open
This study was conducted to evaluate the influences of supplementing Ampelopsis grossedentata flavonoids (AGF) on the rumen bacterial microbiome, plasma physiology and biochemistry, and growth performance of goats. Twenty-four Nubian kids …
View article: Carrier‐Free ATP‐Activated Nanoparticles for Combined Photodynamic Therapy and Chemotherapy under Near‐Infrared Light (Small 11/2023)
Carrier‐Free ATP‐Activated Nanoparticles for Combined Photodynamic Therapy and Chemotherapy under Near‐Infrared Light (Small 11/2023) Open
Carrier-Free ATP-Activated Nanoparticles In article number 2205825, Wen Sun and co-workers develop ingenious adenosine triphosphate (ATP)-activated nanoparticles (CDNPs) that are directly self-assembled from photosensitizer (Cy-I) and amph…
View article: Compare analysis of the PRNP gene indels polymorphism and expression among Yellow cattle, Zhongdian Yak and their hybrid
Compare analysis of the PRNP gene indels polymorphism and expression among Yellow cattle, Zhongdian Yak and their hybrid Open
Background Bovine spongiform encephalopathy (BSE) is a fatal disease in cattle caused by misfolded prion protein and linked to indel polymorphisms in promoter and intron1 of PRNP gene. The aim of this study was to determine the allele, gen…
View article: Low-expression of miR-1929-3p mediates murine cytomegalovirus-induced fibrosis in cardiac fibroblasts via targeting endothelin A receptor/NLRP3 inflammasome pathway
Low-expression of miR-1929-3p mediates murine cytomegalovirus-induced fibrosis in cardiac fibroblasts via targeting endothelin A receptor/NLRP3 inflammasome pathway Open
It has shown that mouse cytomegalovirus (MCMV) infection induced low-expression of miR-1929-3p is closely related to hypertensive myocardial remodeling in our previous research. In this study, we further explored the molecular mechanism of…
View article: [Corrigendum] MicroRNA‑1929‑3p participates in murine cytomegalovirus‑induced hypertensive vascular remodeling through Ednra/NLRP3 inflammasome activation
[Corrigendum] MicroRNA‑1929‑3p participates in murine cytomegalovirus‑induced hypertensive vascular remodeling through Ednra/NLRP3 inflammasome activation Open
Following the publication of this article, the authors have realized that the images selected for the 'MCMV+miR‑NC' and 'MCMV+miR‑1929‑3p' data panels (15 months), as featured in the lower of the two rows of data shown in Fig. 4A on p. 726…
View article: A Sequential Dual‐Model Strategy Based on Photoactivatable Metallopolymer for On‐Demand Release of Photosensitizers and Anticancer Drugs (Adv. Sci. 23/2021)
A Sequential Dual‐Model Strategy Based on Photoactivatable Metallopolymer for On‐Demand Release of Photosensitizers and Anticancer Drugs (Adv. Sci. 23/2021) Open
Photoactivatable Metallopolymer In article number 2103334, Zhiyong Wei, Yang Li, Wen Sun, and co‐workers demonstrate the on‐demand release of photosensitizers and anticancer drugs based on photoactivatable metallopolymer Poly(Ru/PTX). Red …
View article: A Sequential Dual‐Model Strategy Based on Photoactivatable Metallopolymer for On‐Demand Release of Photosensitizers and Anticancer Drugs
A Sequential Dual‐Model Strategy Based on Photoactivatable Metallopolymer for On‐Demand Release of Photosensitizers and Anticancer Drugs Open
The synergistic combination of chemotherapy and photodynamic therapy has attracted considerable attention for its enhanced antitumoral effects; however, it remains challenging to successfully delivery photosensitizers and anticancer drugs …