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Transcription factor ZNF266 suppresses cancer progression by modulating CA9-mediated intracellular pH alteration in lung adenocarcinoma Open
Our study demonstrated that ZNF266 inhibits LUAD progression in a pH-dependent manner via modulating CA9 expression, uncovering its therapeutic significance for LUAD treatment.
tRF3a-MetCAT Promotes EGFR-Targeted Therapeutic Resistance through the TRIM21–STAT1–C5a Axis in Lung Adenocarcinoma Open
Despite the effectiveness of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in treating lung adenocarcinoma with epidermal growth factor receptor (EGFR) mutations, many patients eventually stop responding to therap…
View article: System Modeling and Simulation of TianWen-2 Sampling on an Asteroid Regolith Surface
System Modeling and Simulation of TianWen-2 Sampling on an Asteroid Regolith Surface Open
As China’s first asteroid exploration mission, the TianWen-2 spacecraft mainly focuses on surface sampling on the near-Earth asteroid 2016 HO3. Different from the usual sampling strategy of releasing a small lander or ejecting a projectile…
Major pathological response obtained after neoadjuvant chemotherapy combined with dual immunotherapy for malignant pleural mesothelioma: a case report Open
MPM might respond well to neoadjuvant chemotherapy and dual immunotherapy, improving the probability of complete surgical resection and attaining an encouraging pathologic response.
UPP1 promotes lung adenocarcinoma progression through the induction of an immunosuppressive microenvironment Open
The complexity of the tumor microenvironment (TME) is a crucial factor in lung adenocarcinoma (LUAD) progression. To gain deeper insights into molecular mechanisms of LUAD, we perform an integrative single-cell RNA sequencing (scRNA-seq) d…
FGL1 in plasma extracellular vesicles is correlated with clinical stage of lung adenocarcinoma and anti-PD-L1 response Open
Fibrinogen-like protein-1 (FGL1) is confirmed a major ligand of lymphocyte activation gene-3 which could inhibit antigen-mediated T-cell response and evade immune supervision. Although hepatocytes secrete large amounts of FGL1, its high ex…
Development of an autoantibody panel for early detection of lung cancer in the Chinese population Open
Introduction Tumor-associated autoantibodies have been revealed as promising biomarkers for the early detection of lung cancer. This study was designed to develop an autoantibody panel for early detection of lung cancer in the Chinese popu…
Indole Diterpenes from Mangrove Sediment-Derived Fungus Penicillium sp. UJNMF0740 Protect PC12 Cells against 6-OHDA-Induced Neurotoxicity via Regulating the PI3K/Akt Pathway Open
In our chemical investigation into Penicillium sp. UJNMF0740 derived from mangrove sediment, fourteen indole diterpene analogs, including four new ones, are purified by multiple chromatographic separation methods, with their structures bei…
View article: Data from DNMT1–MicroRNA126 Epigenetic Circuit Contributes to Esophageal Squamous Cell Carcinoma Growth via ADAM9–EGFR–AKT Signaling
Data from DNMT1–MicroRNA126 Epigenetic Circuit Contributes to Esophageal Squamous Cell Carcinoma Growth via ADAM9–EGFR–AKT Signaling Open
Purpose: MicroRNAs (miRNA) are involved in and are controlled by epigenetic regulation, and thereby form a reciprocal regulatory circuit. Using next-generation sequencing (NGS)–based miRNA profiling, this study aimed to discover esophageal…
Supplementary Figure S3 from DNMT1–MicroRNA126 Epigenetic Circuit Contributes to Esophageal Squamous Cell Carcinoma Growth via ADAM9–EGFR–AKT Signaling Open
Supplementary Figure S3. Suppressive effect of miR-126 on ESCC cell migration and growth.
Supplementary Tables from DNMT1–MicroRNA126 Epigenetic Circuit Contributes to Esophageal Squamous Cell Carcinoma Growth via ADAM9–EGFR–AKT Signaling Open
The file included six supplementary tables as following: Table S1.Clinicopathological Characteristics; Table S2. Differently expressed miRNAs between ECs and NMs; Table S3. Univariate and Multivariate analysis of factors associated with di…
Supplementary Figure S6 from DNMT1–MicroRNA126 Epigenetic Circuit Contributes to Esophageal Squamous Cell Carcinoma Growth via ADAM9–EGFR–AKT Signaling Open
Supplementary Figure S6.Other targets of miR-126 in ESCC.
Supplementary Figure S3 from DNMT1–MicroRNA126 Epigenetic Circuit Contributes to Esophageal Squamous Cell Carcinoma Growth via ADAM9–EGFR–AKT Signaling Open
Supplementary Figure S3. Suppressive effect of miR-126 on ESCC cell migration and growth.
Data from DNMT1–MicroRNA126 Epigenetic Circuit Contributes to Esophageal Squamous Cell Carcinoma Growth via ADAM9–EGFR–AKT Signaling Open
Purpose: MicroRNAs (miRNA) are involved in and are controlled by epigenetic regulation, and thereby form a reciprocal regulatory circuit. Using next-generation sequencing (NGS)–based miRNA profiling, this study aimed to discover esophageal…
Supplementary Figure S2 from DNMT1–MicroRNA126 Epigenetic Circuit Contributes to Esophageal Squamous Cell Carcinoma Growth via ADAM9–EGFR–AKT Signaling Open
Supplementary Figure S2. MiR-126 promotes ECa-109 and KYSE-510 cell apoptosis, but has no effect on cell cycle.
Supplementary Figure S6 from DNMT1–MicroRNA126 Epigenetic Circuit Contributes to Esophageal Squamous Cell Carcinoma Growth via ADAM9–EGFR–AKT Signaling Open
Supplementary Figure S6.Other targets of miR-126 in ESCC.
Supplementary Figure S5 from DNMT1–MicroRNA126 Epigenetic Circuit Contributes to Esophageal Squamous Cell Carcinoma Growth via ADAM9–EGFR–AKT Signaling Open
Supplementary Figure S5. DNMT1 is the direct target of miR-126.
Supplementary Figure S4 from DNMT1–MicroRNA126 Epigenetic Circuit Contributes to Esophageal Squamous Cell Carcinoma Growth via ADAM9–EGFR–AKT Signaling Open
Supplementary Figure S4. Expressions of ADAM9 in ESCC specimens, and interference efficiencies of siRNAs against ADAM9.
Supplementary Figure S5 from DNMT1–MicroRNA126 Epigenetic Circuit Contributes to Esophageal Squamous Cell Carcinoma Growth via ADAM9–EGFR–AKT Signaling Open
Supplementary Figure S5. DNMT1 is the direct target of miR-126.
Supplementary Figure S1 from DNMT1–MicroRNA126 Epigenetic Circuit Contributes to Esophageal Squamous Cell Carcinoma Growth via ADAM9–EGFR–AKT Signaling Open
Supplementary Figure S1. Overexpression of DNMT1 suppresses ESCC cell proliferation and migration.
Supplementary Tables from DNMT1–MicroRNA126 Epigenetic Circuit Contributes to Esophageal Squamous Cell Carcinoma Growth via ADAM9–EGFR–AKT Signaling Open
The file included six supplementary tables as following: Table S1.Clinicopathological Characteristics; Table S2. Differently expressed miRNAs between ECs and NMs; Table S3. Univariate and Multivariate analysis of factors associated with di…
Supplementary Figure S2 from DNMT1–MicroRNA126 Epigenetic Circuit Contributes to Esophageal Squamous Cell Carcinoma Growth via ADAM9–EGFR–AKT Signaling Open
Supplementary Figure S2. MiR-126 promotes ECa-109 and KYSE-510 cell apoptosis, but has no effect on cell cycle.
Supplementary Figure S1 from DNMT1–MicroRNA126 Epigenetic Circuit Contributes to Esophageal Squamous Cell Carcinoma Growth via ADAM9–EGFR–AKT Signaling Open
Supplementary Figure S1. Overexpression of DNMT1 suppresses ESCC cell proliferation and migration.
Supplementary Figure S4 from DNMT1–MicroRNA126 Epigenetic Circuit Contributes to Esophageal Squamous Cell Carcinoma Growth via ADAM9–EGFR–AKT Signaling Open
Supplementary Figure S4. Expressions of ADAM9 in ESCC specimens, and interference efficiencies of siRNAs against ADAM9.
Supplementary Materials and Methods from DNMT1–MicroRNA126 Epigenetic Circuit Contributes to Esophageal Squamous Cell Carcinoma Growth via ADAM9–EGFR–AKT Signaling Open
This file contained the supplementary materials and methods including RNA extraction and quantitative real-time PCR, miRNA overexpression and RNA interference (RNAi), Cell proliferation and migration assays, Immunohistochemistry (IHC) and …
Supplementary Materials and Methods from DNMT1–MicroRNA126 Epigenetic Circuit Contributes to Esophageal Squamous Cell Carcinoma Growth via ADAM9–EGFR–AKT Signaling Open
This file contained the supplementary materials and methods including RNA extraction and quantitative real-time PCR, miRNA overexpression and RNA interference (RNAi), Cell proliferation and migration assays, Immunohistochemistry (IHC) and …