Dongning Chen
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View article: XIST Loss Induces Variable Transcriptional Responses Dependent on Cell States
XIST Loss Induces Variable Transcriptional Responses Dependent on Cell States Open
Background/Objectives: The X-inactivation specific transcript (XIST) is a long noncoding RNA playing a crucial regulatory role in X chromosome inactivation (XCI)—a transcriptional regulatory process that silences one of the two X chromosom…
View article: Versican binds collagen via its G3 domain and regulates the organization and mechanics of collagenous matrices
Versican binds collagen via its G3 domain and regulates the organization and mechanics of collagenous matrices Open
Type I collagen is the most abundant structural protein in the body and, with other fibrillar collagens, forms the fibrous network of the extracellular matrix. Another group of extracellular matrix polymers, the glycosaminoglycans, and gly…
View article: Q-learning improved golden jackal optimization algorithm and its application to reliability optimization of hydraulic system
Q-learning improved golden jackal optimization algorithm and its application to reliability optimization of hydraulic system Open
To endow the prey with intelligent movement behavior and improve the performance of Golden Jackal Optimization (GJO), a Q-learning Improved Gold Jackal Optimization (QIGJO) algorithm is proposed. This paper introduces five update mechanism…
View article: Prevalence and Clinical Characteristics of Myelinated Retinal Nerve Fibers in a Healthy Population: A Big-data Analysis
Prevalence and Clinical Characteristics of Myelinated Retinal Nerve Fibers in a Healthy Population: A Big-data Analysis Open
Objective: To analyze the prevalence, clinical characteristics, and related factors of myelinated retinal nerve fibers (MRNFs) in a community-based cohort. Methods: From March 2017 to June 2020, a total of 10,341 adults undergoing health e…
View article: Matrix viscoelasticity promotes liver cancer progression in the pre-cirrhotic liver
Matrix viscoelasticity promotes liver cancer progression in the pre-cirrhotic liver Open
Type 2 diabetes mellitus is a major risk factor for hepatocellular carcinoma (HCC). Changes in extracellular matrix (ECM) mechanics contribute to cancer development 1,2 , and increased stiffness is known to promote HCC progression in cirrh…
View article: Multi-dimensional T-S dynamic fault tree analysis method involving failure correlation
Multi-dimensional T-S dynamic fault tree analysis method involving failure correlation Open
The lack of effective failure correlation analysis is one main reason for the gap between the reliability models and the actual complex systems with mixed static and dynamic characteristics. Takagi and Sugeno (T-S) dynamic fault tree is on…
View article: Microcystin-RR is a biliary toxin selective for neonatal cholangiocytes
Microcystin-RR is a biliary toxin selective for neonatal cholangiocytes Open
BACKGROUND AND AIMS Biliary atresia is a fibrosing cholangiopathy affecting neonates that is thought to be caused by a prenatal environmental insult to the bile duct. Biliatresone, a plant toxin with an α-methylene ketone group, was previo…
View article: Supplementary Figure 1 from Profiling Lipoxygenase Metabolism in Specific Steps of Colorectal Tumorigenesis
Supplementary Figure 1 from Profiling Lipoxygenase Metabolism in Specific Steps of Colorectal Tumorigenesis Open
Supplementary Figure 1 from Profiling Lipoxygenase Metabolism in Specific Steps of Colorectal Tumorigenesis
View article: Supplementary Figure 1 from Profiling Lipoxygenase Metabolism in Specific Steps of Colorectal Tumorigenesis
Supplementary Figure 1 from Profiling Lipoxygenase Metabolism in Specific Steps of Colorectal Tumorigenesis Open
Supplementary Figure 1 from Profiling Lipoxygenase Metabolism in Specific Steps of Colorectal Tumorigenesis
View article: Data from Profiling Lipoxygenase Metabolism in Specific Steps of Colorectal Tumorigenesis
Data from Profiling Lipoxygenase Metabolism in Specific Steps of Colorectal Tumorigenesis Open
Lipoxygenases (LOX) are key enzymes for the oxidative metabolism of polyunsaturated fatty acids into biologically active products. Clinical data on comparative levels of various LOX products in tumorigenesis are lacking. Therefore, we exam…
View article: Data from Profiling Lipoxygenase Metabolism in Specific Steps of Colorectal Tumorigenesis
Data from Profiling Lipoxygenase Metabolism in Specific Steps of Colorectal Tumorigenesis Open
Lipoxygenases (LOX) are key enzymes for the oxidative metabolism of polyunsaturated fatty acids into biologically active products. Clinical data on comparative levels of various LOX products in tumorigenesis are lacking. Therefore, we exam…
View article: Injury and a program of fetal wound healing in the fetal and neonatal extrahepatic bile duct
Injury and a program of fetal wound healing in the fetal and neonatal extrahepatic bile duct Open
Introduction Biliary atresia (BA) is an obstructive cholangiopathy that initially affects the extrahepatic bile ducts (EHBDs) of neonates. The etiology is uncertain, but evidence points to a prenatal cause; however, the response of the fet…
View article: Extracellular Matrix Viscoelasticity Drives Liver Cancer Progression in Pre-Cirrhotic NASH
Extracellular Matrix Viscoelasticity Drives Liver Cancer Progression in Pre-Cirrhotic NASH Open
Type 2 diabetes mellitus (T2DM) is a major risk factor for hepatocellular carcinoma (HCC). Changes in extracellular matrix (ECM) mechanics contribute to cancer development, and increased stiffness is known to promote HCC progression in cir…
View article: Shc Is Implicated in Calreticulin-Mediated Sterile Inflammation in Alcoholic Hepatitis
Shc Is Implicated in Calreticulin-Mediated Sterile Inflammation in Alcoholic Hepatitis Open
Alcohol induces p46Shc-dependent activation of pre-apoptotic pathways and translocation of CRT to the membrane, where it acts as a damage-associated molecular pattern, instigating immunogenicity. Shc inhibition could be a novel treatment s…
View article: Study on Health Indicator Construction and Health Status Evaluation of Hydraulic Pumps Based on LSTM–VAE
Study on Health Indicator Construction and Health Status Evaluation of Hydraulic Pumps Based on LSTM–VAE Open
This paper addresses the difficulty of evaluating operating status in widely used gear pumps. A method for constructing hydraulic pump health indicators and evaluating health status is proposed based on LSTM–VAE. In this study, the vibrati…
View article: Investigation of systemic immune-inflammation index, neutrophil/high-density lipoprotein ratio, lymphocyte/high-density lipoprotein ratio, and monocyte/high-density lipoprotein ratio as indicators of inflammation in patients with schizophrenia and bipolar disorder
Investigation of systemic immune-inflammation index, neutrophil/high-density lipoprotein ratio, lymphocyte/high-density lipoprotein ratio, and monocyte/high-density lipoprotein ratio as indicators of inflammation in patients with schizophrenia and bipolar disorder Open
Background The systemic immune-inflammation index (SII), system inflammation response index (SIRI), neutrophil/high-density lipoprotein (HDL) ratio (NHR), lymphocyte/HDL ratio (LHR), monocyte/HDL ratio (MHR), and platelet/HDL ratio (PHR) h…
View article: Increasing obstructive sleep apnea risk is associated with hearing impairment in middle-aged Chinese men—A cross-sectional study
Increasing obstructive sleep apnea risk is associated with hearing impairment in middle-aged Chinese men—A cross-sectional study Open
Objective Midlife males with obstructive sleep apnea (OSA) bear a high risk for cardiovascular diseases. However, the association of OSA and hearing impairment is controversial. Our objective was to observe the incidence of hearing loss in…
View article: Glycosaminoglycans modulate long-range mechanical communication between cells in collagen networks
Glycosaminoglycans modulate long-range mechanical communication between cells in collagen networks Open
Significance Glycosaminoglycans (GAGs) are carbohydrates that are expressed ubiquitously in the human body and are among the key macromolecules that influence the development, homeostasis, and pathology of native tissues. Abnormal accumula…
View article: Versican binds collagen via its G3 domain and regulates the organization and mechanics of collagenous matrices
Versican binds collagen via its G3 domain and regulates the organization and mechanics of collagenous matrices Open
Type I collagen is the most abundant structural protein in the body and, with other fibrillar collagens, forms the fibrous network of the extracellular matrix (ECM). Another group of ECM polymers, the glycosaminoglycans (GAGs) and GAG-modi…
View article: Multi-strategy improved salp swarm algorithm and its application in reliability optimization
Multi-strategy improved salp swarm algorithm and its application in reliability optimization Open
To improve the convergence speed and solution precision of the standard Salp Swarm Algorithm (SSA), a hybrid Salp Swarm Algorithm based on Dimension-by-dimension Centroid Opposition-based learning strategy, Random factor and Particle Swar…
View article: Glycosaminoglycans Modulate Long-Range Mechanical Communication Between Cells in Collagen Networks
Glycosaminoglycans Modulate Long-Range Mechanical Communication Between Cells in Collagen Networks Open
Cells can sense and respond to mechanical forces in fibrous extracellular matrices (ECM) over distances much greater than their size. This phenomenon, termed long-range force transmission, is enabled by the realignment (buckling) of collag…
View article: Multi-stage Adaptive BA-ACO Hybrid Swarm Intelligence Algorithm
Multi-stage Adaptive BA-ACO Hybrid Swarm Intelligence Algorithm Open
摘要: 针对蝙蝠算法在优化过程中未充分利用蝙蝠间搜索信息交互影响的不足,借鉴拟态物理学中的作用力规则,基于阶段性搜索策略将搜索过程分为两个阶段,分别构造符合算法阶段性搜索特点的作用力规则,提出多形态作用力蝙蝠算法,并利用Benchmark函数对所提算法与标准蝙蝠算法、变异蝙蝠算法、标准微粒群算法、两阶段微粒群算法进行性能对比测试,结果表明,所提算法具有更好的寻优能力。针对标准蚁群算法在离散空间优化时信息素更新机制单一、容易早熟收敛的不足,结合蚁群的实际社会活动提出多阶段自适…
View article: Continuous-time Multi-dimensional T-S Dynamic Fault Tree Analysis Methodology
Continuous-time Multi-dimensional T-S Dynamic Fault Tree Analysis Methodology Open
摘要: 复杂系统的可靠性往往受工作时间、应力冲击、工作温度等多因素影响,仅考虑工作时间单一因素的故障树分析方法存在局限性,提出考虑工作时间、应力冲击、工作温度等多因素影响的连续时间多维T-S动态故障树分析(Continuous-time multi-dimensional T-S dynamic fault tree analysis,CM-TSdFTA)方法。构造多因素影响下的下级事件故障概率密度函数,基于下级事件的顺序规则及上级事件的输出规则提出T-S动态门及其事件顺序…
View article: Distinct effects of different matrix proteoglycans on collagen fibrillogenesis and cell-mediated collagen reorganization
Distinct effects of different matrix proteoglycans on collagen fibrillogenesis and cell-mediated collagen reorganization Open
The extracellular matrix (ECM) is a complex mixture composed of fibrillar collagens as well as additional protein and carbohydrate components. Proteoglycans (PGs) contribute to the heterogeneity of the ECM and play an important role in its…
View article: [Analysis of hearing screening results in adult health check-up population].
[Analysis of hearing screening results in adult health check-up population]. Open
Objective:To obtain incidence of hearing loss and the influence factors in adult health check-up population, and to provide supporting information for the prevention of hearing loss. Method:Hearing Handicap Inventory for the Adult-screenin…