Dongsheng Jiang
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View article: Isolation of acephate-degrading bacteria and phytoremediation–microbial remediation from soil for the project of water diversion from the Yangtze River to Chaohu Lake
Isolation of acephate-degrading bacteria and phytoremediation–microbial remediation from soil for the project of water diversion from the Yangtze River to Chaohu Lake Open
Introduction Efficient and safe governance of soil contaminated with organophosphate pesticides is of crucial significance for the protection of the ecosystem. This study focuses on soils from typical riparian zones along the project of wa…
View article: Theoretical framework and reliability verification of the loaded three-zone structural model in coal mine overburden strata
Theoretical framework and reliability verification of the loaded three-zone structural model in coal mine overburden strata Open
View article: Diabetic Wound Repair: From Mechanism to Therapeutic Opportunities
Diabetic Wound Repair: From Mechanism to Therapeutic Opportunities Open
Diabetic wound healing, characterized by persistent inflammation, impaired angiogenesis, and dysfunctional cellular responses, remains a major clinical challenge due to its complex pathophysiology. This challenge is most evident in diabeti…
View article: Exploring Early Symptom Experiences and Self-Management Strategies Among Postoperative Kidney Transplant Patients on Symptom Management Theory: A Qualitative Study
Exploring Early Symptom Experiences and Self-Management Strategies Among Postoperative Kidney Transplant Patients on Symptom Management Theory: A Qualitative Study Open
This study indicates that kidney transplant patients exhibit various symptoms and reactions in the early postoperative period and these reactions change irregularly. This also emphasizes the importance for clinical nursing researchers to d…
View article: PRMT2-mediated upregulation of miR-323-3p in sensory neurons promotes trigeminal neuropathic pain by targeting Kv2.1 channels
PRMT2-mediated upregulation of miR-323-3p in sensory neurons promotes trigeminal neuropathic pain by targeting Kv2.1 channels Open
Herein, we show a molecular pathway driven by an evolutionarily conserved microRNA (miRNA) in sensory neurons to control neuropathic pain. By employing high-throughput sequencing analysis, we find that miRNA-323-3p (miR-323-3p) exhibits th…
View article: Mechanisms and therapeutic opportunities in metabolic aberrations of diabetic wounds: a narrative review
Mechanisms and therapeutic opportunities in metabolic aberrations of diabetic wounds: a narrative review Open
View article: ProReflow: Progressive Reflow with Decomposed Velocity
ProReflow: Progressive Reflow with Decomposed Velocity Open
Diffusion models have achieved significant progress in both image and video generation while still suffering from huge computation costs. As an effective solution, flow matching aims to reflow the diffusion process of diffusion models into…
View article: SETDB2-Mediated Epigenetic Repression of IDE in Sensory Neurons Promotes Migraine-Like Pain Behaviors
SETDB2-Mediated Epigenetic Repression of IDE in Sensory Neurons Promotes Migraine-Like Pain Behaviors Open
View article: H3K27 Trimethylation-Mediated Downregulation of miR-216a-3p in Sensory Neurons Regulates Neuropathic Pain Behaviors via Targeting STIM1
H3K27 Trimethylation-Mediated Downregulation of miR-216a-3p in Sensory Neurons Regulates Neuropathic Pain Behaviors via Targeting STIM1 Open
Although the therapeutic potential of microRNA-mediated gene regulation has been investigated, its precise functional regulatory mechanism in neuropathic pain remains incompletely understood. In this study, we elucidate that miR-216a-3p se…
View article: Sensory neurons: unveiling the symphony of wound healing
Sensory neurons: unveiling the symphony of wound healing Open
View article: Recirculated transport mechanism aggravates ozone pollution over the mountainous coastal region: Increased contribution from vertical mixing
Recirculated transport mechanism aggravates ozone pollution over the mountainous coastal region: Increased contribution from vertical mixing Open
In coastal areas where many highly developed metropolis and city agglomeration are located, high ozone (O3) concentrations are one of the most severe environmental problems, which is gravely impacted by the sea-land breeze (SLB) circulatio…
View article: FOXD3-mediated transactivation of ALKBH5 promotes neuropathic pain via m <sup>6</sup> A-dependent stabilization of 5-HT3A mRNA in sensory neurons
FOXD3-mediated transactivation of ALKBH5 promotes neuropathic pain via m <sup>6</sup> A-dependent stabilization of 5-HT3A mRNA in sensory neurons Open
The N6-methyladenosine (m 6 A) modification of RNA is an emerging epigenetic regulatory mechanism that has been shown to participate in various pathophysiological processes. However, its involvement in modulating neuropathic pain is still …
View article: The Multifaceted Functions of TRPV4 and Calcium Oscillations in Tissue Repair
The Multifaceted Functions of TRPV4 and Calcium Oscillations in Tissue Repair Open
The transient receptor potential vanilloid 4 (TRPV4) specifically functions as a mechanosensitive ion channel and is responsible for conveying changes in physical stimuli such as mechanical stress, osmotic pressure, and temperature. TRPV4 …
View article: Penetration Enhanced Nanomedicine Through Hypoxia Regulated Ligand-Controllable Shielding
Penetration Enhanced Nanomedicine Through Hypoxia Regulated Ligand-Controllable Shielding Open
View article: Author Correction: CD201+ fascia progenitors choreograph injury repair
Author Correction: CD201+ fascia progenitors choreograph injury repair Open
View article: CD201+ fascia progenitors choreograph injury repair
CD201+ fascia progenitors choreograph injury repair Open
Optimal tissue recovery and organismal survival are achieved by spatiotemporal tuning of tissue inflammation, contraction and scar formation 1 . Here we identify a multipotent fibroblast progenitor marked by CD201 expression in the fascia,…
View article: Epigenetic regulation of beta-endorphin synthesis in hypothalamic arcuate nucleus neurons modulates neuropathic pain in a rodent pain model
Epigenetic regulation of beta-endorphin synthesis in hypothalamic arcuate nucleus neurons modulates neuropathic pain in a rodent pain model Open
Although beta-endorphinergic neurons in the hypothalamic arcuate nucleus (ARC) synthesize beta-endorphin (β-EP) to alleviate nociceptive behaviors, the underlying regulatory mechanisms remain unknown. Here, we elucidated an epigenetic path…
View article: CD201+ fascia progenitors choreograph injury repair
CD201+ fascia progenitors choreograph injury repair Open
<p>File Sample, days post-injury (dpi) </p><p>muc8424 En1xmTmG dpi 0 </p><p>muc9827 En1xmTmG dpi 5 </p><p>muc8423 En1xmTmG dpi 14 </p><p>muc8422 En1xmTmG dpi 27 </p><p>muc12…
View article: CD201+ fascia progenitors choreograph injury repair
CD201+ fascia progenitors choreograph injury repair Open
File Sample, days post-injury (dpi) muc8424 En1xmTmG dpi 0 muc9827 En1xmTmG dpi 5 muc8423 En1xmTmG dpi 14 muc8422 En1xmTmG dpi 27 muc12460 En1xmTmG dpi 3 muc12464 En1xmTmG dpi 1 muc12465 En1xmTmG dpi 7
View article: Adiponectin receptor 1-mediated stimulation of Cav3.2 channels in trigeminal ganglion neurons induces nociceptive behaviors in mice
Adiponectin receptor 1-mediated stimulation of Cav3.2 channels in trigeminal ganglion neurons induces nociceptive behaviors in mice Open
Background Adipokines, including adiponectin, are implicated in nociceptive pain; however, the underlying cellular and molecular mechanisms remain unknown. Methods Using electrophysiological recording, immunostaining, molecular biological …
View article: Fibroblasts – the cellular choreographers of wound healing
Fibroblasts – the cellular choreographers of wound healing Open
Injuries to our skin trigger a cascade of spatially- and temporally-synchronized healing processes. During such endogenous wound repair, the role of fibroblasts is multifaceted, ranging from the activation and recruitment of innate immune …
View article: Wound infiltrating adipocytes are not myofibroblasts
Wound infiltrating adipocytes are not myofibroblasts Open
View article: Immunomodulatory Nanosystems: Advanced Delivery Tools for Treating Chronic Wounds
Immunomodulatory Nanosystems: Advanced Delivery Tools for Treating Chronic Wounds Open
The increasingly aging society led to a rise in the prevalence of chronic wounds (CWs), posing a significant burden to public health on a global scale. One of the key features of CWs is the presence of a maladjusted immune microenvironment…
View article: Therapeutic Silencing of p120 in Fascia Fibroblasts Ameliorates Tissue Repair
Therapeutic Silencing of p120 in Fascia Fibroblasts Ameliorates Tissue Repair Open
View article: Prevalence and Clinical Characteristics of Calciphylaxis in Chinese Hemodialysis Patients
Prevalence and Clinical Characteristics of Calciphylaxis in Chinese Hemodialysis Patients Open
Background Calciphylaxis is a grievous life-threatening vascular disease that commonly affects dialysis population. This is the first epidemiological survey of calciphylaxis initiated in China. Methods In the cross-sectional survey, a stra…
View article: Genital Wound Repair and Scarring
Genital Wound Repair and Scarring Open
Skin wound repair has been the central focus of clinicians and scientists for almost a century. Insights into acute and chronic wound healing as well as scarring have influenced and ameliorated wound treatment. Our knowledge of normal skin…
View article: Histone methylation-mediated microRNA-32-5p down-regulation in sensory neurons regulates pain behaviors via targeting Cav3.2 channels
Histone methylation-mediated microRNA-32-5p down-regulation in sensory neurons regulates pain behaviors via targeting Cav3.2 channels Open
Significance In this study, we identify microRNA-32-5p (miR-32-5p) as a key functional noncoding RNA in trigeminal-mediated neuropathic pain. We report that injury-induced histone methylation attenuates the binding of glucocorticoid recept…
View article: The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD
The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD Open
View article: Interleukin 33-mediated inhibition of A-type K<sup>+</sup> channels induces sensory neuronal hyperexcitability and nociceptive behaviors in mice
Interleukin 33-mediated inhibition of A-type K<sup>+</sup> channels induces sensory neuronal hyperexcitability and nociceptive behaviors in mice Open
Background: Interleukin-33 (IL-33) has been implicated in nociceptive pain behaviors. However, the underlying molecular and cellular mechanisms remain unclear. Methods: Using electrophysiological recording, immunoblot analysi…
View article: Converting fibroblastic fates leads to wound healing without scar
Converting fibroblastic fates leads to wound healing without scar Open