Explanipedia

Research progress on the mechanisms of comorbidity between functional gastrointestinal disorders and mental disorders: A review Open

Ruirui Tan, Chao Han, Donglin Sun, Xiaomei Zhang, Tong Liu , et al. · 2025

A growing body of evidence suggests a high prevalence of comorbidity between functional gastrointestinal disorders (FGIDs) and mental health conditions, with clinical studies consistently highlighting strong associations between FGIDs and …

Integrative Single-Cell and Bulk RNA Sequencing Identifies a Glycolysis-Related Prognostic Signature for Predicting Prognosis in Pancreatic Cancer Open

Nan Wu, Chong Zhou, Yan Xu, Ziqing Liu, Ruohan Jiang , et al. · 2025

Alterations in glycolysis play a crucial role in cancer cells, influencing tumor aggressiveness and therapeutic effect, particularly in pancreatic adenocarcinoma (PAAD). However, the specific glycolysis-related genes involved in PAAD progr…

RPL22L1 fosters malignant features of cervical cancer via the modulation of DUSP6-ERK axis Open

Dongmei Zhang, Meiqi Zhao, Ping Jiang, Yunzhen Zhou, Yan Xu , et al. · 2025

RPL22L1 promotes malignant biological behavior of cervical cancer cells by competitively binding with DUSP6, thereby activating the ERK pathway. The combined use of Sorafenib and an ERK inhibitor is a potentially effective molecular target…

Application of Laennec extrathecal blockade combined with indocyanine green fluorescence imaging in laparoscopic anatomic hepatectomy Open

Yong Yang, Chong‐yuan Yu, Fang Lin, Donglin Sun, Ke‐jia Wu , et al. · 2024

Objective To investigate the safety and application value of combining Laennec extracapsular occlusion with ICG fluorescence imaging in laparoscopic anatomic hepatectomy. Methods Complete laparoscopic dissection was performed outside the L…

RPL22L1, a novel candidate oncogene promotes temozolomide resistance by activating STAT3 in glioblastoma Open

Yunping Chen, Yu Mu, Qing Guan, Chenlong Li, Yangong Zhang , et al. · 2023

Aggressiveness and drug resistance are major challenges in the clinical treatment of glioblastoma (GBM). Our previously research reported a novel candidate oncogene ribosomal protein L22 like 1 (RPL22L1). The aim of this study was to eluci…

Prognostic impact of the HS-mGPS on patients undergoing radical surgery for hepatocellular carcinoma Authorship Open

Baoyang Luo, Yun Zhang, Yong Yang, Tianhao Ji, Longqing Shi , et al. · 2023

Objiective: Our study aimed to assess the ability of High-Sensitivity modified Glasgow Prognostic Score (HS-mGPS) predicting survival in patients undergoing radical surgery for hepatocellular carcinoma (HCC) and to compare the impact with …

Supplementary Tables 1-3, Supplementary Figures 1-5 from Overexpression of RCC2 Enhances Cell Motility and Promotes Tumor Metastasis in Lung Adenocarcinoma by Inducing Epithelial–Mesenchymal Transition Open

Bo Pang, Nan Wu, Rongwei Guan, Lin Pang, Xinlei Li , et al. · 2023

Table S1: Primary antibodies used for western blot analysis; Table S2: Univariate and multivariate Cox regression analysis of different prognosis factors in patients with LUAD from TMAS; Table S3: related to Figure 4 and 6. Correlation bet…

Supplementary Tables 1-3, Supplementary Figures 1-5 from Overexpression of RCC2 Enhances Cell Motility and Promotes Tumor Metastasis in Lung Adenocarcinoma by Inducing Epithelial–Mesenchymal Transition Open

Bo Pang, Nan Wu, Rongwei Guan, Lin Pang, Xinlei Li , et al. · 2023

Table S1: Primary antibodies used for western blot analysis; Table S2: Univariate and multivariate Cox regression analysis of different prognosis factors in patients with LUAD from TMAS; Table S3: related to Figure 4 and 6. Correlation bet…

Treatment of hepatic venous system hemorrhage and carbon dioxide gas embolization during laparoscopic hepatectomy via hepatic vein approach Open

Zhen Qu, Ke‐jia Wu, Jia-wei Feng, Ding-sen Shi, Yuxiang Chen , et al. · 2023

With the improvement of laparoscopic surgery, the feasibility and safety of laparoscopic hepatectomy have been affirmed, but intraoperative hepatic venous system hemorrhage and carbon dioxide gas embolism are the difficulties in laparoscop…

RPL22L1, a Novel Candidate Oncogene Promotes Temozolomide Resistance by Activating STAT3 in Glioblastoma Open

Yunping Chen, Qing Guan, Chenlong Li, Yangong Zhang, Yinzhi Xu , et al. · 2022

Aggressiveness and drug resistant are major challenges in the clinical treatment of glioblastoma (GBM). Our previously research reported a novel candidate oncogene ribosomal protein L22 like 1 (RPL22L1). The aim of this study was to elucid…

Clinical application of regional and intermittent hepatic inflow occlusion in laparoscopic hepatectomy Open

Longqing Shi, Baoyang Luo, Yong Yang, Yurong Miao, Xin Li , et al. · 2022

Aim The aim of this study is to investigate the advantages and disadvantages of regional and intermittent hepatic inflow occlusion in laparoscopic hepatectomy. Methods The clinical data of 180 patients who underwent laparoscopic liver surg…

Bioinformatics and systems-biology analysis to determine the effects of Coronavirus disease 2019 on patients with allergic asthma Open

Hongwei Fang, Zhun Sun, Zhouyi Chen, Anning Chen, Donglin Sun , et al. · 2022

Background The coronavirus disease (COVID-19) pandemic has posed a significant challenge for global health systems. Increasing evidence shows that asthma phenotypes and comorbidities are major risk factors for COVID-19 symptom severity. Ho…

Ribosomal protein L22-like1 (RPL22L1) mediates sorafenib sensitivity via ERK in hepatocellular carcinoma Open

Dongmei Zhang, Yunzhen Zhou, Yanan Ma, Ping Jiang, Hongchao Lv , et al. · 2022

Analysis of Related Risk Factors of Microvascular Invasion in Hepatocellular Carcinoma Open

Longqing Shi, Zhen Qu, Yue Yang, Yue Zhang, Donglin Sun · 2022

Objective. To forecast the onset of microvascular invasion (MVI) in patients with hepatoma by evaluating the preoperative aspartate aminotransferase-to-platelet ratio index (APRI), alpha-fetoprotein (AFP), neutrophil-to-lymphocyte ratio (N…

Downregulated Expression of miRNA-130a-5p Aggravates Hepatoma Progression via Targeting PTP4A2 Open

Longqing Shi, Fengbo Wang, Yue Zhang, Yue Yang, Zheng Qu , et al. · 2021

Background. Hepatoma is a leading cause of death worldwide, with high metastasis and recurrence rates. The aberrant expression of miRNA-130a-5p is involved in the development and progression of various cancers. However, there are no studie…

MicroRNA-708 inhibits the proliferation and chemoresistance of pancreatic cancer cells Open

Wensong Liu, Yunjie Lu, Dong Zhang, Longqing Shi, Guangchen Zu , et al. · 2020

Pancreatic cancer is one of the most aggressive malignancies with poor prognosis and high mortality. Recent studies showed that microRNAs are dysregulated and involved in the initiation and progression of pancreatic cancer. In this study, …

Identification of ENTPD8 and cytidine in pancreatic cancer by metabolomic and transcriptomic conjoint analysis Open

Yong An, Huihua Cai, Yang Yong, Yue Zhang, Shengyong Liu , et al. · 2018

To identify metabolic pathways that were perturbed in pancreatic cancer ( PC ), we investigated gene‐metabolite networks by integration of metabolomic and transcriptomic. In this research, we undertook the metabolomic study of 43 paired hu…

MiR-216b inhibits pancreatic cancer cell progression and promotes apoptosis by down-regulating KRAS Open

Xinquan Wu, Weibo Chen, Huihua Cai, Jun Hu, Baoqiang Wu , et al. · 2018

MiR-216b might inhibit pancreatic cancer cell progression and stimulate apoptosis by silencing KRAS.

circZMYM2 Competed Endogenously with miR-335-5p to Regulate JMJD2C in Pancreatic Cancer Open

Yong An, Huihua Cai, Yue Zhang, Shengyong Liu, Yunfei Duan , et al. · 2018

Background/Aims: We aimed to study the involvement of circZMYM2 (hsa_circ_0099999) in pancreatic cancer (PC) cell proliferation, apoptosis and invasion and to figured out the underlying mechanism of circZMYM2 regulating miR-335-5p and JMJD…

COX-2 expression in ovarian cancer: an updated meta-analysis Open

Haiming Sun, Xuelong Zhang, Donglin Sun, Xueyuan Jia, Lidan Xu , et al. · 2017

The prognostic role of COX-2 expression in ovarian cancer patients has been studied for years, while results remain controversial. Thus we performed a meta-analysis to evaluate the prognostic impact of COX-2 expression on survival of ovari…

TRIB1 promotes colorectal cancer cell migration and invasion through activation MMP-2 via FAK/Src and ERK pathways Open

Yuhui Wang, Nan Wu, Bo Pang, Dandan Tong, Donglin Sun , et al. · 2017

Colorectal cancer (CRC) is the third most common cancer in the world and distant metastasis is the leading cause of death among CRC patients. However, the underlying mechanisms of distant metastasis remain largely unknown. Amplification of…

ABCG2 and NCF4 polymorphisms are associated with clinical outcomes in diffuse large B-cell lymphoma patients treated with R-CHOP Open

Duo Liu, Nan Wu, Haiming Sun, Mei Dong, Tian-Zhu Guo , et al. · 2017

The impact of pharmacogenetics on predicting survival in diffuse large B-cell lymphoma (DLBCL) remains unclear. We tested 337 DLBCL patients treated with rituximab-cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) for 9 s…

NUBPL, a novel metastasis‐related gene, promotes colorectal carcinoma cell motility by inducing epithelial–mesenchymal transition Open

Yuhui Wang, Nan Wu, Donglin Sun, Haiming Sun, Dandan Tong , et al. · 2017

Nucleotide binding protein‐like, NUBPL , is an assembly factor for human mitochondrial complex I, which is the biggest member of the mitochondrial respiratory chain. However, the relationship between NUBPL and carcinoma progression remains…

Associations between STAT Gene Polymorphisms and Psoriasis in Northeastern China Open

Jing Zhou, Yuzhen Li, Donglin Sun · 2017

Background: Psoriasis is an autoimmune disease with genetic and environmental factors. Based on the roles of STATs (signaling transducers and activators of transcription) in autoimmune diseases, it is assumed STAT gene polymo…

Demethylation effects of elemene on the GSTP1 gene in HCC cell line QGY7703 Open

Baoqiang Wu, Yong Jiang, Feng Zhu, Donglin Sun, Hongjun Huang · 2016

The present study aimed to investigate elemene's effects on cell proliferation, apoptosis, and the cell cycle in the hepatocellular carcinoma (HCC) cell line, QYG7703, and to investigate GSTP1 gene methylation change in QGY7703 cells after…

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