Dongzhen Yu
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View article: Unilateral peripheral vestibular dysfunction disrupts motion-evoked neuronal responses in primary visual cortex
Unilateral peripheral vestibular dysfunction disrupts motion-evoked neuronal responses in primary visual cortex Open
Acute unilateral peripheral vestibular destruction (AUPVD) causes dizziness, characterized by both visual and motion-related disturbances. Although it is well established that the vestibular nuclei receive auditory and visual sensory input…
View article: Sleep deprivation disrupts vestibular compensation by activating TLR4/NF-κB/NLRP3 signalling in the deafferented vestibular nuclei
Sleep deprivation disrupts vestibular compensation by activating TLR4/NF-κB/NLRP3 signalling in the deafferented vestibular nuclei Open
We aimed to investigate whether sleep deprivation (SD) affects vestibular compensation and explore the underlying mechanisms. After unilateral labyrinthectomy (UL), adult mice were subjected to 6 h of SD for 5 days. Behavioural tests were …
View article: Integrating single-cell and spatial transcriptomics reveals the cellular heterogeneity of vestibular schwannoma
Integrating single-cell and spatial transcriptomics reveals the cellular heterogeneity of vestibular schwannoma Open
View article: Ipsilateral cochlear implantation in cases with vestibular schwannoma
Ipsilateral cochlear implantation in cases with vestibular schwannoma Open
Background Vestibular schwannomas (VS) are the most common tumors in the cerebellopontine angle, which can lead to hearing loss, particularly following tumor resection. For patients with bilateral VS associated with neurofibromatosis type …
View article: Global burden and prevalence of otitis media-induced hearing loss in children: 32-year study
Global burden and prevalence of otitis media-induced hearing loss in children: 32-year study Open
Although the global burden of OM-induced hearing loss has improved, South Asia and low-middle SDI regions continue to face a significant burden, with insufficient healthcare resources likely being a major issue. Additionally, continuing to…
View article: <scp>VDAC1</scp> Inhibition Protects Against Noise‐Induced Hearing Loss via the <scp>PINK1</scp>/Parkin Pathway
<span>VDAC1</span> Inhibition Protects Against Noise‐Induced Hearing Loss via the <span>PINK1</span>/Parkin Pathway Open
Aims This study examined the effect of 4,4′‐diisothiocyanostilbene‐2,2′‐disulfonic acid (DIDS), an anion channel blocker of voltage‐dependent anion channel 1 (VDAC1), on noise‐induced hearing loss (NIHL) and its underlying mechanisms. Meth…
View article: Trends in the incidence and burden of otitis media in children: a global analysis from 1990 to 2021
Trends in the incidence and burden of otitis media in children: a global analysis from 1990 to 2021 Open
View article: The Global Burden of Migraine: A 30-Year Trend Review and Future Projections by Age, Sex, Country, and Region
The Global Burden of Migraine: A 30-Year Trend Review and Future Projections by Age, Sex, Country, and Region Open
View article: [Application of internal carotid artery stent in glomus jugular paraganglioma surgery].
[Application of internal carotid artery stent in glomus jugular paraganglioma surgery]. Open
Objective:To summarize the application of internal carotid artery stent in glomus jugular paraganglioma surgery, and to provide an effective strategy for reducing the risk of internal carotid artery injury. Methods:This artic…
View article: Electroencephalography microstate alterations reflect potential double‐edged cognitive adaptation in Ménière's disease
Electroencephalography microstate alterations reflect potential double‐edged cognitive adaptation in Ménière's disease Open
Purpose To explore the microstate characteristics and underlying brain network activity of Ménière's disease (MD) patients based on high‐density electroencephalography (EEG), elucidate the association between microstate dynamics and clinic…
View article: Inhibition of the NLRP3 inflammasome attenuates spiral ganglion neuron degeneration in aminoglycoside-induced hearing loss
Inhibition of the NLRP3 inflammasome attenuates spiral ganglion neuron degeneration in aminoglycoside-induced hearing loss Open
JOURNAL/nrgr/04.03/01300535-202510000-00031/figure1/v/2024-11-26T163120Z/r/image-tiff Aminoglycosides are a widely used class of antibacterials renowned for their effectiveness and broad antimicrobial spectrum. However, their use leads to …
View article: Assessments of Subjective Visual Gravity and Spontaneous Nystagmus in Patients With Vestibular Neuritis
Assessments of Subjective Visual Gravity and Spontaneous Nystagmus in Patients With Vestibular Neuritis Open
Objective This study aimed to assess the correlation between the spontaneous nystagmus (SN) and the subjective visual vertical/horizontal (SVV/SVH) among patients with vestibular neuritis (VN) at the different head positions. Study Design …
View article: [An analysis of clinical efficacy of microvascular decompression for 21 inpatients suffering from primary hemifacial spasm].
[An analysis of clinical efficacy of microvascular decompression for 21 inpatients suffering from primary hemifacial spasm]. Open
Objective:To assess the effectiveness of microvascular decompression（MVD） in treating inpatients suffering from primary hemifacial spasm（HFS）. Methods:A total of 21 inpatients with HFS underwent MVD. The clinical effect was f…
View article: Complete trisomy 22 -extended survival and hirschsprung’s disease: a case report
Complete trisomy 22 -extended survival and hirschsprung’s disease: a case report Open
View article: Comparison of healing of acute total tympanic membrane perforation between rats with and without excision of the mallear handle
Comparison of healing of acute total tympanic membrane perforation between rats with and without excision of the mallear handle Open
Objective We compared the histological changes and hearing restoration during the healing of acute total tympanic membrane (TM) perforations between Sprague–Dawley (SD) rats with and without excision of the mallear handle. Materials and me…
View article: Redistribution of the astrocyte phenotypes in the medial vestibular nuclei after unilateral labyrinthectomy
Redistribution of the astrocyte phenotypes in the medial vestibular nuclei after unilateral labyrinthectomy Open
Astrocytes are highly heterogeneous and involved in different aspects of fundamental functions in the central nervous system (CNS). However, whether and how this heterogeneous population of cells reacts to the pathophysiological challenge …
View article: TMEM30A is essential for hair cell polarity maintenance in postnatal mouse cochlea
TMEM30A is essential for hair cell polarity maintenance in postnatal mouse cochlea Open
Background Phosphatidylserine is translocated to the inner leaflet of the phospholipid bilayer membrane by the flippase function of type IV P-tape ATPase (P4-ATPase), which is critical to maintain cellular stability and homeostasis. Transm…
View article: Aucubin protects mouse cochlear hair cells from cisplatin-induced ototoxicity via activation of the PI3K/AKT/STAT3 pathway
Aucubin protects mouse cochlear hair cells from cisplatin-induced ototoxicity via activation of the PI3K/AKT/STAT3 pathway Open
Cisplatin is commonly used to treat cancers and is associated with a significant risk of irreversible sensorineural hearing loss. However, no effective preventive strategies are available for cisplatin-induced HL. Therefore, significant ef…
View article: [Research progress on non-surgical treatment of vestibular schwannomas].
[Research progress on non-surgical treatment of vestibular schwannomas]. Open
At present, the main treatment for vestibular schwannomas is surgery. Considering the risk of multiple complications from surgery and the subjective and objective conditions of patients, a non-surgical treatment modality, namely st…
View article: The Spectrum of Vestibular Disorders Presenting With Acute Continuous Vertigo
The Spectrum of Vestibular Disorders Presenting With Acute Continuous Vertigo Open
Objective To explore the composition of vestibular disorders presenting with the acute vestibular syndrome (AVS). Methods We performed a case analysis of 209 AVS patients between January 2016 and December 2020. These patients were grouped …
View article: Single-Cell RNA-Seq Reveals Heterogeneity of Cell Communications between Schwann Cells and Fibroblasts within Vestibular Schwannoma Microenvironment
Single-Cell RNA-Seq Reveals Heterogeneity of Cell Communications between Schwann Cells and Fibroblasts within Vestibular Schwannoma Microenvironment Open
View article: RETRACTED: A Deep Learning Model for Three-Dimensional Nystagmus Detection and Its Preliminary Application
RETRACTED: A Deep Learning Model for Three-Dimensional Nystagmus Detection and Its Preliminary Application Open
Symptoms of vertigo are frequently reported and are usually accompanied by eye-movements called nystagmus. In this article, we designed a three-dimensional nystagmus recognition model and a benign paroxysmal positional vertigo automatic di…
View article: A reduced form of nicotinamide riboside protects the cochlea against aminoglycoside-induced ototoxicity by SIRT1 activation
A reduced form of nicotinamide riboside protects the cochlea against aminoglycoside-induced ototoxicity by SIRT1 activation Open
NRH ameliorates aminoglycoside-induced ototoxicity by inhibiting HC apoptosis by activating SIRT1 and decreasing ROS. NRH is an effective therapeutic option for aminoglycoside-induced ototoxicity.
View article: Changes of Vestibular Symptoms in Menière's Disease After Triple Semicircular Canal Occlusion: A Long-Term Follow-Up Study
Changes of Vestibular Symptoms in Menière's Disease After Triple Semicircular Canal Occlusion: A Long-Term Follow-Up Study Open
Background The clinical efficacy of triple semicircular canal occlusion (TSCO) and vestibular nerve resection (VNS) for patients with Ménière's disease has been unclear. Objective To explore changes in vestibular symptoms after TSCO and it…
View article: Single-Cell RNA-Seq Reveals the Heterogeneity of Cell Communications Between Schwann Cells and Fibroblasts Within the Microenvironment in Vestibular Schwannoma
Single-Cell RNA-Seq Reveals the Heterogeneity of Cell Communications Between Schwann Cells and Fibroblasts Within the Microenvironment in Vestibular Schwannoma Open
View article: Pyroptosis Accelerates Spiral Ganglion Neuronal Degeneration Induced by Aminoglycosides in the Cochlea
Pyroptosis Accelerates Spiral Ganglion Neuronal Degeneration Induced by Aminoglycosides in the Cochlea Open
Background In aminoglycoside-induced hearing loss, damage to spiral ganglion neurons (SGNs) accelerates gradually after the acute outer hair cell death, accompanied by macrophage infiltration and cytokine release. Pyroptosis plays a critic…
View article: Trehalose protects against cisplatin-induced cochlear hair cell damage by activating TFEB-mediated autophagy
Trehalose protects against cisplatin-induced cochlear hair cell damage by activating TFEB-mediated autophagy Open
Cisplatin is a widely used chemotherapeutic agent for the treatment of various tumors, but its side effects limit its application. Ototoxicity, a major adverse effect of cisplatin, causes irreversible sensorineural hearing loss. Unfortunat…
View article: Essential Role of Sptan1 in Cochlear Hair Cell Morphology and Function Via Focal Adhesion Signaling
Essential Role of Sptan1 in Cochlear Hair Cell Morphology and Function Via Focal Adhesion Signaling Open
Hearing loss is the most common human sensory deficit. Hearing relies on stereocilia, inserted into the cuticular plate of hair cells (HCs), where they play an important role in the perception of sound and its transmission. Although numero…
View article: Multisensory Exercise Improves Balance in People with Balance Disorders: A Systematic Review
Multisensory Exercise Improves Balance in People with Balance Disorders: A Systematic Review Open
Objective To examine the effect of multisensory exercise on balance disorders. Methods PubMed, Scopus and Web of Science were searched to identify eligible studies published before January 1, 2020. Eligible studies included randomized cont…
View article: Transcriptomic Analysis Reveals an Altered Hcy Metabolism in the Stria Vascularis of the Pendred Syndrome Mouse Model
Transcriptomic Analysis Reveals an Altered Hcy Metabolism in the Stria Vascularis of the Pendred Syndrome Mouse Model Open
Purpose. Slc26a4-/- mice exhibit severer defects in the development of the cochlea and develop deafness, while the underlying mechanisms responsible for these effects remain unclear. Our study was to investigate the potential mechanism lin…