Donna Denton
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View article: Identification of new candidates regulating autophagy-dependent midgut degradation in Drosophila melanogaster
Identification of new candidates regulating autophagy-dependent midgut degradation in Drosophila melanogaster Open
Autophagy-dependent cell death (ADCD) is a context-specific form of programmed cell death that plays an important role in development and homeostasis. During Drosophila metamorphosis, hormonal cues modulate growth and other signalling casc…
View article: Understanding Developmental Cell Death Using Drosophila as a Model System
Understanding Developmental Cell Death Using Drosophila as a Model System Open
Cell death plays an essential function in organismal development, wellbeing, and ageing. Many types of cell deaths have been described in the past 30 years. Among these, apoptosis remains the most conserved type of cell death in metazoans …
View article: The Drosophila ZNRF1/2 homologue, detour, interacts with HOPS complex and regulates autophagy
The Drosophila ZNRF1/2 homologue, detour, interacts with HOPS complex and regulates autophagy Open
Autophagy, the process of elimination of cellular components by lysosomal degradation, is essential for animal development and homeostasis. Using the autophagy-dependent Drosophila larval midgut degradation model we identified an autophagy…
View article: Autophagy captures the retromer-TBC1D5 complex to inhibit receptor recycling
Autophagy captures the retromer-TBC1D5 complex to inhibit receptor recycling Open
Retromer prevents the destruction of numerous receptors by recycling them from endosomes to the trans-Golgi network or plasma membrane. This enables retromer to fine-tune the activity of many signaling pathways in parallel. However, the me…
View article: Receptor Recycling by Retromer
Receptor Recycling by Retromer Open
The highly conserved retromer complex controls the fate of hundreds of receptors that pass through the endolysosomal system and is a central regulatory node for diverse metabolic programs. More than 20 years ago, retromer was discovered as…
View article: Autophagy captures the retromer-TBC1D5 complex to inhibit receptor recycling
Autophagy captures the retromer-TBC1D5 complex to inhibit receptor recycling Open
Retromer prevents the destruction of numerous receptors by recycling them from endosomes to the trans-Golgi network or plasma membrane. This enables retromer to fine-tune the activity of many signaling pathways in parallel. However, the me…
View article: Cp1/cathepsin L is required for autolysosomal clearance in <i>Drosophila</i>
Cp1/cathepsin L is required for autolysosomal clearance in <i>Drosophila</i> Open
Macroautophagy/autophagy is a highly conserved lysosomal degradative pathway important for maintaining cellular homeostasis. Much of our current knowledge of autophagy is focused on the initiation steps in this process. Recently, an unders…
View article: Using<i>Drosophila</i>Models of Amyloid Toxicity to Study Autophagy in the Pathogenesis of Alzheimer’s Disease
Using<i>Drosophila</i>Models of Amyloid Toxicity to Study Autophagy in the Pathogenesis of Alzheimer’s Disease Open
Autophagy is a conserved catabolic pathway that involves the engulfment of cytoplasmic components such as large protein aggregates and organelles that are delivered to the lysosome for degradation. This process is important in maintaining …
View article: Autophagy regulates the survival of cells with chromosomal instability
Autophagy regulates the survival of cells with chromosomal instability Open
Chromosomal instability (CIN) refers to genomic instability in which cells have gained or lost chromosomes or chromosomal fragments. A high level of CIN is common in solid tumours and is associated with cancer drug resistance and poor prog…