Explanipedia

A bitter anti-inflammatory drug binds at two distinct sites of a human bitter taste GPCR Open

Lior Peri, Donna Matzov, Dominic R. Huxley, Alon Rainish, Fabrizio Fierro , et al. · 2024

Intracellular binding pocket revealed in the human bitter taste receptor TAS2R14 Open

Lior Peri, Donna Matzov, Dominic R. Huxley, Alon Rainish, Fabrizio Fierro , et al. · 2024

Bitter taste receptors (TAS2Rs), a subfamily of G-protein coupled receptors (GPCRs) expressed orally and extraorally, elicit signaling in response to a large set of ligands. Among the 25 functional TAS2Rs encoded in the human genome, TAS2R…

Rhodopsin-bestrophin fusion proteins from unicellular algae form gigantic pentameric ion channels Open

Andrey Rozenberg, Igor Kaczmarczyk, Donna Matzov, Johannes Vierock, Takashi Nagata , et al. · 2022

The tethered peptide activation mechanism of adhesion GPCRs Open

Ximena Barros-Álvarez, Robert M. Nwokonko, Alexander Vizurraga, Donna Matzov, Feng He , et al. · 2022

Rational prioritization strategy allows the design of macrolide derivatives that overcome antibiotic resistance Open

Gerhard König, Pandian Sokkar, Niclas Pryk, Sascha Heinrich, David R. Möller , et al. · 2021

Significance Due to the development of resistance against commonly used antibiotics, new derivatives that avoid resistance mechanisms need to be developed. To address this problem, a rational prioritization strategy is outlined for macroli…

Ribosome-binding and anti-microbial studies of the mycinamicins, 16-membered macrolide antibiotics from Micromonospora griseorubida Open

Elinor Breiner-Goldstein, Zohar Eyal, Donna Matzov, Yehuda Halfon, Giuseppe Cimicata , et al. · 2021

Macrolides have been effective clinical antibiotics for over 70 years. They inhibit protein biosynthesis in bacterial pathogens by narrowing the nascent protein exit tunnel in the ribosome. The macrolide class of natural products consist o…

Cryo-EM structure of the highly atypical cytoplasmic ribosome of Euglena gracilis Open

Donna Matzov, Masato Taoka, Yuko Nobe, Yoshio Yamauchi, Yehuda Halfon , et al. · 2020

Ribosomal RNA is the central component of the ribosome, mediating its functional and architectural properties. Here, we report the cryo-EM structure of a highly divergent cytoplasmic ribosome from the single-celled eukaryotic alga Euglena …

Dynamic RNA acetylation revealed by quantitative cross-evolutionary mapping Open

Aldema Sas‐Chen, Justin M. Thomas, Donna Matzov, Masato Taoka, Kellie D. Nance , et al. · 2020

The large repertoire of 2’-O-methylation guided by C/D snoRNAs on Trypanosoma brucei rRNA Open

K. Shanmugha Rajan, Yinzhou Zhu, Katerina Adler, Tirza Doniger, Smadar Cohen‐Chalamish , et al. · 2020

The parasite Trypanosoma brucei cycles between insect and mammalian hosts, and is the causative agent of sleeping sickness. Here, we performed genome-wide mapping of 2'-O-methylations (Nms) on trypanosome rRNA using three hig…

The large repertoire of 2ʹ-O-methylation guided by C/D snoRNAs on Trypanosoma brucei rRNA Open

K. Shanmugha Rajan, Yinzhou Zhu, Katerina Adler, Tirza Doniger, Smadar Cohen‐Chalamish , et al. · 2020

The parasite Trypanosoma brucei cycles between insect and mammalian hosts, and is the causative agent of sleeping sickness. Here, we performed genome-wide mapping of 2ʹ-O-methylations (Nms) on trypanosome rRNA using three hig…

The large repertoire of 2’-O-methylation guided by C/D snoRNAs on Trypanosoma brucei rRNA Open

K. Shanmugha Rajan, Yinzhou Zhu, Katerina Adler, Tirza Doniger, Smadar Cohen‐Chalamish , et al. · 2020

The parasite Trypanosoma brucei cycles between insect and mammalian hosts, and is the causative agent of sleeping sickness. Here, we performed genome-wide mapping of 2ʹ-O-methylations (Nms) on trypanosome rRNA using three hig…

Structure of Pseudomonas aeruginosa ribosomes from an aminoglycoside-resistant clinical isolate Open

Yehuda Halfon, Alicia Jiménez‐Fernández, Ruggero La Rosa, Rocio Espinosa, Helle Krogh Johansen , et al. · 2019

Resistance to antibiotics has become a major threat to modern medicine. The ribosome plays a fundamental role in cell vitality by the translation of the genetic code into proteins; hence, it is a major target for clinically useful antibiot…

Exit tunnel modulation as resistance mechanism of S. aureus erythromycin resistant mutant Open

Yehuda Halfon, Donna Matzov, Zohar Eyal, Anat Bashan, Ella Zimmerman , et al. · 2019

Stress response as implemented by hibernating ribosomes: a structural overview Open

Donna Matzov, Anat Bashan, Mee‐Ngan F. Yap, Ada Yonath · 2019

Protein synthesis is one of the most energy demanding cellular processes. The ability to regulate protein synthesis is essential for cells under normal as well as stress conditions, such as nutrient deficiencies. One mechanism for protein …

Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin Open

Moran Shalev-Benami, Yan Zhang, H. Rozenberg, Yuko Nobe, Masato Taoka , et al. · 2017

Leishmania is a single-celled eukaryotic parasite afflicting millions of humans worldwide, with current therapies limited to a poor selection of drugs that mostly target elements in the parasite’s cell envelope. Here we determined the atom…

The cryo-EM structure of hibernating 100S ribosome dimer from pathogenic Staphylococcus aureus Open

Donna Matzov, Shintaro Aibara, Arnab Basu, Ella Zimmerman, Anat Bashan , et al. · 2017

Structural insights of lincosamides targeting the ribosome of Staphylococcus aureus Open

Donna Matzov, Zohar Eyal, Raphael I. Benhamou, Moran Shalev-Benami, Yehuda Halfon , et al. · 2017

Antimicrobial resistance within a wide range of pathogenic bacteria is an increasingly serious threat to global public health. Among these pathogenic bacteria are the highly resistant, versatile and possibly aggressive bacteria, Staphyloco…

The Ribosomal Protein uL22 Modulates the Shape of the Protein Exit Tunnel Open

Itai Wekselman, Ella Zimmerman, Chen Davidovich, Matthew J. Belousoff, Donna Matzov , et al. · 2017

A Bright Future for Antibiotics? Open

Donna Matzov, Anat Bashan, Ada Yonath · 2017

Multidrug resistance is a global threat as the clinically available potent antibiotic drugs are becoming exceedingly scarce. For example, increasing drug resistance among gram-positive bacteria is responsible for approximately one-third of…

Structural Basis for Linezolid Binding Site Rearrangement in the Staphylococcus aureus Ribosome Open

Matthew J. Belousoff, Zohar Eyal, Mazdak Radjainia, Tofayel Ahmed, Rebecca S. Bamert , et al. · 2017

An unorthodox, surprising mechanism of resistance to the antibiotic linezolid was revealed by cryo-electron microscopy (cryo-EM) in the 70S ribosomes from a clinical isolate of Staphylococcus aureus . This high-resolution structural inform…

A novel pleuromutilin antibacterial compound, its binding mode and selectivity mechanism Open

Zohar Eyal, Donna Matzov, Miri Krupkin, Susanne Paukner, Rosemarie Riedl , et al. · 2016

The increasing appearance of pathogenic bacteria with antibiotic resistance is a global threat. Consequently, clinically available potent antibiotics that are active against multidrug resistant pathogens are becoming exceedingly scarce. Ri…

Avilamycin and evernimicin induce structural changes in rProteins uL16 and CTC that enhance the inhibition of A-site tRNA binding Open

Miri Krupkin, Itai Wekselman, Donna Matzov, Zohar Eyal, Yael Diskin‐Posner , et al. · 2016

Significance Resistance to antibiotics poses a serious threat in contemporary medicine. Avilamycin and evernimicin, polysaccharide antibiotics belonging to the orthosomycin family, possess inhibitory activity against multidrug-resistant pa…

2.8-Å Cryo-EM Structure of the Large Ribosomal Subunit from the Eukaryotic Parasite Leishmania Open

Moran Shalev-Benami, Yan Zhang, Donna Matzov, Yehuda Halfon, Arie Zackay , et al. · 2016

Ribosomal Antibiotics: Contemporary Challenges Open

T. Auerbach-Nevo, David Baram, Anat Bashan, Matthew J. Belousoff, Elinor Breiner , et al. · 2016

Most ribosomal antibiotics obstruct distinct ribosomal functions. In selected cases, in addition to paralyzing vital ribosomal tasks, some ribosomal antibiotics are involved in cellular regulation. Owing to the global rapid increase in the…

Structural insights into species-specific features of the ribosome from the pathogen Staphylococcus aureus Open

Zohar Eyal, Donna Matzov, Miri Krupkin, Itai Wekselman, Susanne Paukner , et al. · 2015

Significance Clinical use of the currently available antibiotics is severely compromised by the increasing resistance to them, acquired by the natural bacterial capability to manipulate their genomes. Many existing antibiotics target the f…

A Recombinant Collagen–mRNA Platform for Controllable Protein Synthesis Open

Liping Sun, Yunjing Xiong, Anat Bashan, Ella Zimmerman, Shirley S. Daube , et al. · 2015

We have developed a collagen–mRNA platform for controllable protein production that is intended to be less prone to the problems associated with commonly used mRNA therapy as well as with collagen skin‐healing procedures. A collagen mimic …

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