Explanipedia

Exploring the potential of digital biomarkers as a measure of brain health ‘capital’ Open

Dylan Powell, Stephanie Adams, Donncha S. Mullin, Miles Welstead, John Harrison , et al. · 2025

From ‘Memory Assessment Please’ to Masterpieces: Refining the Referral Process Open

Donncha S. Mullin, Anthony Lindsay, Helen Smith, Linda Mitchell, I Smith · 2025

Aims: Inappropriate or incomplete referrals for memory assessment were a recurrent issue within our Old Age Psychiatry community multidisciplinary team (MDT) triage meetings. These referrals often lacked essential information, such as dura…

Life-course exposure to air pollution and the risk of dementia in the Lothian Birth Cohort 1936 Open

Otto‐Emil Ilmari Jutila, Donncha S. Mullin, Massimo Vieno, Sam Tomlinson, Adele Taylor , et al. · 2024

Background: Air pollution in later life has been associated with dementia; however, limited research has investigated the association between air pollution across the life course, either at specific life periods or cumulatively. The projec…

Next generation brain health: transforming global research and public health to promote prevention of dementia and reduce its risk in young adult populations Open

Francesca R Farina, Katie Bridgeman, Sarah Gregory, Lucía Crivelli, Isabelle F. Foote , et al. · 2024

Efforts to prevent dementia can benefit from precision interventions delivered to the right population at the right time; that is, when the potential to reduce risk is the highest. Young adults (aged 18-39 years) are a neglected population…

Interplay between polygenic effects and polypharmacy on dementia: An investigation in an elderly Scottish cohort Open

Vasilis Raptis, Donncha S. Mullin, Sumbul Syed, Ian J. Deary, Simon R. Cox , et al. · 2024

INTRODUCTION Polygenic Risk Scores for Alzheimer dementia (AD-PRS), a measure of aggregate AD genetic risk and polypharmacy have been associated with dementia. Here, we test their interaction’s association with future dementia among older …

DNAm scores for serum GDF15 and NT-proBNP levels associate with a range of traits affecting the body and brain Open

Danni A. Gadd, Hannah M. Smith, Donncha S. Mullin, Aleksandra D. Chybowska, Robert F. Hillary , et al. · 2024

Uncovering the multivariate genetic architecture of frailty with genomic structural equation modelling Open

Isabelle F. Foote, Jonny P Flint, Anna E. Fürtjes, Donncha S. Mullin, John D. Fisk , et al. · 2024

Frailty is a multifaceted clinical state associated with accelerated aging and adverse health outcomes. Informed etiological models of frailty hold promise for producing widespread health improvements across the aging population. Frailty i…

Malawi Mental Health Guide: Overview and Evaluation of a Mental Health Quick Reference Guide and Phone App for Use in Non-specialist Settings Open

Donncha S. Mullin, Kazione Kulisewa, Owen Mwale, Rui-Shian Lee, Robert Stewart · 2024

Aims In Malawi, there are three Consultant psychiatrists for a population of approximately 20 million people. We cannot rely solely on specialists to provide mental health care. We produced the Malawi Quick Guide to Mental Health (the Guid…

Breaking down barriers: promoting journals beyond the page with open access journal clubs Open

Angharad N. de Cates, Donncha S. Mullin, Lucy Stirland, Mariana Pinto da Costa, Derek K. Tracy · 2024

Summary In 2020, during the early days of the COVID-19 pandemic, the British Journal of Psychiatry ( BJPsych ) established a series of free online teaching sessions called BJPsych Journal Clubs. Their educational purpose is two-fold: (a) t…

Epigenetic scores of blood-based proteins as biomarkers of general cognitive function and brain health Open

Hannah M. Smith, Joanna E. Moodie, Karla Monterrubio‐Gómez, Danni A. Gadd, Robert F. Hillary , et al. · 2024

Life course exposure to air pollution and the risk of mild cognitive impairment and dementia in the Lothian Birth Cohort 1936 Open

Otto‐Emil Ilmari Jutila, Miles Welstead, Donncha S. Mullin, Sam Tomlinson, Massimo Vieno , et al. · 2023

Background Air pollution has been associated with the risk of pathological cognitive decline and dementia (Chandra et al., 2022). Past research has focused on cross‐sectional associations or short‐term exposure measurement, and there is a …

Trajectories of Motoric Cognitive Risk and Incident Dementia in Scotland Open

Donncha S. Mullin · 2023

Background Motoric cognitive risk syndrome (MCR) ‐ objective slow gait and subjective cognitive complaints ‐ is quick and easy to measure, making it a potentially useful clinical tool for identifying those at high risk of developing dement…

TRAJECTORIES OF MOTORIC COGNITIVE RISK SYNDROME AND INCIDENT DEMENTIA IN SCOTLAND Open

Donncha S. Mullin, Danni A. Gadd, Michelle Luciano, Tom C. Russ, Graciela Muñiz‐Terrera · 2023

Background Motoric cognitive risk syndrome (MCR) - objective slow gait and subjective cognitive complaints - is quick and easy to measure, making it a potentially useful clinical tool for identifying those at high risk of developing dement…

Epigenetic scores of blood-based proteins as biomarkers of general cognitive function and brain health Open

Hannah M. Smith, Joanna E. Moodie, Karla Monterrubio‐Gómez, Danni A. Gadd, Robert F. Hillary , et al. · 2023

Background Blood-based biomarkers of brain health could provide a cost-effective contribution to detecting individuals at risk of dementia. Epigenetic scores (EpiScores) for blood protein levels have previously associated with several dise…

DNAm scores for serum GDF15 and NT-proBNP levels associate with a range of traits affecting the body and brain Open

Danni A. Gadd, Hannah M. Smith, Donncha S. Mullin, Aleksandra D. Chybowska, Robert F. Hillary , et al. · 2023

Background Plasma growth differentiation factor 15 (GDF15) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are cardiovascular biomarkers that associate with a range of diseases. Epigenetic scores (EpiScores) for GDF15 and NT-proB…

Motoric Cognitive Risk syndrome trajectories and incident dementia over 10 years Open

Donncha S. Mullin, Danni A. Gadd, Tom C. Russ, Michelle Luciano, Graciela Muñiz‐Terrera · 2023

Background Motoric Cognitive Risk (MCR) syndrome is a high-risk state for adverse health outcomes in older adults characterised by measured slow gait speed and self-reported cognitive complaints. The recent addition to the Lothian Birth Co…

Identifying dementia using medical data linkage in a longitudinal cohort study: Lothian Birth Cohort 1936 Open

Donncha S. Mullin, Lucy Stirland, Emily Buchanan, Catherine-Anne Convery, Simon R. Cox , et al. · 2023

Socioeconomic status as a risk factor for motoric cognitive risk syndrome in a community‐dwelling population: A longitudinal observational study Open

Donncha S. Mullin, Lucy Stirland, Tom C. Russ, Michelle Luciano, Graciela Muñiz‐Terrera · 2023

Background Motoric cognitive risk (MCR) is a syndrome characterised by measured slow gait speed and self‐reported cognitive complaints. MCR is a high‐risk state for adverse health outcomes in older adults, particularly cognitive impairment…

Motoric cognitive risk syndrome trajectories and incident dementia over 10 years Open

Donncha S. Mullin, Danni A. Gadd, Tom C. Russ, Michelle Luciano, Graciela Muñiz‐Terrera · 2023

MCR showed similar prognostic ability for dementia in a Scottish cohort as for other populations. MCR could identify a target group for early interventions of modifiable risk factors to prevent incident dementia. This study illustrates the…

Dementia diagnosis and prevalence in the Lothian Birth Cohort 1936 using medical data linkage Open

Donncha S. Mullin, Lucy Stirland, Emily Buchanan, Catherine-Anne Convery, Simon R. Cox , et al. · 2022

Background The Lothian Birth Cohort 1936 (LBC1936) is a longitudinal study of ageing with well-characterised assessments, but until now, it has relied on self-report or proxies for dementia outcomes. This report describes a framework for c…

PREVALENCE AND FACTORS ASSOCIATED WITH MOTORIC COGNITIVE RISK IN A COMMUNITY-DWELLING OLDER SCOTTISH POPULATION Open

Donncha S. Mullin, Lucy Stirland, Tom C. Russ, Michelle Luciano, Graciela Muñiz‐Terrera · 2022

Motoric Cognitive Risk (MCR) syndrome combines slow walking and self-reported cognitive complaints. It is a quick and simple way of identifying individuals at high risk of developing dementia. MCR has not been described in a Scottish popul…

Prevalence and predictors of Motoric Cognitive Risk syndrome in a community‐dwelling older Scottish population: A longitudinal observational study Open

Donncha S. Mullin, Lucy Stirland, Miles Welstead, Tom C. Russ, Michelle Luciano , et al. · 2022

Objectives Motoric Cognitive Risk (MCR) is a gait‐based predementia syndrome that is easy to measure and prognostic of dementia and falls. We aimed to examine the prevalence and risk factors for MCR, and assess its overlap with Mild Cognit…

Prevalence and predictors of Motoric Cognitive Risk syndrome in a community-dwelling older Scottish population: a longitudinal observational study Open

Donncha S. Mullin, Lucy Stirland, Miles Welstead, Tom C. Russ, Michelle Luciano , et al. · 2022

Objectives This study aimed to determine the prevalence of Motoric Cognitive Risk (MCR), describe associated risk factors for this syndrome, and assess its overlap with Mild Cognitive Impairment, Prefrailty, and Frailty, in a cohort of old…

Mechanisms of motoric cognitive risk—Hypotheses based on a systematic review and meta‐analysis of longitudinal cohort studies of older adults Open

Donncha S. Mullin, Alastair Cockburn, Miles Welstead, Michelle Luciano, Tom C. Russ , et al. · 2022

We aimed to refine the hypothesis that motoric cognitive risk (MCR), a syndrome combining measured slow gait speed and self‐reported cognitive complaints, is prognostic of incident dementia and other major causes of morbidity in older age.…

Trajectories of Frailty With Aging: Coordinated Analysis of Five Longitudinal Studies Open

Natalie Jenkins, Emiel O. Hoogendijk, Joshua Armstrong, Nathan A. Lewis, Janice M. Ranson , et al. · 2022

Background and Objectives There is an urgent need to better understand frailty and its predisposing factors. Although numerous cross-sectional studies have identified various risk and protective factors of frailty, there is a limited under…

Motoric Cognitive Risk Syndrome: Its prognostic value for dementia and other health outcomes. A systematic review Open

Donncha S. Mullin, Alastair Cockburn, Miles Welstead, Michelle Luciano, Graciela Muñiz‐Terrera , et al. · 2021

Motoric cognitive risk syndrome (MCR) is a recently defined concept combining objective slow gait and subjective cognitive complaints, in the absence of dementia or significant functional impairment. MCR is associated with an increased ris…

PREPRINT: Mechanisms of Motoric Cognitive Risk – hypotheses based on a systematic review and meta-analysis of longitudinal cohort studies of older adults Open

Donncha S. Mullin, Alastair Cockburn, Miles Welstead, Michelle Luciano, Tom C. Russ , et al. · 2021

We aimed to refine the hypothesis that Motoric Cognitive Risk (MCR), a syndrome combining measured slow gait speed and self-reported cognitive complaints, is prognostic of incident dementia and other major causes of morbidity in older age.…

Predictors of Mild Cognitive Impairment Stability, Progression, or Reversion in the Lothian Birth Cohort 1936 Open

Miles Welstead, Michelle Luciano, Graciela Muñiz‐Terrera, Stina Saunders, Donncha S. Mullin , et al. · 2021

Background: Mild cognitive impairment (MCI) describes a borderland between healthy cognition and dementia. Progression to and reversion from MCI is relatively common but more research is required to understand the factors affecting this fl…

Measuring multimorbidity beyond counting diseases: systematic review of community and population studies and guide to index choice Open

Lucy Stirland, Laura González-Saavedra, Donncha S. Mullin, Craig Ritchie, Graciela Muñiz‐Terrera , et al. · 2020

Objectives To identify and summarise existing indices for measuring multimorbidity beyond disease counts, to establish which indices include mental health comorbidities or outcomes, and to develop recommendations based on applicability, pe…

Health Education and Activity – Lessening The Inequalities in mental health (HEA – LTI mental health) Open

Georgia Richmond, Conor Kenny, Jabed Ahmed, Lucy Stephenson, Jamie Lindsay , et al. · 2017

Patients suffering from mental health illness have considerably more physical health disease burden than the rest of the population and are more likely to die 10 to 20 years younger compared with their peers. Diabetes, cardiovascular and r…

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