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View article: IF1 Promotes Cellular Proliferation and Inhibits Oxidative Phosphorylation in Mouse Embryonic Fibroblasts under Normoxia and Hypoxia
IF1 Promotes Cellular Proliferation and Inhibits Oxidative Phosphorylation in Mouse Embryonic Fibroblasts under Normoxia and Hypoxia Open
ATP synthase inhibitory factor subunit 1 (IF1) is an inhibitory subunit of mitochondrial ATP synthase, playing a crucial role in regulating mitochondrial respiration and energetics. It is well-established that IF1 interacts with the F1 sec…
View article: Real-Time Visualization of Cytosolic and Mitochondrial ATP Dynamics in Response to Metabolic Stress in Cultured Cells
Real-Time Visualization of Cytosolic and Mitochondrial ATP Dynamics in Response to Metabolic Stress in Cultured Cells Open
Adenosine 5′ triphosphate (ATP) is the energy currency of life, which is produced in mitochondria (~90%) and cytosol (less than 10%). Real-time effects of metabolic changes on cellular ATP dynamics remain indeterminate. Here we report the …
View article: Multi-Phenotypic Breast Cancer Post-Radiotherapy for Hodgkin Lymphoma: A Case of Secondary Malignancy
Multi-Phenotypic Breast Cancer Post-Radiotherapy for Hodgkin Lymphoma: A Case of Secondary Malignancy Open
Morbidity and mortality associated with radiation-induced secondary malignancies (RISMs) have shifted treatment paradigms to minimize or eliminate radiation from treatment regimens. In this case, a 48-year-old woman was diagnosed with Hodg…
View article: Assessing Immune Response to 3rd Dose of COVID-19 Vaccine Series in Patients Undergoing Cancer Treatment at University Medical Center- New Orleans
Assessing Immune Response to 3rd Dose of COVID-19 Vaccine Series in Patients Undergoing Cancer Treatment at University Medical Center- New Orleans Open
Background: COVID-19 pandemic remains a global emergencies. Vaccines against the virus SARS-CoV-2 have been shown to reduce incidence and severe complications from COVID-19 infection. Previous studies have shown that patients receiving act…
View article: Genetically Encoded ATP Biosensors for Direct Monitoring of Cellular ATP Dynamics
Genetically Encoded ATP Biosensors for Direct Monitoring of Cellular ATP Dynamics Open
Adenosine 5′-triphosphate, or ATP, is the primary molecule for storing and transferring energy in cells. ATP is mainly produced via oxidative phosphorylation in mitochondria, and to a lesser extent, via glycolysis in the cytosol. In genera…