Donovan Low
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View article: Reprint of: Manipulation of microbiota reveals altered callosal myelination and white matter plasticity in a model of Huntington disease
Reprint of: Manipulation of microbiota reveals altered callosal myelination and white matter plasticity in a model of Huntington disease Open
Structural and molecular myelination deficits represent early pathological features of Huntington disease (HD). Recent evidence from germ-free (GF) animals suggests a role for microbiota-gut-brain bidirectional communication in the regulat…
View article: Perturbation of the immune cells and prenatal neurogenesis by the triplication of the <i>Erg</i> gene in mouse models of Down syndrome
Perturbation of the immune cells and prenatal neurogenesis by the triplication of the <i>Erg</i> gene in mouse models of Down syndrome Open
Some mouse models of Down syndrome (DS), including Ts1Cje mice, exhibit impaired prenatal neurogenesis with yet unknown molecular mechanism. To gain insights into the impaired neurogenesis, a transcriptomic and flow cytometry analysis of E…
View article: Biphasic impact of prenatal inflammation and macrophage depletion on the wiring of neocortical inhibitory circuits
Biphasic impact of prenatal inflammation and macrophage depletion on the wiring of neocortical inhibitory circuits Open
SUMMARY The etiology of neurodevelopmental disorders is linked to defects in Parvalbumin (PV)-expressing cortical interneurons and to prenatal immune challenges. Mouse models of maternal immune activation (MIA) and microglia deficits incre…
View article: Manipulation of microbiota reveals altered myelination and white matter plasticity in a model of Huntington disease
Manipulation of microbiota reveals altered myelination and white matter plasticity in a model of Huntington disease Open
Structural and molecular myelination deficits represent early pathological features of Huntington disease (HD). Recent evidence from germ-free (GF) animals suggests a role for microbiota-gut-brain bidirectional communication in the regulat…
View article: Multifactorial development of microglia and its dysregulation
Multifactorial development of microglia and its dysregulation Open
Microglia, the resident macrophages of the central nervous system (CNS), provide immune protection and contribute to brain development and homeostasis by constantly sensing and interacting with their environment. They are implicated in num…
View article: Zika Virus Infects Human Fetal Brain Microglia and Induces Inflammation
Zika Virus Infects Human Fetal Brain Microglia and Induces Inflammation Open
Our results highlight an important role for microglia and neuroinflammation during congenital ZIKV pathogenesis.
View article: Targeting innate immunity for neurodegenerative disorders of the central nervous system
Targeting innate immunity for neurodegenerative disorders of the central nervous system Open
Neuroinflammation is critically involved in numerous neurodegenerative diseases, and key signaling steps of innate immune activation hence represent promising therapeutic targets. This mini review series originated from the 4th Venusberg M…