Dor Simkin
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View article: IRS2 as a driver of brain metastasis in colorectal cancer: A potential target for novel therapeutic strategies
IRS2 as a driver of brain metastasis in colorectal cancer: A potential target for novel therapeutic strategies Open
Background Colorectal cancer (CRC) ranks as the fourth most common cause of brain metastasis (BM), with its incidence on the rise. However, the molecular mechanisms driving the formation of these lesions from CRC remain unclear. Methods We…
View article: Glioma spatialomics dataset
Glioma spatialomics dataset Open
Data related to the paper "Integrative spatial analysis reveals a multi-layered organization of glioblastoma" (Greenwald*, Galili-Darnell*, Hoefflin* et al., 2024. Cell 187(10): 2485-2501). See visium_dataset_description.csv and readme_COD…
View article: Integrative spatial analysis reveals a multi-layered organization of glioblastoma
Integrative spatial analysis reveals a multi-layered organization of glioblastoma Open
Glioma contains malignant cells in diverse states. Here, we combine spatial transcriptomics, spatial proteomics, and computational approaches to define glioma cellular states and uncover their organization. We find three prominent modes of…
View article: Integrative spatial analysis reveals a multi-layered organization of glioblastoma
Integrative spatial analysis reveals a multi-layered organization of glioblastoma Open
Summary Glioma contains malignant cells in diverse states. Hypoxic regions are associated with a unique histology of pseudopalisading cells, while other regions appear to have limited histological organization, reflecting the diffuse natur…
View article: Glioma spatialomics dataset
Glioma spatialomics dataset Open
See visium_dataset_description.csv and readme_CODEX.txt Thirteen fresh frozen GBM samples profiled by 10x Visium Six fresh frozen IDH mutant samples profiled by 10x Visium Twelve fresh frozen GBM samples profiled by CODEX
View article: Genomic alterations drive brain metastases formation in colorectal cancer: The role of IRS2
Genomic alterations drive brain metastases formation in colorectal cancer: The role of IRS2 Open
Colorectal cancer (CRC) is currently the fourth leading etiology of brain metastasis (BM). Yet, mechanisms supporting the formation of CRC BM are mostly unknown. In order to identify drivers that lead to tropism and adaptation of CRC cells…
View article: The transcriptional hallmarks of intra-tumor heterogeneity across a thousand tumors
The transcriptional hallmarks of intra-tumor heterogeneity across a thousand tumors Open
Each tumor contains malignant cells that differ in genotype, phenotype, and in their interactions with the tumor micro-environment (TME). This results in distinct integrated cellular states that govern intra-tumor heterogeneity (ITH), a ce…