Dora Kolić
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View article: Outlining the A-series of organophosphorus compounds: Cholinesterase inhibition, reactivation, cytotoxicity, and acute toxicity in mice
Outlining the A-series of organophosphorus compounds: Cholinesterase inhibition, reactivation, cytotoxicity, and acute toxicity in mice Open
Given the scarcity of experimental studies on A-series nerve agents (NAs), this paper provides ground-breaking insights and, for the first time, describes the inhibition and reactivation of human acetylcholinesterase (AChE) and butyrylchol…
View article: Evaluation of Anticholinesterase Activity of the Fungicides Mefentrifluconazole and Pyraclostrobin
Evaluation of Anticholinesterase Activity of the Fungicides Mefentrifluconazole and Pyraclostrobin Open
Triazoles are compounds with various biological activities, including fungicidal action. They became popular through cholinesterase studies after the successful synthesis of the dual binding femtomolar triazole inhibitor of acetylcholinest…
View article: Cholesterol Oxime Olesoxime Assessed as a Potential Ligand of Human Cholinesterases
Cholesterol Oxime Olesoxime Assessed as a Potential Ligand of Human Cholinesterases Open
Olesoxime, a cholesterol derivative with an oxime group, possesses the ability to cross the blood–brain barrier, and has demonstrated excellent safety and tolerability properties in clinical research. These characteristics indicate it may …
View article: Environmental exposure to glyphosate does not inhibit human acetylcholinesterase and butyrylcholinesterase
Environmental exposure to glyphosate does not inhibit human acetylcholinesterase and butyrylcholinesterase Open
Glyphosate has remained the leading herbicide on the global market to date, despite the continuous debate between consumers, scientific community, and regulatory agencies over its carcinogenicity, genotoxicity, environmental persistence, a…
View article: <i>N</i>‐methyl‐<scp>d</scp>‐aspartate receptors: <scp>Structure</scp>, function, and role in organophosphorus compound poisoning
<i>N</i>‐methyl‐<span>d</span>‐aspartate receptors: <span>Structure</span>, function, and role in organophosphorus compound poisoning Open
Acute organophosphorus compound (OP) poisoning induces symptoms of the cholinergic crises with the occurrence of severe epileptic seizures. Seizures are induced by hyperstimulation of the cholinergic system, but are enhanced by hyperactiva…
View article: Assessment of four organophosphorus pesticides as inhibitors of human acetylcholinesterase and butyrylcholinesterase
Assessment of four organophosphorus pesticides as inhibitors of human acetylcholinesterase and butyrylcholinesterase Open
Toxicity of organophosphorus compounds (OPs) remains a major public health concern due to their widespread use as pesticides and the existence of nerve agents. Their common mechanism of action involves inhibition of enzymes acetylcholinest…