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View article: Growth Differentiation Factor 15 as a Biomarker for Risk Stratification in the Cardiothoracic Surgery Intensive Care Unit
Growth Differentiation Factor 15 as a Biomarker for Risk Stratification in the Cardiothoracic Surgery Intensive Care Unit Open
Growth Differentiation Factor 15 (GDF15) is an emerging biomarker that significantly increases during acute stress responses, such as infections, and is moderately elevated in chronic and inflammation-driven conditions. While evidence sugg…
View article: Immunomodulatory Effects and Protection in Sepsis by the Antibiotic Moxifloxacin
Immunomodulatory Effects and Protection in Sepsis by the Antibiotic Moxifloxacin Open
Sepsis is a leading cause of death in Intensive Care Units. Despite its prevalence, sepsis remains insufficiently understood, with no substantial qualitative improvements in its treatment in the past decades. Immunomodulatory agents may ho…
View article: The impact of cardiopulmonary bypass time on the Sequential Organ Failure Assessment score after cardiac surgery
The impact of cardiopulmonary bypass time on the Sequential Organ Failure Assessment score after cardiac surgery Open
OBJECTIVES Postoperative organ dysfunction is common after cardiac surgery, particularly when cardiopulmonary bypass (CPB) is used. The Sequential Organ Failure Assessment (SOFA) score is validated to predict morbidity and mortality in car…
View article: <i>CLOCK</i> gene circannual expression in cluster headache
<i>CLOCK</i> gene circannual expression in cluster headache Open
Background Cluster headache is a primary headache disorder characterized by bouts with circadian and circannual patterns. The CLOCK gene has a central role in regulating circadian rhythms. Here, we investigate the circannual CLOCK expressi…
View article: DNA damage independent inhibition of NF-κB transcription by anthracyclines
DNA damage independent inhibition of NF-κB transcription by anthracyclines Open
Anthracyclines are among the most used and effective anticancer drugs. Their activity has been attributed to DNA double-strand breaks resulting from topoisomerase II poisoning and to eviction of histones from select sites in the genome. He…
View article: Murine Bone Marrow Derived Macrophages (BMDM's) stimulated with LPS and treated with PBS, Epirubicin and Aclarubicin
Murine Bone Marrow Derived Macrophages (BMDM's) stimulated with LPS and treated with PBS, Epirubicin and Aclarubicin Open
This dataset was used in the analysis which composes the GitHub repository: https://github.com/andrebolerbarros/Chora_etal_2022 The files presented here correspond to: gene_counts.tab: the table for the gene counts produced by the alignmen…
View article: Murine Bone Marrow Derived Macrophages (BMDM's) stimulated with LPS and treated with PBS, Epirubicin and Aclarubicin
Murine Bone Marrow Derived Macrophages (BMDM's) stimulated with LPS and treated with PBS, Epirubicin and Aclarubicin Open
This dataset was used in the analysis which composes the GitHub repository: https://github.com/andrebolerbarros/Chora_etal_2022 The files presented here correspond to: gene_counts.tab: the table for the gene counts produced by the alignmen…
View article: Role of Omega-6 Fatty Acid Metabolism in Cardiac Surgery Postoperative Bleeding Risk
Role of Omega-6 Fatty Acid Metabolism in Cardiac Surgery Postoperative Bleeding Risk Open
OBJECTIVES: Cardiac surgery is frequently associated with significant postoperative bleeding. Platelet-dysfunction is the main cardiopulmonary bypass (CPB)-induced hemostatic defect. Not only the number of platelets decreases, but also the…
View article: Tetracycline Antibiotics Induce Host-Dependent Disease Tolerance to Infection
Tetracycline Antibiotics Induce Host-Dependent Disease Tolerance to Infection Open
Several classes of antibiotics have long been known to have beneficial effects that cannot be explained strictly on the basis of their capacity to control the infectious agent. Here, we report that tetracycline antibiotics, which target th…
View article: Crosstalk between metabolism and immunity: the 3rd Annual Research Symposium of Instituto Gulbenkian de Ciência
Crosstalk between metabolism and immunity: the 3rd Annual Research Symposium of Instituto Gulbenkian de Ciência Open
The ‘Crosstalks of immunity and metabolism’ Symposium was focused on how the intercommunication between different organs and the immune system affects organismal health. At this meeting, experts in immunology and metabolic research provide…
View article: CXCL5-mediated recruitment of neutrophils into the peritoneal cavity of <i>Gdf15</i> -deficient mice protects against abdominal sepsis
CXCL5-mediated recruitment of neutrophils into the peritoneal cavity of <i>Gdf15</i> -deficient mice protects against abdominal sepsis Open
Significance Sepsis remains a leading cause of death. New insights into its pathophysiology are likely to be key to the development of effective therapeutic strategies against sepsis. Given the role of GDF15 in metabolism regulation and in…
View article: DNA damage independent inhibition of NF-κB transcription by anthracyclines
DNA damage independent inhibition of NF-κB transcription by anthracyclines Open
Anthracyclines are among the most used and effective anticancer drugs. Their activity has been attributed to DNA double-strand breaks resulting from topoisomerase II poisoning and to eviction of histones from select sites in the genome. He…
View article: Host-dependent induction of disease tolerance to infection by tetracycline antibiotics
Host-dependent induction of disease tolerance to infection by tetracycline antibiotics Open
Summary Synergy of resistance and disease tolerance mechanisms is necessary for an effective immune response leading to survival and return to homeostasis when an organism is challenged by infection. Antibiotics are used for their resistan…
View article: A Th2 Cytokine Profile in Appendicular Lavage Fluid Suggests Allergy as a Possible Etiology for Acute Appendicitis
A Th2 Cytokine Profile in Appendicular Lavage Fluid Suggests Allergy as a Possible Etiology for Acute Appendicitis Open
Acute appendicitis is the most frequent surgical abdominal emergency, but its etiology remains poorly understood. Histological examination of the appendix, following its removal due to acute appendicitis, consistently shows features in com…
View article: Alkaline Comet Assay using the monocytic cell line THP-1
Alkaline Comet Assay using the monocytic cell line THP-1 Open
This protocol details the experimental procedure for performing the comet assay, a very sensitive DNA break assay based on single cell gel electrophoresis.The analysis of DNA strand breaks, both single- and double-strand breaks (SSBs and D…
View article: Alkaline Comet Assay using the monocytic cell line THP-1
Alkaline Comet Assay using the monocytic cell line THP-1 Open
This protocol details the experimental procedure for performing the comet assay, a very sensitive DNA break assay based on single cell gel electrophoresis.The analysis of DNA strand breaks, both single- and double-strand breaks (SSBs and D…
View article: Th2 cytokine profile in appendicular lavage fluid is compatible with allergy as an etiology for acute appendicitis
Th2 cytokine profile in appendicular lavage fluid is compatible with allergy as an etiology for acute appendicitis Open
Acute appendicitis is the most frequent surgical abdominal emergency, but its etiology remains poorly understood. Histological examination of the appendix, following its removal due to acute appendicitis, consistently shows features in com…
View article: Changes in Expression of the CLOCK Gene in Obstructive Sleep Apnea Syndrome Patients Are Not Reverted by Continuous Positive Airway Pressure Treatment
Changes in Expression of the CLOCK Gene in Obstructive Sleep Apnea Syndrome Patients Are Not Reverted by Continuous Positive Airway Pressure Treatment Open
CPAP treatment does not correct substantial changes in expression of core clock genes in OSAS patients. Because CPAP treatment is also unable to normalize the SWS in these patients, it is likely that additional therapeutic interventions th…