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View article: Interaction of early life stress and NAD + /SIRT1 pathway genetic risk promotes depression
Interaction of early life stress and NAD + /SIRT1 pathway genetic risk promotes depression Open
A recent study demonstrated that rodents exposed to early life stress (ELS) showed changes in fat tissue composition and exhibited depression-like phenotype. Decreased Sirt1 expression in the reward-related nucleus accumbens (NAc) was a ke…
View article: Pharmacological profiling of major depressive disorder-related multimorbidity clusters
Pharmacological profiling of major depressive disorder-related multimorbidity clusters Open
We previously identified seven distinct multimorbidity clusters associated with major depressive disorder through a comprehensive analysis of 1.2 million individuals of multiple cohorts. These clusters, characterized by unique clinical, ge…
View article: From Childhood Woes to Adult Blues: Unmasking the Role of Early Traumas, P2X7 Receptor, and Neuroinflammation in Anxiety and Depression
From Childhood Woes to Adult Blues: Unmasking the Role of Early Traumas, P2X7 Receptor, and Neuroinflammation in Anxiety and Depression Open
Early-life stress may increase the risk of neuropsychiatric disorders via immune activation. While the purinergic signaling pathway is implicated in psychiatric disorders, the specific role of the P2X7 receptor (P2X7R) in anxiety, depressi…
View article: The interictal transcriptomic map of migraine without aura
The interictal transcriptomic map of migraine without aura Open
Background The present study aimed to deliver a replicable transcriptomic map of migraine without aura (MO) and its comprehensive, genome- and drug discovery focused analysis to identify hypotheses for future research- and clinical attempt…
View article: Hypothalamic connectivity strength is decreasing with polygenic risk in migraine without aura patients
Hypothalamic connectivity strength is decreasing with polygenic risk in migraine without aura patients Open
Migraine is a heritable primary headache disorder which pathophysiology involves altered hypothalamic activity during migraine attacks. To explore the relationship between hypothalamic functional connectivity (HYPT FC) and genetic predispo…
View article: Chronotypes are significantly associated with emotional well-being in a general population cohort in Hungary
Chronotypes are significantly associated with emotional well-being in a general population cohort in Hungary Open
Chronotypes reflect individual differences in the preference for wake and sleep times within a 24-hour period. They have been linked to emotional well-being, yet findings remain inconsistent, potentially due to variations in study populati…
View article: Acute neuroendocrine challenge elicits enhanced cortisol response and parallel transcriptomic changes in patients with migraine
Acute neuroendocrine challenge elicits enhanced cortisol response and parallel transcriptomic changes in patients with migraine Open
Introduction: Migraine is a neurological disorder with recurrent attacks characterized by headaches and sensitivity to stimuli. Stress is a significant trigger for attacks; however, molecular mechanisms of the connection are poorly underst…
View article: Evening Chronotype Associates With Worse Physical and Mental Health and Headache‐Related Disability Among Migraine Patients
Evening Chronotype Associates With Worse Physical and Mental Health and Headache‐Related Disability Among Migraine Patients Open
Migraine has been linked to chronotype, but with mixed results. Here, we tested chronotype in association with physical and mental health and headache characteristics in a large database of migraine patients and controls. A sample of the U…
View article: Genetic factors in the development of suicidal ideation – results of a GWAS study
Genetic factors in the development of suicidal ideation – results of a GWAS study Open
Introduction Psychiatric disorders are risk factors for suicidality, but it is also considered a multifactorial phenomenon. Genome-wide association studies may provide an insight into the etiological background of distinct phenomena along …
View article: Polygenic risk score for autoimmune disorder SLE predicts current depression but independently of exposure to recent stress
Polygenic risk score for autoimmune disorder SLE predicts current depression but independently of exposure to recent stress Open
Introduction Inflammation has emerged in recent year as one potential contributor pathway in the background of several neuropsychiatric disorders, including depression. It is also increasingly understood that inflammation may exert its rol…
View article: Genome-wide by trait interaction analyses with neuroticism reveal chronic pain-associated depression as a distinct genetic subtype
Genome-wide by trait interaction analyses with neuroticism reveal chronic pain-associated depression as a distinct genetic subtype Open
View article: The stress dependent role of chronotypes in the genetic background of depression symptoms
The stress dependent role of chronotypes in the genetic background of depression symptoms Open
View article: New Evidence for the Role of the Blood-Brain Barrier and Inflammation in Stress-Associated Depression: A Gene-Environment Analysis Covering 19,296 Genes in 109,360 Humans
New Evidence for the Role of the Blood-Brain Barrier and Inflammation in Stress-Associated Depression: A Gene-Environment Analysis Covering 19,296 Genes in 109,360 Humans Open
Mounting evidence supports the key role of the disrupted integrity of the blood-brain barrier (BBB) in stress- and inflammation-associated depression. We assumed that variations in genes regulating the expression and coding proteins constr…
View article: Improved polygenic risk prediction in migraine-first patients
Improved polygenic risk prediction in migraine-first patients Open
Background Recent meta-analyses estimated 14.6% and 11.2% SNP-based heritability of migraine, compared to twin-heritability estimates of 30–60%. This study aimed to investigate heritability estimates in “migraine-first” individuals, patien…
View article: Olfactory genes affect major depression in highly educated, emotionally stable, lean women: a bridge between animal models and precision medicine
Olfactory genes affect major depression in highly educated, emotionally stable, lean women: a bridge between animal models and precision medicine Open
View article: GWAS in interaction with childhood traumas implicates novel variants and genes previously associated with suicide-related factors in the background of suicidal ideation
GWAS in interaction with childhood traumas implicates novel variants and genes previously associated with suicide-related factors in the background of suicidal ideation Open
Introduction Although suicide claims more lives than war and homicide, we still have no sufficient and effective methods either for its prediction or for its prevention. Our screening methods are laborous and subjective both on the side of…
View article: Larks under pressure: The genetic background of the morning chronotype may contribute to depression in interaction with stress
Larks under pressure: The genetic background of the morning chronotype may contribute to depression in interaction with stress Open
Introduction Depression is a highly prevalent, multifactorial, complex disorder, its etiology is assumed to involve both genetic and environmental factors. Genetic factors, including biological clock genes such as CLOCK and SIRT1 , have be…
View article: Unique Effects of (R)-Ketamine Compared to (S)-Ketamine on EEG Theta Power in Rats
Unique Effects of (R)-Ketamine Compared to (S)-Ketamine on EEG Theta Power in Rats Open
Differences in the pharmacological effects of (S)-ketamine and (R)-ketamine are at the focus of research. Clinical data and our rat studies confirmed the antidepressant effect of (S)- but not (R)-ketamine, with similar differences in quant…
View article: Embers of the Past: Early Childhood Traumas Interact with Variation in P2RX7 Gene Implicated in Neuroinflammation on Markers of Current Suicide Risk
Embers of the Past: Early Childhood Traumas Interact with Variation in P2RX7 Gene Implicated in Neuroinflammation on Markers of Current Suicide Risk Open
Both early childhood traumatic experiences and current stress increase the risk of suicidal behaviour, in which immune activation might play a role. Previous research suggests an association between mood disorders and P2RX7 gene encoding P…
View article: MECP2-gén-duplikáció gyermekkori és praenatalis diagnózisa
MECP2-gén-duplikáció gyermekkori és praenatalis diagnózisa Open
A MECP2 -duplikációs szindróma (Lubs-féle mentális fejlődési zavar) X-kromoszómához kötött öröklődésmenetet mutató ritka kórállapot, amely hemizigóta fiúkban mindig előidéz klinikai tüneteket, míg az eltérést hordozó nők általában tünetmen…
View article: Genetic predisposition to depression in chronic pain patients is mitigated by trait neuroticism: results from polygenic risk score analyses
Genetic predisposition to depression in chronic pain patients is mitigated by trait neuroticism: results from polygenic risk score analyses Open
View article: Anxious temperament polygenic risk score predicts current depressive symptoms in a general population sample
Anxious temperament polygenic risk score predicts current depressive symptoms in a general population sample Open
View article: Depression related to stressful life events is associated with immunological gene -sets and response to cognitive-behavioural therapy
Depression related to stressful life events is associated with immunological gene -sets and response to cognitive-behavioural therapy Open
View article: Examining the role of circadian rhythm gene-sets and their interactions with stress factors behind depression
Examining the role of circadian rhythm gene-sets and their interactions with stress factors behind depression Open
View article: Revisiting affective temperaments in GWAS partially replicates previous results, and yields a novel significant variant for depressive temperament in ULK4
Revisiting affective temperaments in GWAS partially replicates previous results, and yields a novel significant variant for depressive temperament in ULK4 Open
View article: Genetic risk for inflammatory conditions may increase risk of depression in those exposed to early childhood stressors
Genetic risk for inflammatory conditions may increase risk of depression in those exposed to early childhood stressors Open
View article: Variation along P2RX7 interacts with early traumas on severity of anxiety suggesting a role for neuroinflammation
Variation along P2RX7 interacts with early traumas on severity of anxiety suggesting a role for neuroinflammation Open
View article: “… wise, amazed, temp’rate, and furious, Loyal and neutral, in a moment”: first heritability analysis of affective temperaments reports remarkably high SNP-based heritability
“… wise, amazed, temp’rate, and furious, Loyal and neutral, in a moment”: first heritability analysis of affective temperaments reports remarkably high SNP-based heritability Open
Introduction Depression shows a moderate heritability of 37-42%, which can be up to 75% in severely depressed samples 75%. At the same time SNP-based heritability of depression in GWAS-s is around 8-9%. Heterogeneity of the depressive phen…
View article: Effect of neuroticism on genetic susceptibility to depression in chronic pain versus non-pain groups: a genome-wide by trait interaction study
Effect of neuroticism on genetic susceptibility to depression in chronic pain versus non-pain groups: a genome-wide by trait interaction study Open
View article: GWAS implicates SDC2 gene encoding Syndecan 2, previously associated with PTSD, insomnia, and autism, in suicidal ideation
GWAS implicates SDC2 gene encoding Syndecan 2, previously associated with PTSD, insomnia, and autism, in suicidal ideation Open