Doris Bachtrog
YOU?
Author Swipe
View article: Diversification and recurrent adaptation of the synaptonemal complex in Drosophila
Diversification and recurrent adaptation of the synaptonemal complex in Drosophila Open
The synaptonemal complex (SC) is a protein-rich structure essential for meiotic recombination and faithful chromosome segregation. Acting like a zipper to paired homologous chromosomes during early prophase I, the complex is a symmetrical …
View article: Sex and neo-sex chromosome evolution in beetles
Sex and neo-sex chromosome evolution in beetles Open
Beetles are the most species-rich group of animals and harbor diverse karyotypes. Most species have XY sex chromosomes, but X0 sex determination mechanisms are also common in some groups. We generated a whole-chromosome assembly of Triboli…
View article: Single-cell RNA-seq of Drosophila miranda testis reveals the evolution and trajectory of germline sex chromosome regulation
Single-cell RNA-seq of Drosophila miranda testis reveals the evolution and trajectory of germline sex chromosome regulation Open
Although sex chromosomes have evolved from autosomes, they often have unusual regulatory regimes that are sex- and cell-type-specific such as dosage compensation (DC) and meiotic sex chromosome inactivation (MSCI). The molecular mechanisms…
View article: Diversification and recurrent adaptation of the synaptonemal complex in<i>Drosophila</i>
Diversification and recurrent adaptation of the synaptonemal complex in<i>Drosophila</i> Open
The synaptonemal complex (SC) is a protein-rich structure essential for meiotic recombination and faithful chromosome segregation. Acting like a zipper to paired chromosomes during early prophase, the complex consists of central elements b…
View article: Multi-locus genomic signatures of local adaptation to snow across the landscape in California populations of a willow leaf beetle
Multi-locus genomic signatures of local adaptation to snow across the landscape in California populations of a willow leaf beetle Open
Organisms living in mountains contend with extreme climatic conditions, including short growing seasons and long winters with extensive snow cover. Anthropogenic climate change is driving unprecedented, rapid warming of montane regions acr…
View article: A chromosome-scale genome assembly and evaluation of mtDNA variation in the willow leaf beetle <i>Chrysomela aeneicollis</i>
A chromosome-scale genome assembly and evaluation of mtDNA variation in the willow leaf beetle <i>Chrysomela aeneicollis</i> Open
The leaf beetle Chrysomela aeneicollis has a broad geographic range across Western North America but is restricted to cool habitats at high elevations along the west coast. Central California populations occur only at high altitudes (2,700…
View article: A chromosome scale genome assembly and evaluation of mtDNA variation in the willow leaf beetle<i>Chrysomela aeneicollis</i>
A chromosome scale genome assembly and evaluation of mtDNA variation in the willow leaf beetle<i>Chrysomela aeneicollis</i> Open
The leaf beetle Chrysomela aeneicollis has a broad geographic range across Western North America, but is restricted to cool habitats at high elevations along the west coast. Central California populations occur only at high altitudes (2900…
View article: Sex chromosome evolution in beetles
Sex chromosome evolution in beetles Open
Beetles are the most species-rich group of animals and harbor diverse karyotypes. Most species have XY sex chromosomes, but X0 sex determination mechanisms are also common in some groups. We generated a whole-chromosome assembly of a beetl…
View article: Single cell RNA-seq in Drosophila testis reveals evolutionary trajectory of sex chromosome regulation
Single cell RNA-seq in Drosophila testis reveals evolutionary trajectory of sex chromosome regulation Open
Although sex chromosomes have evolved from autosomes, they often have unusual regulatory regimes that are sex- and cell-type-specific such as dosage compensation (DC) and meiotic sex chromosome inactivation (MSCI). The molecular mechanisms…
View article: Neo-sex chromosome evolution shapes sex-dependent asymmetrical introgression barrier
Neo-sex chromosome evolution shapes sex-dependent asymmetrical introgression barrier Open
Significance It is increasingly recognized that sex chromosomes are not only the battlegrounds between sexes but also the Great Walls fencing off introgression between diverging lineages. Here we dissect the multifaceted roles of sex chrom…
View article: Transposable element accumulation drives size differences among polymorphic Y Chromosomes in <i>Drosophila</i>
Transposable element accumulation drives size differences among polymorphic Y Chromosomes in <i>Drosophila</i> Open
Y Chromosomes of many species are gene poor and show low levels of nucleotide variation, yet they often display high amounts of structural diversity. Dobzhansky cataloged several morphologically distinct Y Chromosomes in Drosophila pseudoo…
View article: Dynamics and Impacts of Transposable Element Proliferation in the <i>Drosophila nasuta</i> Species Group Radiation
Dynamics and Impacts of Transposable Element Proliferation in the <i>Drosophila nasuta</i> Species Group Radiation Open
Transposable element (TE) mobilization is a constant threat to genome integrity. Eukaryotic organisms have evolved robust defensive mechanisms to suppress their activity, yet TEs can escape suppression and proliferate, creating strong sele…
View article: Origins and evolution of extreme life span in Pacific Ocean rockfishes
Origins and evolution of extreme life span in Pacific Ocean rockfishes Open
A fishy tale of long and short life span Fish have wide variations in life span even within closely related species. One such example are the rockfish species found along North Pacific coasts, which have life spans ranging from 11 to more …
View article: Dynamics and impacts of transposable element proliferation during the <i>Drosophila nasuta</i> species group radiation
Dynamics and impacts of transposable element proliferation during the <i>Drosophila nasuta</i> species group radiation Open
Transposable element (TE) mobilization is a constant threat to genome integrity. Eukaryotic organisms have evolved robust defensive mechanisms to suppress their activity, yet TEs can escape suppression and proliferate, creating strong sele…
View article: Neo-sex chromosome evolution shapes sex-dependent asymmetrical introgression barrier
Neo-sex chromosome evolution shapes sex-dependent asymmetrical introgression barrier Open
It is increasingly recognized that sex chromosomes are not only the “battlegrounds” between sexes, but also the “Great Walls” fencing-off introgression between diverging lineages. Here we describe conflicting roles of nascent sex chromosom…
View article: Establishment of H3K9me3-dependent heterochromatin during embryogenesis in Drosophila miranda
Establishment of H3K9me3-dependent heterochromatin during embryogenesis in Drosophila miranda Open
Heterochromatin is a key architectural feature of eukaryotic genomes crucial for silencing of repetitive elements. During Drosophila embryonic cellularization, heterochromatin rapidly appears over repetitive sequences, but the molecular de…
View article: Transposable element accumulation drives size differences among polymorphic Y chromosomes in Drosophila
Transposable element accumulation drives size differences among polymorphic Y chromosomes in Drosophila Open
Y chromosomes of many species are gene poor and show low levels of nucleotide variation, yet often display high amounts of structural diversity. Dobzhansky cataloged several morphologically distinct Y chromosomes in Drosophila pseudoobscur…
View article: Toxic Y chromosome: Increased repeat expression and age-associated heterochromatin loss in male Drosophila with a young Y chromosome
Toxic Y chromosome: Increased repeat expression and age-associated heterochromatin loss in male Drosophila with a young Y chromosome Open
Sex-specific differences in lifespan are prevalent across the tree of life and influenced by heteromorphic sex chromosomes. In species with XY sex chromosomes, females often outlive males. Males and females can differ in their overall repe…
View article: Epigenetics drive the evolution of sex chromosomes in animals and plants
Epigenetics drive the evolution of sex chromosomes in animals and plants Open
We review how epigenetics affect sex chromosome evolution in animals and plants. In a few species, sex is determined epigenetically through the action of Y-encoded small RNAs. Epigenetics is also responsible for changing the sex of individ…
View article: Author response: Establishment of H3K9me3-dependent heterochromatin during embryogenesis in Drosophila miranda
Author response: Establishment of H3K9me3-dependent heterochromatin during embryogenesis in Drosophila miranda Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Heterochromatin is a key architectural fea…
View article: Toxic Y chromosome: increased repeat expression and age-associated heterochromatin loss in male Drosophila with a young Y chromosome
Toxic Y chromosome: increased repeat expression and age-associated heterochromatin loss in male Drosophila with a young Y chromosome Open
Sex‐specific differences in lifespan are prevalent across the tree of life and influenced by heteromorphic sex chromosomes. In species with XY sex chromosomes, females often outlive males. Males and females can differ in their overall repe…
View article: Epigenetic conflict on a degenerating Y chromosome increases mutational burden in Drosophila males
Epigenetic conflict on a degenerating Y chromosome increases mutational burden in Drosophila males Open
Large portions of eukaryotic genomes consist of transposable elements (TEs), and the establishment of transcription-repressing heterochromatin during early development safeguards genome integrity in Drosophila. Repeat-rich Y chromosomes ca…
View article: The Theory and Applications of Measuring Broad-Range and Chromosome-Wide Recombination Rate from Allele Frequency Decay around a Selected Locus
The Theory and Applications of Measuring Broad-Range and Chromosome-Wide Recombination Rate from Allele Frequency Decay around a Selected Locus Open
Recombination is the exchange of genetic material between homologous chromosomes via physical crossovers. High-throughput sequencing approaches detect crossovers genome wide to produce recombination rate maps but are difficult to scale as …
View article: The Drosophila Y Chromosome Affects Heterochromatin Integrity Genome-Wide
The Drosophila Y Chromosome Affects Heterochromatin Integrity Genome-Wide Open
The Drosophila Y chromosome is gene poor and mainly consists of silenced, repetitive DNA. Nonetheless, the Y influences expression of hundreds of genes genome-wide, possibly by sequestering key components of the heterochromatin machinery a…
Complex Evolutionary History of the Y Chromosome in Flies of the Drosophila obscura Species Group Open
The Drosophila obscura species group shows dramatic variation in karyotype, including transitions among sex chromosomes. Members of the affinis and pseudoobscura subgroups contain a neo-X chromosome (a fusion of the X with an autosome), an…
View article: Chromosome-Level Assembly of <i>Drosophila bifasciata</i> Reveals Important Karyotypic Transition of the X Chromosome
Chromosome-Level Assembly of <i>Drosophila bifasciata</i> Reveals Important Karyotypic Transition of the X Chromosome Open
The Drosophila obscura species group is one of the most studied clades of Drosophila and harbors multiple distinct karyotypes. Here we present a de novo genome assembly and annotation of D. bifasciata, a species which represents an importa…
View article: Complex evolutionary history of the Y chromosome in flies of the<i>Drosophila obscura</i>species group
Complex evolutionary history of the Y chromosome in flies of the<i>Drosophila obscura</i>species group Open
The Drosophila obscura species group shows dramatic variation in karyotype, including transitions among sex chromosomes. Members of the affinis and pseudoobscura subgroups contain a neo-X chromosome (a fusion of the X with an autosome), an…