Doris M. Salgado
YOU?
Author Swipe
View article: A low pre-existing anti-NS1 humoral immunity to DENV is associated with microcephaly development after gestational ZIKV exposure
A low pre-existing anti-NS1 humoral immunity to DENV is associated with microcephaly development after gestational ZIKV exposure Open
Background Gestational Zika virus (ZIKV) infection is associated with the development of congenital Zika syndrome (CZS), which includes microcephaly and fetal demise. The magnitude and quality of orthoflavivirus-specific humoral immunity h…
View article: Erythema nodosum leprosum: A pediatric case report successfully treated with thalidomide
Erythema nodosum leprosum: A pediatric case report successfully treated with thalidomide Open
We present the case of a 10-year-old patient who visited our hospital with prolonged fever, multiple nodular lesions on the skin, and diagnostic studies that confirmed leprosy. As a complication, there is a type 2 leprosy reaction that doe…
View article: A low pre-existing anti-NS1 humoral immunity to DENV is associated with microcephaly development after gestational ZIKV exposure
A low pre-existing anti-NS1 humoral immunity to DENV is associated with microcephaly development after gestational ZIKV exposure Open
Background Gestational Zika virus (ZIKV) infection is associated with the development of congenital Zika syndrome (CZS), which includes microcephaly and fetal demise. The magnitude and quality of orthoflavivirus-specific humoral immunity h…
View article: Efficiency of Automated Viral RNA Purification for Pediatric Studies of Dengue and Zika in Hyperendemic Areas
Efficiency of Automated Viral RNA Purification for Pediatric Studies of Dengue and Zika in Hyperendemic Areas Open
The isolation of nucleic acids is a critical and limiting step for molecular assays, which prompted the arrival in Colombia of automated purification instruments during the SARS-CoV-2 pandemic. The local application of this technology in t…
View article: Seguimiento neurológico de niños con exposición prenatal al virus del Zika
Seguimiento neurológico de niños con exposición prenatal al virus del Zika Open
Introducción: el virus del Zika (ZIKV) es un flavivirus que en mujeres gestantes puede causar afecciones neurológicas en sus hijos.El objetivo de este artículo fue describir el neurodesarrollo de 104 niños con exposición prenatal a ZIKV en…
View article: A Case Series of Severe Dengue with Neurological Presentation in Children from a Colombian Hyperendemic Area
A Case Series of Severe Dengue with Neurological Presentation in Children from a Colombian Hyperendemic Area Open
Dengue transmission is sustained in Colombia with increasing prevalence mainly in children. This work aimed to describe a case series of children diagnosed with dengue presenting neurological disease in Huila Province of Colombia. Eleven p…
View article: Neurological Presentation of Severe Dengue in Children From a Colombian Hyperendemic Area
Neurological Presentation of Severe Dengue in Children From a Colombian Hyperendemic Area Open
Objective : Dengue transmission is sustained in Colombia with increasing prevalence mainly in children. This work was aimed to describe a cases series of children diagnosed with dengue presenting neurological disease in the Huila province …
View article: Anticuerpos IgG4 específicos anti Aedes aegypti como factor protector en niños con dengue grave
Anticuerpos IgG4 específicos anti Aedes aegypti como factor protector en niños con dengue grave Open
Introducción: la infección por el virus del dengue es un problema de salud pública mundial. El virus es transmitido por la picadura de mosquitos del género Aedes. Las proteínas de la saliva del vector Aedes aegypti inducen anticuerpos IgE …
View article: Clinical, laboratory and immune aspects of Zika virus-associated encephalitis in children
Clinical, laboratory and immune aspects of Zika virus-associated encephalitis in children Open
View article: Evaluation of variants in IL6R, TLR3, and DC-SIGN genes associated with dengue in sampled Colombian population
Evaluation of variants in IL6R, TLR3, and DC-SIGN genes associated with dengue in sampled Colombian population Open
Introduction: Host genetics is recognized as an influential factor for the development of dengue disease.Objective: This study evaluated the association of dengue with the polymorphisms rs8192284 for gene IL6R, rs3775290 for TLR3, and rs72…
View article: Association of IL4R-rs1805016 and IL6R-rs8192284 polymorphisms with clinical dengue in children from Colombian populations
Association of IL4R-rs1805016 and IL6R-rs8192284 polymorphisms with clinical dengue in children from Colombian populations Open
For the first time, we report SNPs in IL4R and IL6R genes associated with clinical dengue, which contributes to understanding the genetic susceptibility to dengue disease. Moreover, these results may be influenced by genetic background and…
View article: Identification and Characterization at the Single-Cell Level of Cytokine-Producing Circulating Cells in Children With Dengue
Identification and Characterization at the Single-Cell Level of Cytokine-Producing Circulating Cells in Children With Dengue Open
In this study, we identified, at the single-cell level, naturally induced cytokine-producing circulating cells (CPCCs) in children with dengue virus (DENV) infection ranging clinically from mild to severe disease. Tumor necrosis factor alp…
View article: Brote urbano de leishmaniasis en Colombia
Brote urbano de leishmaniasis en Colombia Open
Objetivos Describir las características epidemiológicas, clínicas y el tratamiento de niños con leishmaniasis visceral en Neiva, Huila.Metodología Se realizó un estudio descriptivo del brote de leshmaniasis visceral en niños de la zona urb…
View article: Análisis descriptivo del compromiso de órganos en niños con dengue grave en Neiva, Colombia
Análisis descriptivo del compromiso de órganos en niños con dengue grave en Neiva, Colombia Open
Introducción. La infección por dengue puede comprometer órganos como el miocardio y el hígado. Tal hecho puede agravar la evolución clínica, por ello estos órganos han sido considerados en la clasificación revisada de la Organización Mundi…
View article: Rapid antigen tests for dengue virus serotypes and Zika virus in patient serum
Rapid antigen tests for dengue virus serotypes and Zika virus in patient serum Open
A low-cost, equipment-free rapid antigen test distinguishes dengue virus serotypes and Zika virus in patient sera without detectable cross-reactivity.
View article: Miocarditis en la infección viral del dengue en pediatría.
Miocarditis en la infección viral del dengue en pediatría. Open
Objetivo: Realizar una revisión sistemática sobre la infección del virus del dengue (DENV), con compromiso cardiovascular, en la población pediátrica, con la finalidad de describir y establecer criterios útiles para el diagnóstico y manejo…
View article: Epidemia por virus chikungunya en pacientes pediátricos en Neiva, Colombia: Presentación clínica, paraclínica y complicaciones
Epidemia por virus chikungunya en pacientes pediátricos en Neiva, Colombia: Presentación clínica, paraclínica y complicaciones Open
Introducción: Colombia fue severamente afectada por un brote de Virus Chikungunya (CHIKV) en 2014-2015, principalmente en la región Caribe y Andina, donde el departamento del Huila registro durante los primeros meses de 2015 un alto número…
View article: Congenital and perinatal complications of chikungunya fever: a Latin American experience
Congenital and perinatal complications of chikungunya fever: a Latin American experience Open
This study presents the largest number of symptomatic neonates with CHIKF analyzed so far in any region and is the first involving infection with the Asian genotype of CHIKV. Although the clinical manifestations found were similar to those…
View article: Total and Envelope Protein-Specific Antibody-Secreting Cell Response in Pediatric Dengue Is Highly Modulated by Age and Subsequent Infections
Total and Envelope Protein-Specific Antibody-Secreting Cell Response in Pediatric Dengue Is Highly Modulated by Age and Subsequent Infections Open
The response of antibody-secreting cells (ASC) induced by dengue has only recently started to be characterized. We propose that young age and previous infections could be simple factors that affect this response. Here, we evaluated the pri…
View article: Infección por chikunguña materno-fetal asociada con miocarditis neonatal
Infección por chikunguña materno-fetal asociada con miocarditis neonatal Open
El virus de chikunguña es un arbovirus de la familia Togaviridae y fue aislado por primera vez en Tanzania y Uganda, en 1953. Esta infección se ha desarrollado de manera endémica y es transmitida por el mosquito del género Aedes. El mecani…
View article: Viability and Functionality of Cryopreserved Peripheral Blood Mononuclear Cells in Pediatric Dengue
Viability and Functionality of Cryopreserved Peripheral Blood Mononuclear Cells in Pediatric Dengue Open
Cryopreserved peripheral blood mononuclear cells (PBMCs) are widely used in studies of dengue. In this disease, elevated frequency of apoptotic PBMCs has been described, and molecules such as soluble tumor necrosis factor (TNF)-related apo…
View article: Infección por chikunguña materno-fetal asociada con miocarditis neonatal
Infección por chikunguña materno-fetal asociada con miocarditis neonatal Open
El virus de chikunguña es un arbovirus de la familia Togaviridae y fue aislado por primera vez en Tanzania y Uganda, en 1953. Esta infección se ha desarrollado de manera endémica y es transmitida por el mosquito del género Aedes. El mecani…