Doron D. Sommer
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View article: Evaluation for the Presence of SARS-CoV-2 in CO <sub>2</sub> Laser Plume
Evaluation for the Presence of SARS-CoV-2 in CO <sub>2</sub> Laser Plume Open
Importance Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly infectious virus that has been reported to be transmitted via aerosolization and other aerosol-generating activities. However, viral plumes from CO 2 laser…
View article: Mixed Signals: An Analysis of the Impact of Preference Signaling on Diagnostic Radiology Residency Applications and Match Outcomes
Mixed Signals: An Analysis of the Impact of Preference Signaling on Diagnostic Radiology Residency Applications and Match Outcomes Open
Signals offer applicants the opportunity to emphasize interest in programs, ultimately increasing their odds of matching to signaled institutions. Unfortunately, overapplication trends continue far beyond the number of signals allotted to …
View article: Novel Vascularized Pedicle Flaps for Dural Reconstruction via Endoscopic Transorbital Approach: Temporalis Muscle and Pericranial Flaps
Novel Vascularized Pedicle Flaps for Dural Reconstruction via Endoscopic Transorbital Approach: Temporalis Muscle and Pericranial Flaps Open
Both TFs and PFs are feasible options for dural reconstruction following ETOA, providing robust vascularization and adaptability to defect size and location. Further clinical studies are warranted to validate their application in live surg…
View article: Promoting Longevity in Surgical Careers: A Narrative Review and Fitness Program to Reduce Occupational Pain
Promoting Longevity in Surgical Careers: A Narrative Review and Fitness Program to Reduce Occupational Pain Open
The existing body of literature supports the positive impact of fitness programs in preventing and managing occupational-related pain. We propose the implementation of a comprehensive program that integrates education, intraoperative break…
View article: Burnout and Stressors in a Single Institution’s Premedical Master of Biomedical Sciences Graduate Students: An Understudied Population
Burnout and Stressors in a Single Institution’s Premedical Master of Biomedical Sciences Graduate Students: An Understudied Population Open
Background With the increasing competitiveness of the medical school application process, concerns have been raised regarding the mental health of premedical students. However, the current literature predominantly examines medical students…
View article: Quality Indicators in Otolaryngology–Head and Neck Surgery: A Scoping Review
Quality Indicators in Otolaryngology–Head and Neck Surgery: A Scoping Review Open
Importance Quality indicators are used to evaluate the quality of healthcare delivery and as a speciality, otolaryngology–head and neck surgery (OHNS) is beginning to transition toward this empirical understanding of healthcare quality and…
View article: Switching biologics in chronic rhinosinusitis with nasal polyps: A multicenter Canadian experience
Switching biologics in chronic rhinosinusitis with nasal polyps: A multicenter Canadian experience Open
Background Type 2 biologics have been used increasingly for the treatment of chronic rhinosinusitis with nasal polyps (CRSwNP). However, patterns of biologic switching are understudied, and established guidelines for sequential or simultan…
View article: Assessing the Feasibility of Selective Piezoelectric Osteotomy in Transorbital Approach to the Middle Cranial Fossa: Anatomical and Quantitative Study and Surgical Implications
Assessing the Feasibility of Selective Piezoelectric Osteotomy in Transorbital Approach to the Middle Cranial Fossa: Anatomical and Quantitative Study and Surgical Implications Open
Piezoelectric orbitotomy may offer a viable, selective, effective, safe alternative to high-speed drilling during SETOA, especially for patients with intra-axial pathologies, in which a watertight closure is mandatory. This procedure could…
View article: Comparison of upper and lower airway expression of SARS‐CoV‐2 receptors in allergic asthma
Comparison of upper and lower airway expression of SARS‐CoV‐2 receptors in allergic asthma Open
Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) which is responsible for Coronavirus disease-19 (COVID-19), infects host cells through the cell surface receptor angiotensin-converting enzyme 2 (ACE2) in conjunction with the ce…
View article: Traumatic penetrating head injury by crossbow projectiles: A case report and literature review
Traumatic penetrating head injury by crossbow projectiles: A case report and literature review Open
Background: Low-energy penetrating head injuries caused by arrows are relatively uncommon. The objective of this report is to describe a case presentation and management of self-inflicted intracranial injury using a crossbow and to provide…
View article: Evaluation of the reproducibility of responses to nasal allergen challenge and effects of inhaled nasal corticosteroids
Evaluation of the reproducibility of responses to nasal allergen challenge and effects of inhaled nasal corticosteroids Open
Background Similar immune responses in the nasal and bronchial mucosa implies that nasal allergen challenge (NAC) is a suitable early phase experimental model for drug development targeting allergic rhinitis (AR) and asthma. We assessed NA…
View article: Integrative proteomics highlight presynaptic alterations and c-Jun misactivation as convergent pathomechanisms in ALS
Integrative proteomics highlight presynaptic alterations and c-Jun misactivation as convergent pathomechanisms in ALS Open
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease mainly affecting upper and lower motoneurons. Several functionally heterogeneous genes have been associated with the familial form of this disorder (fALS), depicting …
View article: Protein expression of <scp>SARS‐CoV</scp>‐2 receptors <scp>ACE2</scp> and <scp>TMPRSS2</scp> in allergic airways after allergen challenge
Protein expression of <span>SARS‐CoV</span>‐2 receptors <span>ACE2</span> and <span>TMPRSS2</span> in allergic airways after allergen challenge Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) utilizes the angiotensin-converting enzyme 2 (ACE2) receptor in conjunction with the cell surface transmembrane protease serine 2 (TMPRSS2) to enter host cells.1 The type 2 (T2) …
View article: P.120 Traumatic penetrating head injury by crossbow projectiles: a case report and literature review
P.120 Traumatic penetrating head injury by crossbow projectiles: a case report and literature review Open
Background: Penetrating head injury secondary to crossbows is a rare encounter in neurosurgical practice with only few cases reported in the literature. Methods: Chart review and literature review. Results: A 31-year-old man with a previou…
View article: Tracheostomy in Critically Ill COVID-19 Patients on Extracorporeal Membrane Oxygenation: A Single-Center Experience
Tracheostomy in Critically Ill COVID-19 Patients on Extracorporeal Membrane Oxygenation: A Single-Center Experience Open
Objectives: Novel coronavirus-19 (COVID-19) has led to over 6 million fatalities globally. An estimated 75% of COVID-19 patients who require critical care admission develop acute respiratory distress syndrome (ARDS) needing invasive mechan…
View article: Multiomics and machine-learning identify novel transcriptional and mutational signatures in amyotrophic lateral sclerosis
Multiomics and machine-learning identify novel transcriptional and mutational signatures in amyotrophic lateral sclerosis Open
Amyotrophic lateral sclerosis is a fatal and incurable neurodegenerative disease that mainly affects the neurons of the motor system. Despite the increasing understanding of its genetic components, their biological meanings are still poorl…
View article: Integrative proteomics highlight presynaptic alterations and c-Jun misactivation as convergent pathomechanisms in ALS
Integrative proteomics highlight presynaptic alterations and c-Jun misactivation as convergent pathomechanisms in ALS Open
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease mainly affecting upper and lower motoneurons. Several functionally heterogeneous genes have been associated with the familial form of this disorder (fALS), depicting …
View article: Mepolizumab improvements in health-related quality of life and disease symptoms in a patient population with very severe chronic rhinosinusitis with nasal polyps: psychometric and efficacy analyses from the SYNAPSE study
Mepolizumab improvements in health-related quality of life and disease symptoms in a patient population with very severe chronic rhinosinusitis with nasal polyps: psychometric and efficacy analyses from the SYNAPSE study Open
Background Although the psychometric properties of patient-reported outcome measures (e.g. the 22-item Sino-nasal Outcomes Test [SNOT-22]) in chronic rhinosinusitis with nasal polyps (CRSwNP) have been defined, these definitions have not b…
View article: Canadian multidisciplinary expert consensus on the use of biologics in upper airways: A Delphi study
Canadian multidisciplinary expert consensus on the use of biologics in upper airways: A Delphi study Open
Background Chronic rhinosinusitis with nasal polyposis (CRSwNP) often coexists with lower airway disease. With the overlap between upper and lower airway disease, optimal management of the upper airways is undertaken in conjunction with th…
View article: Quantifying Surgical Completeness in Patients with Aspirin Exacerbated Respiratory Disease
Quantifying Surgical Completeness in Patients with Aspirin Exacerbated Respiratory Disease Open
Background Aspirin exacerbated respiratory disease (AERD) in patients who have had sinus surgery remains a management challenge. Aspirin desensitization and biologics are additional treatment options. It remains unclear if patients require…
View article: Early-Onset Juvenile Nasopharyngeal Angiofibroma (JNA): A Systematic Review
Early-Onset Juvenile Nasopharyngeal Angiofibroma (JNA): A Systematic Review Open
Background Juvenile Nasopharyngeal Angiofibroma (JNA) is a fibrovascular tumor of the nasopharynx that classically presents in adolescent males. The reported mean age of onset is between 13 and 22 years old [1–6]. Significant androgen stim…
View article: Aging-Dependent Altered Transcriptional Programs Underlie Activity Impairments in Human C9orf72-Mutant Motor Neurons
Aging-Dependent Altered Transcriptional Programs Underlie Activity Impairments in Human C9orf72-Mutant Motor Neurons Open
Amyotrophic Lateral Sclerosis (ALS) is an incurable neurodegenerative disease characterized by dysfunction and loss of upper and lower motor neurons (MN). Despite several studies identifying drastic alterations affecting synaptic compositi…
View article: Correction: Image guidance system use amongst Canadian otolaryngologists: A nationwide survey
Correction: Image guidance system use amongst Canadian otolaryngologists: A nationwide survey Open
View article: Image guidance system use amongst Canadian otolaryngologists: A nationwide survey
Image guidance system use amongst Canadian otolaryngologists: A nationwide survey Open
Background The use of image guidance systems has gained widespread acceptance as an adjunctive tool for endoscopic sinus surgery. However, the accessibility and usage of this technology is variable across hospitals in Canada. Study objecti…
View article: Diagnosis and Localization of Cerebrospinal Fluid Rhinorrhea: A Systematic Review
Diagnosis and Localization of Cerebrospinal Fluid Rhinorrhea: A Systematic Review Open
Background Cerebrospinal fluid (CSF) rhinorrhea results from abnormal communications between the subarachnoid and sinonasal spaces. Accurate preoperative diagnosis and localization are vital for positive clinical outcomes. However, the dia…
View article: Self‐reported olfactory and gustatory dysfunction and psychophysical testing in screening for COVID‐19: A systematic review and meta‐analysis
Self‐reported olfactory and gustatory dysfunction and psychophysical testing in screening for COVID‐19: A systematic review and meta‐analysis Open
Background A substantial proportion of coronavirus disease‐2019 (COVID‐19) patients demonstrate olfactory and gustatory dysfunction (OGD). Self‐reporting for OGD is widely used as a predictor of COVID‐19. Although psychophysical assessment…
View article: Synaptic disruption and CREB‐regulated transcription are restored by K <sup>+</sup> channel blockers in ALS
Synaptic disruption and CREB‐regulated transcription are restored by K <sup>+</sup> channel blockers in ALS Open
View article: An Update on Select Topics in Chronic Rhinosinusitis With Nasal Polyps
An Update on Select Topics in Chronic Rhinosinusitis With Nasal Polyps Open
Chronic rhinosinusitis affects approximately 5-15% of the population and has an economic burden estimated to be between $22 – $64.5 billion US dollars per year. The condition causes significant reductions in quality of life, productivity a…
View article: Association of Tracheostomy With Outcomes in Patients With COVID-19 and SARS-CoV-2 Transmission Among Health Care Professionals
Association of Tracheostomy With Outcomes in Patients With COVID-19 and SARS-CoV-2 Transmission Among Health Care Professionals Open
The findings of this systematic review and meta-analysis indicate that enhanced personal protective equipment is associated with low rates of SARS-CoV-2 transmission during tracheostomy. Early tracheostomy in patients with COVID-19 may red…
View article: Assessing the Risk of SARS-CoV-2 Transmission via Surgical Electrocautery Plume
Assessing the Risk of SARS-CoV-2 Transmission via Surgical Electrocautery Plume Open
This quality improvement study used a nonhuman subject research approach to examine whether SARS-CoV-2 from aerosolized virus is present in and potentially transmissible from a electrocautery plume in surgery.