Dorota A. Doherty
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View article: Endometriosis Quality of Life Cohort Study: Long-term Impact of Radical Laparoscopic Excision of Endometriosis
Endometriosis Quality of Life Cohort Study: Long-term Impact of Radical Laparoscopic Excision of Endometriosis Open
Objectives: The objectives of this study were to determine if radical laparoscopic excision of endometriosis (RLEE) improves long-term outcomes in the quality of life (QOL) and symptomatology experienced by women with the disease. Secondar…
View article: Double-blind, randomised, placebo-controlled trial to evaluate the effectiveness of late gestation oral melatonin supplementation in reducing induction of labour rates in nulliparous women: the MyTIME study protocol
Double-blind, randomised, placebo-controlled trial to evaluate the effectiveness of late gestation oral melatonin supplementation in reducing induction of labour rates in nulliparous women: the MyTIME study protocol Open
Introduction Around the world, rates of induction of labour (IOL) among nulliparous mothers have increased in the last 10 years. In Australia, rates have increased over the last decade by 43%, from 32% to 46%. There is growing concern abou…
View article: Perinatal mortality among term births: Informing decisions about singleton early term births in Western Australia
Perinatal mortality among term births: Informing decisions about singleton early term births in Western Australia Open
Background To minimise the risk of perinatal mortality, clinicians and expectant mothers must understand the risks and benefits associated with continuing the pregnancy. Objectives Report the gestation‐specific risk of perinatal mortality …
View article: A double-blind, randomised, placebo-controlled trial to evaluate the effectiveness of late gestation oral melatonin supplementation in reducing induction of labour rates in nulliparous women. The MyTIME study protocol
A double-blind, randomised, placebo-controlled trial to evaluate the effectiveness of late gestation oral melatonin supplementation in reducing induction of labour rates in nulliparous women. The MyTIME study protocol Open
Introduction Around the world, rates of induction of labour (IOL) amongst nulliparous mothers have increased in the last 10 years. In Australia, rates have increased over the last decade by 43%, from 32% to 46%. There is growing concern ab…
View article: Routine transabdominal cervical length screening in mid‐pregnancy for the prevention of preterm birth: Is it good enough to use as a screening test?
Routine transabdominal cervical length screening in mid‐pregnancy for the prevention of preterm birth: Is it good enough to use as a screening test? Open
Background Preterm birth (PTB) is a major pregnancy complication. There is evidence that a short cervical length in mid‐pregnancy may predict women at increased risk of PTB. Aims To evaluate the utility of population‐based, transabdominal …
View article: Ascertainment of Aboriginal and Torres Strait Islander status for assessment of perinatal health outcomes: Reported versus derived maternal ethnicity in Western Australian pregnancy data
Ascertainment of Aboriginal and Torres Strait Islander status for assessment of perinatal health outcomes: Reported versus derived maternal ethnicity in Western Australian pregnancy data Open
Background Under‐identification of Aboriginal and Torres Strait Islander (hereafter referred to as Aboriginal) people can result in inaccurate estimation of health outcomes. Data linkage has improved identification of Aboriginal people in …
View article: Second trimester maternal serum progesterone and estradiol concentrations with live and demised fetuses: Secondary analysis results from a randomized controlled trial
Second trimester maternal serum progesterone and estradiol concentrations with live and demised fetuses: Secondary analysis results from a randomized controlled trial Open
Objective To provide data on maternal levels of estradiol and progesterone in the second trimester of pregnancy with a live foetus and those complicated by a spontaneous foetal demise. Methods Within a randomised trial to assess efficacy o…
View article: Effects of a live vs heat-inactivated probiotic Bifidobacterium spp in preterm infants (the ProPara study)- a randomized clinical trial
Effects of a live vs heat-inactivated probiotic Bifidobacterium spp in preterm infants (the ProPara study)- a randomized clinical trial Open
Background Heat-inactivated probiotics may provide an effective alternative to live probiotics by avoiding the risk of probiotic sepsis, altered immune responses and antimicrobial resistance while retaining probiotic benefits. Objective We…
View article: Characterisation of Mid-Gestation Amniotic Fluid Cytokine and Bacterial DNA Profiles in Relation to Pregnancy Outcome in a Small Australian Cohort
Characterisation of Mid-Gestation Amniotic Fluid Cytokine and Bacterial DNA Profiles in Relation to Pregnancy Outcome in a Small Australian Cohort Open
A well-established association exists between intrauterine bacteria and preterm birth. This study aimed to explore this further through documenting bacterial and cytokine profiles in Australian mid-gestation amniotic fluid samples from pre…
View article: Maternal complications associated with second trimester medical abortion using mifepristone priming and subsequent misoprostol
Maternal complications associated with second trimester medical abortion using mifepristone priming and subsequent misoprostol Open
Second trimester medical abortion with mifepristone and misoprostol is generally safe, however, on occasions serious complications may occur. All health care units providing a medical abortion service require the facilities and expertise t…
View article: Registry randomised trials: a methodological perspective
Registry randomised trials: a methodological perspective Open
Registry randomised clinical trials (RRCTs) have the potential to provide pragmatic answers to important clinical questions. RRCTs can be embedded into large population-based registries or smaller single site registries to provide timely a…
View article: Mifepristone priming and subsequent misoprostol for second trimester medical abortion in women with previous caesarean delivery
Mifepristone priming and subsequent misoprostol for second trimester medical abortion in women with previous caesarean delivery Open
Aims To assess clinical outcomes and complications in women with ≥1 prior caesarean delivery (CS) during mid‐pregnancy medical abortion with misoprostol following mifepristone priming. Materials and Methods Retrospective analysis of aborti…
View article: The Western Australian preterm birth prevention initiative: a whole of state singleton pregnancy cohort study showing the need to embrace alternative models of care for Aboriginal women
The Western Australian preterm birth prevention initiative: a whole of state singleton pregnancy cohort study showing the need to embrace alternative models of care for Aboriginal women Open
Background Preterm birth (PTB) is the greatest cause of mortality and morbidity in children up to five years of age globally. The Western Australian (WA) PTB Prevention Initiative, the world’s first whole-of-population whole-of-state progr…
View article: Associations between Prenatal Exposure to Phthalates and Features of the Metabolic Syndrome in Males from Childhood into Adulthood
Associations between Prenatal Exposure to Phthalates and Features of the Metabolic Syndrome in Males from Childhood into Adulthood Open
Phthalate metabolites are detectable within the majority of the population. Evidence suggests that a prenatal exposure to phthalates may be associated with the subsequent risks of obesity and elevated blood pressure. We hypothesised that a…
View article: Longitudinal effects of prenatal exposure to plastic‐derived chemicals and their metabolites on asthma and lung function from childhood into adulthood
Longitudinal effects of prenatal exposure to plastic‐derived chemicals and their metabolites on asthma and lung function from childhood into adulthood Open
Background and Objective Environmental exposure to phthalates and bisphenol A (BPA), chemicals used in the production of plastics, may increase risk for asthma and allergies. However, little is known about the long‐term effects of early li…
View article: A project to validate the GLU test for preterm birth prediction in First Nations women
A project to validate the GLU test for preterm birth prediction in First Nations women Open
The protocol described in the present article aims to validate the GLU test, a test of mid-pregnancy vaginal microbiome, for PTB risk prediction in pregnant First Nations women. Preterm birth (PTB; birth before 37 completed weeks gestation…
View article: O-087 Asthma and allergies in a cohort of adolescents conceived after assisted reproductive technologies (ART)
O-087 Asthma and allergies in a cohort of adolescents conceived after assisted reproductive technologies (ART) Open
Study question Are adolescents conceived after assisted reproductive technologies (ART) at an increased risk of asthma and allergies, compared to their counterparts conceived without ART? Summary answer No difference in asthma prevalence, …
View article: Consistency in the transabdominal ultrasound measurement of cervical length in mid‐pregnancy
Consistency in the transabdominal ultrasound measurement of cervical length in mid‐pregnancy Open
Purpose The Western Australian Preterm Birth Prevention Initiative recommends a transabdominal cervical length (TACL) measurement at the mid‐pregnancy ultrasound to screen low‐risk women for preterm birth risk. In view of this recommendati…
View article: Comparison of the cardiometabolic profiles of adolescents conceived through ART with those of a non-ART cohort
Comparison of the cardiometabolic profiles of adolescents conceived through ART with those of a non-ART cohort Open
STUDY QUESTION Is the cardiometabolic health of adolescents conceived through ART worse than that of their counterparts conceived without ART? SUMMARY ANSWER The majority of cardiometabolic and vascular health parameters of adolescents con…
View article: Offspring conceived through ART have normal thyroid function in adolescence and as young adults
Offspring conceived through ART have normal thyroid function in adolescence and as young adults Open
STUDY QUESTION Are there differences in thyroid function between adolescents and young adults conceived with and without ART? SUMMARY ANSWER This study demonstrated no evidence of clinically relevant differences in thyroid function between…
View article: Composition of early life leukocyte populations in preterm infants with and without late-onset sepsis
Composition of early life leukocyte populations in preterm infants with and without late-onset sepsis Open
Background Composition of leukocyte populations in the first month of life remains incompletely characterised, particularly in preterm infants who go on to develop late-onset sepsis (LOS). Aim To characterise and compare leukocyte populati…
View article: Health, social and economic implications of adolescent risk behaviours/states: protocol for Raine Study Gen2 cohort data linkage study
Health, social and economic implications of adolescent risk behaviours/states: protocol for Raine Study Gen2 cohort data linkage study Open
Background: Risk-taking behaviours are a major contributor to youth morbidity and mortality. Vulnerability to these negative outcomes is constructed from individual behaviour including risk-taking, and from social context, ecological deter…
View article: Effect of single versus multistrain probiotic in extremely preterm infants: a randomised trial
Effect of single versus multistrain probiotic in extremely preterm infants: a randomised trial Open
Objective Evidence indicates that multistrain probiotics benefit preterm infants more than single-strain (SS) probiotics. We assessed the effects of SS versus triple-strain (TS) probiotic supplementation (PS) in extremely preterm (EP) infa…
View article: Time to regain birth weight - a marker to predict the severity of retinopathy of prematurity?
Time to regain birth weight - a marker to predict the severity of retinopathy of prematurity? Open
Background Poor weight gain in the first few weeks of life has been studied as a predictor of retinopathy of prematurity (ROP). Our aim was to assess whether time taken to regain birthweight (BW) be used as an additional marker to identify…
View article: Time to Regain Birth Weight - A Marker to Predict the Severity of Retinopathy of Prematurity?
Time to Regain Birth Weight - A Marker to Predict the Severity of Retinopathy of Prematurity? Open
Background: Poor weight gain in the first few weeks of life has been studied as a predictor of retinopathy of prematurity (ROP). Our aim was to assess whether time taken to regain birthweight be used as an additional marker to identify inf…
View article: The health and educational costs of preterm birth to 18 years of age in Australia
The health and educational costs of preterm birth to 18 years of age in Australia Open
Background Preterm birth is the greatest cause of death up to five years of age and an important contributor to lifelong disability. There is increasing evidence that a meaningful proportion of early births may be prevented, but widespread…
View article: Sex-dependent associations between maternal prenatal stressful life events, BMI trajectories and obesity risk in offspring: The Raine Study
Sex-dependent associations between maternal prenatal stressful life events, BMI trajectories and obesity risk in offspring: The Raine Study Open
View article: Associations between Prenatal Exposure to Phthalates and Timing of Menarche and Growth and Adiposity into Adulthood: A Twenty-Years Birth Cohort Study
Associations between Prenatal Exposure to Phthalates and Timing of Menarche and Growth and Adiposity into Adulthood: A Twenty-Years Birth Cohort Study Open
Phthalates are ubiquitous environmental chemicals with endocrine disrupting properties and potentially obesogenic effects. We hypothesised that antenatal phthalate exposure may influence growth and adiposity patterns in girls through child…
View article: Effect of shift work on fatigue and sleep in neonatal registrars
Effect of shift work on fatigue and sleep in neonatal registrars Open
Objective We aimed to study fatigue and sleep in registrars working 12-hour rotating shifts in our tertiary neonatal intensive unit. Methods and participants This study involved neonatal registrar’s working day (08:00–21:00) and night (20:…
View article: Supplementary Material for: Pulmonary Gas Exchange Improves over the First Year in Preterm Infants with and without Bronchopulmonary Dysplasia
Supplementary Material for: Pulmonary Gas Exchange Improves over the First Year in Preterm Infants with and without Bronchopulmonary Dysplasia Open
Background: Right shift of the peripheral oxyhaemoglobin saturation (SpO2) versus inspired oxygen pressure (PIO2) curve is a sensitive marker of pulmonary gas exchange. Objectives: