Dorota Matyszewska
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View article: Structural characterization of the lipid exchange between lipidic cubic phase nanoparticles and lipid monolayers using neutron reflectometry.
Structural characterization of the lipid exchange between lipidic cubic phase nanoparticles and lipid monolayers using neutron reflectometry. Open
Cubosomes are self-assembled lipid nanoparticles with a unique structure that hold significant promise for drug delivery. Cubosomes can encapsulate and transport a wide range of pharmaceuticals and imaging agents, potentially enhancing tar…
View article: Synergistic Effect of Paclitaxel and Epirubicin Coadministration─Insight into the Mechanisms of Interactions with Model Breast Cancer Cell Membranes
Synergistic Effect of Paclitaxel and Epirubicin Coadministration─Insight into the Mechanisms of Interactions with Model Breast Cancer Cell Membranes Open
This study investigates the synergistic interaction mechanism of paclitaxel (PTX) and epirubicin (EPI) coadministration with model breast cancer cell membranes formed by monocomponent and ternary phospholipid monolayers composed of DPPC, c…
View article: Oxidation of lipid membrane cholesterol by cholesterol oxidase and its effects on raft model membrane structure
Oxidation of lipid membrane cholesterol by cholesterol oxidase and its effects on raft model membrane structure Open
The effects of a peripheral protein - cholesterol oxidase (3β-hydroxysteroid oxidase, ChOx) on the characteristics of model lipid membranes composed of cholesterol, cholesterol:sphingomyelin (1:1), and the raft model composed of DOPC:Chol:…
View article: Statin Action Targets Lipid Rafts of Cell Membranes: GIXD/PM-IRRAS Investigation of Langmuir Monolayers
Statin Action Targets Lipid Rafts of Cell Membranes: GIXD/PM-IRRAS Investigation of Langmuir Monolayers Open
Lipid rafts are condensed regions of cell membranes rich in cholesterol and sphingomyelin, which constitute the target for anticholesterolemic drugs - statins. In this work, we use for the first time a combined grazing-incidence X-ray diff…
View article: Is lipophilicity the main factor determining the effective drug penetration through lipid membranes? Combined GIXD and PM-IRRAS studies on the example of anthracyclines
Is lipophilicity the main factor determining the effective drug penetration through lipid membranes? Combined GIXD and PM-IRRAS studies on the example of anthracyclines Open
Cell membranes constitute the first barrier for the drugs on their way to the cell. Therefore, their penetration determines the effectivity of the treatment and is defined by the drug-lipid interactions. A systematic, comprehensive study t…
View article: Interfacial Behavior of Cubosomes: Combined Langmuir–Blodgett/Langmuir–Schaefer and AFM Investigations
Interfacial Behavior of Cubosomes: Combined Langmuir–Blodgett/Langmuir–Schaefer and AFM Investigations Open
The Langmuir technique was applied for the first time to compare the layers obtained by spreading lipid liquid-crystalline nanoparticles monoolein 1-oleoyl-rac-glycerol (GMO)/Pluronic F108 cubosomes with the monolayers obtained by mixing t…
View article: CCDC 2212751: Experimental Crystal Structure Determination
CCDC 2212751: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2212750: Experimental Crystal Structure Determination
CCDC 2212750: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2212752: Experimental Crystal Structure Determination
CCDC 2212752: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Revealing the structure and mechanisms of action of a synthetic opioid with model biological membranes at the air-water interface
Revealing the structure and mechanisms of action of a synthetic opioid with model biological membranes at the air-water interface Open
Synthetic opioids such as piperazine derivative called MT-45 interact with opioid receptors in a manner similar to morphine leading to euphoria, a sense of relaxation and pain relief and are commonly used as substituents of natural opioids…
View article: Model Lipid Raft Membranes for Embedding Integral Membrane Proteins: Reconstitution of HMG-CoA Reductase and Its Inhibition by Statins
Model Lipid Raft Membranes for Embedding Integral Membrane Proteins: Reconstitution of HMG-CoA Reductase and Its Inhibition by Statins Open
For the first time, HMG-CoA reductase, the membrane protein responsible for cholesterol synthesis, was incorporated into a lipid membrane consisting of DOPC:Chol:SM at a 1:1:1 molar ratio, which mimics the lipid rafts of cell membranes. Th…
View article: Influence of lipophilicity of anthracyclines on the interactions with cholesterol in the model cell membranes – Langmuir monolayer and SEIRAS studies
Influence of lipophilicity of anthracyclines on the interactions with cholesterol in the model cell membranes – Langmuir monolayer and SEIRAS studies Open
The interactions of anthracyclines with biological membranes strongly depend on the drug lipophilicity, which might also determine the specific affinity to cholesterol molecules. Therefore, in this work we show the studies concerning the e…
View article: Designing a Useful Lipid Raft Model Membrane for Electrochemical and Surface Analytical Studies
Designing a Useful Lipid Raft Model Membrane for Electrochemical and Surface Analytical Studies Open
A model biomimetic system for the study of protein reconstitution or drug interactions should include lipid rafts in the mixed lipid monolayer, since they are usually the domains embedding membrane proteins and peptides. Four model lipid f…
View article: Surface and electrochemical properties of lipid raft model membranes and how they are affected by incorporation of statin
Surface and electrochemical properties of lipid raft model membranes and how they are affected by incorporation of statin Open
Cerivastatin belongs to the class of statins, drugs lowering blood cholesterol level by inhibiting the enzyme HMG-CoA reductase. The enzyme is located in the endoplasmic reticulum (ER) membrane, which is enriched in cholesterol and sphingo…
View article: The effect of acyl chain length and saturation on the interactions of pirarubicin with phosphatidylethanolamines in 2D model urothelial cancer cell membranes
The effect of acyl chain length and saturation on the interactions of pirarubicin with phosphatidylethanolamines in 2D model urothelial cancer cell membranes Open
The interactions of an anticancer drug pirarubicin (THP) with a series of phosphatidylethanolamine (PE) lipids differing in the length and unsaturation degree of acyl chains were investigated using the Langmuir technique supplemented with …
View article: The influence of charge and lipophilicity of daunorubicin and idarubicin on their penetration of model biological membranes – Langmuir monolayer and electrochemical studies
The influence of charge and lipophilicity of daunorubicin and idarubicin on their penetration of model biological membranes – Langmuir monolayer and electrochemical studies Open
The interactions of two selected anthracyclines, daunorubicin (DNR) and idarubicin (IDA), with phospholipid monolayers used as simple models of cell membranes, were investigated. The results of Langmuir experiments together with Brewster a…
View article: Structure of surfactant and phospholipid monolayers at the air/water interface modeled from neutron reflectivity data
Structure of surfactant and phospholipid monolayers at the air/water interface modeled from neutron reflectivity data Open
Specular neutron reflectometry is a powerful technique to resolve interfacial compositions and structures in soft matter. Surprisingly however, even after several decades, a universal modeling approach for the treatment of data of surfacta…
View article: Comparison of the interactions of daunorubicin in a free form and attached to single-walled carbon nanotubes with model lipid membranes
Comparison of the interactions of daunorubicin in a free form and attached to single-walled carbon nanotubes with model lipid membranes Open
In this work the interactions of an anticancer drug daunorubicin (DNR) with model thiolipid layers composed of 1,2-dipalmitoyl- sn -glycero-3-phosphothioethanol (DPPTE) were investigated using Langmuir technique. The results obtained for a…