Dorota Sobolewska-Sztychny
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View article: Effect of SMART DNA Therapy Retix.C Application on Skin Microbiome
Effect of SMART DNA Therapy Retix.C Application on Skin Microbiome Open
Background: The skin microbiome plays a key role in maintaining skin health, and its composition can be influenced by cosmetic treatments. This study aimed to investigate the effects of SMART DNA Therapy treatment on facial skin microbiome…
View article: Effective treatment of refractory auricular keloids with combined intralesional triamcinolone/5-FU and CO2 laser surgery: A case series
Effective treatment of refractory auricular keloids with combined intralesional triamcinolone/5-FU and CO2 laser surgery: A case series Open
View article: Molecular mechanisms of keloid development
Molecular mechanisms of keloid development Open
View article: Gene Therapies in Dermatological Diseases: A Breakthrough in Treatment
Gene Therapies in Dermatological Diseases: A Breakthrough in Treatment Open
Gene therapy involves introducing genetic material into cells to treat or prevent disease and offers highly targeted and potentially curative approaches for both inherited and acquired conditions. The skin is an especially suitable organ f…
View article: Targeting Biomarkers of Proliferation and Inflammation (Ki67, p53, and COX-2) in Actinic Keratoses with Photodynamic Therapy
Targeting Biomarkers of Proliferation and Inflammation (Ki67, p53, and COX-2) in Actinic Keratoses with Photodynamic Therapy Open
Background: Actinic keratoses (AKs) are common pre-neoplastic lesions that may progress to cutaneous squamous cell carcinoma (cSCC). Photodynamic therapy (PDT) is an effective field-directed treatment for AK, but its impact on key biomarke…
View article: New insight into the role of the pathway NLRP1 and NLRP3 inflammasomes and IL-33 in ultraviolet-induced cutaneous carcinogenesis
New insight into the role of the pathway NLRP1 and NLRP3 inflammasomes and IL-33 in ultraviolet-induced cutaneous carcinogenesis Open
Introduction Inflammasomes NLRP1 (NLR family pyrin domain containing 1) and NLRP3 are pivotal regulators of the innate immune response, activated by a spectrum of endogenous and exogenous stressors, including ultraviolet radiation (UVR). T…
View article: Optimal management strategies for paediatric morphea – insights from a case series
Optimal management strategies for paediatric morphea – insights from a case series Open
Juvenile localized scleroderma, or morphea, is a rare chronic inflammatory disease primarily affecting the skin and subcutaneous tissue. Treatment options for paediatric cases are diverse, with a lack of standardised guidelines. This case …
View article: Terra Firma–Forme Dermatosis: Clinical Insights, Dermoscopic and Ultraviolet‐Induced Fluorescence Dermoscopy Findings—A Case Report and Literature Review
Terra Firma–Forme Dermatosis: Clinical Insights, Dermoscopic and Ultraviolet‐Induced Fluorescence Dermoscopy Findings—A Case Report and Literature Review Open
Terra firma–forme dermatosis (TFFD) is a benign skin condition characterized by persistent brownish, yellowish, or gray–black patches, primarily affecting children and young adults. Diagnosis is typically clinical but can be enhanced using…
View article: Actinic keratosis: comprehensive review of current treatments and emerging therapeutic innovations
Actinic keratosis: comprehensive review of current treatments and emerging therapeutic innovations Open
Actinic keratosis (AK) is a prevalent benign intraepidermal dysplasia, classified as squamous cell carcinoma in situ (SCC in situ). Chronic ultraviolet (UV) light exposure is the primary etiological factor for AK, which predo…
View article: Port-wine stain and its influence on patients’ quality of life and psychosocial issues
Port-wine stain and its influence on patients’ quality of life and psychosocial issues Open
PWS affects psychosocial well-being of patients including their quality of life, self-perception of the body or feeling of stigmatization. Interdisciplinary approach is needed to provide patients with necessary psychological or psychiatric…
View article: Effects of antioxidant-anti-inflammatory therapy on skinrejuvenation and repair. The clinical case series study
Effects of antioxidant-anti-inflammatory therapy on skinrejuvenation and repair. The clinical case series study Open
The described three-step therapeutic regimen demonstrated excellent tolerability and safety. The observed improvements in nearly all measured skin parameters underscore the efficacy of this comprehensive approach to skin rejuvenation.
View article: Coinfection of syphilis and HIV: epidemiological evaluation at the Dermatology Department in Lodz, Poland
Coinfection of syphilis and HIV: epidemiological evaluation at the Dermatology Department in Lodz, Poland Open
In our study we observed a considerable increase in the number of patients diagnosed with the coinfection of syphilis and HIV in the last few years. The above analysis underscores the ongoing public health challenges associated with these …
View article: Factors Influencing the Clinical Course of Bullous Pemphigoid among Geriatric Patients: A Pilot Study
Factors Influencing the Clinical Course of Bullous Pemphigoid among Geriatric Patients: A Pilot Study Open
Background and Objectives: Bullous pemphigoid (BP) is the most common autoimmune blistering disease affecting mainly elderly patients. Still, little is known about the pathogenesis of pruritus in BP or the factors that affect the clinical …
View article: Prospective Clinical Study: Full-Body Blue Irradiation in the Treatment of Atopic Dermatitis
Prospective Clinical Study: Full-Body Blue Irradiation in the Treatment of Atopic Dermatitis Open
View article: Effectiveness and Safety of Etanercept in Paediatric Patients with Plaque-Type Psoriasis: Real-World Evidence
Effectiveness and Safety of Etanercept in Paediatric Patients with Plaque-Type Psoriasis: Real-World Evidence Open
Background: Psoriasis is a chronic, multisystemic, inflammatory disease affecting approximately 1% of children and significantly reducing their health-related quality of life. Etanercept is a biologic fusion protein-blocking TNF-α and belo…
View article: Case report: Successful treatment with biologics in a pediatric patient with a severe inflammatory skin disease and novel CARD14 mutation
Case report: Successful treatment with biologics in a pediatric patient with a severe inflammatory skin disease and novel CARD14 mutation Open
CARD14 (caspase activation and recruitment domain) mutations have been associated with psoriasis vulgaris, psoriatic arthritis, generalized and palmoplantar pustular psoriasis, pityriasis rubra pilaris, and atopic dermatitis. We present a …
View article: The effectiveness of omalizumab therapy in patients with chronic spontaneous urticaria: the experience of a single-centre study in Poland
The effectiveness of omalizumab therapy in patients with chronic spontaneous urticaria: the experience of a single-centre study in Poland Open
Our study confirmed that omalizumab is an effective medicine in a long-term treatment which improves a physical as well as psychological condition of the patients with antihistamine-resistant CSU. To our knowledge, it is the first study in…
View article: A rare clinical presentation of mastocytosis in an infant
A rare clinical presentation of mastocytosis in an infant Open
View article: Pruritus prevalence and characteristics in Care and Treatment Facility and Geriatric Outpatient Clinic patients: a cross-sectional study using a standardized pruritus questionnaires
Pruritus prevalence and characteristics in Care and Treatment Facility and Geriatric Outpatient Clinic patients: a cross-sectional study using a standardized pruritus questionnaires Open
One of the most common causes of pruritus is xerosis. It is essential to provide appropriate education to patients and caregivers on the use of emollients. Therefore, the development of recommendations would be desirable. Many drugs common…
View article: Rare complications of pediculosis capitis
Rare complications of pediculosis capitis Open
View article: Gut microbiota in alopecia areata
Gut microbiota in alopecia areata Open
This study describes, for the first time, the characteristics of the gut microbiome in AA patients and may provide new insight into the gut microbiome that may play a role in the development of AA.
View article: More Than Skin Deep – the Effects of Ultraviolet Radiation on Cathepsin K and Progerin Expression in Cultured Dermal Fibroblasts
More Than Skin Deep – the Effects of Ultraviolet Radiation on Cathepsin K and Progerin Expression in Cultured Dermal Fibroblasts Open
The results suggest that there could be another progerin/cathepsin K regulatory pathway, which has not been described yet. Being contradictory with previous research, the influence of ultraviolet radiation on progerin and cathepsin K needs…
View article: TaaI/Cdx-2 AA Variant of VDR Defines the Response to Phototherapy amongst Patients with Psoriasis
TaaI/Cdx-2 AA Variant of VDR Defines the Response to Phototherapy amongst Patients with Psoriasis Open
1,25-dihydroxyvitamin-D3 plays a central role in the immune system via binding to the vitamin D receptor. VDR polymorphisms have been associated with multiple autoimmune disorders, including psoriasis. Until now, five VDR polymorphisms, Fo…
View article: The Role of NLRP1, NLRP3, and AIM2 Inflammasomes in Psoriasis: Review
The Role of NLRP1, NLRP3, and AIM2 Inflammasomes in Psoriasis: Review Open
Inflammasomes are high-molecular-weight protein complexes that may cleave the two main proinflammatory cytokines, pro-interleukin-1β and pro-interleukin-18, into active forms, and contribute to psoriasis. Despite recent advances made in th…
View article: Alterations of the Skin and Gut Microbiome in Psoriasis and Psoriatic Arthritis
Alterations of the Skin and Gut Microbiome in Psoriasis and Psoriatic Arthritis Open
Numerous scientific studies in recent years have shown significant skin and gut dysbiosis among patients with psoriasis. A significant decrease in microbiome alpha-diversity (abundance of different bacterial taxa measured in one sample) as…
View article: Ultraviolet Radiation and Chronic Inflammation—Molecules and Mechanisms Involved in Skin Carcinogenesis: A Narrative Review
Ultraviolet Radiation and Chronic Inflammation—Molecules and Mechanisms Involved in Skin Carcinogenesis: A Narrative Review Open
The process of skin carcinogenesis is still not fully understood. Both experimental and epidemiological evidence indicate that chronic inflammation is one of the hallmarks of microenvironmental-agent-mediated skin cancers and contributes t…