Dorothée Bourges
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View article: Increased endogenous antigen presentation in the periphery enhances susceptibility to inflammation‐induced gastric autoimmunity in mice
Increased endogenous antigen presentation in the periphery enhances susceptibility to inflammation‐induced gastric autoimmunity in mice Open
How the immune system maintains peripheral tolerance under inflammatory conditions is poorly understood. Here we assessed the fate of gastritogenic T cells following inflammatory activation in vivo. Self‐reactive T cells (A23 T cells) spec…
View article: Neutrophils and MC are the dominant inflammatory phagocytic cells in lung following <i>L</i>. <i>pneumophila</i> infection.
Neutrophils and MC are the dominant inflammatory phagocytic cells in lung following <i>L</i>. <i>pneumophila</i> infection. Open
C57BL/6 mice were infected with L. pneumophila and CD45+ cells were analysed on day 2 after infection. A. Gating strategy to identify neutrophils (Neut), AM, MC and cDC. Upper panels, uninfected mice, Lower panels, infected mice. Dashed li…
View article: MC are required for optimal clearance of <i>L</i>. <i>pneumophila</i>.
MC are required for optimal clearance of <i>L</i>. <i>pneumophila</i>. Open
Wild type C57BL/6 or CCR2-/- mice were infected with L. pneumophila and analysed for MC number in the lung (at day 2 in A and at day 3 and 5 in B) and L. pneumophila CFU in lung (C). In B and C mean ± SEM is shown. B, n ≥ 9 for all groups …
View article: IFNγ production by memory T cells in the acute phase of the response to <i>L</i>. <i>pneumophila</i> is non-cognate and can contribute to bacterial clearance.
IFNγ production by memory T cells in the acute phase of the response to <i>L</i>. <i>pneumophila</i> is non-cognate and can contribute to bacterial clearance. Open
A-C. C57BL/6 mice were injected with 107 gBT-I.IFNγ-YFP T cells that had been stimulated in vitro with antigen. After 30 days mice were infected with L. pneumophila. A. Number of T cells derived from the recipient mice (Endogenous) and gBT…
View article: NK cells and memory T cells produce IFNγ in the acute response <i>L</i>. <i>pneumophila</i>.
NK cells and memory T cells produce IFNγ in the acute response <i>L</i>. <i>pneumophila</i>. Open
IFNγ-YFP reporter mice (GREAT mice, A-F), IFNγ-YFP.IL12p35-/- (A,D,E) or C57BL/6 mice (G) were infected with L. pneumophila and analysed on day 2 (A, D-F) or as indicated (B, C, G). A. YFP fluorescence in the cell types indicated. NK cells…
View article: An innate immune network in the acute response to a bacterial lung pathogen.
An innate immune network in the acute response to a bacterial lung pathogen. Open
We propose the following model for the role and interactions of phagocytic and lymphoid cells in the acute phase of L. pneumophila infection. 1. Tissue resident alveolar macrophages and conventional dendritic cells (not shown) are the firs…
View article: MC are a major source of IL12, a key driver of IFNγ production in lung after <i>L</i>. <i>pneumophila</i> infection.
MC are a major source of IL12, a key driver of IFNγ production in lung after <i>L</i>. <i>pneumophila</i> infection. Open
C57BL/6 mice (B,C), IL12p40-YFP mice (E,F) or the indicated mouse strains (A,D,G) were infected with L. pneumophila. A, D, G. IFNγ (A, G) or IL12p70 (D) levels were measured in BALF of the indicated strains. B, C. Quantitative PCR was used…
View article: Cooperation between Monocyte-Derived Cells and Lymphoid Cells in the Acute Response to a Bacterial Lung Pathogen
Cooperation between Monocyte-Derived Cells and Lymphoid Cells in the Acute Response to a Bacterial Lung Pathogen Open
Legionella pneumophila is the causative agent of Legionnaires' disease, a potentially fatal lung infection. Alveolar macrophages support intracellular replication of L. pneumophila, however the contributions of other immune cell types to b…
View article: Differential use of autophagy by primary dendritic cells specialized in cross-presentation
Differential use of autophagy by primary dendritic cells specialized in cross-presentation Open
Antigen-presenting cells survey their environment and present captured antigens bound to major histocompatibility complex (MHC) molecules. Formation of MHC-antigen complexes occurs in specialized compartments where multiple protein traffic…
View article: Differential use of autophagy by primary dendritic cells specialized in cross-presentation
Differential use of autophagy by primary dendritic cells specialized in cross-presentation Open
Antigen-presenting cells survey their environment and present captured antigens bound to major histocompatibility complex (MHC) molecules. Formation of MHC-antigen complexes occurs in specialized compartments where multiple protein traffic…
View article: Differential use of autophagy by primary dendritic cells specialised in cross-presentation
Differential use of autophagy by primary dendritic cells specialised in cross-presentation Open
Antigen presenting cells survey their environment and present captured antigens bound to major histocompatibility complex (MHC) molecules. Formation of MHC-antigen complexes occurs in specialized compartments where multiple protein traffic…