Dorrain Yanwen Low
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View article: Brief Communications: Phenome-wide Association Study of Cognitive Function in Multiethnic Asian population
Brief Communications: Phenome-wide Association Study of Cognitive Function in Multiethnic Asian population Open
s Cognition is one of the most widely used measure of brain health. Poor cognitive function reflects both the progression of neurodegenerative disorders and the decline of cardiometabolic conditions. Moreover, the genetic determinants of c…
View article: Blood serum from individuals with Alzheimer’s disease alters microglial phagocytosis in vitro
Blood serum from individuals with Alzheimer’s disease alters microglial phagocytosis in vitro Open
In Alzheimer’s disease, microglial phagocytosis is engaged in the pathogenesis as it clears abnormal protein accumulations, debris, and apoptotic cells in the early stages of Alzheimer’s disease, but fuels neuroinflammation and accelerates…
View article: Nuclear regulatory disturbances precede and predict the development of Type-2 diabetes in Asian populations
Nuclear regulatory disturbances precede and predict the development of Type-2 diabetes in Asian populations Open
To identify biomarkers and pathways to Type-2 diabetes (T2D), a major global disease, we completed array-based epigenome-wide association in whole blood in 5,709 Asian people. We found 323 Sentinel CpGs (from 314 genetic loci) that predict…
View article: The relationships between sleep and adiposity amongst multi-ethnic Asian populations: a cross-sectional analysis of the Health for Life in Singapore (HELIOS) study
The relationships between sleep and adiposity amongst multi-ethnic Asian populations: a cross-sectional analysis of the Health for Life in Singapore (HELIOS) study Open
View article: A Catalogue of Structural Variation across Ancestrally Diverse Asian Genomes
A Catalogue of Structural Variation across Ancestrally Diverse Asian Genomes Open
Structural variants (SVs) are significant contributors to inter-individual genetic variation associated with traits and diseases. Current SV studies using whole-genome sequencing (WGS) have a largely Eurocentric composition, with little kn…
View article: Adiposity and metabolic health in Asian populations: an epidemiological study using dual-energy x-ray absorptiometry in Singapore
Adiposity and metabolic health in Asian populations: an epidemiological study using dual-energy x-ray absorptiometry in Singapore Open
View article: The Health for Life in Singapore (HELIOS) Study: delivering Precision Medicine research for Asian populations
The Health for Life in Singapore (HELIOS) Study: delivering Precision Medicine research for Asian populations Open
Asian people are under-represented in population-based, clinical, and genomic research. 1,2 To address this gap, we have initiated the HELIOS longitudinal cohort study, comprising comprehensive behavioural, phenotypic, and genomic measurem…
View article: Coffee polyphenols ameliorate early-life stress-induced cognitive deficits in male mice
Coffee polyphenols ameliorate early-life stress-induced cognitive deficits in male mice Open
View article: Metabolome-wide association of carotid intima media thickness identifies FDX1 as a determinant of cholesterol metabolism and cardiovascular risk in Asian populations
Metabolome-wide association of carotid intima media thickness identifies FDX1 as a determinant of cholesterol metabolism and cardiovascular risk in Asian populations Open
The burden of cardiovascular disease (CVD) is rising in the Asia-Pacific region, in contrast to falling CVD mortality rates in Europe and North America. To provide new insights into the pathways influencing cardiovascular risk in Asian pop…
View article: Association of dietary and nutritional factors with cognitive decline, dementia, and depressive symptomatology in older individuals according to a neurogenesis-centred biological susceptibility to brain ageing
Association of dietary and nutritional factors with cognitive decline, dementia, and depressive symptomatology in older individuals according to a neurogenesis-centred biological susceptibility to brain ageing Open
Hippocampal neurogenesis (HN) occurs throughout the life course and is important for memory and mood. Declining with age, HN plays a pivotal role in cognitive decline (CD), dementia, and late-life depression, such that altered HN could rep…
View article: The development and validation of a macronutrient and taste preference ranking task in multiethnic Asian population
The development and validation of a macronutrient and taste preference ranking task in multiethnic Asian population Open
View article: Metabolic variation reflects dietary intake in a multi-ethnic Asian population
Metabolic variation reflects dietary intake in a multi-ethnic Asian population Open
Dietary biomarkers reflecting habitual diet are explored largely in European and American populations. However, the “food metabolome” is highly complex, with its composition varying to region and culture. Here, by assessing 1,055 plasma me…
View article: A Catalogue of Structural Variation across Ancestrally Diverse Asian Genomes
A Catalogue of Structural Variation across Ancestrally Diverse Asian Genomes Open
Structural variants (SVs) are significant contributors to inter-individual genetic variation associated with traits and diseases. Current SV studies using whole-genome sequencing (WGS) have a largely Eurocentric composition, with little kn…
View article: P03-054-23 Validation of Dietary Biomarkers in Multi-Ethnic Asian Population
P03-054-23 Validation of Dietary Biomarkers in Multi-Ethnic Asian Population Open
View article: Exploration of the Gut–Brain Axis through Metabolomics Identifies Serum Propionic Acid Associated with Higher Cognitive Decline in Older Persons
Exploration of the Gut–Brain Axis through Metabolomics Identifies Serum Propionic Acid Associated with Higher Cognitive Decline in Older Persons Open
The gut microbiome is involved in nutrient metabolism and produces metabolites that, via the gut–brain axis, signal to the brain and influence cognition. Human studies have so far had limited success in identifying early metabolic alterati…
View article: Implicit satiety goals and food-related expectations predict portion size in older adults: Findings from the BAMMBE cohort
Implicit satiety goals and food-related expectations predict portion size in older adults: Findings from the BAMMBE cohort Open
View article: Loss of FOCAD, operating via the SKI messenger RNA surveillance pathway, causes a pediatric syndrome with liver cirrhosis
Loss of FOCAD, operating via the SKI messenger RNA surveillance pathway, causes a pediatric syndrome with liver cirrhosis Open
View article: Impaired hippocampal neurogenesis in vitro is modulated by dietary-related endogenous factors and associated with depression in a longitudinal ageing cohort study
Impaired hippocampal neurogenesis in vitro is modulated by dietary-related endogenous factors and associated with depression in a longitudinal ageing cohort study Open
View article: Four Dietary Patterns Observed Within an Elderly Asian Cohort
Four Dietary Patterns Observed Within an Elderly Asian Cohort Open
View article: Diet-Associated Variability in the Elderly Gut Microbiome
Diet-Associated Variability in the Elderly Gut Microbiome Open
OBJECTIVES: The gut microbiome adapts to diet variations, which contribute to interindividual variability in human host metabolism and environmental factors. Microbe-diet studies have largely focused on specific diets (e.g., high-fat Weste…
View article: Apolipoprotein E and sex modulate fatty acid metabolism in a prospective observational study of cognitive decline
Apolipoprotein E and sex modulate fatty acid metabolism in a prospective observational study of cognitive decline Open
View article: Food and Microbiota Metabolites Associate with Cognitive Decline in Older Subjects: A 12‐Year Prospective Study
Food and Microbiota Metabolites Associate with Cognitive Decline in Older Subjects: A 12‐Year Prospective Study Open
Scope Diet is considered an important modulator of cognitive decline and dementia, but the available evidence is, however, still fragmented and often inconsistent. Methods and Results The article studies the long‐term prospective Three‐Cit…
View article: The serum metabolome mediates the concert of diet, exercise, and neurogenesis, determining the risk for cognitive decline and dementia
The serum metabolome mediates the concert of diet, exercise, and neurogenesis, determining the risk for cognitive decline and dementia Open
Introduction Diet and exercise influence the risk of cognitive decline (CD) and dementia through the food metabolome and exercise‐triggered endogenous factors, which use the blood as a vehicle to communicate with the brain. These factors m…
View article: Regional Diets Targeting Gut Microbial Dynamics to Support Prolonged Healthspan
Regional Diets Targeting Gut Microbial Dynamics to Support Prolonged Healthspan Open
In the last 150 years, we have seen a significant increase in average life expectancy, associated with a shift from infectious to non-communicable diseases. The rising incidence of these diseases, for which age is often the largest risk fa…
View article: Data sharing in PredRet for accurate prediction of retention time: Application to plant food bioactive compounds
Data sharing in PredRet for accurate prediction of retention time: Application to plant food bioactive compounds Open
View article: Early signature in the blood lipidome associated with subsequent cognitive decline in the elderly: A case-control analysis nested within the Three-City cohort study
Early signature in the blood lipidome associated with subsequent cognitive decline in the elderly: A case-control analysis nested within the Three-City cohort study Open
View article: Caffeine Compromises Proliferation of Human Hippocampal Progenitor Cells
Caffeine Compromises Proliferation of Human Hippocampal Progenitor Cells Open
The age-associated reduction in the proliferation of neural stem cells (NSCs) has been associated with cognitive decline. Numerous factors have been shown to modulate this process, including dietary components. Frequent consumption of caff…
View article: Diet‐Related Metabolites Associated with Cognitive Decline Revealed by Untargeted Metabolomics in a Prospective Cohort
Diet‐Related Metabolites Associated with Cognitive Decline Revealed by Untargeted Metabolomics in a Prospective Cohort Open
Scope Untargeted metabolomics may reveal preventive targets in cognitive aging, including within the food metabolome. Methods and results A case‐control study nested in the prospective Three‐City study includes participants aged ≥65 years …
View article: Interlaboratory Coverage Test on Plant Food Bioactive Compounds and Their Metabolites by Mass Spectrometry-Based Untargeted Metabolomics
Interlaboratory Coverage Test on Plant Food Bioactive Compounds and Their Metabolites by Mass Spectrometry-Based Untargeted Metabolomics Open
Bioactive compounds present in plant-based foods, and their metabolites derived from gut microbiota and endogenous metabolism, represent thousands of chemical structures of potential interest for human nutrition and health. State-of-the-ar…