Doudou Yu
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View article: HypoAD: volumetric and single-cell analysis reveals changes in the human hypothalamus in aging and Alzheimer’s disease
HypoAD: volumetric and single-cell analysis reveals changes in the human hypothalamus in aging and Alzheimer’s disease Open
Alterations in metabolism, stress response, sleep, circadian rhythms, and neuroendocrine processes are key features of aging and neurodegeneration. These fundamental processes are regulated by the hypothalamus, yet how its functionally dis…
View article: Hospitalization experience and associated factors among Chinese patients with cancer: a cross-sectional study
Hospitalization experience and associated factors among Chinese patients with cancer: a cross-sectional study Open
Not applicable.
View article: Risk factors for pneumonia after radical gastrectomy for gastric cancer: a systematic review and meta-analysis
Risk factors for pneumonia after radical gastrectomy for gastric cancer: a systematic review and meta-analysis Open
This study identified 15 independent risk factors significantly associated with pneumonia after radical gastrectomy for gastric cancer, with a pooled prevalence of 11.0%. These findings emphasize the importance of targeted preventive strat…
View article: Understanding the Relationship Between Chinese Nurses’ Attitudes Toward Incontinence‐Related Dermatitis and Achievement Motivation Through a Person‐Centered Method: A Theory‐Driven Cross‐Sectional Study
Understanding the Relationship Between Chinese Nurses’ Attitudes Toward Incontinence‐Related Dermatitis and Achievement Motivation Through a Person‐Centered Method: A Theory‐Driven Cross‐Sectional Study Open
Background Incontinence‐associated dermatitis (IAD) is a common nursing challenge in clinical practice, imposing a significant burden on both patients and healthcare providers. Studies have reported that nurses’ preventive attitudes toward…
View article: Risk factors of skin tear in older persons: a protocol for systematic review and meta-analysis
Risk factors of skin tear in older persons: a protocol for systematic review and meta-analysis Open
Introduction Skin tear (ST) will prolong the hospitalisation time of an older person, increase the cost of medical expenses and the difficulty in care for nursing staff, and seriously affect the quality of life of the older person. Early i…
View article: Single-cell RNA Sequencing Reveals the Role of Heat Shock Protein 90 in Müller Cells Proliferation via the Necroptosis/MAPK Pathway in Diabetes
Single-cell RNA Sequencing Reveals the Role of Heat Shock Protein 90 in Müller Cells Proliferation via the Necroptosis/MAPK Pathway in Diabetes Open
Purpose Understanding the complex pathology of diabetic retinopathy (DR) was challenging due to the intricate cellular structure of the retina. Methods We performed single-cell RNA sequencing (scRNA-seq) on retinas from 4 diabetic patients…
View article: Risk factors for pneumonia after radical gastrectomy for gastric cancer: A systematic review and meta-analysis
Risk factors for pneumonia after radical gastrectomy for gastric cancer: A systematic review and meta-analysis Open
Objective The objective is to systematically gather the relevant research to determine and quantify the risk factors for pneumonia after a radical gastrectomy for gastric cancer. Methods The reporting procedures of this meta-analysis confo…
View article: The effect of micronutrient on thyroid cancer risk: a Mendelian randomization study
The effect of micronutrient on thyroid cancer risk: a Mendelian randomization study Open
Background The effect of micronutrients on thyroid cancer has been studied in observational studies, however, the cause of relationships has not yet been determined. Thyroid cancer was the subject of a Mendelian randomization (MR) analysis…
View article: Incidence and influencing factors of fertility concerns in breast cancer in young women: a systematic review and meta-analysis
Incidence and influencing factors of fertility concerns in breast cancer in young women: a systematic review and meta-analysis Open
Objective This systematic review and meta-analysis aimed to evaluate the prevalence and influencing factors of fertility concerns in breast cancer in young women. Methods A literature search on PubMed, Embase, Web of Science, and Cochrane …
View article: Risk factors of incontinence-associated dermatitis in older adults: a protocol for systematic review and meta-analysis
Risk factors of incontinence-associated dermatitis in older adults: a protocol for systematic review and meta-analysis Open
Introduction Due to their ageing skin, older adults are more likely to develop incontinence-associated dermatitis (IAD). Although previous attempts to look at the risk factors for IAD in older adults were done, methodological barriers hind…
View article: Fertility concerns in cancer patients: a bibliometric analysis via CiteSpace: A review
Fertility concerns in cancer patients: a bibliometric analysis via CiteSpace: A review Open
Fertility concerns are a pervasive issue but very subtle in patients with cancer. Though various studies have focused on fertility concerns, limited research endeavor has been dedicated to bibliometric analysis. Given this, to visually ana…
View article: Figure S7 from Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis
Figure S7 from Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis Open
Supplementary Figure 7, CARMIL3 regulates β-catenin. Related to Fig. 7. A. qRT-PCR measurement of Ctnnb1 mRNA level in WT and Carmil3 KO 4T1 cells. B. HEK293T cells were transfected with CARMIL3-His or β-catenin-FLAG expressing plasmid. Af…
View article: Supplementary Table 1A from Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis
Supplementary Table 1A from Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis Open
Supplementary Table 1A shows multivariate Cox regression analysis of prognostic factors of breast cancer patients (cohort TCGA-BRCA PAM50 Luminal A, N=303)
View article: Figure S1 from Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis
Figure S1 from Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis Open
Supplementary Figure 1, CARIML3 expression is upregulated among various types of cancer. Related to Figure 1. A. CARMIL3 copy number variance (CNV) level across various types of cancer in TCGA. B. CARMIL3 mRNA (RNA-Seq) expression among di…
View article: Figure S8 from Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis
Figure S8 from Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis Open
Supplementary Figure 8, Summary of the modality of CARMIL3 in cancer metastasis.
View article: Supplementary Table 1B from Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis
Supplementary Table 1B from Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis Open
Supplementary Table 1B shows multivariate Cox regression analysis of prognostic factors of breast cancer patients (cohort GSE42568, N=104)
View article: Figure S8 from Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis
Figure S8 from Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis Open
Supplementary Figure 8, Summary of the modality of CARMIL3 in cancer metastasis.
View article: Data from Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis
Data from Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis Open
Metastasis accounts for 90% of deaths caused by solid tumors, but the multitude of mechanisms underlying tumor metastasis remains poorly understood. CARMIL1 and 2 proteins are capping protein (CP) interactants and multidomain regulators of…
View article: Figure S5 from Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis
Figure S5 from Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis Open
Supplementary Figure 5, Molecular pathway enrichment of CARMIL3. Related to Fig. 5. A. KEGG pathway enrichment plots of Gene Set Enrichment Analysis (GSEA) with gene ex-pression profiles of 4T1 WT and Carmil3 KO cells. B. Biological Proces…
View article: Figure S5 from Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis
Figure S5 from Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis Open
Supplementary Figure 5, Molecular pathway enrichment of CARMIL3. Related to Fig. 5. A. KEGG pathway enrichment plots of Gene Set Enrichment Analysis (GSEA) with gene ex-pression profiles of 4T1 WT and Carmil3 KO cells. B. Biological Proces…
View article: Supplemental Materials and Methods from Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis
Supplemental Materials and Methods from Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis Open
All Supplemental Materials and Methods
View article: Figure S1 from Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis
Figure S1 from Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis Open
Supplementary Figure 1, CARIML3 expression is upregulated among various types of cancer. Related to Figure 1. A. CARMIL3 copy number variance (CNV) level across various types of cancer in TCGA. B. CARMIL3 mRNA (RNA-Seq) expression among di…
View article: Figure S6 from Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis
Figure S6 from Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis Open
Supplementary Figure 6, CARMIL3 regulates Cdh1 transcription. Related to Fig. 6. A. Result of qRT-PCR detecting mRNA level of the main Cdh1 transcriptional repressors in WT and Carmil3 KO 4T1 cells. B. WT and Carmil3 KO 4T1 cells were trea…
View article: Supplementary Table 2 from Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis
Supplementary Table 2 from Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis Open
Supplementary Table 2 shows the interacting proteins of CARMIL3 identified by immunoprecipitation coupled with mass spectrometry analysis.
View article: Figure S4 from Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis
Figure S4 from Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis Open
Supplementary Figure 4, EGFP-mCARMI3 localizes at cortical plasma membrane as well as in cytoplasm. Related to Fig. 4. A. HEK293T cells were transfected with empty vector(MSCV-FLAG) or FLAG tag CAR-MIL3(MSCV-FLAG-CARMIL3), followed by immu…
View article: Figure S3 from Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis
Figure S3 from Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis Open
Supplementary Figure 3, Carmil3 KO in tumor cells reduces metastasis. Related to Fig. 3. A. Analysis of tumor cells migration with scratch assay. B. Result of transwell assay measur-ing tumor cell migratory capacity. Cells which migrated d…
View article: Figure S2 from Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis
Figure S2 from Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis Open
Supplementary Figure 2, Carmil3 deficiency attenuates proliferation of tumor cells. Re-lated to Fig. 2. A and B. Carmil3 KO 4T1 tumor cell line was generated by CRISPR/Cas9 technology with a pair of sgRNA, which resulted in deleting a DNA …
View article: Figure S2 from Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis
Figure S2 from Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis Open
Supplementary Figure 2, Carmil3 deficiency attenuates proliferation of tumor cells. Re-lated to Fig. 2. A and B. Carmil3 KO 4T1 tumor cell line was generated by CRISPR/Cas9 technology with a pair of sgRNA, which resulted in deleting a DNA …
View article: Supplemental Materials and Methods from Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis
Supplemental Materials and Methods from Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis Open
All Supplemental Materials and Methods