Dougall M. Norris
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View article: Phage-encoded sRNA counteracts xenogenic silencing in pathogenic <i>E. coli</i>
Phage-encoded sRNA counteracts xenogenic silencing in pathogenic <i>E. coli</i> Open
Horizontal gene transfer introduces foreign DNA that can disrupt cellular processes and is therefore subject to xenogenic silencing by nucleoid-associated proteins such as H-NS and Hha. In Enterohaemorrhagic Escherichia coli (EHEC), propha…
View article: Author Correction: Limited oxygen in standard cell culture alters metabolism and function of differentiated cells
Author Correction: Limited oxygen in standard cell culture alters metabolism and function of differentiated cells Open
View article: Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake
Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake Open
View article: Phosphoproteomics reveals rewiring of the insulin signaling network and multi-nodal defects in insulin resistance
Phosphoproteomics reveals rewiring of the insulin signaling network and multi-nodal defects in insulin resistance Open
View article: Nonvesicular trafficking of cholesterol by Aster proteins
Nonvesicular trafficking of cholesterol by Aster proteins Open
In a recent article published in Nature Metabolism, Peter Tontonoz and colleagues found that the Aster/GramD1 proteins were required for plasma membrane cholesterol to reach the endoplasmic reticulum in mouse liver during fasting, LDL upta…
View article: Limited oxygen availability in standard cell culture alters metabolism and function in terminally-differentiated cells
Limited oxygen availability in standard cell culture alters metabolism and function in terminally-differentiated cells Open
SUMMARY Cell culture is generally considered to be hyperoxic. However, the importance of cellular oxygen consumption is often underappreciated, with rates of oxygen consumption often sufficient to cause hypoxia at cell monolayers. We initi…
View article: PI(3)P and DFCP1 regulate the biogenesis of lipid droplets
PI(3)P and DFCP1 regulate the biogenesis of lipid droplets Open
PI(3)P and DFCP1, both known for their association with autophagy initiation, regulate the biogenesis of lipid droplets.
View article: Phosphoproteomics reveals rewiring of the insulin signaling network and multi-nodal defects in insulin resistance
Phosphoproteomics reveals rewiring of the insulin signaling network and multi-nodal defects in insulin resistance Open
The failure of metabolic tissues to appropriately respond to insulin (“insulin resistance”) is an early marker in the pathogenesis of type 2 diabetes. Protein phosphorylation is central to the adipocyte insulin response, but how adipocyte …
View article: Trafficking regulator of GLUT4-1 (TRARG1) is a GSK3 substrate
Trafficking regulator of GLUT4-1 (TRARG1) is a GSK3 substrate Open
Trafficking regulator of GLUT4-1, TRARG1, positively regulates insulin-stimulated GLUT4 trafficking and insulin sensitivity. However, the mechanism(s) by which this occurs remain(s) unclear. Using biochemical and mass spectrometry analyses…
View article: Akt phosphorylates insulin receptor substrate to limit PI3K-mediated PIP3 synthesis.
Akt phosphorylates insulin receptor substrate to limit PI3K-mediated PIP3 synthesis. Open
The phosphoinositide 3-kinase (PI3K)-Akt network is tightly controlled by feedback mechanisms that regulate signal flow and ensure signal fidelity. A rapid overshoot in insulin-stimulated recruitment of Akt to the plasma membrane has previ…
View article: Author response: Akt phosphorylates insulin receptor substrate to limit PI3K-mediated PIP3 synthesis
Author response: Akt phosphorylates insulin receptor substrate to limit PI3K-mediated PIP3 synthesis Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The phosphoinositide 3-kinase…
View article: Signaling Heterogeneity is Defined by Pathway Architecture and Intercellular Variability in Protein Expression
Signaling Heterogeneity is Defined by Pathway Architecture and Intercellular Variability in Protein Expression Open
View article: Trafficking regulator of GLUT4-1 (TRARG1) is a GSK3 substrate
Trafficking regulator of GLUT4-1 (TRARG1) is a GSK3 substrate Open
Trafficking regulator of GLUT4-1, TRARG1, positively regulates insulin-stimulated GLUT4 trafficking and insulin sensitivity. However, the mechanism(s) by which this occurs remain(s) unclear. Using biochemical and mass spectrometry analyses…
View article: Phosphoproteomics reveals conserved exercise‐stimulated signaling and AMPK regulation of store‐operated calcium entry
Phosphoproteomics reveals conserved exercise‐stimulated signaling and AMPK regulation of store‐operated calcium entry Open
View article: Before the Pump
Before the Pump Open
View article: First person – Dougall Norris
First person – Dougall Norris Open
First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Dougall Norris is co-first author on ‘…