Benjamin D. Smith
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View article: Metronomic dose decitabine therapy for TP53 complex karyotype myeloid neoplasms
Metronomic dose decitabine therapy for TP53 complex karyotype myeloid neoplasms Open
Introduction: Hypomethylating agent and venetoclax (VEN)–based therapy has transformed the treatment landscape for older adults with AML, offering improved remission rates and survival compared to traditional chemotherapy. However, patient…
View article: Ivosidenib or venetoclax combined with hypomethylating agents in IDH1-mutated acute myeloid leukemia: a real-world study
Ivosidenib or venetoclax combined with hypomethylating agents in IDH1-mutated acute myeloid leukemia: a real-world study Open
Approximately 10% of patients with newly diagnosed acute myeloid leukemia (ND-AML) harbor the isocitrate dehydrogenase 1 gene mutation (mIDH1). In this real-world study evaluating ivosidenib (IVO) + hypomethylating agents (HMAs; n = 181) v…
View article: Disabling PSGL-1 abrogates immune suppression and resistance to PD-1 blockade in pancreatic cancer
Disabling PSGL-1 abrogates immune suppression and resistance to PD-1 blockade in pancreatic cancer Open
Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer for which there is a critical need to identify novel therapeutic targets. Herein we define PSGL-1 as a checkpoint inhibitor using a syngeneic orthotopic model of PDAC. As with PDAC…
View article: The impact of breast radiotherapy on the tumor genome and immune ecosystem
The impact of breast radiotherapy on the tumor genome and immune ecosystem Open
Radiotherapy is a pillar of breast cancer treatment; however, it remains unclear how radiotherapy modulates the tumor microenvironment. We investigated this question in a cohort of 20 patients with estrogen-receptor positive (ER+) breast t…
View article: Cardiovascular Disease and Breast Cancer Stage at Diagnosis
Cardiovascular Disease and Breast Cancer Stage at Diagnosis Open
Importance Cardiovascular disease (CVD) and cancer are the leading causes of mortality in the US. Large-scale population-based and mechanistic studies support a direct effect of CVD on accelerated tumor growth and spread, specifically in b…
View article: Creating a Cooperative AI Policymaking Platform through Open Source Collaboration
Creating a Cooperative AI Policymaking Platform through Open Source Collaboration Open
Advances in artificial intelligence (AI) present significant risks and opportunities, requiring improved governance to mitigate societal harms and promote equitable benefits. Current incentive structures and regulatory delays may hinder re…
View article: Stability of Mg IG/GSH combo injection
Stability of Mg IG/GSH combo injection Open
Objective: To investigate the stability of magnesium isoglycyrrhizinate (Mg IG) injection solution when mixed with reduced glutathione (GSH) injection solution at room temperature. Method: High-performance liquid chromatography was used to…
View article: Outcomes By Frailty in IC-Ineligible Newly Diagnosed AML - a Real-World Evidence Comparison By Treatment with Hypomethylating Agents + Ivosidenib or Venetoclax
Outcomes By Frailty in IC-Ineligible Newly Diagnosed AML - a Real-World Evidence Comparison By Treatment with Hypomethylating Agents + Ivosidenib or Venetoclax Open
BACKGROUND: Nearly 50% of newly diagnosed (nd) patients with AML are ineligible for intensive chemotherapy (ICi) and are commonly referred to as “unfit”. However, the ICi population is heterogeneous, and evidence supporting treatment succe…
View article: Associations of pulmonary microvascular blood volume with per cent emphysema and CT emphysema subtypes in the community: the MESA Lung study
Associations of pulmonary microvascular blood volume with per cent emphysema and CT emphysema subtypes in the community: the MESA Lung study Open
Background Pulmonary microvasculature alterations are implicated in emphysema pathogenesis, but the association between pulmonary microvascular blood volume (PMBV) and emphysema has not been directly assessed at scale, and prior studies ha…
View article: Financial toxicity in breast cancer patients receiving regional nodal irradiation: Variation by cancer subtype
Financial toxicity in breast cancer patients receiving regional nodal irradiation: Variation by cancer subtype Open
Among patients with breast cancer receiving RNI, triple negative subtype was associated with severe FT, suggesting that tumor receptor subtype may help identify a key breast cancer subpopulation for early FT intervention.
View article: O-220 Ovarify: a deep learning model for automatic calculation of ovarian morphological features in pelvic ultrasonography
O-220 Ovarify: a deep learning model for automatic calculation of ovarian morphological features in pelvic ultrasonography Open
Study question Can a deep learning model accurately characterize ovarian features on pelvic ultrasounds? Summary answer We developed a deep learning model, Ovarify, that can accurately classify and segment ovarian features on pelvic ultras…
View article: Clinical Outcomes for <i>BRCA</i> Pathogenic Variant Carriers With Breast Cancer Undergoing Breast Conservation
Clinical Outcomes for <i>BRCA</i> Pathogenic Variant Carriers With Breast Cancer Undergoing Breast Conservation Open
Importance Although most women with BRCA- associated breast cancer choose bilateral mastectomy, current guidelines support breast-conserving therapy as an option. As the indications for genetic testing expand and targeted therapies emerge,…
View article: The Importance of Digital Rectal Examination in Identifying Early-Onset Rectal Malignancies
The Importance of Digital Rectal Examination in Identifying Early-Onset Rectal Malignancies Open
Colorectal cancer (CRC) is the second most diagnosed cancer and the second leading cause of cancer-related deaths in the United States. Rectal cancers, specifically, are the second most common cancer of the large intestine. Although once p…
View article: Premastectomy Radiotherapy and Immediate Breast Reconstruction
Premastectomy Radiotherapy and Immediate Breast Reconstruction Open
Importance Premastectomy radiotherapy (PreMRT) is a new treatment sequence to avoid the adverse effects of radiotherapy on the final breast reconstruction while achieving the benefits of immediate breast reconstruction (IMBR). Objective To…
View article: Polyamorous Scheduling
Polyamorous Scheduling Open
Finding schedules for pairwise meetings between the members of a complex social group without creating interpersonal conflict is challenging, especially when different relationships have different needs. We formally define and study the un…
View article: Patient-Reported Outcomes of Omission of Breast Surgery Following Neoadjuvant Systemic Therapy
Patient-Reported Outcomes of Omission of Breast Surgery Following Neoadjuvant Systemic Therapy Open
Importance Patients should have an active role in decisions about pursuing or forgoing specific therapies in treatment de-escalation trials. Objective To evaluate longitudinal patient-reported outcomes (PROs) encompassing decisional comfor…
View article: PB1966: THE EFFECT OF BODY MASS INDEX ON THE SAFETY OF BOSUTINIB IN PATIENTS WITH CHRONIC MYELOID LEUKEMIA: A POST HOC POOLED DATA ANALYSIS
PB1966: THE EFFECT OF BODY MASS INDEX ON THE SAFETY OF BOSUTINIB IN PATIENTS WITH CHRONIC MYELOID LEUKEMIA: A POST HOC POOLED DATA ANALYSIS Open
Topic: 8. Chronic myeloid leukemia - Clinical Background: Bosutinib is approved for the treatment of Philadelphia chromosome–positive (Ph+) chronic myeloid leukemia (CML) resistant/intolerant to prior therapy and newly diagnosed Ph+ chroni…
View article: Household Mobility, Networks, and Gentrification of Minority Neighborhoods in the US
Household Mobility, Networks, and Gentrification of Minority Neighborhoods in the US Open
We study how recent gentrification shocks impact Black and Hispanic neighborhoods, including where minority households move to after a shock and if the subsequent spatial distribution of households within a labor market area affects segreg…