Douglas Colby
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View article: TET knockout cells transit between pluripotent states and exhibit precocious germline entry
TET knockout cells transit between pluripotent states and exhibit precocious germline entry Open
TET1, TET2 and TET3 are DNA demethylases with important roles in development and differentiation. To assess the contributions of TET proteins to cell function during early development, single and compound knockouts of Tet genes in mouse pl…
View article: TET knockout cells transit between pluripotent states and exhibit precocious germline entry
TET knockout cells transit between pluripotent states and exhibit precocious germline entry Open
Summary TET1, TET2 and TET3 are DNA demethylases with critical roles in development and differentiation. To assess the contributions of TET proteins to cell function during early development, single and compound knockouts of Tet genes in m…
View article: Phosphorylation of NANOG by casein kinase I regulates embryonic stem cell self‐renewal
Phosphorylation of NANOG by casein kinase I regulates embryonic stem cell self‐renewal Open
The self‐renewal efficiency of mouse embryonic stem cells (ESCs) is determined by the concentration of the transcription factor NANOG. While NANOG binds thousands of sites in chromatin, the regulatory systems that control DNA binding are p…
View article: Analysis of pluripotency transcription factor interactions reveals preferential binding of NANOG to SOX2 rather than NANOG or OCT4
Analysis of pluripotency transcription factor interactions reveals preferential binding of NANOG to SOX2 rather than NANOG or OCT4 Open
The pluripotency transcription factors (TFs) Nanog, Sox2, and Oct4 are at the centre of the gene regulatory network that controls cell identity in embryonic stem (ES) cells. However, the mechanisms by which these factors control cell fate,…
View article: Endogenous epitope-tagging of <i>Tet1</i>, <i>Tet2</i> and <i>Tet3</i> identifies TET2 as a naïve pluripotency marker
Endogenous epitope-tagging of <i>Tet1</i>, <i>Tet2</i> and <i>Tet3</i> identifies TET2 as a naïve pluripotency marker Open
Tet1 , Tet2 , and Tet3 encode DNA demethylases that play critical roles during stem cell differentiation and reprogramming to pluripotency. Although all three genes are transcribed in pluripotent cells, little is known about the expression…
View article: Esrrb extinction triggers dismantling of naïve pluripotency and marks commitment to differentiation
Esrrb extinction triggers dismantling of naïve pluripotency and marks commitment to differentiation Open
View article: Distinct SoxB1 networks are required for naïve and primed pluripotency
Distinct SoxB1 networks are required for naïve and primed pluripotency Open
Deletion of Sox2 from mouse embryonic stem cells (ESCs) causes trophectodermal differentiation. While this can be prevented by enforced expression of the related SOXB1 proteins, SOX1 or SOX3, the roles of SOXB1 proteins in epiblast stem ce…
View article: Author response: Distinct SoxB1 networks are required for naïve and primed pluripotency
Author response: Distinct SoxB1 networks are required for naïve and primed pluripotency Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Deletion of Sox2 from mouse embryonic stem…
View article: Distinct SoxB1 networks are required for naïve and primed pluripotency
Distinct SoxB1 networks are required for naïve and primed pluripotency Open
Deletion of Sox2 from embryonic stem cells (ESCs) causes trophectodermal differentiation. While this can be prevented by enforced expression of the related SOXB1 proteins, SOX1 or SOX3, the roles of SOXB1 proteins in epiblast stem cell (Ep…
View article: Distinct Contributions of Tryptophan Residues within the Dimerization Domain to Nanog Function
Distinct Contributions of Tryptophan Residues within the Dimerization Domain to Nanog Function Open
The level of the transcription factor Nanog directly determines the efficiency of mouse embryonic stem cell self-renewal. Nanog protein exists as a dimer with the dimerization domain composed of a simple repeat region in which every fifth …
View article: Distinct Signaling Requirements for the Establishment of ESC Pluripotency in Late-Stage EpiSCs
Distinct Signaling Requirements for the Establishment of ESC Pluripotency in Late-Stage EpiSCs Open
View article: Selective influence of Sox2 on <scp>POU</scp> transcription factor binding in embryonic and neural stem cells
Selective influence of Sox2 on <span>POU</span> transcription factor binding in embryonic and neural stem cells Open