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View article: Corrigendum to “Auto-antibodies against interferons are common in people living with chronic hepatitis B virus infection and associate with PegIFNα non-response” [J Hepatol (2025) 101382]
Corrigendum to “Auto-antibodies against interferons are common in people living with chronic hepatitis B virus infection and associate with PegIFNα non-response” [J Hepatol (2025) 101382] Open
[This corrects the article DOI: 10.1016/j.jhepr.2025.101382.].
View article: Auto-antibodies against interferons are common in people living with chronic hepatitis B virus infection and associate with PegIFNα non-response
Auto-antibodies against interferons are common in people living with chronic hepatitis B virus infection and associate with PegIFNα non-response Open
HBV and PegIFNα individually may induce broad autoreactivity associated with dysregulated antiviral immune responses. Auto-Ab screening prior to PegIFNα treatment or other immunotherapies may play a critical role in predicting treatment re…
View article: VIVALDI Cohort Profile: Using linked, routinely collected data and longitudinal blood sampling to characterise COVID-19 infections, vaccinations, and related outcomes in care home staff and residents in England
VIVALDI Cohort Profile: Using linked, routinely collected data and longitudinal blood sampling to characterise COVID-19 infections, vaccinations, and related outcomes in care home staff and residents in England Open
VIVALDI (ISRCTN14447421) is a government-funded longitudinal open observational cohort study of staff and residents in care homes for older people in England. The study aimed to describe epidemiology (including seroprevalence) and immune r…
View article: Preservation of memory B cell homeostasis in an individual producing broadly neutralising antibodies against HIV-1
Preservation of memory B cell homeostasis in an individual producing broadly neutralising antibodies against HIV-1 Open
Immunological determinants favouring emergence of broadly neutralising antibodies are crucial to the development of HIV-1 vaccination strategies. Here, we combined RNAseq and B cell cloning approaches to isolate a broadly neutralising anti…
View article: VIVALDI Cohort Profile: Using linked, routinely collected data and longitudinal blood sampling to characterise COVID-19 infections, vaccinations, and related outcomes in care home staff and residents in England
VIVALDI Cohort Profile: Using linked, routinely collected data and longitudinal blood sampling to characterise COVID-19 infections, vaccinations, and related outcomes in care home staff and residents in England Open
VIVALDI (ISRCTN14447421) is a government-funded longitudinal open observational cohort study of staff and residents in care homes for older people in England. The study aimed to describe epidemiology (including seroprevalence) and immune r…
View article: Clinical features and management of individuals admitted to hospital with monkeypox and associated complications across the UK: a retrospective cohort study
Clinical features and management of individuals admitted to hospital with monkeypox and associated complications across the UK: a retrospective cohort study Open
View article: BHIVA guidelines on antiretroviral treatment for adults living with HIV‐1 2022
BHIVA guidelines on antiretroviral treatment for adults living with HIV‐1 2022 Open
Contents 1 Introduction7 1.1 Scope and purpose7 1.2 Methodology7 1.2.1 Guideline development process7 1.2.2 Involvement of people living with HIV8 1.2.3 GRADE8 1.2.4 Good practice points9 1.2.5 Dissemination and implementation9 1.2.6 Guide…
View article: SARS-COV-2 antibody responses to AZD1222 vaccination in West Africa
SARS-COV-2 antibody responses to AZD1222 vaccination in West Africa Open
Real-world data on vaccine-elicited neutralising antibody responses for two-dose AZD1222 in African populations are limited. We assessed baseline SARS-CoV-2 seroprevalence and levels of protective neutralizing antibodies prior to vaccinati…
View article: SARS-CoV-2 Antibody Responses to AZD1222 Vaccination in West Africa
SARS-CoV-2 Antibody Responses to AZD1222 Vaccination in West Africa Open
There is a paucity of real-world data on vaccine elicited neutralising antibody responses for AZD1222, in African populations following vaccination scale up. Here, we first measured baseline SARS-CoV-2 seroprevalence and levels of protecti…
View article: Antibody responses to AZD1222 vaccination in West Africa
Antibody responses to AZD1222 vaccination in West Africa Open
Background There are no real world data on vaccine elicited neutralising antibody responses for the world’s most widely used vaccine, AZD1222, in African populations following scale up. Here, we measured i) baseline SARS-CoV-2 seroprevalen…
View article: HIV-2/SIV Vpx antagonises NF-κB activation by targeting p65
HIV-2/SIV Vpx antagonises NF-κB activation by targeting p65 Open
View article: A Multicentre Observational Study of HIV, TB and Risk of Chronic Lung Disease in Urban West Africa
A Multicentre Observational Study of HIV, TB and Risk of Chronic Lung Disease in Urban West Africa Open
View article: Clinical Features and Management of Individuals Hospitalised with Monkeypox and Associated Complications in the UK: A Retrospective Analysis Across 16 Hospitals
Clinical Features and Management of Individuals Hospitalised with Monkeypox and Associated Complications in the UK: A Retrospective Analysis Across 16 Hospitals Open
View article: HIV-2/SIV Vpx antagonises NF-<i>κ</i>B activation by targeting p65
HIV-2/SIV Vpx antagonises NF-<i>κ</i>B activation by targeting p65 Open
The NF- κ B family of transcription factors and associated signalling pathways are abundant and ubiquitous in human immune responses. Activation of NF- κ B transcription factors by viral pathogen-associated molecular patterns, such as vira…
View article: 110 A Single Centre Study on the Thirty-Day Hospital Reattendance and Readmission of Older Patients During the SARS-CoV-2 Pandemic
110 A Single Centre Study on the Thirty-Day Hospital Reattendance and Readmission of Older Patients During the SARS-CoV-2 Pandemic Open
Introduction Hospital and social care suffered major alterations during the SARS-CoV-2 pandemic in the UK. Older adults were disproportionally affected by routine care disruption. To our knowledge, no data has been published so far on the …
View article: Ratio of Oxygen Saturation Index to Guide Management of COVID-19 Pneumonia
Ratio of Oxygen Saturation Index to Guide Management of COVID-19 Pneumonia Open
View article: HIV-1 Vpr antagonizes innate immune activation by targeting karyopherin-mediated NF-κB/IRF3 nuclear transport
HIV-1 Vpr antagonizes innate immune activation by targeting karyopherin-mediated NF-κB/IRF3 nuclear transport Open
HIV-1 must replicate in cells that are equipped to defend themselves from infection through intracellular innate immune systems. HIV-1 evades innate immune sensing through encapsidated DNA synthesis and encodes accessory genes that antagon…
View article: Author response: HIV-1 Vpr antagonizes innate immune activation by targeting karyopherin-mediated NF-κB/IRF3 nuclear transport
Author response: HIV-1 Vpr antagonizes innate immune activation by targeting karyopherin-mediated NF-κB/IRF3 nuclear transport Open
View article: Development and internal validation of a diagnostic prediction model for COVID-19 at time of admission to hospital
Development and internal validation of a diagnostic prediction model for COVID-19 at time of admission to hospital Open
Summary Background Early coronavirus disease 2019 (COVID-19) diagnosis prior to laboratory testing results is crucial for infection control in hospitals. Models exist predicting COVID-19 diagnosis, but significant concerns exist regarding …
View article: High prevalence of COVID-19-associated diabetic ketoacidosis in UK secondary care
High prevalence of COVID-19-associated diabetic ketoacidosis in UK secondary care Open
View article: Shortening duration of ertapenem in outpatient parenteral antimicrobial therapy for complicated urinary tract infections: A retrospective study
Shortening duration of ertapenem in outpatient parenteral antimicrobial therapy for complicated urinary tract infections: A retrospective study Open
Short duration ertapenem via OPAT with or without adjunctive fosfomycin is safe and effective for the treatment of complicated UTIs. Further studies are required to inform optimal treatment strategies and publication of guidelines in this …
View article: Musculoskeletal symptoms and non-prescribed treatments are common in an urban African population of people living with HIV
Musculoskeletal symptoms and non-prescribed treatments are common in an urban African population of people living with HIV Open
There are no data from West Africa reporting musculoskeletal (MSK) disease in people living with HIV (PLWH). Our primary outcome was to measure the prevalence of MSK symptoms in PLWH in urban West Africa. Our secondary outcomes were to des…
View article: Building a rheumatology team for Africa: enhancing the roles of patients and non-specialists
Building a rheumatology team for Africa: enhancing the roles of patients and non-specialists Open
View article: Are Evolution and the Intracellular Innate Immune System Key Determinants in HIV Transmission?
Are Evolution and the Intracellular Innate Immune System Key Determinants in HIV Transmission? Open
HIV-1 is the single most important sexually transmitted disease in humans from a global health perspective. Among human lentiviruses, HIV-1 M group has uniquely achieved pandemic levels of human-to-human transmission. The requirement to tr…
View article: Febrile illness in healthcare workers caring for Ebola virus disease patients in a high-resource setting
Febrile illness in healthcare workers caring for Ebola virus disease patients in a high-resource setting Open
Ebola virus disease (EVD) patients treated in high-resource facilities are cared for by large numbers of healthcare staff. Monitoring these healthcare workers (HCWs) for any illness that may represent transmission of Ebola virus is importa…
View article: Lick of death:<i>Capnocytophaga canimorsus</i>is an important cause of sepsis in the elderly
Lick of death:<i>Capnocytophaga canimorsus</i>is an important cause of sepsis in the elderly Open
A 70-year-old Caucasian woman was treated for Capnocytophaga canimorsus septicaemia. The source of bacteraemia was very likely to be her household pet, an Italian greyhound. The patient presented with a presumed complex partial seizure but…
View article: Blood culture fluorescence rates predict severity and mortality of invasive pneumococcal pneumonia
Blood culture fluorescence rates predict severity and mortality of invasive pneumococcal pneumonia Open