Douglas G. Walker
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View article: Translational framework linking perfluoroheptanoic acid (PFHpA) exposure to metabolic dysfunction associated steatotic liver disease in adolescents
Translational framework linking perfluoroheptanoic acid (PFHpA) exposure to metabolic dysfunction associated steatotic liver disease in adolescents Open
This study offers evidence implicating PFHpA, a short-chain unregulated PFAS congener, in MASLD development in adolescents, and highlights the critical role of protein dysregulation in disease pathogenesis. The molecular mechanisms identif…
View article: Artificial Intelligence and Machine Learning for Environmental Health Study
Artificial Intelligence and Machine Learning for Environmental Health Study Open
View article: Integrated Spheroid-to-Population Framework for Evaluating PFHpA-Associated Metabolic Dysfunction and Steatotic Liver Disease
Integrated Spheroid-to-Population Framework for Evaluating PFHpA-Associated Metabolic Dysfunction and Steatotic Liver Disease Open
View article: Contaminant Exposure Profiles Demonstrate Similar Physiological Effects Across Environments Despite Unique Profile Composition in Formosa, Argentina, and Connecticut, <scp>USA</scp>
Contaminant Exposure Profiles Demonstrate Similar Physiological Effects Across Environments Despite Unique Profile Composition in Formosa, Argentina, and Connecticut, <span>USA</span> Open
Objective Exposure to environmental contaminants is globally universal. However, communities vary in the specific combination of contaminants to which they are exposed, potentially contributing to variation in human health and creating “lo…
View article: High-Resolution Mass Spectrometry for Human Exposomics: Expanding Chemical Space Coverage
High-Resolution Mass Spectrometry for Human Exposomics: Expanding Chemical Space Coverage Open
In the modern "omics" era, measurement of the human exposome is a critical missing link between genetic drivers and disease outcomes. High-resolution mass spectrometry (HRMS), routinely used in proteomics and metabolomics, has emerged as a…
View article: Changes in Plasma Concentrations of Per- and Polyfluoroalkyl Substances after Bariatric Surgery in Adolescents from the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-Labs) Study
Changes in Plasma Concentrations of Per- and Polyfluoroalkyl Substances after Bariatric Surgery in Adolescents from the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-Labs) Study Open
View article: Biochemical analyses of tau and other neuronal markers in the submandibular gland and frontal cortex across stages of Alzheimer disease
Biochemical analyses of tau and other neuronal markers in the submandibular gland and frontal cortex across stages of Alzheimer disease Open
View article: Socioeconomic deprivation is associated with reduced response and lower treatment persistence with TNF inhibitors in rheumatoid arthritis
Socioeconomic deprivation is associated with reduced response and lower treatment persistence with TNF inhibitors in rheumatoid arthritis Open
Objective To investigate the association between socioeconomic deprivation and outcomes following TNF inhibitor (TNFi) treatment. Methods Individuals commencing their first TNFi in the British Society for Rheumatology Biologics Register fo…
View article: Open and FAIR sample based data sharing through the IEDA2 facility
Open and FAIR sample based data sharing through the IEDA2 facility Open
IEDA, the Interdisciplinary Earth Data Alliance, is a unique collaborative data infrastructure that provides and continuously evolves a comprehensive ecosystem of data, tools, and services that support researchers in the Geosciences to sha…
View article: Non-trough adalimumab and certolizumab drug levels associated with a therapeutic EULAR response in adherent patients with rheumatoid arthritis
Non-trough adalimumab and certolizumab drug levels associated with a therapeutic EULAR response in adherent patients with rheumatoid arthritis Open
Objectives Interventions aimed at increasing TNF-α inhibitor serum drug levels (SDLs) may improve treatment response; however, previous studies suggesting SDL cut-offs have not accounted for treatment adherence. The aim of this study was t…
View article: Localization of Thioredoxin-Interacting Protein in Aging and Alzheimer’s Disease Brains
Localization of Thioredoxin-Interacting Protein in Aging and Alzheimer’s Disease Brains Open
Thioredoxin-Interacting Protein (TXNIP) has been shown to have significant pathogenic roles in many human diseases, particularly those associated with diabetes and hyperglycemia. Its main mode of action is to sequester thioredoxins, result…
View article: Characterization of a Conformation-Restricted Amyloid β Peptide and Immunoreactivity of Its Antibody in Human AD brain
Characterization of a Conformation-Restricted Amyloid β Peptide and Immunoreactivity of Its Antibody in Human AD brain Open
Characterization of amyloid β (Aβ) oligomers, the transition species present prior to the formation of Aβ fibrils and that have cytotoxicity, has become one of the major topics in the investigations of Alzheimer's disease (AD) pathogenesis…
View article: Loss of Lysosomal Proteins Progranulin and Prosaposin Associated with Increased Neurofibrillary Tangle Development in Alzheimer Disease
Loss of Lysosomal Proteins Progranulin and Prosaposin Associated with Increased Neurofibrillary Tangle Development in Alzheimer Disease Open
Alzheimer disease (AD) is a progressive neurodegenerative disease causing cognitive decline in the aging population. To develop disease-modifying treatments, understanding the mechanisms behind the pathology is important, which should incl…
View article: Increased Risk of Autopsy-Proven Pneumonia with Sex, Season and Neurodegenerative Disease
Increased Risk of Autopsy-Proven Pneumonia with Sex, Season and Neurodegenerative Disease Open
There has been a markedly renewed interest in factors associated with pneumonia, a leading cause of death worldwide, due to its frequent concurrence with pandemics of influenza and Covid-19 disease. Reported predisposing factors to both ba…
View article: Thioredoxin-Interacting Protein (TXNIP) with Focus on Brain and Neurodegenerative Diseases
Thioredoxin-Interacting Protein (TXNIP) with Focus on Brain and Neurodegenerative Diseases Open
The development of new therapeutic approaches to diseases relies on the identification of key molecular targets involved in amplifying disease processes. One such molecule is thioredoxin-interacting protein (TXNIP), also designated thiored…
View article: Does loss of interaction of progranulin and prosaposin promote neurofibrillary tangle development?
Does loss of interaction of progranulin and prosaposin promote neurofibrillary tangle development? Open
Background Progranulin (PGRN) and prosaposin (PSAP) have lysosomal and neurotrophic properties. Reduced amounts of PGRN in mutant tau‐expressing Alzheimer’s disease (AD) model mice exacerbated phosphorylated tau pathology. The implication …
View article: Novel fluorinated derivative of curcumin negatively regulates thioredoxin-interacting protein expression in retinal pigment epithelial and macrophage cells
Novel fluorinated derivative of curcumin negatively regulates thioredoxin-interacting protein expression in retinal pigment epithelial and macrophage cells Open
Thioredoxin-interacting protein (TXNIP) has multiple disease-associated functions including inducing oxidative stress by inhibiting the anti-oxidant and thiol reducing activity of thioredoxin (TRX), reducing cellular glucose transport, and…
View article: Defining activation states of microglia in human brain tissue: an unresolved issue for Alzheimer’s disease
Defining activation states of microglia in human brain tissue: an unresolved issue for Alzheimer’s disease Open
Neuroimmunology and Neuroinflammation is an open access journal, with focuses on neuroimmunology and neuroinflammation research, and coverage extending to other basic and clinical studies related to neuroscience.
View article: Effects of FTMT Expression by Retinal Pigment Epithelial Cells on Features of Angiogenesis
Effects of FTMT Expression by Retinal Pigment Epithelial Cells on Features of Angiogenesis Open
Aberrant angiogenesis is a pathological feature of a number of diseases and arises from the uncoordinated expression of angiogenic factors as response to different cellular stresses. Age-related macular degeneration (AMD), a leading cause …
View article: Patterns of Expression of Purinergic Receptor P2RY12, a Putative Marker for Non-Activated Microglia, in Aged and Alzheimer’s Disease Brains
Patterns of Expression of Purinergic Receptor P2RY12, a Putative Marker for Non-Activated Microglia, in Aged and Alzheimer’s Disease Brains Open
Neuroinflammation is considered a key pathological process in neurodegenerative diseases of aging, including Alzheimer’s disease (AD). Many studies have defined phenotypes of reactive microglia, the brain-resident macrophages, with differe…
View article: Next Generation Cyberinfrastructure for Geochemistry & Petrology: Connecting Data (EarthChem) and Models (ENKI)
Next Generation Cyberinfrastructure for Geochemistry & Petrology: Connecting Data (EarthChem) and Models (ENKI) Open
View article: Characterization of lysosomal proteins Progranulin and Prosaposin and their interactions in Alzheimer’s disease and aged brains: increased levels correlate with neuropathology
Characterization of lysosomal proteins Progranulin and Prosaposin and their interactions in Alzheimer’s disease and aged brains: increased levels correlate with neuropathology Open
View article: Alzheimer’s Disease Research Using Human Microglia
Alzheimer’s Disease Research Using Human Microglia Open
Experimental studies of neuroinflammation in Alzheimer’s disease (AD) have mostly investigated microglia, the brain-resident macrophages. This review focused on human microglia obtained at rapid autopsies. Studies employing methods to isol…
View article: Microglial Phenotyping in Neurodegenerative Disease Brains: Identification of Reactive Microglia with an Antibody to Variant of CD105/Endoglin
Microglial Phenotyping in Neurodegenerative Disease Brains: Identification of Reactive Microglia with an Antibody to Variant of CD105/Endoglin Open
Inflammation is considered a key pathological process in neurodegenerative diseases, including Alzheimer’s disease (AD) and Parkinson’s disease (PD), but there are still mechanisms not understood. In the brain, most microglia are performin…
View article: P1‐185: CHARACTERIZATION OF PROGRANULIN EXPRESSION AND LOCALIZATION IN HUMAN BRAIN TISSUES OF AGED, ALZHEIMER'S DISEASE AND FRONTOTEMPORAL DEMENTIA CASES
P1‐185: CHARACTERIZATION OF PROGRANULIN EXPRESSION AND LOCALIZATION IN HUMAN BRAIN TISSUES OF AGED, ALZHEIMER'S DISEASE AND FRONTOTEMPORAL DEMENTIA CASES Open
Progranulin (PGRN) is a multi-functional protein with growth factor, anti-inflammatory and lysosomal properties. Loss of PGRN is one cause of frontotemporal dementia. Localization of PGRN has been shown in microglia in Alzheimer's disease …
View article: P4‐510: IMMUNOPHENOTYPING OF MICROGLIA: CHARACTERIZATION OF A VARIANT OF CD105 AS A MARKER OF ACTIVATED MICROGLIA IN ALZHEIMER'S DISEASE AND AGED BRAINS
P4‐510: IMMUNOPHENOTYPING OF MICROGLIA: CHARACTERIZATION OF A VARIANT OF CD105 AS A MARKER OF ACTIVATED MICROGLIA IN ALZHEIMER'S DISEASE AND AGED BRAINS Open
Identification of different phenotypes of microglia in Alzheimer's disease (AD) will aid in understanding of inflammatory processes. CD105 is a co-receptor that modulates transforming growth factor beta (TGFβ) signaling. CD105 has long bee…
View article: P2‐430: RELATIONSHIPS BETWEEN LONGITUDINAL RATES OF LEARNING AND MEMORY DECLINE AND DIFFERENT FORMS OF CEREBROVASCULAR PATHOLOGY IN COGNITIVELY UNIMPAIRED BRAIN DONORS
P2‐430: RELATIONSHIPS BETWEEN LONGITUDINAL RATES OF LEARNING AND MEMORY DECLINE AND DIFFERENT FORMS OF CEREBROVASCULAR PATHOLOGY IN COGNITIVELY UNIMPAIRED BRAIN DONORS Open
Antemortem MRI studies have shown that white matter hyperintensity (WMH) volumes are associated with accelerated rates of verbal learning decline in older adults. Antemortem-postmortem studies are needed to clarify whether that association…
Faster cognitive decline in dementia due to Alzheimer disease with clinically undiagnosed Lewy body disease Open
View article: Microglial Progranulin: Involvement in Alzheimer’s Disease and Neurodegenerative Diseases
Microglial Progranulin: Involvement in Alzheimer’s Disease and Neurodegenerative Diseases Open
Neurodegenerative diseases such as Alzheimer’s disease have proven resistant to new treatments. The complexity of neurodegenerative disease mechanisms can be highlighted by accumulating evidence for a role for a growth factor, progranulin …
View article: Differences in Gene Expression Profiles and Phenotypes of Differentiated SH-SY5Y Neurons Stably Overexpressing Mitochondrial Ferritin
Differences in Gene Expression Profiles and Phenotypes of Differentiated SH-SY5Y Neurons Stably Overexpressing Mitochondrial Ferritin Open
Mitochondrial ferritin (FtMt) is an iron-transport protein with ferroxidase properties localized to mitochondria. Levels are generally low in all tissues, while increasing the expression of FtMt in neuronal-like cells has been shown to be …