Douglas Hanes
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View article: Impact of Patient Positioning and Endotracheal Intubation During Ercp: Insights From a Large Database
Impact of Patient Positioning and Endotracheal Intubation During Ercp: Insights From a Large Database Open
Introduction Endoscopic retrograde cholangiopancreatography (ERCP) is conventionally performed in the prone position after intubating the airway. However, ERCP can also be performed in the left lateral and supine positions without endotrac…
View article: Importance of Surgical Margins in Patients with Early-Stage Merkel Cell Carcinoma
Importance of Surgical Margins in Patients with Early-Stage Merkel Cell Carcinoma Open
Achieving negative surgical margins is associated with improved OS in MCC, suggesting that MMS and conventional excision are both suitable approaches for the treatment of primary MCC.
View article: Surgical Management of Thick Primary Cutaneous Melanoma in the <scp>US</scp>
Surgical Management of Thick Primary Cutaneous Melanoma in the <span>US</span> Open
Background There remains significant variability in the surgical management of thick melanoma patients with clinically node‐negative disease. We evaluated factors influencing overall survival (OS) in these patients, focusing on the surgica…
View article: Individualized Prediction for Risk of Recurrence in Stage I/<scp>II</scp> Melanoma Patients With Negative Sentinel Lymph Node
Individualized Prediction for Risk of Recurrence in Stage I/<span>II</span> Melanoma Patients With Negative Sentinel Lymph Node Open
Background Despite the favorable prognosis of AJCC stage I/II melanoma patients, up to 20%–30% will develop metastases. Our objective is to predict long‐term risk (probability) of recurrence in early‐stage melanoma patients. Methods A Risk…
View article: Are Nomograms Useful for Predicting Sentinel Lymph Node Status in Melanoma Patients?
Are Nomograms Useful for Predicting Sentinel Lymph Node Status in Melanoma Patients? Open
Background and Objectives Clinical nomograms have been developed to predict sentinel lymph node (SLN) status in early‐stage melanoma patients, but the clinical utility of these tools remains debatable. We created and validated a nomogram u…
View article: Widespread Adoption of Precision Anticancer Therapies After Implementation of Pathologist-Directed Comprehensive Genomic Profiling Across a Large US Health System
Widespread Adoption of Precision Anticancer Therapies After Implementation of Pathologist-Directed Comprehensive Genomic Profiling Across a Large US Health System Open
PURPOSE Precision therapies and immunotherapies have revolutionized cancer care, with novel genomic biomarker-associated therapies being introduced into clinical practice rapidly, resulting in notable gains in patient survival. Despite thi…
View article: Impact of Cryopreserved Placental Allografts on Biochemical Recurrence in Prostate Cancer
Impact of Cryopreserved Placental Allografts on Biochemical Recurrence in Prostate Cancer Open
Background: Human placental allografts are widely used to promote wound healing. Placental (or amniotic membrane/umbilical cord) allografts are placed along the neurovascular bundles during radical prostatectomy to improve continence and e…
View article: Clinical impact for advanced non-small-cell lung cancer patients tested using comprehensive genomic profiling at a large USA health care system
Clinical impact for advanced non-small-cell lung cancer patients tested using comprehensive genomic profiling at a large USA health care system Open
Background: New breakthroughs in precision therapies are transforming cancer care for patients with advanced non-small-cell lung cancer (NSCLC). To this effect, comprehensive genomic profiling (CGP) has emerged as a streamlined workflow to…
View article: Immunogenomics and spatial proteomic mapping highlight distinct neuro-immune architectures in melanoma vs. non-melanoma-derived brain metastasis
Immunogenomics and spatial proteomic mapping highlight distinct neuro-immune architectures in melanoma vs. non-melanoma-derived brain metastasis Open
Background Brain metastases (BrMs) are a devastating complication of solid tumours. A better understanding of BrMs biology is needed to address their challenging clinical management. Methods Immunogenomic and digital spatial analyses were …
View article: Correction: Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial
Correction: Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial Open
Aging | doi:10.18632/aging.205700. Kara N. Fitzgerald, Romilly Hodges, Douglas Hanes, Emily Stack, David Cheishvili, Moshe Szyf, Janine Henkel, Melissa W. Twedt, Despina Giannopoulou, Josette Herdell, Sally Logan, Ryan Bradley
View article: Virtually delivered Mindfulness-Oriented Recovery Enhancement (MORE) reduces daily pain intensity in patients with lumbosacral radiculopathy: a randomized controlled trial
Virtually delivered Mindfulness-Oriented Recovery Enhancement (MORE) reduces daily pain intensity in patients with lumbosacral radiculopathy: a randomized controlled trial Open
Introduction: Lumbosacral radiculopathy (LR), also known as sciatica, is a common type of radiating neurologic pain involving burning, tingling, and numbness in the lower extremities. It has an estimated lifetime prevalence as high as 43%.…
View article: Integrative medicine for hypermobility spectrum disorders (HSD) and Ehlers-Danlos syndromes (EDS): a feasibility study
Integrative medicine for hypermobility spectrum disorders (HSD) and Ehlers-Danlos syndromes (EDS): a feasibility study Open
Hypermobility spectrum disorders (HSD) and Ehlers-Danlos syndromes (EDS) are multisystem conditions marked by dysfunctional connective tissue. This feasibility study evaluated a 9-week integrative medicine program in this population. Using…
View article: Widespread adoption of precision anticancer therapies after implementation of pathologist-directed comprehensive genomic profiling across a large US health system
Widespread adoption of precision anticancer therapies after implementation of pathologist-directed comprehensive genomic profiling across a large US health system Open
Precision therapies and immunotherapies have revolutionized cancer care, resulting in significant gains in patient survival across tumor types. Despite this transformation in care, there is variability in the utilization of tumor molecular…
View article: 1484 An interplay between innate/adaptive/humoral immunity leads to increased immunogenicity of melanoma vs. non-melanoma derived brain metastases
1484 An interplay between innate/adaptive/humoral immunity leads to increased immunogenicity of melanoma vs. non-melanoma derived brain metastases Open
Background Brain metastases (BrMs) are a devastating complication of solid tumors. Despite improvements in tumor detection and local treatment as well as the introduction of new therapies including immune checkpoint blockade (ICB) and targ…
View article: Characterization of Lymph Node Tumor Burden in Node-Positive Prostate Cancer Patients after Robotic-Assisted Radical Prostatectomy with Extended Pelvic Lymph Node Dissection
Characterization of Lymph Node Tumor Burden in Node-Positive Prostate Cancer Patients after Robotic-Assisted Radical Prostatectomy with Extended Pelvic Lymph Node Dissection Open
Background: Prostate cancer (PCa) nodal staging does not account for lymph node (LN) tumor burden. The LN anatomical compartment involved with the tumor or the quantified extent of extranodal extension (ENE) have not yet been studied in re…
View article: Creating a Comprehensive Pandemic Response to Decrease Hospitalist Burnout During COVID-19: Intervention vs Control Results in 2 Comparable Hospitals (HOSP-CPR)
Creating a Comprehensive Pandemic Response to Decrease Hospitalist Burnout During COVID-19: Intervention vs Control Results in 2 Comparable Hospitals (HOSP-CPR) Open
Background Physician burnout increased during the COVID-19 pandemic. Objective To evaluate the effectiveness of a multimodal workplace intervention designed to reduce hospitalist burnout. Design Participants and setting : Our intervention …
View article: The gastrointestinal and microbiome impact of a resistant starch blend from potato, banana, and apple fibers: A randomized clinical trial using smart caps
The gastrointestinal and microbiome impact of a resistant starch blend from potato, banana, and apple fibers: A randomized clinical trial using smart caps Open
The gastrointestinal (GI) impact of fibers including resistant starch (RS) consumption depends on various types and amounts of fibers, the initial microbiome states, and accurate intake measurements. A randomized clinical trial evaluated t…
View article: Correction for: Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial
Correction for: Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial Open
Aging | doi:10.18632/aging.204197. Kara N. Fitzgerald, Romilly Hodges, Douglas Hanes, Emily Stack, David Cheishvili, Moshe Szyf, Janine Henkel, Melissa W. Twedt, Despina Giannopoulou, Josette Herdell, Sally Logan, Ryan Bradley
View article: Whole-Person, Urobiome-Centric Therapy for Uncomplicated Urinary Tract Infection
Whole-Person, Urobiome-Centric Therapy for Uncomplicated Urinary Tract Infection Open
A healthy urinary tract contains a variety of microbes resulting in a diverse urobiome. Urobiome dysbiosis, defined as an imbalance in the microbial composition in the microenvironments along the urinary tract, is found in women with uncom…
View article: Inflammatory Bowel Disease and Neutrophil–Lymphocyte Ratio: A Systematic Scoping Review
Inflammatory Bowel Disease and Neutrophil–Lymphocyte Ratio: A Systematic Scoping Review Open
Neutrophil–lymphocyte ratio (NLR) is a biomarker of the systemic inflammatory response. The objective of this systematic scoping review was to examine the literature on NLR and inflammatory bowel disease (IBD). PubMed, Embase, Cochrane CEN…
View article: Naturopathic Management of Urinary Tract Infections: A Retrospective Chart Review
Naturopathic Management of Urinary Tract Infections: A Retrospective Chart Review Open
Introduction: Antibiotic overuse is a significant driver of bacterial resistance. Urinary tract infections (UTIs, cystitis) are the most common condition for which antibiotics are prescribed in the ambulatory setting. Many complementary an…