Douglas N. Greve
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View article: Automated Segmentation of the Pituitary and Pineal Glands
Automated Segmentation of the Pituitary and Pineal Glands Open
The pituitary and pineal glands are two small yet critical brain structures that help to modulate the human endocrine system. Unfortunately, very little research has been devoted to segmenting the pineal gland, and existing methods for pit…
View article: A multi-ancestry polygenic risk score for Alzheimer disease is associated with cognitive decline, hippocampal atrophy and neuropathological hallmarks in diverse populations
A multi-ancestry polygenic risk score for Alzheimer disease is associated with cognitive decline, hippocampal atrophy and neuropathological hallmarks in diverse populations Open
Alzheimer disease (AD) has a strong genetic basis, yet previously derived polygenic risk scores (PRS) are heavily weighted by the APOE locus and perform inconsistently across diverse ancestries. We developed an APOE -independent multi-ance…
View article: A Contrast‐Agnostic Method for Ultra‐High Resolution Claustrum Segmentation
A Contrast‐Agnostic Method for Ultra‐High Resolution Claustrum Segmentation Open
The claustrum is a band‐like gray matter structure located between putamen and insula whose exact functions are still actively researched. Its sheet‐like structure makes it barely visible in in vivo magnetic resonance imaging (MRI) scans a…
View article: Late-onset unexplained epilepsy as a risk factor for cognitive impairment and dementia: Protocol for a multi-center prospective longitudinal observational study (ELUCID)
Late-onset unexplained epilepsy as a risk factor for cognitive impairment and dementia: Protocol for a multi-center prospective longitudinal observational study (ELUCID) Open
Background Late-onset unexplained epilepsy (LoUE), defined as epilepsy onset after age 55 without an obvious cause, is an important risk factor for dementia. Studies have shown that 10-25% of individuals with LoUE develop dementia within t…
View article: On the analysis of functional PET (fPET)-FDG: Baseline mischaracterization can introduce artifactual metabolic (de)activations
On the analysis of functional PET (fPET)-FDG: Baseline mischaracterization can introduce artifactual metabolic (de)activations Open
Functional Positron Emission Tomography (fPET) with (bolus plus) constant infusion of [18F]-fluorodeoxyglucose (FDG), known as fPET-FDG, is a recently introduced technique in human neuroimaging, enabling the detection of dynamic glucose me…
View article: A Contrast-Agnostic Method for Ultra-High Resolution Claustrum Segmentation
A Contrast-Agnostic Method for Ultra-High Resolution Claustrum Segmentation Open
The claustrum is a band-like gray matter structure located between putamen and insula whose exact functions are still actively researched. Its sheet-like structure makes it barely visible in in vivo Magnetic Resonance Imaging (MRI) scans a…
View article: [<sup>11</sup>C]PS13 Demonstrates Pharmacologically Selective and Substantial Binding to Cyclooxygenase-1 in the Human Brain
[<sup>11</sup>C]PS13 Demonstrates Pharmacologically Selective and Substantial Binding to Cyclooxygenase-1 in the Human Brain Open
Our laboratory recently developed [11C]PS13 as a PET radioligand to selectively measure cyclooxygenase-1 (COX-1). The cyclooxygenase enzyme family converts arachidonic acid into prostaglandins and thromboxanes, which mediate inf…
View article: Neuroinflammation at the Gray–White Matter Interface in Active-Duty U.S. Special Operations Forces
Neuroinflammation at the Gray–White Matter Interface in Active-Duty U.S. Special Operations Forces Open
Emerging evidence from autopsy studies indicates that interface astroglial scarring (IAS) at the gray-white matter junction is a pathological signature of repeated blast brain injury in military personnel. However, there is currently no
View article: On the analysis of functional PET (fPET)-FDG: baseline mischaracterization can introduce artifactual metabolic (de)activations
On the analysis of functional PET (fPET)-FDG: baseline mischaracterization can introduce artifactual metabolic (de)activations Open
Functional Positron Emission Tomography (fPET) with (bolus plus) constant infusion of [18F]-fluorodeoxyglucose FDG), known as fPET-FDG, is a recently introduced technique in human neuroimaging, enabling the detection of dynamic glucose met…
View article: Recon-all-clinical: Cortical surface reconstruction and analysis of heterogeneous clinical brain MRI
Recon-all-clinical: Cortical surface reconstruction and analysis of heterogeneous clinical brain MRI Open
Surface-based analysis of the cerebral cortex is ubiquitous in human neuroimaging with MRI. It is crucial for cortical registration, parcellation, and thickness estimation. Traditionally, these analyses require high-resolution, isotropic s…
View article: High-resolution segmentations of the hypothalamus and its subregions for training of segmentation models
High-resolution segmentations of the hypothalamus and its subregions for training of segmentation models Open
Segmentation of brain structures on magnetic resonance imaging (MRI) is a highly relevant neuroimaging topic, as it is a prerequisite for different analyses such as volumetry or shape analysis. Automated segmentation facilitates the study …
View article: Summary of the National Cancer Institute 2023 Virtual Workshop on Medical Image De-identification—Part 2: Pathology Whole Slide Image De-identification, De-facing, the Role of AI in Image De-identification, and the NCI MIDI Datasets and Pipeline
Summary of the National Cancer Institute 2023 Virtual Workshop on Medical Image De-identification—Part 2: Pathology Whole Slide Image De-identification, De-facing, the Role of AI in Image De-identification, and the NCI MIDI Datasets and Pipeline Open
De-identification of medical images intended for research is a core requirement for data sharing initiatives, particularly as the demand for data for artificial intelligence (AI) applications grows. The Center for Biomedical Informatics an…
View article: High-resolution segmentations of the hypothalamus and its subregions for training of segmentation models
High-resolution segmentations of the hypothalamus and its subregions for training of segmentation models Open
Segmentation of brain structures on magnetic resonance imaging (MRI) is a highly relevant neuroimaging topic, as it is a prerequisite for different analyses such as volumetry or shape analysis. Automated segmentation facilitates the study …
View article: Neural Network Correlates of Apathy, Disinhibition, and Executive Dysfunction in Active-Duty United States Special Operations Forces
Neural Network Correlates of Apathy, Disinhibition, and Executive Dysfunction in Active-Duty United States Special Operations Forces Open
United States Special Operations Forces (SOF) experience neurobehavioral symptoms that can adversely affect training and combat operations. Understanding the neurobiological basis for these symptoms may guide prevention and treatment. In 2…
View article: Neuroinflammation at the Grey-White Matter Interface in Active-Duty United States Special Operations Forces
Neuroinflammation at the Grey-White Matter Interface in Active-Duty United States Special Operations Forces Open
Emerging evidence from autopsy studies indicates that interface astroglial scarring (IAS) at the grey-white matter junction is a pathological signature of repeated blast brain injury in military personnel. However, there is currently no ne…
View article: Multimodal MRI reveals brainstem connections that sustain wakefulness in human consciousness
Multimodal MRI reveals brainstem connections that sustain wakefulness in human consciousness Open
Consciousness is composed of arousal (i.e., wakefulness) and awareness. Substantial progress has been made in mapping the cortical networks that underlie awareness in the human brain, but knowledge about the subcortical networks that susta…
View article: Impact of repeated blast exposure on active-duty United States Special Operations Forces
Impact of repeated blast exposure on active-duty United States Special Operations Forces Open
United States (US) Special Operations Forces (SOF) are frequently exposed to explosive blasts in training and combat, but the effects of repeated blast exposure (RBE) on SOF brain health are incompletely understood. Furthermore, there is n…
View article: H-SynEx: Using synthetic images and ultra-high resolution ex vivo MRI for hypothalamus subregion segmentation
H-SynEx: Using synthetic images and ultra-high resolution ex vivo MRI for hypothalamus subregion segmentation Open
The hypothalamus is a small structure located in the center of the brain and is involved in significant functions such as sleeping, temperature, and appetite control. Various neurological disorders are also associated with hypothalamic abn…
View article: Anatomy-aware and acquisition-agnostic joint registration with SynthMorph
Anatomy-aware and acquisition-agnostic joint registration with SynthMorph Open
Affine image registration is a cornerstone of medical-image analysis. While classical algorithms can achieve excellent accuracy, they solve a time-consuming optimization for every image pair. Deep-learning (DL) methods learn a function tha…
View article: Assessing individual variability of the entorhinal subfields in health and disease
Assessing individual variability of the entorhinal subfields in health and disease Open
Investigating interindividual variability is a major field of interest in neuroscience. The entorhinal cortex (EC) is essential for memory and affected early in the progression of Alzheimer's disease (AD). We combined histology ground‐trut…
View article: Sustaining wakefulness: Brainstem connectivity in human consciousness
Sustaining wakefulness: Brainstem connectivity in human consciousness Open
Consciousness is comprised of arousal (i.e., wakefulness) and awareness. Substantial progress has been made in mapping the cortical networks that modulate awareness in the human brain, but knowledge about the subcortical networks that sust…
View article: Cardiovascular and metabolic health is associated with functional brain connectivity in middle-aged and older adults: Results from the Human Connectome Project-Aging study
Cardiovascular and metabolic health is associated with functional brain connectivity in middle-aged and older adults: Results from the Human Connectome Project-Aging study Open
Several cardiovascular and metabolic indicators, such as cholesterol and blood pressure have been associated with altered neural and cognitive health as well as increased risk of dementia and Alzheimer's disease in later life. In this cros…
View article: Cortical analysis of heterogeneous clinical brain MRI scans for large-scale neuroimaging studies
Cortical analysis of heterogeneous clinical brain MRI scans for large-scale neuroimaging studies Open
Surface analysis of the cortex is ubiquitous in human neuroimaging with MRI, e.g., for cortical registration, parcellation, or thickness estimation. The convoluted cortical geometry requires isotropic scans (e.g., 1mm MPRAGEs) and good gra…
View article: SynthSeg: Segmentation of brain MRI scans of any contrast and resolution without retraining
SynthSeg: Segmentation of brain MRI scans of any contrast and resolution without retraining Open
Despite advances in data augmentation and transfer learning, convolutional neural networks (CNNs) difficultly generalise to unseen domains. When segmenting brain scans, CNNs are highly sensitive to changes in resolution and contrast: even …
View article: Anatomy-aware and acquisition-agnostic joint registration with SynthMorph
Anatomy-aware and acquisition-agnostic joint registration with SynthMorph Open
Affine image registration is a cornerstone of medical image analysis. While classical algorithms can achieve excellent accuracy, they solve a time-consuming optimization for every image pair. Deep-learning (DL) methods learn a function tha…
View article: An open-source tool for longitudinal whole-brain and white matter lesion segmentation
An open-source tool for longitudinal whole-brain and white matter lesion segmentation Open
View article: Columnar Encoding of Personal Space and Visual Space in Human Parietal Cortex
Columnar Encoding of Personal Space and Visual Space in Human Parietal Cortex Open
Personal space (PS) is the distance that people prefer to maintain between themselves and unfamiliar others. Intrusion into the PS evokes discomfort, and an urge to move further apart. Behavioral aspects of PS regulation have been well stu…
View article: T1 relaxation time of ISMRM/NIST T1 phantom spheres at 7 T
T1 relaxation time of ISMRM/NIST T1 phantom spheres at 7 T Open
T1 relaxation times of the 14 T1 phantom spheres that make up the standard International Society for Magnetic Resonance in Medicine (ISMRM)/National Institute of Standards and Technology (NIST) system phantom are reported at 7 T. T1 values…
View article: Interdigitated Columnar Representation of Personal Space and Visual Space in Human Parietal Cortex
Interdigitated Columnar Representation of Personal Space and Visual Space in Human Parietal Cortex Open
Personal space (PS) is the space around the body that people prefer to maintain between themselves and unfamiliar others. Intrusion into personal space evokes discomfort and an urge to move away. Physiologic studies in nonhuman primates su…
View article: Different loneliness types, cognitive function, and brain structure in midlife: Findings from the Framingham Heart Study
Different loneliness types, cognitive function, and brain structure in midlife: Findings from the Framingham Heart Study Open
US National Institute on Aging.