Douglas P. Kiel
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View article: A comprehensive multi-layered analysis reveals genetic pleiotropy underlying coronary artery calcification and bone mineral density
A comprehensive multi-layered analysis reveals genetic pleiotropy underlying coronary artery calcification and bone mineral density Open
Our study demonstrates that the observed association between CAC and eBMD is mainly driven by pleiotropic associations.
View article: Identifying observable medication use time in administrative databases: a tutorial using nursing home residents
Identifying observable medication use time in administrative databases: a tutorial using nursing home residents Open
Nursing home (NH) residents are an important population for pharmacoepidemiologic research due to their prevalence of multimorbidity and polypharmacy. Medicare claims are commonly used to study medication use in this population, but medica…
View article: The genetic architecture of trabecular bone score and association with fracture: a genome-wide association and meta-analysis
The genetic architecture of trabecular bone score and association with fracture: a genome-wide association and meta-analysis Open
Background Trabecular bone score (TBS) is a texture-based measurement derived from DXA scans, which describes the distribution of mineral across the vertebral bodies. Identifying its genetic determinants is crucial for enhancing understand…
View article: Family history of fracture and fracture risk: a meta-analysis to update the FRAX® risk assessment tool
Family history of fracture and fracture risk: a meta-analysis to update the FRAX® risk assessment tool Open
A family history of fracture is confirmed as a significant BMD-independent predictor of future fracture risk. While parental hip fracture appears the strongest factor for future hip fracture, a family history of other fractures might be ap…
View article: A randomized, double-blind, placebo-controlled clinical study to evaluate the efficacy of the synbiotic medical food, SBD111, for the clinical dietary management of bone loss in menopausal women
A randomized, double-blind, placebo-controlled clinical study to evaluate the efficacy of the synbiotic medical food, SBD111, for the clinical dietary management of bone loss in menopausal women Open
These findings indicate SBD111 did not significantly reduce BMD loss for the full cohort. However, the trial produced evidence that SBD111 reduced bone loss in women with osteopenia and BMI ≥ 30.
View article: Body mass index and subsequent fracture risk: a meta-analysis to update FRAX
Body mass index and subsequent fracture risk: a meta-analysis to update FRAX Open
The aim of this international meta-analysis was to quantify the predictive value of BMI for incident fracture and relationship of this risk with age, sex, follow-up time, and BMD. A total of 1 667 922 men and women from 32 countries (63 co…
View article: A randomized, double-blind, placebo-controlled clinical study to evaluate the efficacy of the synbiotic medical food, SBD111, for the clinical dietary management of bone loss in menopausal women
A randomized, double-blind, placebo-controlled clinical study to evaluate the efficacy of the synbiotic medical food, SBD111, for the clinical dietary management of bone loss in menopausal women Open
Summary This 12-month study in 286 early postmenopausal women evaluated the efficacy and safety of SBD111, a synbiotic medical food, in reducing bone loss. SBD111 did not significantly reduce bone loss for the full cohort, but did produce …
View article: Combining Exercise Training and Testosterone Therapy in Older Women After Hip Fracture
Combining Exercise Training and Testosterone Therapy in Older Women After Hip Fracture Open
Importance Despite receiving postacute rehabilitation services, many older women with a recent hip fracture repair are unable to return to their prefracture level of function. Whether testosterone therapy can enhance recovery after hip fra…
View article: Digital Advertising for Recruitment of Older Women in Nutrition Research
Digital Advertising for Recruitment of Older Women in Nutrition Research Open
View article: Multi-ancestry whole genome sequencing analysis of lean body mass
Multi-ancestry whole genome sequencing analysis of lean body mass Open
Our comprehensive analysis, encompassing a large-scale WGS meta-analysis and functional investigations, reveals novel genomic loci and genes associated with lean mass traits, shedding new insights into pathways influencing muscle metabolis…
View article: Concerns about the paper, “benefits of targeted vibration for bone strength and bone density in postmenopausal women with osteopenia: a randomized, sham-controlled trial.”
Concerns about the paper, “benefits of targeted vibration for bone strength and bone density in postmenopausal women with osteopenia: a randomized, sham-controlled trial.” Open
We write to raise serious concerns regarding the clinical significance and conclusions of a paper recently published in JBMR-Plus, “Benefits of Targeted Vibration for Bone Strength and Bone Density in Postmenopausal Women with Osteopenia: …
View article: Concerns about the paper, “Benefits of targeted vibration for bone strength and bone density in postmenopausal women with osteopenia: a randomized, sham-controlled trial”
Concerns about the paper, “Benefits of targeted vibration for bone strength and bone density in postmenopausal women with osteopenia: a randomized, sham-controlled trial” Open
View article: The association of gut microbiome composition with musculoskeletal features in middle-aged and older adults: a two-cohort joint study
The association of gut microbiome composition with musculoskeletal features in middle-aged and older adults: a two-cohort joint study Open
Background Bones and muscles are connected anatomically, and functionally. Preliminary evidence has shown the gut microbiome influences the aging process of bone and muscle in animal studies. However, such evidence in humans is still scarc…
View article: Selecting Appropriate Clinical Trial Endpoints for Geroscience Trials: A Path Towards Consensus
Selecting Appropriate Clinical Trial Endpoints for Geroscience Trials: A Path Towards Consensus Open
View article: OPPORTUNISTIC ASSESSMENT OF CARDIOVASCULAR RISK USING AI-DERIVED STRUCTURAL AORTIC AND CARDIAC PHENOTYPES FROM NON-CONTRAST CHEST COMPUTED TOMOGRAPHY
OPPORTUNISTIC ASSESSMENT OF CARDIOVASCULAR RISK USING AI-DERIVED STRUCTURAL AORTIC AND CARDIAC PHENOTYPES FROM NON-CONTRAST CHEST COMPUTED TOMOGRAPHY Open
Background Primary prevention of cardiovascular disease relies on accurate risk assessment using scores such as the Pooled Cohort Equations (PCE) and PREVENT. However, necessary input variables for these scores are often unavailable in the…
View article: Deep Learning Chest X-Ray Age, Epigenetic Aging Clocks and Associations with Age-Related Subclinical Disease in the Project Baseline Health Study
Deep Learning Chest X-Ray Age, Epigenetic Aging Clocks and Associations with Age-Related Subclinical Disease in the Project Baseline Health Study Open
Chronological age is a cornerstone of medical decision-making but is limited because individuals age at different rates. We recently released an open-source deep learning model to assess biological age from chest radiograph images (CXR-Age…
View article: THE STEP-HI STUDY: IMPACT OF TESTOSTERONE AND RESISTANCE EXERCISE ON SPPB, LEG STRENGTH, AND APPENDICULAR LEAN MASS
THE STEP-HI STUDY: IMPACT OF TESTOSTERONE AND RESISTANCE EXERCISE ON SPPB, LEG STRENGTH, AND APPENDICULAR LEAN MASS Open
The STEP-HI Study tested if testosterone replacement therapy in combination with resistance exercise training for 6 months could improve functional recovery from hip fracture in older women more than resistance exercise alone or standard o…
View article: THE STARTING A TESTOSTERONE AND EXERCISE PROGRAM AFTER HIP INJURY (STEP-HI) TRIAL: STUDY RESULTS AND IMPLICATIONS
THE STARTING A TESTOSTERONE AND EXERCISE PROGRAM AFTER HIP INJURY (STEP-HI) TRIAL: STUDY RESULTS AND IMPLICATIONS Open
Hip fractures are common among older women and can have a devastating impact on their ability to remain independent. Many women who were high functioning before the hip fracture do not return to their pre-fracture level of function, have p…
View article: ASSOCIATION OF PRO-INFLAMMATORY DIET WITH FRAILTY ONSET AMONG ADULTS WITH AND WITHOUT DEPRESSIVE SYMPTOMS
ASSOCIATION OF PRO-INFLAMMATORY DIET WITH FRAILTY ONSET AMONG ADULTS WITH AND WITHOUT DEPRESSIVE SYMPTOMS Open
Dietary inflammation is associated with increased risk of frailty. Those with depressive symptoms may be at higher risk of frailty onset since they typically have higher levels of inflammation. The study objective was to determine the asso…
View article: Low-Magnitude Mechanical Signals to Preserve Skeletal Health in Female Adolescents With Anorexia Nervosa
Low-Magnitude Mechanical Signals to Preserve Skeletal Health in Female Adolescents With Anorexia Nervosa Open
Importance Malnourished adolescents and young adults with anorexia nervosa (AN) are at high risk for skeletal deficits. Objective To examine whether low-magnitude mechanical signals (LMMS) could preserve bone mineral density (BMD) througho…
View article: Association of vertebral fractures with worsening degenerative changes of the spine: a longitudinal study
Association of vertebral fractures with worsening degenerative changes of the spine: a longitudinal study Open
Vertebral compression fractures (VFs) and spinal degeneration are both common causes of back pain, particularly in older adults. Previous cross-sectional studies have shown a potential association between these entities, but there is limit…
View article: Impact of provision of abdominal aortic calcification results on fruit and vegetable intake: 12-week randomized phase 2 controlled trial
Impact of provision of abdominal aortic calcification results on fruit and vegetable intake: 12-week randomized phase 2 controlled trial Open
Provision of non-invasive vascular imaging results to individuals has been shown to improve cardiovascular disease risk factor control: its impact on diet remains uncertain. In this two-arm, single-blind, parallel, 12-week randomized contr…
View article: Challenges and recommendations for the translation of biomarkers of aging
Challenges and recommendations for the translation of biomarkers of aging Open
View article: Goal-directed osteoporosis treatment: ASBMR/BHOF task force position statement 2024
Goal-directed osteoporosis treatment: ASBMR/BHOF task force position statement 2024 Open
The overarching goal of osteoporosis management is to prevent fractures. A goal-directed approach to long-term management of fracture risk helps ensure that the most appropriate initial treatment and treatment sequence is selected for indi…
View article: An executive summary on the Global conceptual definition of Sarcopenia
An executive summary on the Global conceptual definition of Sarcopenia Open
View article: Improving the value and interpretation of observational studies comparing treatment effects of osteoporosis medications depends on standardized reporting of methods
Improving the value and interpretation of observational studies comparing treatment effects of osteoporosis medications depends on standardized reporting of methods Open
Journal Article Improving the value and interpretation of observational studies comparing treatment effects of osteoporosis medications depends on standardized reporting of methods Get access Kaleen N Hayes, Kaleen N Hayes Department of He…
View article: A clinical study to evaluate the efficacy of the medical food, SBD111, versus placebo for the clinical dietary management of postmenopausal bone loss and menopause symptoms in otherwise healthy menopausal women: a randomized, double blind placebo-controlled trial.
A clinical study to evaluate the efficacy of the medical food, SBD111, versus placebo for the clinical dietary management of postmenopausal bone loss and menopause symptoms in otherwise healthy menopausal women: a randomized, double blind placebo-controlled trial. Open
Background Adverse shifts in the diversity and abundance of the intestinal microbiome contribute to the progression of musculoskeletal diseases. Hormonal changes that occur during menopause with reduction in estrogen levels, affect bone de…
View article: Vascular function and skeletal fragility: a study of tonometry, brachial hemodynamics, and bone microarchitecture
Vascular function and skeletal fragility: a study of tonometry, brachial hemodynamics, and bone microarchitecture Open
Osteoporosis and cardiovascular disease frequently occur together in older adults; however, a causal relationship between these 2 common conditions has not been established. By the time clinical cardiovascular disease develops, it is often…
View article: Association of bone fracture with 30-year body mass index (BMI) trajectories: findings from the Framingham Heart Study
Association of bone fracture with 30-year body mass index (BMI) trajectories: findings from the Framingham Heart Study Open
View article: A perspective on muscle phenotyping in musculoskeletal research
A perspective on muscle phenotyping in musculoskeletal research Open