Douglas W. Barrett
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View article: Cognitive improvement and prefrontal network interactions in individuals with remitted bipolar disorder after transcranial infrared laser stimulation
Cognitive improvement and prefrontal network interactions in individuals with remitted bipolar disorder after transcranial infrared laser stimulation Open
Background Converging evidence suggests that bipolar disorder (BD) involves mitochondrial dysfunction and prefrontal cortex (PFC) hypometabolism associated with cognitive impairment, which persists in remitted BD individuals. Transcranial …
View article: Augmenting Internet-Based Cognitive Behavioral Therapy for Major Depressive Disorder With Transcranial Infrared Laser Stimulation
Augmenting Internet-Based Cognitive Behavioral Therapy for Major Depressive Disorder With Transcranial Infrared Laser Stimulation Open
View article: Machine Learning Prediction of the Cognitive Responses to Transcranial Prefrontal Photobiomodulation in Individuals With Bipolar Disorder Using Functional Near-Infrared Spectroscopy
Machine Learning Prediction of the Cognitive Responses to Transcranial Prefrontal Photobiomodulation in Individuals With Bipolar Disorder Using Functional Near-Infrared Spectroscopy Open
People with bipolar disorder often experience impaired prefrontal cortex function and cognitive decline. While current treatments primarily focus on mood stabilization, they do not specifically target cognitive performance or brain oxygena…
View article: Dietary omega-3 polyunsaturated fatty acids reduce cytochrome c oxidase in brain white matter and sensorimotor regions while increasing functional interactions between neural systems related to escape behavior in postpartum rats
Dietary omega-3 polyunsaturated fatty acids reduce cytochrome c oxidase in brain white matter and sensorimotor regions while increasing functional interactions between neural systems related to escape behavior in postpartum rats Open
Introduction Previously, we showed that omega-3 polyunsaturated fatty acid n-3 (PUFA) supplementation improved the performance of postpartum rats in the shuttle box escape test (SBET). Methods The brains of these rats were used in the curr…
View article: Prefrontal photobiomodulation produces beneficial mitochondrial and oxygenation effects in older adults with bipolar disorder
Prefrontal photobiomodulation produces beneficial mitochondrial and oxygenation effects in older adults with bipolar disorder Open
There is growing evidence of mitochondrial dysfunction and prefrontal cortex (PFC) hypometabolism in bipolar disorder (BD). Older adults with BD exhibit greater decline in PFC-related neurocognitive functions than is expected for age-match…
View article: Histochemical mapping of the duration of action of photobiomodulation on cytochrome c oxidase in the rat brain
Histochemical mapping of the duration of action of photobiomodulation on cytochrome c oxidase in the rat brain Open
Introduction This is the first study mapping the duration of action of in vivo photobiomodulation (PBM) on cytochrome-c-oxidase (CCO). In cellular bioenergetics, CCO is the terminal rate-limiting enzyme in the mitochondrial electron transp…
View article: Photobiomodulation of Cytochrome c Oxidase by Chronic Transcranial Laser in Young and Aged Brains
Photobiomodulation of Cytochrome c Oxidase by Chronic Transcranial Laser in Young and Aged Brains Open
In cellular bioenergetics, cytochrome c oxidase (CCO) is the enzyme responsible for oxygen consumption in the mitochondrial electron transport chain, which drives oxidative phosphorylation for adenosine triphosphate (ATP) production. CCO i…
View article: Transcranial laser stimulation: Mitochondrial and cerebrovascular effects in younger and older healthy adults
Transcranial laser stimulation: Mitochondrial and cerebrovascular effects in younger and older healthy adults Open
The findings support the use of transcranial photobiomodulation for cerebral oxygenation and alleviation of age-related decline in mitochondrial respiration. They justify further research on its therapeutic potential in neurologic and psyc…
View article: Methylene Blue Preserves Cytochrome Oxidase Activity and Prevents Neurodegeneration and Memory Impairment in Rats With Chronic Cerebral Hypoperfusion
Methylene Blue Preserves Cytochrome Oxidase Activity and Prevents Neurodegeneration and Memory Impairment in Rats With Chronic Cerebral Hypoperfusion Open
Chronic cerebral hypoperfusion in neurocognitive disorders diminishes cytochrome oxidase activity leading to neurodegenerative effects and impairment of learning and memory. Methylene blue at low doses stimulates cytochrome oxidase activit…
View article: Cognitive Enhancement by Transcranial Photobiomodulation Is Associated With Cerebrovascular Oxygenation of the Prefrontal Cortex
Cognitive Enhancement by Transcranial Photobiomodulation Is Associated With Cerebrovascular Oxygenation of the Prefrontal Cortex Open
Transcranial infrared laser stimulation (TILS) is a novel, safe, non-invasive method of brain photobiomodulation. Laser stimulation of the human prefrontal cortex causes cognitive enhancement. To investigate the hemodynamic effects in pref…
View article: Maternal omega-3 fatty acid intake during neurodevelopment does not affect pup behavior related to depression, novelty, or learning
Maternal omega-3 fatty acid intake during neurodevelopment does not affect pup behavior related to depression, novelty, or learning Open
View article: MOESM5 of Maternal omega-3 fatty acid intake during neurodevelopment does not affect pup behavior related to depression, novelty, or learning
MOESM5 of Maternal omega-3 fatty acid intake during neurodevelopment does not affect pup behavior related to depression, novelty, or learning Open
Additional file 5. Table displaying results of linear mixed effects regression analysis of reference and working memory.
View article: MOESM2 of Maternal omega-3 fatty acid intake during neurodevelopment does not affect pup behavior related to depression, novelty, or learning
MOESM2 of Maternal omega-3 fatty acid intake during neurodevelopment does not affect pup behavior related to depression, novelty, or learning Open
Additional file 2. Table of activity parameters in the novel versus familiar open field.
View article: MOESM3 of Maternal omega-3 fatty acid intake during neurodevelopment does not affect pup behavior related to depression, novelty, or learning
MOESM3 of Maternal omega-3 fatty acid intake during neurodevelopment does not affect pup behavior related to depression, novelty, or learning Open
Additional file 3. Table showing results of linear mixed effects regression analysis of open field activity parameters.
View article: MOESM4 of Maternal omega-3 fatty acid intake during neurodevelopment does not affect pup behavior related to depression, novelty, or learning
MOESM4 of Maternal omega-3 fatty acid intake during neurodevelopment does not affect pup behavior related to depression, novelty, or learning Open
Additional file 4. Table of memory ratios by day in the hole board test.
View article: Beneficial neurocognitive effects of transcranial laser in older adults
Beneficial neurocognitive effects of transcranial laser in older adults Open
View article: Up-regulation of cerebral cytochrome-c-oxidase and hemodynamics by transcranial infrared laser stimulation: A broadband near-infrared spectroscopy study
Up-regulation of cerebral cytochrome-c-oxidase and hemodynamics by transcranial infrared laser stimulation: A broadband near-infrared spectroscopy study Open
Transcranial infrared laser stimulation (TILS) is a noninvasive form of brain photobiomulation. Cytochrome-c-oxidase (CCO), the terminal enzyme in the mitochondrial electron transport chain, is hypothesized to be the primary intracellular …
View article: Multimodal Randomized Functional MR Imaging of the Effects of Methylene Blue in the Human Brain
Multimodal Randomized Functional MR Imaging of the Effects of Methylene Blue in the Human Brain Open
Purpose To investigate the sustained-attention and memory-enhancing neural correlates of the oral administration of methylene blue in the healthy human brain. Materials and Methods The institutional review board approved this prospective, …
View article: Methylene blue modulates functional connectivity in the human brain
Methylene blue modulates functional connectivity in the human brain Open