Dovini Jayasinghe
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View article: Precise estimation of in-depth relatedness in biobank-scale datasets using deepKin
Precise estimation of in-depth relatedness in biobank-scale datasets using deepKin Open
Accurate relatedness estimation is essential in biobank-scale genetic studies. We present deepKin, a method-of-moments framework that accounts for sampling variance to enable statistical inference and classification of relatedness. Unlike …
View article: Analyzing Complex Traits and Diseases using GxE PRS: Genotype-Environment Interaction in Polygenic Risk Score Models
Analyzing Complex Traits and Diseases using GxE PRS: Genotype-Environment Interaction in Polygenic Risk Score Models Open
A deeper understanding of how environmental factors influence genetic risks is crucial for exploring their combined effects on health outcomes. This can be effectively achieved by incorporating genotype-environment (GxE) interactions in po…
View article: DeepKin: precise estimation of in-depth relatedness and its application in UK Biobank
DeepKin: precise estimation of in-depth relatedness and its application in UK Biobank Open
Accurately estimating relatedness between samples is crucial in genetics and epidemiological analysis. Using genome-wide single nucleotide polymorphisms (SNPs), it is now feasible to measure realized relatedness even in the absence of pedi…
View article: Mitigating type 1 error inflation and power loss in GxE PRS: Genotype–environment interaction in polygenic risk score models
Mitigating type 1 error inflation and power loss in GxE PRS: Genotype–environment interaction in polygenic risk score models Open
The use of polygenic risk score (PRS) models has transformed the field of genetics by enabling the prediction of complex traits and diseases based on an individual's genetic profile. However, the impact of genotype–environment interaction …
View article: GxE PRS: Genotype-environment interaction in polygenic risk score models for quantitative and binary traits
GxE PRS: Genotype-environment interaction in polygenic risk score models for quantitative and binary traits Open
The use of polygenic risk score (PRS) models has transformed the field of genetics by enabling the prediction of complex traits and diseases based on an individual’s genetic profile. However, the impact of genotype-environment interaction …
View article: A Review on Misleading COVID-19 Statistics
A Review on Misleading COVID-19 Statistics Open
The Sri Lankan Journal of Applied Statistics(SLJAS) is an open-access, international, double-blind peer-reviewed journal published by the Institute of Applied Statistics, Sri Lanka (IASSL). The main purpose of the journal is to publish the…
View article: Fast Tail Index Estimation for Power Law Distributions in R
Fast Tail Index Estimation for Power Law Distributions in R Open
Power law distributions, in particular Pareto distributions, describe data across diverse areas of study. We have developed a package in R to estimate the tail index for such datasets focusing on speed (in particular with large datasets), …