Robert D. Brown
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View article: Deep Learning-Based Automatic Delineation of Liver Domes in kV Triggered Images for Online Breath-hold Reproducibility Verification of Liver Stereotactic Body Radiation Therapy
Deep Learning-Based Automatic Delineation of Liver Domes in kV Triggered Images for Online Breath-hold Reproducibility Verification of Liver Stereotactic Body Radiation Therapy Open
Stereotactic Body Radiation Therapy (SBRT) can be a precise, minimally invasive treatment method for liver cancer and liver metastases. However, the effectiveness of SBRT relies on the accurate delivery of the dose to the tumor while spari…
View article: PRIMARY CENTRAL NERVOUS SYSTEM VASCULITIS WITH INTRACRANIAL ANEURYSM
PRIMARY CENTRAL NERVOUS SYSTEM VASCULITIS WITH INTRACRANIAL ANEURYSM Open
Background Unruptured intracranial aneurysms (UIAs) are rarely reported in primary central nervous system vasculitis (PCNSV). In this study we described the clinical findings, response to therapy, and outcomes of UIA in a large cohort of P…
View article: Boston criteria v2.0 for cerebral amyloid angiopathy without hemorrhage: An MRI-neuropathological validation study
Boston criteria v2.0 for cerebral amyloid angiopathy without hemorrhage: An MRI-neuropathological validation study Open
BACKGROUND Updated criteria for the clinical-MRI diagnosis of cerebral amyloid angiopathy (CAA) have recently been proposed. However, their performance in individuals without intracerebral hemorrhage (ICH) or transient focal neurological e…
View article: Unilateral Relapsing Primary CNS Vasculitis
Unilateral Relapsing Primary CNS Vasculitis Open
Unilateral relapsing involvement represents a rare subset of PCNSV with peculiar characteristics and can be observed in all neuropathologic patterns.
View article: Cerebral and Retinal Infarction in Bicuspid Aortic Valve
Cerebral and Retinal Infarction in Bicuspid Aortic Valve Open
Background Description of cerebral and retinal infarction in patients with bicuspid aortic valve (BAV) is limited to case reports. We aimed to characterize cerebral and retinal infarction and examine outcomes in patients with BAV. Methods …
View article: Exploring Gene Expression Profiles in Primary Central Nervous System Vasculitis
Exploring Gene Expression Profiles in Primary Central Nervous System Vasculitis Open
Objective This study was undertaken to explore the gene expression profile of primary central nervous system vasculitis (PCNSV). Methods Brain specimens of 4 patients with granulomatous vasculitis (GV), 5 with lymphocytic vasculitis (LV), …
View article: Electroencephalogram (EEG) With or Without Transcranial Magnetic Stimulation (TMS) as Biomarkers for Post-stroke Recovery: A Narrative Review
Electroencephalogram (EEG) With or Without Transcranial Magnetic Stimulation (TMS) as Biomarkers for Post-stroke Recovery: A Narrative Review Open
Stroke is one of the leading causes of death and disability. Despite the high prevalence of stroke, characterizing the acute neural recovery patterns that follow stroke and predicting long-term recovery remains challenging. Objective metho…
View article: Predictors of Short- and Long-Term Mortality in Ischemic Stroke: A Community-Based Study in Brno, Czech Republic
Predictors of Short- and Long-Term Mortality in Ischemic Stroke: A Community-Based Study in Brno, Czech Republic Open
Background and Objective: Short- and long-term mortality following ischemic stroke (IS) and their predictors have not been defined in the Czech population, and studies on long-term mortality are largely missing for the populations of Centr…
View article: Contemporary Neuroscience Core Curriculum for Medical Schools
Contemporary Neuroscience Core Curriculum for Medical Schools Open
Medical students need to understand core neuroscience principles as a foundation for their required clinical experiences in neurology. In fact, they need a solid neuroscience foundation for their clinical experiences in all other medical d…
View article: Safety of select headache medications in patients with cerebral and spinal cavernous malformations
Safety of select headache medications in patients with cerebral and spinal cavernous malformations Open
Background: Patients with cerebral or spinal cavernous malformations (CM) and a primary headache disorder are often limited in medication options due to concern for bleeding risk. Methods: From a prospective cohort of CM patients (2015–202…
View article: Incidence of Stroke and Ischemic Stroke Subtypes: A Community-Based Study in Brno, Czech Republic
Incidence of Stroke and Ischemic Stroke Subtypes: A Community-Based Study in Brno, Czech Republic Open
Background: There are few contemporary epidemiological data on stroke for Central Europe. We performed a population-based study evaluating the incidence of stroke, stroke types, and ischemic stroke (IS) subtypes in Brno, the second biggest…
View article: The CREST-2 experience with the evolving challenges of COVID-19
The CREST-2 experience with the evolving challenges of COVID-19 Open
The coronavirus disease 2019 pandemic has disrupted the lives of whole communities and nations. The multinational multicenter National Institute of Neurological Disorders and Stroke Carotid Revascularization and Medical Management for Asym…
View article: Aneurysmal subarachnoid hemorrhage: long-term trends in incidence and survival in Olmsted County, Minnesota
Aneurysmal subarachnoid hemorrhage: long-term trends in incidence and survival in Olmsted County, Minnesota Open
OBJECTIVE Recent population-based and hospital cohort studies have reported a decreasing incidence of aneurysmal subarachnoid hemorrhage (aSAH) and declining aSAH-associated case-fatality rates. Principal drivers of these trends are debate…
View article: Cavernous Malformation Hemorrhagic Presentation at Diagnosis Associated with Low 25-Hydroxy-Vitamin D Level
Cavernous Malformation Hemorrhagic Presentation at Diagnosis Associated with Low 25-Hydroxy-Vitamin D Level Open
Background: Cavernous malformations (CM) are angiographically occult vascular malformations that may be incidental or present with intracerebral or spinal hemorrhage, seizures, or nonhemorrhagic focal neurologic deficit (FND). Recently in …
View article: Clinical Reasoning: 63-Year-old woman with thoracic cavernous malformation and delayed worsening myelopathy
Clinical Reasoning: 63-Year-old woman with thoracic cavernous malformation and delayed worsening myelopathy Open
A 63-year-old woman presented with marked, progressive worsening of lower extremity spasticity and decreased upper extremity strength. In 1980, she developed lower extremity paresthesias and was found to have an intramedullary hemorrhagic …
View article: Cerebral microbleed incidence, relationship to amyloid burden
Cerebral microbleed incidence, relationship to amyloid burden Open
Age and APOE4 carrier status act through amyloid load to increase the risk of subsequent lobar CMBs, but the presence of baseline CMBs is the most important risk factor for future CMBs.
View article: White matter hyperintensities: relationship to amyloid and tau burden
White matter hyperintensities: relationship to amyloid and tau burden Open
Although white matter hyperintensities have traditionally been viewed as a marker of vascular disease, recent pathology studies have found an association between white matter hyperintensities and Alzheimer’s disease pathologies. The object…
View article: Cerebral microbleeds
Cerebral microbleeds Open
The prevalence of CMBs increases with age. In this population-based sample, β-amyloid load was associated with lobar but not with deep CMBs.
View article: Characteristics of Spontaneous Spinal Cord Infarction and Proposed Diagnostic Criteria
Characteristics of Spontaneous Spinal Cord Infarction and Proposed Diagnostic Criteria Open
This large series of spontaneous SCIs provides clinical, laboratory, and MRI clues to SCI diagnosis. The diagnostic criteria proposed here will aid clinicians in making the correct diagnosis and ideally improve future care for patients wit…