Dilshad Ahmed Khan
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View article: Diagnostic and Prognostic Implications of FGFR3, TP53 Mutation and Urinary Biomarkers in Urothelial Carcinoma in Pakistani Cohort
Diagnostic and Prognostic Implications of FGFR3, TP53 Mutation and Urinary Biomarkers in Urothelial Carcinoma in Pakistani Cohort Open
Background: Urothelial carcinoma (UC) presents with clinically heterogeneous disease. There is an emerging need to explore the prognosis of non-muscle-invasive bladder cancer (NMIBC) and muscle-invasive bladder cancer (MIBC). Therefore, we…
View article: Ribosome biogenesis and its regulation by the exportin, CSE1L, are targetable vulnerabilities in childhood and young adult Acute Myeloid Leukemia
Ribosome biogenesis and its regulation by the exportin, CSE1L, are targetable vulnerabilities in childhood and young adult Acute Myeloid Leukemia Open
There are fundamental differences in the genomic drivers of childhood, adolescent and young adult (AYA) acute myeloid leukemia (AML) compared to AML that develops in older adults. Despite this, little is known about the downstream pathways…
View article: BIOM-50. IDENTIFICATION OF A NOVEL BIOMARKER IN PERILESIONAL CSF DURING BRAIN METASTASIS RESECTION
BIOM-50. IDENTIFICATION OF A NOVEL BIOMARKER IN PERILESIONAL CSF DURING BRAIN METASTASIS RESECTION Open
Brain metastases occur when cancer cells from a pre-existing tumor “break off” and spread to the brain via the bloodstream. Treatment often consists of surgical excision alongside radiation for a solitary metastasis, while radiation and/or…
View article: Association of ABCG2 421G>T (rs2231142) Polymorphism with rosuvastatin induced adverse effects in dyslipidemic patients: Implication for personalized medicine
Association of ABCG2 421G>T (rs2231142) Polymorphism with rosuvastatin induced adverse effects in dyslipidemic patients: Implication for personalized medicine Open
Statins are considered as the first line drugs for the treatment of hyperlipidemia. Despite proven efficacy of rosuvastatin, inter-individual variations in plasma rosuvastatin levels have been documented in various studies which causes var…
View article: Comparative Analysis of Metabolic and Inflammatory Biomarker Profiles in Phenotypes of Metabolic Dysfunction-Associated Fatty Liver Disease
Comparative Analysis of Metabolic and Inflammatory Biomarker Profiles in Phenotypes of Metabolic Dysfunction-Associated Fatty Liver Disease Open
Metabolic dysfunction-associated fatty liver disease, T2D MAFLD, Obese -MAFLD, Lean-MAFLD, Biochemical and inflammatory markers.
View article: <b>The impact of hospital admissions for infected diabetic foot ulcers at Hayatabad Medical Complex</b>
<b>The impact of hospital admissions for infected diabetic foot ulcers at Hayatabad Medical Complex</b> Open
.Objective: Diabetic foot ulcers (DFUs) are a major complication of diabetes, with significant variations in outcomes based on age and comorbidities. This study aimed to compare clinical characteristics and treatment outcomes between young…
View article: Efficacy of Different Beta Blockers in Reducing Mortality in Heart-Failure Patients
Efficacy of Different Beta Blockers in Reducing Mortality in Heart-Failure Patients Open
This study evaluated the comparative efficacy of different beta blockers bisoprolol, carvedilol, and metoprolol in reducing mortality and hospitalizations among 120 heart-failure (HF) patients. The sample had an equal gender distribution (…
View article: A Comparative Study of Early Versus Delayed Rehabilitation on Long-Term Cardiopulmonary Health in Patients with Left Ventricular Dysfunction Post- PCI
A Comparative Study of Early Versus Delayed Rehabilitation on Long-Term Cardiopulmonary Health in Patients with Left Ventricular Dysfunction Post- PCI Open
Background: Early rehabilitation is crucial for enhancing recovery in patients with left ventricular dysfunction following percutaneous coronary intervention (PCI). This study aimed to compare the outcomes of early versus delayed rehabilit…
View article: Comparative efficacy of tocotrienol and tocopherol (vitamin E) on atherosclerotic cardiovascular diseases in humans
Comparative efficacy of tocotrienol and tocopherol (vitamin E) on atherosclerotic cardiovascular diseases in humans Open
Objectives: To compare the efficacy of tocotrienol and tocopherol in the management of patients with atherosclerotic cardiovascular diseases. Method: The systematic review was conducted in line with Preferred Reporting Items for Systematic…
View article: Jane Austen’s Implicit Feminist Literary Narrative: Breaking the Norms
Jane Austen’s Implicit Feminist Literary Narrative: Breaking the Norms Open
This paper was conducted to apprise and depict Jane Austen’s feminist thought, highlighting the depiction of women in the contemporary Regency era and her fiction. For the study, first-hand data was acquired from the corpus of Austen’s lit…
View article: B-218 Role of Delta Tocotrienol and Resveratrol Supplementation in Regulation of Micro RNAs in Patients With Metabolic Syndrome: A Randomized Controlled Trial
B-218 Role of Delta Tocotrienol and Resveratrol Supplementation in Regulation of Micro RNAs in Patients With Metabolic Syndrome: A Randomized Controlled Trial Open
Background Micro-RNAs (miRNAs) are involve in the regulation of central obesity, insulin resistance, inflammation and dyslipidemia in development of MetS. δ-tocotrienol and resveratrol improve the insulin resistance, inflammation and clini…
View article: COMPARATIVE ANALYSIS OF BIODISPOSITION OF DIFFERENT ISOMERS OF TOCOPHEROLS
COMPARATIVE ANALYSIS OF BIODISPOSITION OF DIFFERENT ISOMERS OF TOCOPHEROLS Open
Tocopherols are indicated as adjuvant therapy in metabolic disorders, various types of carcinomas and as neuroprotective and cardioprotective agents. Their use is limited due to poor water solubility, variable absorption and low bioavailab…
View article: "Diagnostic Potential of Micro RNA Panel for Coronary Artery Disease in Patients with Angina"
"Diagnostic Potential of Micro RNA Panel for Coronary Artery Disease in Patients with Angina" Open
Diagnosis of the coronary artery disease (CAD) in patients with angina is a challenge in clinical settings without invasive coronary angiography. Our objective was to find out non-invasive molecular diagnosis by relative expression of micr…
View article: Pharmacokinetics and bioavailability of tocotrienols in healthy human volunteers: a systematic review
Pharmacokinetics and bioavailability of tocotrienols in healthy human volunteers: a systematic review Open
Objectives: To evaluate and compare the pharmacokinetic parameters, especially bioavailability, of annatto-based tocotrienol with palm tocotrienol-rich fraction in healthy human volunteers for better therapeutic outcome. Method: The system…
View article: Protective effects of selenium against cypermethrin induced hepatorenal damage in Sprague Dawley rats
Protective effects of selenium against cypermethrin induced hepatorenal damage in Sprague Dawley rats Open
Introduction: Alpha-Cypermethrin is a synthetic pyrethroid insecticide. Pyrethroids are derived from pyrethrins, which are toxic components found in the Chrysanthemum cinerariaefolium flowers. They have been employed in agriculture, home a…
View article: Protective effects of selenium against cypermethrin induced hepatorenal damage in Sprague Dawley rats
Protective effects of selenium against cypermethrin induced hepatorenal damage in Sprague Dawley rats Open
Introduction: Alpha-Cypermethrin is a synthetic pyrethroid insecticide. Pyrethroids are derived from pyrethrins, which are toxic components found in the Chrysanthemum cinerariaefolium flowers. They have been employed in agriculture, home a…
View article: Hepato-Protective Effects of Delta-Tocotrienol and Alpha-Tocopherol in Patients with Non-Alcoholic Fatty Liver Disease: Regulation of Circulating MicroRNA Expression
Hepato-Protective Effects of Delta-Tocotrienol and Alpha-Tocopherol in Patients with Non-Alcoholic Fatty Liver Disease: Regulation of Circulating MicroRNA Expression Open
MicroRNAs (miRNAs) play a key role in the regulation of genes for normal metabolism in the liver. Dysregulation of miRNAs is involved in the development and progression of non-alcoholic fatty liver disease (NAFLD). We aimed to explore chan…
View article: Preventive effects of selenium against cypermethrin induced haematological toxicity in Sprague-Dawley rats
Preventive effects of selenium against cypermethrin induced haematological toxicity in Sprague-Dawley rats Open
Purpose: Cypermethrin (class II) belongs to pyrethroid insecticides which have been in wide use to control various pests including moth pests of cotton, fruit and vegetable crops. This study was aimed to investigate the effects of cypermet…
View article: Preventive effects of selenium against cypermethrin induced haematological toxicity in Sprague-Dawley rats
Preventive effects of selenium against cypermethrin induced haematological toxicity in Sprague-Dawley rats Open
Purpose: Cypermethrin (class II) belongs to pyrethroid insecticides which have been in wide use to control various pests including moth pests of cotton, fruit and vegetable crops. This study was aimed to investigate the effects of cypermet…
View article: Spectrum of Disorders Leading to Sudden Cardiac Death
Spectrum of Disorders Leading to Sudden Cardiac Death Open
Objective: To determine the frequency of disorders leading to sudden cardiac death (SCD). Study Design: Cross-sectional study. Place and duration of study: Pathology Lab in collaboration with the Cardiology Department, AFIC & NIHD, Rawalpi…
View article: Comparison of delta-tocotrienol and alpha-tocopherol effects on hepatic steatosis and inflammatory biomarkers in patients with non-alcoholic fatty liver disease: A randomized double-blind active-controlled trial
Comparison of delta-tocotrienol and alpha-tocopherol effects on hepatic steatosis and inflammatory biomarkers in patients with non-alcoholic fatty liver disease: A randomized double-blind active-controlled trial Open
δ-tocotrienol and α-tocopherol exerted equally beneficial effects in terms of improvement in hepatic steatosis, oxidative stress, and insulin resistance in patients with NAFLD. However, δ-tocotrienol was more potent than α-tocopherol in re…
View article: Role of resveratrol supplementation in regulation of glucose hemostasis, inflammation and oxidative stress in patients with diabetes mellitus type 2: A randomized, placebo-controlled trial
Role of resveratrol supplementation in regulation of glucose hemostasis, inflammation and oxidative stress in patients with diabetes mellitus type 2: A randomized, placebo-controlled trial Open
Resveratrol supplementation contributes in improvement of glycemic control by reducing insulin resistance. It has significant beneficial impact on chronic inflammation, oxidative stress and associated microRNA expression in diabetic patien…
View article: Challenges in Hemoglobin A1C Measurement in 183 Patients with Diabetes having Hemoglobin Variants and Chemically Modified Derivatives
Challenges in Hemoglobin A1C Measurement in 183 Patients with Diabetes having Hemoglobin Variants and Chemically Modified Derivatives Open
Diabetes is considered as one of the most common metabolic disorder. It has challenged in terms of diagnosis,monitoring and management in the patients with type-2 diabetes. Glycosylated Hemoglobin (HbA1c) hasrecently been validated for the…
View article: QUASI-EXPERIMENTAL EVALUATION OF ZINC SUPPLEMENTATION ON MEAN SERUM INSULIN LIKE GROWTH FACTOR-1 (IGF-1) AND INSULIN LIKE GROWTH FACTOR BINDING PROTEIN-3 (IGFBP-3) LEVELS IN PAKISTANI SHORT STATURED CHILDREN
QUASI-EXPERIMENTAL EVALUATION OF ZINC SUPPLEMENTATION ON MEAN SERUM INSULIN LIKE GROWTH FACTOR-1 (IGF-1) AND INSULIN LIKE GROWTH FACTOR BINDING PROTEIN-3 (IGFBP-3) LEVELS IN PAKISTANI SHORT STATURED CHILDREN Open
Objective: To investigate the influence of supplemental zinc on the levels of insulin like growth factor-1 (IGF-1) and insulin like growth factor binding protein-3 (IGFBP-3) in short statured Pakistani children of 3-6 years of age. Study D…
View article: PREMATURE CORONARY ARTERY DISEASE
PREMATURE CORONARY ARTERY DISEASE Open
Introduction: Integrative genomics may help in the identification of novelbiological pathways in the pathogenesis of CAD. Objectives: To find out the association of 5Cytokine SNPs and 13 CAD SNPs gene risk scores with serum cytokine levels…