Dragan Maric
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View article: Spatially-restricted inflammation-induced senescent-like glia in multiple sclerosis and patient-derived organoids
Spatially-restricted inflammation-induced senescent-like glia in multiple sclerosis and patient-derived organoids Open
View article: Age-dependent integration of cortical progenitors transplanted at CSF-neurogenic niche interface
Age-dependent integration of cortical progenitors transplanted at CSF-neurogenic niche interface Open
There has been renewed interest in neural transplantation of cells and tissues for brain repair. Recent studies have demonstrated the ability of transplanted neural precursor cells and in vitro grown organoids to mature and locally integra…
View article: Evidence for ApoE receptor 2-Disabled homolog-1 pathway disruption in the amygdala in sporadic Alzheimer’s disease
Evidence for ApoE receptor 2-Disabled homolog-1 pathway disruption in the amygdala in sporadic Alzheimer’s disease Open
INTRODUCTION The ApoE receptor 2-Disabled homolog-1 (ApoER2-Dab1) pathway suppresses Tau phosphorylation as part of a multi-arm pathway that regulates cytoskeletal and synaptic integrity. We previously showed that multiple ApoER2-Dab1 path…
View article: Optimizing Colocalized Cell Counting Using Automated and Semiautomated Methods
Optimizing Colocalized Cell Counting Using Automated and Semiautomated Methods Open
View article: Activating antiviral immune responses potentiates immune checkpoint inhibition in glioblastoma models
Activating antiviral immune responses potentiates immune checkpoint inhibition in glioblastoma models Open
Viral mimicry refers to the activation of innate antiviral immune responses due to the induction of endogenous retroelements (REs). Viral mimicry augments antitumor immune responses and sensitizes solid tumors to immunotherapy. Here, we fo…
View article: Efficient removal of naturally-occurring lipofuscin autofluorescence in human nervous tissue using high-intensity white light
Efficient removal of naturally-occurring lipofuscin autofluorescence in human nervous tissue using high-intensity white light Open
Background autofluorescence is enhanced in human tissue relative to small animals and presents a barrier to fully realizing the potential of novel multiplex methods in human studies. In particular, lipofuscin (LF) is an interfering pigment…
View article: PRMT5 inhibition sensitizes glioblastoma tumor models to temozolomide
PRMT5 inhibition sensitizes glioblastoma tumor models to temozolomide Open
View article: Targeting ZNF638 activates antiviral immune responses and potentiates immune checkpoint inhibition in glioblastoma
Targeting ZNF638 activates antiviral immune responses and potentiates immune checkpoint inhibition in glioblastoma Open
Viral mimicry refers to the activation of innate anti-viral immune responses due to the induction of endogenous retroelement (RE) expression. Viral mimicry has been previously described to augment anti-tumor immune responses and sensitize …
View article: The μ-opioid receptor differentiates two distinct human nociceptive populations relevant to clinical pain
The μ-opioid receptor differentiates two distinct human nociceptive populations relevant to clinical pain Open
The shortfall in new analgesic agents is a major impediment to reducing reliance on opioid medications for control of severe pain. In both animals and man, attenuating nociceptive transmission from primary afferent neurons with a μ-opioid …
View article: Supplementary Methods and Key Resources Table 1 from Proteostasis modulation in germline missense von Hippel Lindau disease
Supplementary Methods and Key Resources Table 1 from Proteostasis modulation in germline missense von Hippel Lindau disease Open
Supplementary Methods and Key Resources Table
View article: Figure S1 from Proteostasis modulation in germline missense von Hippel Lindau disease
Figure S1 from Proteostasis modulation in germline missense von Hippel Lindau disease Open
Figure S1
View article: Figure S4 from Proteostasis modulation in germline missense von Hippel Lindau disease
Figure S4 from Proteostasis modulation in germline missense von Hippel Lindau disease Open
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View article: Figure S6 from Proteostasis modulation in germline missense von Hippel Lindau disease
Figure S6 from Proteostasis modulation in germline missense von Hippel Lindau disease Open
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View article: Supplementary Tables 1 from Proteostasis modulation in germline missense von Hippel Lindau disease
Supplementary Tables 1 from Proteostasis modulation in germline missense von Hippel Lindau disease Open
Supplementary tables in tabs.
View article: Figure S5 from Proteostasis modulation in germline missense von Hippel Lindau disease
Figure S5 from Proteostasis modulation in germline missense von Hippel Lindau disease Open
Figure S5
View article: Supplementary Tables 1 from Proteostasis modulation in germline missense von Hippel Lindau disease
Supplementary Tables 1 from Proteostasis modulation in germline missense von Hippel Lindau disease Open
Supplementary tables in tabs.
View article: Figure S4 from Proteostasis modulation in germline missense von Hippel Lindau disease
Figure S4 from Proteostasis modulation in germline missense von Hippel Lindau disease Open
Figure S4
View article: Supplementary Methods and Key Resources Table 1 from Proteostasis modulation in germline missense von Hippel Lindau disease
Supplementary Methods and Key Resources Table 1 from Proteostasis modulation in germline missense von Hippel Lindau disease Open
Supplementary Methods and Key Resources Table
View article: Figure S3 from Proteostasis modulation in germline missense von Hippel Lindau disease
Figure S3 from Proteostasis modulation in germline missense von Hippel Lindau disease Open
Figure S3
View article: Figure S6 from Proteostasis modulation in germline missense von Hippel Lindau disease
Figure S6 from Proteostasis modulation in germline missense von Hippel Lindau disease Open
Figure S6
View article: Figure S5 from Proteostasis modulation in germline missense von Hippel Lindau disease
Figure S5 from Proteostasis modulation in germline missense von Hippel Lindau disease Open
Figure S5
View article: Figure S3 from Proteostasis modulation in germline missense von Hippel Lindau disease
Figure S3 from Proteostasis modulation in germline missense von Hippel Lindau disease Open
Figure S3
View article: Data from Proteostasis modulation in germline missense von Hippel Lindau disease
Data from Proteostasis modulation in germline missense von Hippel Lindau disease Open
Purpose: Missense mutated von Hippel Lindau (VHL) protein (pVHL) maintains intrinsic function but undergoes proteasomal degradation and tumor initiation/progression in VHL disease. Vorinostat can rescue missense mutated pVHL and arrest tum…
View article: Figure S2 from Proteostasis modulation in germline missense von Hippel Lindau disease
Figure S2 from Proteostasis modulation in germline missense von Hippel Lindau disease Open
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View article: Figure S2 from Proteostasis modulation in germline missense von Hippel Lindau disease
Figure S2 from Proteostasis modulation in germline missense von Hippel Lindau disease Open
Figure S2
View article: Figure S1 from Proteostasis modulation in germline missense von Hippel Lindau disease
Figure S1 from Proteostasis modulation in germline missense von Hippel Lindau disease Open
Figure S1
View article: Multiplex fluorescence in situ hybridization using RNAScope on paraffin embedded human nervous system tissue with optional photobleaching for autofluorescence mitigation v1
Multiplex fluorescence in situ hybridization using RNAScope on paraffin embedded human nervous system tissue with optional photobleaching for autofluorescence mitigation v1 Open
This protocol is to perform the RNAScope in situ hybridization procedure in human central nervous system tissue with modifications from our newly established method to reduce endogenous autofluorescence from lipofuscin. This procedure shou…
View article: Age Dependent Integration of Cortical Progenitors Transplanted at the Adult CSF-Brain Interface
Age Dependent Integration of Cortical Progenitors Transplanted at the Adult CSF-Brain Interface Open
There has been renewed interest in neural transplantation of cells and tissues for brain repair. Recent studies have demonstrated the ability of transplanted neural precursor cells and in vitro grown organoids to mature and locally integra…
View article: Epigenetic reactivation of a neurodevelopmental phosphoprotein program in pituitary adenomas
Epigenetic reactivation of a neurodevelopmental phosphoprotein program in pituitary adenomas Open
Background: The protein kinase-phosphatase equilibrium is essential for eukaryotic development and homeostasis, but its epigenomic dysregulation in human tumors remains unexplored.Objectives/Methods: We employed an omics-based approach to …
View article: TDP-43 proteinopathy in ALS is triggered by loss of ASRGL1 and associated with HML-2 expression
TDP-43 proteinopathy in ALS is triggered by loss of ASRGL1 and associated with HML-2 expression Open