Dragos Peptanariu
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View article: Siloxane-spaced salen-type Schiff base cobalt complex. Experimental and docking analysis—a dual approach for evaluating anti-cancer efficacy
Siloxane-spaced salen-type Schiff base cobalt complex. Experimental and docking analysis—a dual approach for evaluating anti-cancer efficacy Open
A complex of Co(II), CoL 1 , with a salen-type Schiff base ligand, H 2 L 1 , having a siloxane spacer, was evaluated from the perspective of anti-cancer activity in comparison with a newly synthesized homologue under similar conditions, Co…
View article: Hierarchical assembly of iron-oxide supraparticles for enhanced photothermal antibacterial activity
Hierarchical assembly of iron-oxide supraparticles for enhanced photothermal antibacterial activity Open
View article: Enhancing Flucytosine Anticandidal Activity Using PEGylated Squalene Nanocarrier
Enhancing Flucytosine Anticandidal Activity Using PEGylated Squalene Nanocarrier Open
There is an emerging necessity for improved therapies against Candida‐related infections, with significant implications for global healthcare. Current antifungal agents, limited in number, target specific pathways, but resistance remains a…
View article: Novel Nanotherapeutic Systems Based on PEGylated Squalene Micelles for Enhanced In Vitro Activity of Methotrexate and Cytarabine
Novel Nanotherapeutic Systems Based on PEGylated Squalene Micelles for Enhanced In Vitro Activity of Methotrexate and Cytarabine Open
Nanomedicine has garnered significant attention due to the advantages it offers in the treatment of cancer-related disorders, some of the deadliest diseases affecting human lives. Conventional medication formulations often encounter issues…
View article: Mucoadhesive Mesoporous Silica Particles as Versatile Carriers for Doxorubicin Delivery in Cancer Therapy
Mucoadhesive Mesoporous Silica Particles as Versatile Carriers for Doxorubicin Delivery in Cancer Therapy Open
Due to their structural, morphological, and behavioral characteristics (e.g., large volume and adjustable pore size, wide functionalization possibilities, excellent biocompatibility, stability, and controlled biodegradation, the ability to…
View article: Towards Regenerative Audiology: Immune Modulation of Adipose-Derived Mesenchymal Cells Preconditioned with Citric Acid-Coated Antioxidant-Functionalized Magnetic Nanoparticles
Towards Regenerative Audiology: Immune Modulation of Adipose-Derived Mesenchymal Cells Preconditioned with Citric Acid-Coated Antioxidant-Functionalized Magnetic Nanoparticles Open
Introduction and Background: Based on stem cells, bioactive molecules and supportive structures, regenerative medicine (RM) is promising for its potential impact on field of hearing loss by offering innovative solutions for hair cell rescu…
View article: CCDC 2175508: Experimental Crystal Structure Determination
CCDC 2175508: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Chemical Attachment of 5-Nitrosalicylaldimine Motif to Silatrane Resulting in an Organic–Inorganic Structure with High Medicinal Significance
Chemical Attachment of 5-Nitrosalicylaldimine Motif to Silatrane Resulting in an Organic–Inorganic Structure with High Medicinal Significance Open
Two chemical motifs of interest for medicinal chemistry, silatrane as 1-(3-aminopropyl) silatrane (SIL M), and nitro group attached in position 5 to salicylaldehyde, are coupled in a new structure, 1-(3-{[(2-hydroxy-5-nitrophenyl)methylide…
View article: Biocompatible Self-Assembled Hydrogen-Bonded Gels Based on Natural Deep Eutectic Solvents and Hydroxypropyl Cellulose with Strong Antimicrobial Activity
Biocompatible Self-Assembled Hydrogen-Bonded Gels Based on Natural Deep Eutectic Solvents and Hydroxypropyl Cellulose with Strong Antimicrobial Activity Open
Natural deep eutectic solvents (NADES)-hydroxypropyl cellulose (HPC) self-assembled gels with potential for pharmaceutical applications are prepared. FT-IR, 1HNMR, DSC, TGA and rheology measurements revealed that hydrogen bond acceptor–hyd…
View article: Hydroxypropyl Cellulose/Pluronic-Based Composite Hydrogels as Biodegradable Mucoadhesive Scaffolds for Tissue Engineering
Hydroxypropyl Cellulose/Pluronic-Based Composite Hydrogels as Biodegradable Mucoadhesive Scaffolds for Tissue Engineering Open
Recently, the development of new materials with the desired characteristics for functional tissue engineering, ensuring tissue architecture and supporting cellular growth, has gained significant attention. Hydrogels, which possess similar …
View article: Functionalized Mesoporous Silica as Doxorubicin Carriers and Cytotoxicity Boosters
Functionalized Mesoporous Silica as Doxorubicin Carriers and Cytotoxicity Boosters Open
Mesoporous silica nanoparticles (MSNs) bearing methyl, thiol or glucose groups were synthesized, and their encapsulation and release behaviors for the anticancer drug Doxorubicin (Dox) were investigated in comparison with nonporous homolog…
View article: Biocompatible Chitosan-Based Hydrogels for Bioabsorbable Wound Dressings
Biocompatible Chitosan-Based Hydrogels for Bioabsorbable Wound Dressings Open
Supramolecular hydrogels based on chitosan and monoaldehydes are biomaterials with high potential for a multitude of bioapplications. This is due to the proper choice of the monoaldehyde that can tune the hydrogel properties for specific p…
View article: A SENSITIVE METHOD FOR SALIVA DETECTION IN FORENSICS USING SALIVARY AMYLASE COUPLED WITH AMPLEX RED OXIDATION
A SENSITIVE METHOD FOR SALIVA DETECTION IN FORENSICS USING SALIVARY AMYLASE COUPLED WITH AMPLEX RED OXIDATION Open
A new sensitive method for saliva detection was developed, based on salivary amylase detection but with a final fluorescent product, which increases its sensitivity. After the starch is degraded due to the presence of salivary amylase, glu…
View article: Cytotoxic substituted indolizines as new colchicine site tubulin polymerisation inhibitors
Cytotoxic substituted indolizines as new colchicine site tubulin polymerisation inhibitors Open
A potential microtubule destabilising series of new indolizine derivatives was synthesised and tested for their anticancer activity against a panel of 60 human cancer cell lines. Compounds 11a, 11b, 15a, and 15j…
View article: RUTHENIUM(II) COMPLEXES WITH CYTOTOXIC ACTIVITY EMBEDDED IN HYDROXYPROPYL METHYLCELLULOSE/SODIUM ALGINATE MUCOADHESIVE HYDROGELS
RUTHENIUM(II) COMPLEXES WITH CYTOTOXIC ACTIVITY EMBEDDED IN HYDROXYPROPYL METHYLCELLULOSE/SODIUM ALGINATE MUCOADHESIVE HYDROGELS Open
Mucoadhesive hydrogels based on hydroxypropylmethyl cellulose/sodium alginate have been prepared and used as matrix for encapsulation and delivery of new ruthenium(II) complexes with selective cytotoxic activity on human melanoma (MEWO) ce…
View article: In Vitro and In Vivo Antioxidant Activity of the New Magnetic-Cerium Oxide Nanoconjugates
In Vitro and In Vivo Antioxidant Activity of the New Magnetic-Cerium Oxide Nanoconjugates Open
Background. Cerium oxide nanoparticles present the mimetic activity of superoxide dismutase, being able to inactivate the excess of reactive oxygen species (ROS) correlated with a large number of pathologies, such as stents restenosis and …
View article: CCDC 1919638: Experimental Crystal Structure Determination
CCDC 1919638: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: The Cytotoxic Properties of Some Tricyclic 1,3-Dithiolium Flavonoids
The Cytotoxic Properties of Some Tricyclic 1,3-Dithiolium Flavonoids Open
Background: Due to the emergence of multidrug resistant microorganisms, new classes of antibiotics are needed. In this paper, we present the cytotoxic effects of five tricyclic flavonoids, one of which was previously identified as a potent…
View article: Synergistic Effect of Low Molecular Weight Polyethylenimine and Polyethylene Glycol Components in Dynamic Nonviral Vector Structure, Toxicity, and Transfection Efficiency
Synergistic Effect of Low Molecular Weight Polyethylenimine and Polyethylene Glycol Components in Dynamic Nonviral Vector Structure, Toxicity, and Transfection Efficiency Open
When studying polyethylenimine derivatives as nonviral vectors for gene delivery, among the important issues to be addressed are high toxicity, low transfection efficiency, and nucleic acid polyplex condensation. The molecular weight of po…
View article: CCDC 1496345: Experimental Crystal Structure Determination
CCDC 1496345: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1496340: Experimental Crystal Structure Determination
CCDC 1496340: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Low Molecular Weight Microfibers with Light Sensing Properties
Low Molecular Weight Microfibers with Light Sensing Properties Open
Microfibers were obtained from organic low molecular weight compounds based on heteroaromatic and aromatic rings connected by aliphatic spacers. The obtaining of microfibers was proved by scanning electron microscopy. The deciphering of th…
View article: Biosynthesis of dextran by Weissella confusa and its In vitro functional characteristics
Biosynthesis of dextran by Weissella confusa and its In vitro functional characteristics Open
View article: DNA-assisted decoration of single-walled carbon nanotubes with gold nanoparticles for applications in surface-enhanced Raman scattering imaging of cells
DNA-assisted decoration of single-walled carbon nanotubes with gold nanoparticles for applications in surface-enhanced Raman scattering imaging of cells Open
View article: Transfection-capable polycationic nanovectors which include PEGylated-cyclodextrin structural units: a new synthesis pathway
Transfection-capable polycationic nanovectors which include PEGylated-cyclodextrin structural units: a new synthesis pathway Open
Polycationic nanoentities with low variability are able to act as cooperating carriers for dsDNA complexation and transport.
View article: Carboxymethyl guar gum nanoparticles for drug delivery applications: Preparation and preliminary in-vitro investigations
Carboxymethyl guar gum nanoparticles for drug delivery applications: Preparation and preliminary in-vitro investigations Open