Drew A. Hall
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View article: Structural basis for control of integrative and conjugative element excision and transfer by the oligomeric winged helix–turn–helix protein RdfS
Structural basis for control of integrative and conjugative element excision and transfer by the oligomeric winged helix–turn–helix protein RdfS Open
Winged helix–turn–helix (wHTH) proteins are diverse DNA-binding proteins that often oligomerize on DNA and participate in DNA recombination and transcriptional regulation. wHTH recombination directionality factors (RDFs) associated with ty…
View article: Benchtop Proton NMR Spectroscopy for High-Throughput Lipoprotein Quantification in Human Serum and Plasma
Benchtop Proton NMR Spectroscopy for High-Throughput Lipoprotein Quantification in Human Serum and Plasma Open
We report the successful development and translation of high-field nuclear magnetic resonance (NMR) based comprehensive lipoprotein analysis to routine benchtop systems. This demonstrates the potential to reimagine population level cardiov…
View article: A GMR enzymatic assay for quantifying nuclease and peptidase activity
A GMR enzymatic assay for quantifying nuclease and peptidase activity Open
Hydrolytic enzymes play crucial roles in cellular processes, and dysregulation of their activities is implicated in various physiological and pathological conditions. These enzymes cleave substrates such as peptide bonds, phosphodiester bo…
View article: Phylochemical mapping of natural products onto the plant tree of life using text mining and large language models.
Phylochemical mapping of natural products onto the plant tree of life using text mining and large language models. Open
Plants produce a staggering array of chemicals that are the basis for organismal function and diversity and also provide essential human nutrients and medicine. However, it is poorly defined how these compounds have evolved and are distrib…
View article: Integrative Molecular Structure Elucidation and Construction of an Extended Metabolic Pathway Associated with an Ancient Innate Immune Response in COVID-19 Patients
Integrative Molecular Structure Elucidation and Construction of an Extended Metabolic Pathway Associated with an Ancient Innate Immune Response in COVID-19 Patients Open
We present compelling evidence for the existence of an extended innate viperin-dependent pathway, which provides crucial evidence for an adaptive response to viral agents, such as SARS-CoV-2. We show the in vivo biosynthesis of a family of…
View article: Guest Editorial Introduction to the Special Section on the 2023 IEEE International Solid-State Circuits Conference (ISSCC)
Guest Editorial Introduction to the Special Section on the 2023 IEEE International Solid-State Circuits Conference (ISSCC) Open
This Special Section of IEEE JOURNAL OF SOLID-STATE CIRCUITS (JSSC) highlights outstanding papers presented at the 2023 IEEE International Solid-State Circuits Conference (ISSCC), which was held from February 19 to 23, 2023, in San Francis…
View article: A dual-binding magnetic immunoassay to predict spontaneous preterm birth
A dual-binding magnetic immunoassay to predict spontaneous preterm birth Open
Complications posed by preterm birth (delivery before 37 weeks of pregnancy) are a leading cause of newborn morbidity and mortality. The previous discovery and validation of an algorithm that includes maternal serum protein biomarkers, sex…
View article: Cardiometabolic disease risk markers are increased following burn injury in children
Cardiometabolic disease risk markers are increased following burn injury in children Open
Introduction Burn injury in children causes prolonged systemic effects on physiology and metabolism leading to increased morbidity and mortality, yet much remains undefined regarding the metabolic trajectory towards specific health outcome…
View article: DUF2285 is a novel helix-turn-helix domain variant that orchestrates both activation and antiactivation of conjugative element transfer in proteobacteria
DUF2285 is a novel helix-turn-helix domain variant that orchestrates both activation and antiactivation of conjugative element transfer in proteobacteria Open
Horizontal gene transfer is tightly regulated in bacteria. Often only a fraction of cells become donors even when regulation of horizontal transfer is coordinated at the cell population level by quorum sensing. Here, we reveal the widespre…
View article: SARS-CoV-2 Infection Biomarkers Reveal Adaptive Evolutionary Chemistry of Antiviral Nucleoside Metabolism
SARS-CoV-2 Infection Biomarkers Reveal Adaptive Evolutionary Chemistry of Antiviral Nucleoside Metabolism Open
We present compelling evidence for the existence of an evolutionary adaptive response to viral agents such as SARS-CoV-2, that results in the human in vivo biosynthesis of a family of compounds with potential antiviral activity. Using nucl…
View article: SARS-CoV-2 Infection Biomarkers Reveal Adaptive Evolutionary Chemistry of Antiviral Nucleoside Metabolism
SARS-CoV-2 Infection Biomarkers Reveal Adaptive Evolutionary Chemistry of Antiviral Nucleoside Metabolism Open
We present compelling evidence for the existence of an evolutionary adaptive response to viral agents such as SARS-CoV-2, that results in the human in vivo biosynthesis of a family of compounds with potential antiviral activity. Using nucl…
View article: A non-invasive wearable stress patch for real-time cortisol monitoring using a pseudoknot-assisted aptamer
A non-invasive wearable stress patch for real-time cortisol monitoring using a pseudoknot-assisted aptamer Open
Stress is part of everyone's life and is exacerbated by traumatic events such as pandemics, disasters, violence, lifestyle changes, and health disorders. Chronic stress has many detrimental health effects and can even be life-threatening. …
View article: Integrated Circuits for Biomedical Applications [Guest Editorial]
Integrated Circuits for Biomedical Applications [Guest Editorial] Open
Biomedical systems that interface with the body and nervous system in wearable and implantable formats are becoming an ever more important tool in our quest to enhance wellness and improve health care. The global medical electronics market…
View article: Quantifying Biomedical Amplifier Efficiency: The noise efficiency factor
Quantifying Biomedical Amplifier Efficiency: The noise efficiency factor Open
There has been a long-standing interest in controlling and instrumenting the human body. Whether to restore lost function with neural prosthetics, monitor blood glucose levels, or augment human capabilities, there are countless opportuniti…
View article: Biometric recognition of newborns and young children for vaccinations and health care: a non-randomized prospective clinical trial
Biometric recognition of newborns and young children for vaccinations and health care: a non-randomized prospective clinical trial Open
Although universal biometrics have been broadly called for, and there are many validated technologies to recognize adults, these technologies have been ineffective in newborns and young children. The present work describes the development …
View article: Electrochemical Carbamazepine Aptasensor for Therapeutic Drug Monitoring at the Point of Care
Electrochemical Carbamazepine Aptasensor for Therapeutic Drug Monitoring at the Point of Care Open
[Image: see text] Monitoring the anti-epileptic drug carbamazepine (CBZ) is crucial for proper dosing, optimizing a patient’s clinical outcome, and managing their medication regimen. Due to its narrow therapeutic window and concentration-r…
View article: Biometric recognition of newborns and young children for vaccinations and health care: A non- randomized prospective clinical trial
Biometric recognition of newborns and young children for vaccinations and health care: A non- randomized prospective clinical trial Open
Although universal biometrics have been broadly called for, and there are many validated technologies to recognize adults, these technologies have been ineffective in newborns and young children. The present work describes the development …
View article: Exploration of Human Serum Lipoprotein Supramolecular Phospholipids Using Statistical Heterospectroscopy in <i>n</i>-Dimensions (SHY-<i>n</i>): Identification of Potential Cardiovascular Risk Biomarkers Related to SARS-CoV-2 Infection
Exploration of Human Serum Lipoprotein Supramolecular Phospholipids Using Statistical Heterospectroscopy in <i>n</i>-Dimensions (SHY-<i>n</i>): Identification of Potential Cardiovascular Risk Biomarkers Related to SARS-CoV-2 Infection Open
SARS-CoV-2 infection causes a significant reduction in lipoprotein-bound serum phospholipids give rise to supramolecular phospholipid composite (SPC) signals observed in diffusion and relaxation edited 1H NMR spectra. To characterize the c…
View article: Molecular electronics sensors on a scalable semiconductor chip: A platform for single-molecule measurement of binding kinetics and enzyme activity
Molecular electronics sensors on a scalable semiconductor chip: A platform for single-molecule measurement of binding kinetics and enzyme activity Open
For nearly 50 years, the vision of using single molecules in circuits has been seen as providing the ultimate miniaturization of electronic chips. An advanced example of such a molecular electronics chip is presented here, with the importa…
View article: J-Edited DIffusional Proton Nuclear Magnetic Resonance Spectroscopic Measurement of Glycoprotein and Supramolecular Phospholipid Biomarkers of Inflammation in Human Serum
J-Edited DIffusional Proton Nuclear Magnetic Resonance Spectroscopic Measurement of Glycoprotein and Supramolecular Phospholipid Biomarkers of Inflammation in Human Serum Open
Proton nuclear magnetic resonance (NMR) N-acetyl signals (Glyc) from glycoproteins and supramolecular phospholipids composite peak (SPC) from phospholipid quaternary nitrogen methyls in subcompartments of lipoprotein particles) can give im…
View article: Direct low field J-edited diffusional proton NMR spectroscopic measurement of COVID-19 inflammatory biomarkers in human serum
Direct low field J-edited diffusional proton NMR spectroscopic measurement of COVID-19 inflammatory biomarkers in human serum Open
A JEDI NMR pulse experiment incorporating relaxation, diffusion and J-modulation peak editing was implemented at a low field (80 MHz) spectrometer system to quantify two recently discovered plasma markers of SARS-CoV-2 infection and genera…
View article: Low-Power RF Wake-Up Receivers: Analysis, Tradeoffs, and Design
Low-Power RF Wake-Up Receivers: Analysis, Tradeoffs, and Design Open
Wake-up receivers (WuRXs) offer a potentially energy-efficient means to enable asynchronous wake-up of higher power and higher performance radios without needing frequent (often energy-expensive) synchronization. Since WuRXs are typically …
View article: Point-of-care human milk testing for maternal secretor status
Point-of-care human milk testing for maternal secretor status Open
We present an electrochemical impedimetric-based biosensor for monitoring the variation in human milk oligosaccharide (HMO) composition. 2′-Fucosyllactose (2’FL) is an HMO associated with infant growth, cognitive development, and protectio…
View article: Cortisol Detection in Undiluted Human Serum Using a Sensitive Electrochemical Structure-Switching Aptamer over an Antifouling Nanocomposite Layer
Cortisol Detection in Undiluted Human Serum Using a Sensitive Electrochemical Structure-Switching Aptamer over an Antifouling Nanocomposite Layer Open
There is a strong and growing need to monitor stress biomarkers in vivo for real-time emotional and wellness assessment. Toward this, we report a reagent-free electrochemical aptasensor with a nanocomposite antifouling layer for sensitive …
View article: Plasmonic Sensing Studies of a Gas-Phase Cystic Fibrosis Marker in Moisture Laden Air
Plasmonic Sensing Studies of a Gas-Phase Cystic Fibrosis Marker in Moisture Laden Air Open
A plasmonic sensing platform was developed as a noninvasive method to monitor gas-phase biomarkers related to cystic fibrosis (CF). The nanohole array (NHA) sensing platform is based on localized surface plasmon resonance (LSPR) and offers…