Drew Helmus
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View article: Wearable devices detect physiological changes that precede and are associated with symptomatic and inflammatory rheumatoid arthritis flares
Wearable devices detect physiological changes that precede and are associated with symptomatic and inflammatory rheumatoid arthritis flares Open
Physiological parameters are altered in rheumatoid arthritis (RA). We evaluated whether changes in physiological metrics, collected from wearable devices, identify and precede the development of both symptomatic and inflammatory RA flares.…
View article: Wearable Devices Detect Physiological Changes that Precede and Are Associated with Symptomatic and Inflammatory Rheumatoid Arthritis Flares
Wearable Devices Detect Physiological Changes that Precede and Are Associated with Symptomatic and Inflammatory Rheumatoid Arthritis Flares Open
Physiological parameters are altered in rheumatoid arthritis (RA). We evaluated whether changes in physiological metrics, collected from wearable devices, identify and precede the development of both symptomatic and inflammatory RA flares.…
View article: Automated Digital Outreach with Human in the Loop is an Effective strategy for Recruitment and Electronic Patient Reported Outcomes: Results from All4IBD Multi-Centric Pragmatic Trial
Automated Digital Outreach with Human in the Loop is an Effective strategy for Recruitment and Electronic Patient Reported Outcomes: Results from All4IBD Multi-Centric Pragmatic Trial Open
Objectives Patient recruitment is a critical factor for successful completion of a clinical trial. Decentralized trial recruitment allows potential subjects to be identified via the electronic health record (EHR) and approached through dig…
View article: Inflammatory disease microbiomes share a functional pathogenicity predicted by C-reactive protein
Inflammatory disease microbiomes share a functional pathogenicity predicted by C-reactive protein Open
We examine disease-specific and cross-disease functions of the human gut microbiome by colonizing germ-free mice, at risk for inflammatory arthritis, colitis, or neuroinflammation, with over 100 human fecal microbiomes from subjects with r…
View article: Age-related patterns of microbial dysbiosis in multiplex inflammatory bowel disease families
Age-related patterns of microbial dysbiosis in multiplex inflammatory bowel disease families Open
Objective IBD is characterised by dysbiosis, but it remains unclear to what extent dysbiosis develops in unaffected at-risk individuals. To address this, we investigated age-related patterns of faecal and serum markers of dysbiosis in high…
View article: Remote Short Sessions of Heart Rate Variability Biofeedback Monitored With Wearable Technology: Open-Label Prospective Feasibility Study
Remote Short Sessions of Heart Rate Variability Biofeedback Monitored With Wearable Technology: Open-Label Prospective Feasibility Study Open
Background Heart rate variability (HRV) biofeedback is often performed with structured education, laboratory-based assessments, and practice sessions. It has been shown to improve psychological and physiological function across populations…
View article: Longitudinal monitoring of IL-6 and CRP in inflammatory bowel disease using IBD-AWARE
Longitudinal monitoring of IL-6 and CRP in inflammatory bowel disease using IBD-AWARE Open
There are limitations to monitoring modalities for chronic inflammatory conditions, including inflammatory bowel disease (IBD). Wearable devices are scalable mobile health technology that present an opportunity to monitor markers that have…
View article: Cytokine signature in convalescent SARS-CoV-2 patients with inflammatory bowel disease receiving vedolizumab
Cytokine signature in convalescent SARS-CoV-2 patients with inflammatory bowel disease receiving vedolizumab Open
While differential antibody responses SARS-CoV-2 in patients with inflammatory bowel disease (IBD) receiving infliximab and vedolizumab are well-characterized, the immune pathways underlying these differences remain unknown. Prior to COVID…
View article: Remote Short Sessions of Heart Rate Variability Biofeedback Monitored With Wearable Technology: Open-Label Prospective Feasibility Study (Preprint)
Remote Short Sessions of Heart Rate Variability Biofeedback Monitored With Wearable Technology: Open-Label Prospective Feasibility Study (Preprint) Open
BACKGROUND Heart rate variability (HRV) biofeedback is often performed with structured education, laboratory-based assessments, and practice sessions. It has been shown to improve psychological and physiological function across population…
View article: Antibody, not Cellular, Immune Responses to SARS-CoV-2 Vaccination Outperform Infection in Inflammatory Bowel Disease Patients
Antibody, not Cellular, Immune Responses to SARS-CoV-2 Vaccination Outperform Infection in Inflammatory Bowel Disease Patients Open
Following the successful development of the first vaccines to protect against SARS-CoV-2 infection, the International Organization for the Study of Inflammatory Bowel Disease (IOIBD) recommended full vaccination of all patients with inflam…
View article: Geography Influences Susceptibility to SARS-CoV-2 Serological Response in Patients With Inflammatory Bowel Disease: Multinational Analysis From the ICARUS-IBD Consortium
Geography Influences Susceptibility to SARS-CoV-2 Serological Response in Patients With Inflammatory Bowel Disease: Multinational Analysis From the ICARUS-IBD Consortium Open
Background Beyond systematic reviews and meta-analyses, there have been no direct studies of serological response to COVID-19 in patients with inflammatory bowel disease (IBD) across continents. In particular, there has been limited data f…
View article: Selective IgA2 deficiency in a patient with small intestinal Crohn’s disease
Selective IgA2 deficiency in a patient with small intestinal Crohn’s disease Open
Selective IgA 2 deficiency in a patient with small intestinal Crohn's disease
View article: A machine learning approach to determine resilience utilizing wearable device data: analysis of an observational cohort
A machine learning approach to determine resilience utilizing wearable device data: analysis of an observational cohort Open
Objective To assess whether an individual’s degree of psychological resilience can be determined from physiological metrics passively collected from a wearable device. Materials and Methods Data were analyzed in this secondary analysis of …
View article: LONGITUDINAL MONITORING OF INFLAMMATORY BOWEL DISEASE ACTIVITY USING WEARABLE DEVICES THROUGH INFLAMMATORY MARKERS IN SWEAT
LONGITUDINAL MONITORING OF INFLAMMATORY BOWEL DISEASE ACTIVITY USING WEARABLE DEVICES THROUGH INFLAMMATORY MARKERS IN SWEAT Open
BACKGROUND Current methods to monitor inflammatory bowel disease (IBD) activity, such as colonoscopy, blood and stool markers, or imaging, are suboptimal and rely on single timepoint assessments that are inconvenient, expensive, or invasiv…
View article: INCORPORATION OF RISK ASSESSMENT TOOL IMPACTS PATIENT AND GASTROENTEROLOGIST CONFIDENCE AND TREATMENT DECISION MAKING IN BIONAIVE CROHN’S DISEASE
INCORPORATION OF RISK ASSESSMENT TOOL IMPACTS PATIENT AND GASTROENTEROLOGIST CONFIDENCE AND TREATMENT DECISION MAKING IN BIONAIVE CROHN’S DISEASE Open
BACKGROUND Clinical guidelines recommend the incorporation of risk stratification assessments when making decisions about Crohn’s disease (CD) treatment. We aimed to evaluate if patient and gastroenterologist (GI) decision making and confi…
View article: PHYSIOLOGICAL METRICS COLLECTED FROM WEARABLE DEVICES IDENTIFY INFLAMMATORY AND CLINICAL INFLAMMATORY BOWEL DISEASE FLARES
PHYSIOLOGICAL METRICS COLLECTED FROM WEARABLE DEVICES IDENTIFY INFLAMMATORY AND CLINICAL INFLAMMATORY BOWEL DISEASE FLARES Open
BACKGROUND Inflammatory bowel disease (IBD) flares are common and unpredictable. Disease monitoring relies on symptom reporting or single timepoint assessments of stool, blood, imaging, or endoscopy—these are inconvenient and invasive and …
View article: Gut microbiota bacterial strain richness is species specific and limits therapeutic engraftment
Gut microbiota bacterial strain richness is species specific and limits therapeutic engraftment Open
Despite the fundamental role of strain variation in gut microbiota function, the number of unique strains of a species that can stably colonize the human gut is still unknown. In this work, we determine the strain richness of common gut sp…
View article: Evaluation of a machine learning approach utilizing wearable data for prediction of SARS-CoV-2 infection in healthcare workers
Evaluation of a machine learning approach utilizing wearable data for prediction of SARS-CoV-2 infection in healthcare workers Open
Objective To determine whether a machine learning model can detect SARS-CoV-2 infection from physiological metrics collected from wearable devices. Materials and Methods Health care workers from 7 hospitals were enrolled and prospectively …
View article: P342 Trans-continental analysis of over, 2000 Inflammatory Bowel Disease patients implicates geography, disease type, and exposure to immunosuppression as drivers of SARS-CoV-2 seroprevalence: data from the ICARUS-IBD Consortium
P342 Trans-continental analysis of over, 2000 Inflammatory Bowel Disease patients implicates geography, disease type, and exposure to immunosuppression as drivers of SARS-CoV-2 seroprevalence: data from the ICARUS-IBD Consortium Open
Background IBD patients on immune-modulatory therapies are considered high-risk for SARS-CoV-2 infection. Direct comparisons of serological responses to SARS-CoV-2 infection in IBD patients across different continents and medications are l…
View article: DOP20 Functional viral neutralisation responses after SARS-CoV-2 infection in Inflammatory Bowel Disease patients receiving infusion therapies: Report from the ICARUS-IBD Consortium
DOP20 Functional viral neutralisation responses after SARS-CoV-2 infection in Inflammatory Bowel Disease patients receiving infusion therapies: Report from the ICARUS-IBD Consortium Open
Background Recent data have highlighted adverse clinical outcomes in IBD patients treated with infliximab/thiopurines (IFX/THIO) upon infection with SARS-CoV-2, as well as attenuated serological responses after infection and vaccination in…
View article: Evaluation of a Machine Learning Approach Utilizing Wearable Data for Prediction of SARS-CoV-2 Infection in Healthcare Workers
Evaluation of a Machine Learning Approach Utilizing Wearable Data for Prediction of SARS-CoV-2 Infection in Healthcare Workers Open
Importance Passive and non-invasive identification of SARS-CoV-2 infection remains a challenge. Widespread use of wearable devices represents an opportunity to leverage physiological metrics and fill this knowledge gap. Objective To determ…
View article: Factors Associated With Longitudinal Psychological and Physiological Stress in Health Care Workers During the COVID-19 Pandemic: Observational Study Using Apple Watch Data
Factors Associated With Longitudinal Psychological and Physiological Stress in Health Care Workers During the COVID-19 Pandemic: Observational Study Using Apple Watch Data Open
Background The COVID-19 pandemic has resulted in a high degree of psychological distress among health care workers (HCWs). There is a need to characterize which HCWs are at an increased risk of developing psychological effects from the pan…
View article: Factors Associated With Longitudinal Psychological and Physiological Stress in Health Care Workers During the COVID-19 Pandemic: Observational Study Using Apple Watch Data (Preprint)
Factors Associated With Longitudinal Psychological and Physiological Stress in Health Care Workers During the COVID-19 Pandemic: Observational Study Using Apple Watch Data (Preprint) Open
BACKGROUND The COVID-19 pandemic has resulted in a high degree of psychological distress among health care workers (HCWs). There is a need to characterize which HCWs are at an increased risk of developing psychological effects from the pa…
View article: P362 Longitudinal antibody response to SARS-CoV-2 infection and antibody responses to COVID-19 vaccination in Inflammatory Bowel Disease patients receiving biologics
P362 Longitudinal antibody response to SARS-CoV-2 infection and antibody responses to COVID-19 vaccination in Inflammatory Bowel Disease patients receiving biologics Open
Background Given that IBD patients were excluded from COVID-19 vaccine trials, there is a lack of vaccine efficacy data in this population. In this study, we evaluated longitudinal serological responses to SARS-CoV-2 infection as well as t…
View article: Safety of administering biologics to IBD patients at an outpatient infusion center In New York City during the COVID-19 pandemic: Sars-CoV-2 seroprevalence and clinical and social characteristics
Safety of administering biologics to IBD patients at an outpatient infusion center In New York City during the COVID-19 pandemic: Sars-CoV-2 seroprevalence and clinical and social characteristics Open
Patients with immune-mediated inflammatory diseases (IMIDs) and acquired and genetic immunodeficiencies receiving therapeutic infusions are considered high risk for SARS-CoV-2 infection. However, the seroprevalance in this group and the sa…