Explanipedia

Clinical sequelae of gut microbiome development and disruption in hospitalized preterm infants Open

Robert Thänert, Drew J. Schwartz, Eric C. Keen, Carla Hall-Moore, Bin Wang , et al. · 2024

Clinical sequelae of gut microbiome development and disruption in hospitalized preterm infants Open

Robert Thänert, Drew J. Schwartz, Eric C. Keen, Carla Hall-Moore, Bin Wang , et al. · 2024

Aberrant preterm infant gut microbiota assembly predisposes to early-life disorders and persistent health problems. Here, we characterize gut microbiome dynamics over the first 3 months of life in 236 preterm infants hospitalized in three …

Effect of amoxicillin on the gut microbiome of children with severe acute malnutrition in Madarounfa, Niger: a retrospective metagenomic analysis of a placebo-controlled trial Open

Drew J. Schwartz, Amy Langdon, Xiaoqing Sun, Céline Langendorf, Fatou Berthé , et al. · 2023

Bill & Melinda Gates Foundation; Médecins sans Frontières Operational Center Paris; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Eunice Kennedy Shriver National Institute of Child H…

Gut pathogen colonization precedes bloodstream infection in the neonatal intensive care unit Open

Drew J. Schwartz, Nitan Shalon, Kate E Wardenburg, Anna L. DeVeaux, Meghan A. Wallace , et al. · 2023

Bacterial bloodstream infections (BSIs) resulting in late-onset sepsis affect up to half of extremely preterm infants and have substantial morbidity and mortality. Bacterial species associated with BSIs in neonatal intensive care units (NI…

The gut metagenome harbors metabolic and antibiotic resistance signatures of moderate-to-severe asthma Open

Naomi G. Wilson, Ariel Hernandez-Leyva, Drew J. Schwartz, Leonard B. Bacharier, Andrew L. Kau · 2023

Asthma is a common allergic airway disease that develops in association with the human microbiome early in life. Both the composition and function of the infant gut microbiota have been linked to asthma risk, but functional alterations in …

Impact of international travel and diarrhea on gut microbiome and resistome dynamics Open

Manish Boolchandani, Kevin S. Blake, Drake H. Tilley, Miguel M. Cabada, Drew J. Schwartz , et al. · 2022

Taxonomic changes in the microbiota are associated with cartilage damage in a mouse model of high-fat diet and OA Open

Kelsey H. Collins, Drew J. Schwartz, Kristin L. Lenz, Charles Harris, Farshid Guilak · 2021

#24: Death is Antibiotic-Microbiota Dependent in a Humanized Mouse Model of Late-Onset Neonatal Sepsis Open

Drew J. Schwartz, Alaric W. D’Souza, Terence S. Crofts, Jie Ning, Nitan Shalon , et al. · 2021

Background Premature infants receive antibiotics frequently for culture-negative sepsis, which diminishes gut microbial diversity and increases susceptibility to infections by antibiotic-resistant pathogens. Neonates with decreased gut mic…

Correction to: Understanding the impact of antibiotic perturbation on the human microbiome Open

Drew J. Schwartz, Amy Langdon, Gautam Dantas · 2021

Improving ICI outcomes with a little help from my microbial friends Open

Olivia N. Rebeck, Gautam Dantas, Drew J. Schwartz · 2021

Additional file 6 of Microbiota restoration reduces antibiotic-resistant bacteria gut colonization in patients with recurrent Clostridioides difficile infection from the open-label PUNCH CD study Open

Amy Langdon, Drew J. Schwartz, Christopher Bulow, Xiaoqing Sun, Tiffany Hink , et al. · 2021

Additional file 6. The two tables show the total ARG hits in RPKM for donors and patients at each sample collection timepoint, as well as the standard deviation and variance over time.

Additional file 3 of Microbiota restoration reduces antibiotic-resistant bacteria gut colonization in patients with recurrent Clostridioides difficile infection from the open-label PUNCH CD study Open

Amy Langdon, Drew J. Schwartz, Christopher Bulow, Xiaoqing Sun, Tiffany Hink , et al. · 2021

Additional file 3. All genomic resistance gene annotations from Resfinder for all MDRO isolates are listed here, with their specific genomic location, predicted phenotype, and % identity to reference genes.

Additional file 4 of Microbiota restoration reduces antibiotic-resistant bacteria gut colonization in patients with recurrent Clostridioides difficile infection from the open-label PUNCH CD study Open

Amy Langdon, Drew J. Schwartz, Christopher Bulow, Xiaoqing Sun, Tiffany Hink , et al. · 2021

Additional file 4. The eradication status of ARO found in each patient is summarized here. If the first sample (notated as Patient ID – Dose number – Days from previous dose) was positive according to the ASV quantified by DADA2 and the la…

Additional file 2 of Microbiota restoration reduces antibiotic-resistant bacteria gut colonization in patients with recurrent Clostridioides difficile infection from the open-label PUNCH CD study Open

Amy Langdon, Drew J. Schwartz, Christopher Bulow, Xiaoqing Sun, Tiffany Hink , et al. · 2021

Additional file 2. This table shows cultured isolates, their associated ASVs, their taxonomy assignments according to DADA2 and MALDI-TOF, and antibiotic sensitivity results in terms of their clearance zone sizes and the interpretations of…

2847. Comparative Genomics and Clonal Tracking of Multi-drug-Resistant Uropathogens Implicates the Fecal Microbiome as a Potential Reservoir for Recurrent Urinary Tract Infections Open

Robert Thänert, Kimberly A. Reske, Tiffany Hink, Meghan A. Wallace, Bin Wang , et al. · 2019

Background Multi-drug-resistant organisms (MDRO) have complicated the treatment of urinary tract infections (UTIs), especially in patients with recurrent UTIs (rUTI). The objective of this pilot prospective cohort study is to determine the…

Complex interactions between the microbiome and cancer immune therapy Open

Drew J. Schwartz, Olivia N. Rebeck, Gautam Dantas · 2019

Immuno-oncology has rapidly grown in the last thirty years, and immunotherapeutic agents are now approved to treat many disparate cancers. Immune checkpoint inhibitors (ICIs) are employed to augment cytotoxic anti-cancer activity by inhibi…

<i>Ureaplasma urealyticum</i> pyelonephritis presenting with progressive dysuria, renal failure, and neurologic symptoms in an immunocompromised patient Open

Drew J. Schwartz, Alexis Elward, Gregory A. Storch, David A. Rosen · 2018

Ureaplasma urealyticum is a bacterial species correlated with urethritis in healthy individuals and invasive infections in immunocompromised patients. We describe a 20‐year‐old female with a history of remote heart transplant on everolimus…

A mucosal imprint left by prior Escherichia coli bladder infection sensitizes to recurrent disease Open

Valerie P. O’Brien, Thomas J. Hannan, Lu Yu, Jonathan Livny, Elisha Roberson , et al. · 2016

Subinhibitory Antibiotic Therapy Alters Recurrent Urinary Tract Infection Pathogenesis through Modulation of Bacterial Virulence and Host Immunity Open

Lee Goneau, Thomas J. Hannan, Roderick A. MacPhee, Drew J. Schwartz, Jean M. Macklaim , et al. · 2015

The capacity of subinhibitory levels of antibiotics to modulate bacterial virulence in vitro has recently been brought to light, raising concerns over the appropriateness of low-dose therapies, including antibiotic prophylaxis for recurren…

Uropathogenic Escherichia coli Superinfection Enhances the Severity of Mouse Bladder Infection Open

Drew J. Schwartz, Matt S. Conover, Thomas J. Hannan, Scott J. Hultgren · 2015

Urinary tract infections (UTIs) afflict over 9 million women in America every year, often necessitating long-term prophylactic antibiotics. One risk factor for UTI is frequent sexual intercourse, which dramatically increases the risk of UT…

Understanding Escherichia coli Urinary Tract Infection: A Niche Perspective Open

Drew J. Schwartz · 2015

Urinary tract infections (UTIs) are among the most common bacterial infections worldwide, costing greater than $2 billion in healthcare costs and lost wages yearly in America alone. The lifetime risk for a woman exceeds 50% with 25-40% of …

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