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View article: Mir-16 Decreases the Expression of VTI1B and SMPD1, Genes Involved in Membrane-Protein Trafficking in Melanoma
Mir-16 Decreases the Expression of VTI1B and SMPD1, Genes Involved in Membrane-Protein Trafficking in Melanoma Open
Introduction: The interface between T cells and the tumor microenvironment, termed the ‘immunological synapse’, consists of multiple checkpoint protein pairs co-expressed on both sides of the synapse. mir-16, a microRNA from a widely known…
View article: The Epidemiology of PCR-Confirmed Cutaneous Leishmaniasis in Israel: A Nationwide Study
The Epidemiology of PCR-Confirmed Cutaneous Leishmaniasis in Israel: A Nationwide Study Open
Background: Leishmaniasis, mainly cutaneous leishmaniasis (CL), is endemic in Israel. In recent years, the diagnosis of leishmaniasis has transitioned to a molecular diagnosis. Objective: To summarize all cases of leishmaniasis and the ide…
View article: The selective effect of Ivermectin on different human coronaviruses; in-vitro study
The selective effect of Ivermectin on different human coronaviruses; in-vitro study Open
Background: The outbreak of coronavirus disease COVID-19, caused by Severe Acute Respiratory Coronavirus-2 (SARS-CoV-2) has become an urgent public health concern worldwide. Although several clinical trials have pointed to new drugs with s…
View article: Abstract 1373 The inhibitory effect of miR-190a on GRHL-1 as a novel avenue for diagnosis and treatment of psoriasis
Abstract 1373 The inhibitory effect of miR-190a on GRHL-1 as a novel avenue for diagnosis and treatment of psoriasis Open
Psoriasis is an incurable auto-inflammatory chronic skin disease. Despite its common prevalence worldwide, it is extensively complex on the cellular, genomic, and genetic levels. Psoriasis is characterized by hyper-proliferation and dediff…
View article: Cutaneous Leishmaniasis Caused by <i>Leishmania infantum</i>, Israel, 2018–2021
Cutaneous Leishmaniasis Caused by <i>Leishmania infantum</i>, Israel, 2018–2021 Open
Cutaneous leishmaniasis (CL) is endemic to Israel. Previously, CL caused by Leishmania infantum had been reported in Israel only once (in 2016). We report 8 L. infantum CL cases; 7 occurred during 2020-2021. None of the patients had system…
View article: MiR-199a-3p Induces Mesenchymal to Epithelial Transition of Keratinocytes by Targeting RAP2B
MiR-199a-3p Induces Mesenchymal to Epithelial Transition of Keratinocytes by Targeting RAP2B Open
Cutaneous squamous cell carcinoma (CSCC) is an epidermal skin cancer that evolves from normal epidermis along several pre-malignant stages. Previously we found specific miRNAs alterations in each step along these stages. miR-199a-3p expres…
View article: Failure to Detect Leishmania in the Blood of Patients with Old-World Cutaneous Leishmaniasis: Implications for Blood Donation
Failure to Detect Leishmania in the Blood of Patients with Old-World Cutaneous Leishmaniasis: Implications for Blood Donation Open
Cutaneous leishmaniasis (CL) is endemic in Israel, caused mainly by Leishmania major ( L. major ) and L. tropica . In addition, returning travelers import another leishmanial species such as L. braziliensis. Although we are dealing with a …
View article: Associations between T cell infiltration, T cell receptor clonality, histology and recurrence in renal cell carcinoma
Associations between T cell infiltration, T cell receptor clonality, histology and recurrence in renal cell carcinoma Open
Summary Renal cell carcinoma (RCC) is comprised of clear-cell (ccRCC) and non-clear-cell (nccRCC) tumors. Despite definitive surgical resection in localized disease, recurrence often occurs. A commercial method based on a multiplex polymer…
View article: Extracellular Vesicles: Schistosomal Long-Range Precise Weapon to Manipulate the Immune Response
Extracellular Vesicles: Schistosomal Long-Range Precise Weapon to Manipulate the Immune Response Open
Schistosomiasis (Bilharziasis), a neglected tropical disease that affects more than 240 million people around the world, is caused by infection with the helminth parasite Schistosoma . As part of their secretome, schistosomes release extra…
View article: Comprehensive Analysis of Correlations in the Expression of miRNA Genes and Immune Checkpoint Genes in Bladder Cancer Cells
Comprehensive Analysis of Correlations in the Expression of miRNA Genes and Immune Checkpoint Genes in Bladder Cancer Cells Open
Personalised medicine is the future and hope for many patients, including those with cancers. Early detection, as well as rapid, well-selected treatment, are key factors leading to a good prognosis. MicroRNA mediated gene regulation is a p…
View article: Giardia lamblia miRNAs as a new diagnostic tool for human giardiasis
Giardia lamblia miRNAs as a new diagnostic tool for human giardiasis Open
Giardia miR5 testing in duodenal biopsies may be a new method for the diagnosis of giardiasis. It seems to be more sensitive when compared with testing for Giardia DNA by qPCR in duodenal biopsies. It will be important to investigate the c…
View article: Decreased A-to-I RNA editing as a source of keratinocytes' dsRNA in psoriasis
Decreased A-to-I RNA editing as a source of keratinocytes' dsRNA in psoriasis Open
Recognition of dsRNA molecules activates the MDA5–MAVS pathway and plays a critical role in stimulating type-I interferon responses in psoriasis. However, the source of the dsRNA accumulation in psoriatic keratinocytes remains largely unkn…
View article: The contribution of feedback loops between miRNAs, cytokines and growth factors to the pathogenesis of psoriasis
The contribution of feedback loops between miRNAs, cytokines and growth factors to the pathogenesis of psoriasis Open
The present review describes in detail the existent data regarding feedback loops between miRNAs and cytokines or growth factors in the psoriatic inflammation. We have chosen to describe the roles of miR‐31, miR‐21, miR‐146a, miR‐155, miR‐…
View article: Schistosomal miRNAs isolated from Extracellular Vesicles in sera of infected patients; a new tool for diagnosis and follow-up of human schistosomiasis
Schistosomal miRNAs isolated from Extracellular Vesicles in sera of infected patients; a new tool for diagnosis and follow-up of human schistosomiasis Open
qRT-PCR of pathogen miRNAs isolated from extracellular vesicles in sera from infected individuals may provide a new tool for diagnosing schistosomiasis in patients with a low parasite burden. This assay could also be used for evaluating th…
View article: Promoter-Associated RNAs Regulate HSPC152 Gene Expression in Malignant Melanoma
Promoter-Associated RNAs Regulate HSPC152 Gene Expression in Malignant Melanoma Open
The threshold of 200 nucleotides (nt) conventionally divides non-coding RNAs (ncRNA) into long ncRNA (lincRNA, that have more than 200 nt in length) and the remaining ones which are grouped as “small” RNAs (microRNAs, small nucleolar RNAs …